11 research outputs found
A Bayesian analysis of pentaquark signals from CLAS data
We examine the results of two measurements by the CLAS collaboration, one of
which claimed evidence for a pentaquark, whilst the other found no
such evidence. The unique feature of these two experiments was that they were
performed with the same experimental setup. Using a Bayesian analysis we find
that the results of the two experiments are in fact compatible with each other,
but that the first measurement did not contain sufficient information to
determine unambiguously the existence of a . Further, we suggest a
means by which the existence of a new candidate particle can be tested in a
rigorous manner.Comment: 5 pages, 3 figure
First measurement of direct photoproduction on the proton
We report on the results of the first measurement of exclusive
meson photoproduction on protons for GeV and GeV. Data were collected with the CLAS detector at the Thomas
Jefferson National Accelerator Facility. The resonance was detected via its
decay in the channel by performing a partial wave analysis of the
reaction . Clear evidence of the meson
was found in the interference between and waves at GeV. The -wave differential cross section integrated in the mass range of
the was found to be a factor of 50 smaller than the cross section
for the meson. This is the first time the meson has been
measured in a photoproduction experiment
Supplemental Association of Clonal Hematopoiesis With Incident Heart Failure
Background: Age-related clonal hematopoiesis of indeterminate potential (CHIP), defined as clonally expanded leukemogenic sequence variations (particularly in DNMT3A, TET2, ASXL1, and JAK2) in asymptomatic individuals, is associated with cardiovascular events, including recurrent heart failure (HF). Objectives: This study sought to evaluate whether CHIP is associated with incident HF. Methods: CHIP status was obtained from whole exome or genome sequencing of blood DNA in participants without prevalent HF or hematological malignancy from 5 cohorts. Cox proportional hazards models were performed within each cohort, adjusting for demographic and clinical risk factors, followed by fixed-effect meta-analyses. Large CHIP clones (defined as variant allele frequency >10%), HF with or without baseline coronary heart disease, and left ventricular ejection fraction were evaluated in secondary analyses. Results: Of 56,597 individuals (59% women, mean age 58 years at baseline), 3,406 (6%) had CHIP, and 4,694 developed HF (8.3%) over up to 20 years of follow-up. CHIP was prospectively associated with a 25% increased risk of HF in meta-analysis (hazard ratio: 1.25; 95% confidence interval: 1.13-1.38) with consistent associations across cohorts. ASXL1, TET2, and JAK2 sequence variations were each associated with an increased risk of HF, whereas DNMT3A sequence variations were not associated with HF. Secondary analyses suggested large CHIP was associated with a greater risk of HF (hazard ratio: 1.29; 95% confidence interval: 1.15-1.44), and the associations for CHIP on HF with and without prior coronary heart disease were homogenous. ASXL1 sequence variations were associated with reduced left ventricular ejection fraction. Conclusions: CHIP, particularly sequence variations in ASXL1, TET2, and JAK2, represents a new risk factor for HF
Partial wave analysis of the reaction gamma p -> p omega$ and the search for nucleon resonances
An event-based partial wave analysis (PWA) of the reaction gamma p -> p omega
has been performed on a high-statistics dataset obtained using the CLAS at
Jefferson Lab for center-of-mass energies from threshold up to 2.4 GeV. This
analysis benefits from access to the world's first high precision spin density
matrix element measurements, available to the event-based PWA through the decay
distribution of omega-> pi+ pi - pi0. The data confirm the dominance of the
t-channel pi0 exchange amplitude in the forward direction. The dominant
resonance contributions are consistent with the previously identified states
F[15](1680) and D[13](1700) near threshold, as well as the G[17](2190) at
higher energies. Suggestive evidence for the presence of a J(P)=5/2(+) state
around 2 GeV, a "missing" state, has also been found. Evidence for other states
is inconclusive
Deeply Virtual Compton Scattering Beam-Spin Asymmetries
The beam spin asymmetries in the hard exclusive electroproduction of photons
on the proton (ep -> epg) were measured over a wide kinematic range and with
high statistical accuracy. These asymmetries result from the interference of
the Bethe-Heitler process and of deeply virtual Compton scattering. Over the
whole kinematic range (x_B from 0.11 to 0.58, Q^2 from 1 to 4.8 GeV^2, -t from
0.09 to 1.8 GeV^2), the azimuthal dependence of the asymmetries is compatible
with expectations from leading-twist dominance, A = a*sin(phi)/[1+c*cos(phi)].
This extensive set of data can thus be used to constrain significantly the
generalized parton distributions of the nucleon in the valence quark sector.Comment: 1 tex file (6 pages), 4 (eps) figure
Measurement of the - and -Dependence of the Asymmetry on the Nucleon
We report results for the virtual photon asymmetry on the nucleon from
new Jefferson Lab measurements. The experiment, which used the CEBAF Large
Acceptance Spectrometer and longitudinally polarized proton (NH) and
deuteron (ND) targets, collected data with a longitudinally
polarized electron beam at energies between 1.6 GeV and 5.7 GeV. In the present
paper, we concentrate on our results for and the related ratio
in the resonance and the deep inelastic regions for our lowest
and highest beam energies, covering a range in momentum transfer from
0.05 to 5.0 GeV and in final-state invariant mass up to about 3 GeV.
