Mosaic tetracycline resistance genes encoding ribosomal protection proteins

First reported in 2003, mosaic tetracycline resistance genes are a subgroup of the genes encoding ribosomal protection proteins (RPPs). They are formed when two or more RPP-encoding genes recombine resulting in a functional chimera. To date, the majority of mosaic genes are derived from sections of three RPP genes, tet(O), tet(W) and tet(32), with others comprising tet(M) and tet(S). In this first review of mosaic genes, we report on their structure, diversity and prevalence, and suggest that these genes may be responsible for an under-reported contribution to tetracycline resistance in bacteria

The galaxy mass-size relation in CARLA clusters and proto-clusters at 1.4 < z < 2.8: larger cluster galaxy sizes

(Abridged) We study the galaxy mass-size relation in CARLA spectroscopically confirmed clusters at $1.4<z<2.8$, which span a total stellar mass $11.3<\mathrm{log}(M^c_*/M_{\odot})<12.6$ (halo mass $13.5 \lesssim \mathrm{log}(M^c_h/M_{\odot}) \lesssim 14.5$). Our main finding is that cluster passive ETG at $z \gtrsim 1.5$ with ${\rm log}(M/M_{\odot})>10.5$ are systematically $\gtrsim 0.2-0.3~{\rm dex}$ larger than field ETGs. The passive ETG average size evolution is slower at $1<z<2$ when compared to the field. This could be explained by differences in the formation and early evolution of galaxies in haloes of a different mass. Strong compaction and gas dissipation in field galaxies, followed by a sequence of mergers may have also played a significant role in the field ETG evolution, but not in the evolution of cluster galaxies. Our passive ETG mass-size relation shows a tendency to flatten at $9.6<{\rm log}(M/M_{\odot})<10.5$, where the average size is $\mathrm{log}(R_e/\mathrm{kpc}) = 0.05 \pm 0.22$. This implies that galaxies in the low end of the mass-size relation do not evolve much from $z\sim 2$ to the present, and that their sizes evolve in a similar way in clusters and in the field. BCGs lie on the same mass-size relation as satellites, suggesting that their size evolution is not different at redshift z $\gtrsim$ 2. Half of the active ETGs ($\sim 30\%$ of the ETGs) follow the field passive galaxy mass-size relation, and the other half follow the field active galaxy mass-size relation. These galaxies likely went through a recent merger or neighbor galaxy interaction, and would most probably quench at a later epoch and increase the fraction of passive ETGs in clusters. We do not observe a large population of compact galaxies, as is observed in the field at these redshifts, implying that the galaxies in our clusters are not observed in an epoch close to their compaction.Comment: 15 pages, 10 figures, accepted for publication in Astronomy & Astrophysic

Canagliflozin and renal outcomes in type 2 diabetes and nephropathy

BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to &lt;90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], &gt;300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of &lt;15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P&lt;0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P&lt;0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years

Morphology-density Relation, Quenching, and Mergers in CARLA Clusters and Proto-Clusters at 1.4<z<2.81.4<z<2.8

(Abridged) To understand if the morphology-density and passive-density relations are already established at z>1.5, we study galaxies in 16 confirmed clusters at $1.3<z<2.8$ from the CARLA survey. Our main finding is that the morphology-density and passive-density relations are already in place at $z\sim2$. The cluster at z = 2.8 shows a similar fraction of ETG as in the other clusters in its densest region. The cluster ETG and passive fractions depend on local environment and mildly on galaxy mass. They do not depend on global environment. At lower local densities, the CARLA clusters exhibit a lower ETG fraction than clusters at z = 1. This implies that the densest regions influence the morphology of galaxies first, with lower density local environments either taking longer or only influencing galaxy morphology at later cosmological times. Interestingly, we find evidence of high merger fractions in our clusters with respect to the field, but the merger fractions do not significantly depend on local environment. This suggests that merger remnants in the lowest density regions can reform disks fuelled by cold gas flows, but those in the highest density regions are cut-off from the gas supply and will become passive ETG. The percentages of active ETG, with respect to the total ETG population, are $21 \pm 6\%$ and $59 \pm 14\%$ at 1.35 < z <1.65 and 1.65 < z < 2.05, respectively, and about half of them are mergers or asymmetric in both redshift bins. All the spectroscopically confirmed CARLA clusters have properties consistent with clusters and proto-clusters. The differences between our results and those that find enhanced star formation and star-bursts in cluster cores at similar redshifts are probably due to the different sample selection criteria, which choose different environments that host galaxies with different accretion and pre-processing histories

