48 research outputs found
A new electrochemical method for the determination of chondroitin sulfate based on its supramolecular interaction with cupferron-lead(II) complex
In this paper, the interaction of cupferron (Cup) and lead (II) complex
[Cup-Pb (II)] with chondroitin sulfate (CS) was investigated by linear sweep
voltammetric method. In the selected medium of pH 5.5 (acetic acid-hexamine
buffer solution), Cup can interact with Pb (II) to form a stable complex of
[Cup-Pb(II)], which has a sensitive second order derivative polarographic
reductive peak at -0.64V (vs.SCE). After the addition of CS into Cup-Pb (II)
complex solution, the reductive peak current decreased without any shift of
the peak potential and no new peak appeared, which indicated that an
unelectroactive supramolecular complex of CS with [Cup-Pb(II)] was formed.
The binding reaction conditions were carefully investigated. Under the
optimal conditions, the interaction mechanism was discussed. The decrease of
reductive peak current was directly proportional to the CS concentration,
thus a new quantitative determination method for CS was established with the
linear regression equation as ΔIp″(nA)=36.97 C/mg L-1+12.45 (n=10, γ=0.995).
The effects of other substances on the determination were carefully
investigated and three synthetic samples were determined with satisfactory
results. The binding constant (βs) and the binding number (m) of CS with
[Cup-Pb(II)] complex were calculated from the voltammetric data with the
results as βs=1.89×1010 and m≈2.5
Genetic and functional characterization of disease associations explains comorbidity
Understanding relationships between diseases, such as
comorbidities, has important socio-economic implications,
ranging from clinical study design to health care planning. Most
studies characterize disease comorbidity using shared genetic
origins, ignoring pathway-based commonalities between diseases.
In this study, we define the disease pathways using an
interactome-based extension of known disease-genes and introduce
several measures of functional overlap. The analysis reveals 206
significant links among 94 diseases, giving rise to a highly
clustered disease association network. We observe that around
95% of the links in the disease network, though not identified
by genetic overlap, are discovered by functional overlap. This
disease network portraits rheumatoid arthritis, asthma,
atherosclerosis, pulmonary diseases and Crohn's disease as hubs
and thus pointing to common inflammatory processes underlying
disease pathophysiology. We identify several described
associations such as the inverse comorbidity relationship
between Alzheimer's disease and neoplasms. Furthermore, we
investigate the disruptions in protein interactions by mapping
mutations onto the domains involved in the interaction,
suggesting hypotheses on the causal link between diseases.
Finally, we provide several proof-of-principle examples in which
we model the effect of the mutation and the change of the
association strength, which could explain the observed
comorbidity between diseases caused by the same genetic
alterations
Integrated mRNA and microRNA analysis identifies genes and small miRNA molecules associated with transcriptional and post-transcriptional-level responses to both drought stress and re-watering treatment in tobacco
Potential for forest vegetation carbon storage in Fujian Province, China, determined from forest inventories
An inverse random source problem in a stochastic fractional diffusion equation
In this work the authors consider an inverse source problem the stochastic fractional diffusion equation. The interested inverse problem is to reconstruct the unknown spatial functions f and g (the latter up to the sign) in the source by the statistics of the final time data u(x, T). Some direct problem results are proved at first, such as the existence, uniqueness, representation and regularity of the solution. Then a reconstruction scheme for f and g up to the sign is given. To tackle the ill-posedness, Tikhonov regularization is adopted and some numerical results are displayed.Peer reviewe
Highly Sensitive Detection of Trace Tetracycline in Water Using a Metal-Organic Framework-Enabled Sensor
Due to the abuse application of antibiotics in the recent decades, a high level of antibiotics has been let out and remains in our environment. Electrochemical sensing is a useful method to sensitively detect antibiotics, and the key factor for a successful electrochemical sensor is the active electrode materials. In this study, a sensitive electrochemical sensing platform based on a metal-organic framework (MOF) of MIL-53 (Fe) was facilely fabricated. It shows highly selective and sensitive detection performance for trace tetracycline. Differential pulse voltammetry (DPV) was applied to analyze the detection of tetracycline. The linear range of tetracycline detection was 0.0643 μmol/L-1.53 μmol/L, and the limit of detection (LOD) is 0.0260 μmol/L. Furthermore, the MOF-enabled sensor can be effectively used in actual water bodies. The results indicate that the electrochemical sensor is a high potential sensing platform for tetracycline
Induced Systemic Resistance against Botrytis cinerea by Bacillus cereus AR156 through a JA/ET- and NPR1-Dependent Signaling Pathway and Activates PAMP-Triggered Immunity in Arabidopsis
Additional file 2 of The role of proteoglycan form of DMP1 in cranial repair
Additional file 2