Our data show detailed structure in the resonance region, which leads to a
strong --dependence of for below 2 GeV. At higher , a
smooth approach to the scaling limit, established by earlier experiments, can
be seen, but is not strictly --independent. We add
significantly to the world data set at high , up to . Our data
exceed the SU(6)-symmetric quark model expectation for both the proton and the
deuteron while being consistent with a negative -quark polarization up to
our highest . This data setshould improve next-to-leading order (NLO) pQCD
fits of the parton polarization distributions.Comment: 7 pages LaTeX, 5 figure
Beam Spin Asymmetries in DVCS with CLAS at 4 .8 GeV
We report measurements of the beam spin asymmetry in Deeply Virtual Compton
Scattering (DVCS) at an electron beam energy of 4.8 GeV using the CLAS detector
at the Thomas Jefferson National Accelerator Facility. The DVCS beam spin
asymmetry has been measured in a wide range of kinematics, 1(GeV/c)
(GeV/c), , and 0.1 (GeV/c)
(GeV/c), using the reaction \pEpX. The number of
H and H events are separated in
each bin by a fit to the line shape of the H
distribution. The validity of the method was studied in detail using
experimental and simulated data. It was shown, that with the achieved missing
mass squared resolution and the available statistics, the separation of DVCS-BH
and events can reliably be done with less than 5% uncertainty. The
- and -dependences of the moments of the asymmetry are
extracted and compared with theoretical calculations
Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential
Human genetic studies support an inverse causal relationship between leukocyte telomere length (LTL) and coronary artery disease (CAD), but directionally mixed effects for LTL and diverse malignancies. Clonal hematopoiesis of indeterminate potential (CHIP), characterized by expansion of hematopoietic cells bearing leukemogenic mutations, predisposes both hematologic malignancy and CAD. TERT (which encodes telomerase reverse transcriptase) is the most significantly associated germline locus for CHIP in genome-wide association studies. Here, we investigated the relationship between CHIP, LTL, and CAD in the Trans-Omics for Precision Medicine (TOPMed) program (n = 63,302) and UK Biobank (n = 47,080). Bidirectional Mendelian randomization studies were consistent with longer genetically imputed LTL increasing propensity to develop CHIP, but CHIP then, in turn, hastens to shorten measured LTL (mLTL). We also demonstrated evidence of modest mediation between CHIP and CAD by mLTL. Our data promote an understanding of potential causal relationships across CHIP and LTL toward prevention of CAD
Electroexcitation of nucleon resonances from CLAS data on single pion electroproduction
We present results on the electroexcitation of the low mass resonances Î(1232)P<sub>33</sub>, N(1440)P<sub>11</sub>, N(1520)D<sub>13</sub>, and N(1535)S<sub>11</sub> in a wide range of Q<sup>2</sup>. The results were obtained in the comprehensive analysis of data from the Continuous Electron Beam Accelerator Facility (CEBAF) large acceptance spectrometer (CLAS) detector at the Thomas Jefferson National Accelerator Facility (JLab) on differential cross sections, longitudinally polarized beam asymmetries, and longitudinal target and beam-target asymmetries for Ï electroproduction off the proton. The data were analyzed using two conceptually different approachesâfixed-t dispersion relations and a unitary isobar modelâallowing us to draw conclusions on the model sensitivity of the obtained electrocoupling amplitudes. The amplitudes for the Î(1232)P<sub>33</sub> show the importance of a meson-cloud contribution to quantitatively explain the magnetic dipole strength, as well as the electric and scalar quadrupole transitions. They do not show any tendency of approaching the pQCD regime for Q<sup>2</sup>â©œ6 GeV<sup>2</sup>. For the Roper resonance, N(1440)P<sub>11</sub>, the data provide strong evidence that this state is a predominantly radial excitation of a three-quark (3q) ground state. Measured in pion electroproduction, the transverse helicity amplitude for the N(1535)S<sub>11</sub> allowed us to obtain the branching ratios of this state to the ÏN and ηN channels via comparison with the results extracted from η electroproduction. The extensive CLAS data also enabled the extraction of the Îł*pâN(1520)D<sub>13</sub> and N(1535)S<sub>11</sub> longitudinal helicity amplitudes with good precision. For the N(1535)S<sub>11</sub>, these results became a challenge for quark models and may be indicative of large meson-cloud contributions or of representations of this state that differ from a 3q excitation. The transverse amplitudes for the N(1520)D<sub>13</sub> clearly show the rapid changeover from helicity-3/2 dominance at the real photon point to helicity-1/2 dominance at Q<sup>2</sup>>1 GeV<sup>2</sup>, confirming a long-standing prediction of the constituent quark model
Measurement of ep->ep beam spin asymmetries above the resonance region
5 pages, 6 figuresThe beam spin asymmetry (BSA) in the exclusive reaction ep->ep pi0 was measured with the CEBAF 5.77 GeV polarized electron beam and Large Acceptance Spectrometer(CLAS). The xB, Q2, t and phi dependences of the pi0 BSA are presented in the deep inelastic regime. The asymmetries are fitted with a sin(phi) function and their amplitudes are extracted. Overall, they are of the order of 0.04 - 0.11 and roughly independent of t. This is the signature of a non-zero longitudinal-transverse interference. The implications concerning the applicability of a formalism based on generalized parton distributions, as well as the extension of a Regge formalism at high photon virtualities, are discussed