Morphology-density Relation, Quenching, and Mergers in CARLA Clusters and Proto-Clusters at 1.4<z<2.81.4<z<2.8

(Abridged) To understand if the morphology-density and passive-density relations are already established at z>1.5, we study galaxies in 16 confirmed clusters at $1.3<z<2.8$ from the CARLA survey. Our main finding is that the morphology-density and passive-density relations are already in place at $z\sim2$. The cluster at z = 2.8 shows a similar fraction of ETG as in the other clusters in its densest region. The cluster ETG and passive fractions depend on local environment and mildly on galaxy mass. They do not depend on global environment. At lower local densities, the CARLA clusters exhibit a lower ETG fraction than clusters at z = 1. This implies that the densest regions influence the morphology of galaxies first, with lower density local environments either taking longer or only influencing galaxy morphology at later cosmological times. Interestingly, we find evidence of high merger fractions in our clusters with respect to the field, but the merger fractions do not significantly depend on local environment. This suggests that merger remnants in the lowest density regions can reform disks fuelled by cold gas flows, but those in the highest density regions are cut-off from the gas supply and will become passive ETG. The percentages of active ETG, with respect to the total ETG population, are $21 \pm 6\%$ and $59 \pm 14\%$ at 1.35 < z <1.65 and 1.65 < z < 2.05, respectively, and about half of them are mergers or asymmetric in both redshift bins. All the spectroscopically confirmed CARLA clusters have properties consistent with clusters and proto-clusters. The differences between our results and those that find enhanced star formation and star-bursts in cluster cores at similar redshifts are probably due to the different sample selection criteria, which choose different environments that host galaxies with different accretion and pre-processing histories

Morphology-density Relation, Quenching, and Mergers in CARLA Clusters and Proto-Clusters at 1.4<z<2.81.4<z<2.8

(Abridged) To understand if the morphology-density and passive-density relations are already established at z>1.5, we study galaxies in 16 confirmed clusters at $1.3<z<2.8$ from the CARLA survey. Our main finding is that the morphology-density and passive-density relations are already in place at $z\sim2$. The cluster at z = 2.8 shows a similar fraction of ETG as in the other clusters in its densest region. The cluster ETG and passive fractions depend on local environment and mildly on galaxy mass. They do not depend on global environment. At lower local densities, the CARLA clusters exhibit a lower ETG fraction than clusters at z = 1. This implies that the densest regions influence the morphology of galaxies first, with lower density local environments either taking longer or only influencing galaxy morphology at later cosmological times. Interestingly, we find evidence of high merger fractions in our clusters with respect to the field, but the merger fractions do not significantly depend on local environment. This suggests that merger remnants in the lowest density regions can reform disks fuelled by cold gas flows, but those in the highest density regions are cut-off from the gas supply and will become passive ETG. The percentages of active ETG, with respect to the total ETG population, are $21 \pm 6\%$ and $59 \pm 14\%$ at 1.35 < z <1.65 and 1.65 < z < 2.05, respectively, and about half of them are mergers or asymmetric in both redshift bins. All the spectroscopically confirmed CARLA clusters have properties consistent with clusters and proto-clusters. The differences between our results and those that find enhanced star formation and star-bursts in cluster cores at similar redshifts are probably due to the different sample selection criteria, which choose different environments that host galaxies with different accretion and pre-processing histories

Morphology-density Relation, Quenching, and Mergers in CARLA Clusters and Proto-Clusters at 1.4<z<2.81.4<z<2.8

