Neutron-proton mass difference from gauge/gravity duality

Using gauge/gravity duality as a tool, we compute the strong sector, isospin breaking induced contribution to the neutron-proton mass difference in the Witten-Sakai-Sugimoto model of large $N$ QCD with two non-degenerate light flavors. The mass difference, for which we provide an analytic expression, turns out to be positive and proportional to the down-up quark mass splitting, consistently with expectations and previous estimates based on effective QCD models. Extrapolating the model parameters to fit QCD hadronic observables, we find that the strong sector contribution to the nucleon mass splitting overcomes the electromagnetic contribution and is about $0.25\%$ of the average nucleon mass in the model, a result which approaches recent lattice QCD estimates. Our formula is extended to resonances and $\Delta$ baryons. We thus use it to compute the strong sector contribution to $\Delta$ baryons mass differences. Finally, we also provide details of how isospin breaking affects the holographic instanton solution describing the baryons.Comment: Latex, 23 pages; v2 clarifications, comments and references added, version published on PR

Exploring Non-Invertible Symmetries in Free Theories

Symmetries corresponding to local transformations of the fundamental fields that leave the action invariant give rise to (invertible) topological defects, which obey group-like fusion rules. One can construct more general (codimension-one) topological defects by specifying a map between gauge-invariant operators from one side of the defect and such operators on the other side. In this work, we apply such construction to Maxwell theory in four dimensions and to the free compact scalar theory in two dimensions. In the case of Maxwell theory, we show that a topological defect that mixes the field strength $F$ and its Hodge dual $\star F$ can be at most an $SO(2)$ rotation. For rational values of the bulk coupling and the $\theta$-angle we find an explicit defect Lagrangian that realizes values of the $SO(2)$ angle $\varphi$ such that $\cos \varphi$ is also rational. We further determine the action of such defects on Wilson and 't Hooft lines and show that they are in general non-invertible. We repeat the analysis for the free compact scalar $\phi$ in two dimensions. In this case we find only four discrete maps: the trivial one, a $Z_2$ map $d\phi \rightarrow -d\phi$, a $\mathcal{T}$-duality-like map $d\phi \rightarrow i \star d\phi$, and the product of the last two.Comment: 30

Vacuum structure of large N QCD3 from holography

We study the vacuum structure of three-dimensional SU(N) gauge theory coupled to a Chern-Simons term at level k and to F fundamental Dirac fermions. We use a large N holographic description based on a D3/D7 system in type IIB string theory compactified on a supersymmetry breaking circle. The multiple vacua of the theory and the transitions between them are nicely captured by the dual holographic background. The resulting phase diagram, which we derive both at leading and first subleading orders in the 1/N expansion, shows a rich structure where topological field theories, non-linear sigma models and first-order phase transitions appear

Serum Albumin Is Inversely Associated With Portal Vein Thrombosis in Cirrhosis

We analyzed whether serum albumin is independently associated with portal vein thrombosis (PVT) in liver cirrhosis (LC) and if a biologic plausibility exists. This study was divided into three parts. In part 1 (retrospective analysis), 753 consecutive patients with LC with ultrasound-detected PVT were retrospectively analyzed. In part 2, 112 patients with LC and 56 matched controls were entered in the cross-sectional study. In part 3, 5 patients with cirrhosis were entered in the in vivo study and 4 healthy subjects (HSs) were entered in the in vitro study to explore if albumin may affect platelet activation by modulating oxidative stress. In the 753 patients with LC, the prevalence of PVT was 16.7%; logistic analysis showed that only age (odds ratio [OR], 1.024; P = 0.012) and serum albumin (OR, -0.422; P = 0.0001) significantly predicted patients with PVT. Analyzing the 112 patients with LC and controls, soluble clusters of differentiation (CD)40-ligand (P = 0.0238), soluble Nox2-derived peptide (sNox2-dp; P < 0.0001), and urinary excretion of isoprostanes (P = 0.0078) were higher in patients with LC. In LC, albumin was correlated with sCD4OL (Spearman's rank correlation coefficient [r(s)], -0.33; P < 0.001), sNox2-dp (r(s), -0.57; P < 0.0001), and urinary excretion of isoprostanes (r(s), -0.48; P < 0.0001) levels. The in vivo study showed a progressive decrease in platelet aggregation, sNox2-dp, and urinary 8-iso prostaglandin F2 alpha-III formation 2 hours and 3 days after albumin infusion. Finally, platelet aggregation, sNox2-dp, and isoprostane formation significantly decreased in platelets from HSs incubated with scalar concentrations of albumin. Conclusion: Low serum albumin in LC is associated with PVT, suggesting that albumin could be a modulator of the hemostatic system through interference with mechanisms regulating platelet activation

International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways.

Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data sets from genome-wide association studies of European subjects (n=2,764 cases and 10,475 controls) followed by validation genotyping in an independent cohort (n=3,716 cases and 4,261 controls). We discover and validate six previously unknown risk loci for PBC (Pcombined<5 × 10(-8)) and used pathway analysis to identify JAK-STAT/IL12/IL27 signalling and cytokine-cytokine pathways, for which relevant therapies exist

Strong coupling in 2+1 dimensions from dualities, holography, and large N

The goal of the original research presented in this thesis is to study the strong coupling regime of Quantum Field Theories (QFTs) with different methods, making concrete predictions about the phase structure and the dynamics of these theories, and on their observables. The focus is on (gauge) field theories in three spacetime dimensions, which are an interesting laboratory to understand the properties of strong coupling in setups that are usually simpler than in the more familiar case of gauge theories in four dimensions. Importantly, topological effects play a relevant role in three dimensions, thanks to the presence of the so-called Chern-Simons term.The thesis contains a short introduction to QFTs in 3d, principles and applications of infrared dualities, large N techniques, and holography. Indeed, the web of infrared dualities, the large N expansion, and the holographic correspondence between QFT and gravity are the main tools which we use to investigate the strongly coupled regimes of 3d QFTs.Then, the original material is presented. In a first line of research, we focus on the study of the phase diagram of a 3d gauge theory making use of conjectured infrared dualities, extending such dualities to the case where more than one mass parameter can be dialed. In a second line of research, we study a class of 3d gauge theories by engineering their gravity dual in a string theory setup. We prove the existence of multiple phase transitions between phases characterized by both massless particles and topological sectors. In a third line of research, we use holography as a tool to explore the interplay between the physics of 4d QCD and 3d gauge theories. In particular, we analyze the properties of 3d domain walls, which appear as soliton-like solutions of 4d QCD in specific parametric regimes. Finally, we propose a boundary construction of 3d large N vector models, which appear as critical points of theories obtained by coupling degrees of freedom localized on a 3d boundary to a 4d bulk theory. This construction allows to prove new dualities and uncovers a new computational tool for 3d vector models.Doctorat en Sciencesinfo:eu-repo/semantics/nonPublishe