(Abridged) To understand if the morphology-density and passive-density relations are already established at z>1.5, we study galaxies in 16 confirmed clusters at $1.3<z<2.8$ from the CARLA survey. Our main finding is that the morphology-density and passive-density relations are already in place at $z\sim2$. The cluster at z = 2.8 shows a similar fraction of ETG as in the other clusters in its densest region. The cluster ETG and passive fractions depend on local environment and mildly on galaxy mass. They do not depend on global environment. At lower local densities, the CARLA clusters exhibit a lower ETG fraction than clusters at z = 1. This implies that the densest regions influence the morphology of galaxies first, with lower density local environments either taking longer or only influencing galaxy morphology at later cosmological times. Interestingly, we find evidence of high merger fractions in our clusters with respect to the field, but the merger fractions do not significantly depend on local environment. This suggests that merger remnants in the lowest density regions can reform disks fuelled by cold gas flows, but those in the highest density regions are cut-off from the gas supply and will become passive ETG. The percentages of active ETG, with respect to the total ETG population, are $21 \pm 6\%$ and $59 \pm 14\%$ at 1.35 < z <1.65 and 1.65 < z < 2.05, respectively, and about half of them are mergers or asymmetric in both redshift bins. All the spectroscopically confirmed CARLA clusters have properties consistent with clusters and proto-clusters. The differences between our results and those that find enhanced star formation and star-bursts in cluster cores at similar redshifts are probably due to the different sample selection criteria, which choose different environments that host galaxies with different accretion and pre-processing histories

Morphology-density Relation, Quenching, and Mergers in CARLA Clusters and Proto-Clusters at 1.4<z<2.81.4<z<2.8

(Abridged) To understand if the morphology-density and passive-density relations are already established at z>1.5, we study galaxies in 16 confirmed clusters at $1.3<z<2.8$ from the CARLA survey. Our main finding is that the morphology-density and passive-density relations are already in place at $z\sim2$. The cluster at z = 2.8 shows a similar fraction of ETG as in the other clusters in its densest region. The cluster ETG and passive fractions depend on local environment and mildly on galaxy mass. They do not depend on global environment. At lower local densities, the CARLA clusters exhibit a lower ETG fraction than clusters at z = 1. This implies that the densest regions influence the morphology of galaxies first, with lower density local environments either taking longer or only influencing galaxy morphology at later cosmological times. Interestingly, we find evidence of high merger fractions in our clusters with respect to the field, but the merger fractions do not significantly depend on local environment. This suggests that merger remnants in the lowest density regions can reform disks fuelled by cold gas flows, but those in the highest density regions are cut-off from the gas supply and will become passive ETG. The percentages of active ETG, with respect to the total ETG population, are $21 \pm 6\%$ and $59 \pm 14\%$ at 1.35 < z <1.65 and 1.65 < z < 2.05, respectively, and about half of them are mergers or asymmetric in both redshift bins. All the spectroscopically confirmed CARLA clusters have properties consistent with clusters and proto-clusters. The differences between our results and those that find enhanced star formation and star-bursts in cluster cores at similar redshifts are probably due to the different sample selection criteria, which choose different environments that host galaxies with different accretion and pre-processing histories

The galaxy mass-size relation in CARLA clusters and proto-clusters at 1.4 < z < 2.8: larger cluster galaxy sizes

(Abridged) We study the galaxy mass-size relation in CARLA spectroscopically confirmed clusters at $1.410.5$ are systematically $\gtrsim 0.2-0.3~{\rm dex}$ larger than field ETGs. The passive ETG average size evolution is slower at $1<z<2$ when compared to the field. This could be explained by differences in the formation and early evolution of galaxies in haloes of a different mass. Strong compaction and gas dissipation in field galaxies, followed by a sequence of mergers may have also played a significant role in the field ETG evolution, but not in the evolution of cluster galaxies. Our passive ETG mass-size relation shows a tendency to flatten at $9.6<{\rm log}(M/M_{\odot})<10.5$, where the average size is $\mathrm{log}(R_e/\mathrm{kpc}) = 0.05 \pm 0.22$. This implies that galaxies in the low end of the mass-size relation do not evolve much from $z\sim 2$ to the present, and that their sizes evolve in a similar way in clusters and in the field. BCGs lie on the same mass-size relation as satellites, suggesting that their size evolution is not different at redshift z $\gtrsim$ 2. Half of the active ETGs ($\sim 30\%$ of the ETGs) follow the field passive galaxy mass-size relation, and the other half follow the field active galaxy mass-size relation. These galaxies likely went through a recent merger or neighbor galaxy interaction, and would most probably quench at a later epoch and increase the fraction of passive ETGs in clusters. We do not observe a large population of compact galaxies, as is observed in the field at these redshifts, implying that the galaxies in our clusters are not observed in an epoch close to their compaction