PRICE AND NON-PRICE INFLUENCES ON WATER CONSERVATION: AN ECONOMETRIC MODEL OF AGGREGATE DEMAND UNDER NONLINEAR BUDGET CONSTRAINT

We study the influence of prices and non-price conservation programs on water consumption and conservation behavior during a drought in the San Francisco Bay Area. The empirical results show that pricing can be effective in reducing water consumption. Use restrictions and landscaping audits are also effective in inducing conservation from consumers.Demand and Price Analysis, Environmental Economics and Policy,

Biofilm formation is a risk factor for mortality in patients with Candida albicans bloodstream infection-Scotland, 2012-2013

Acknowledgements This work was supported by the Wellcome Trust Strategic Award for Medical Mycology and Fungal Immunology 097377/Z/11/Z. Data collection was supported by a grant from Pfizer. G. Ramage was also supported by a research fellowship grant from Gilead Sciences. We are grateful to microbiology colleagues throughout Scotland for submitting isolates.Peer reviewedPublisher PD

Stem cell-like populations and immunoregulatory molecules in periodontal granulation tissue

Background and Objectives: Determine the presence of mesenchymal stem cells (MSCs) in healthy periodontal tissue and periodontal granulation tissue (GT) and explore associations between immuno‐regulatory molecules and selected subgingival microorganisms. Material and Methods: Mesenchymal stem cells were isolated, propagated and characterised by flow cytometry from a region of healthy gingival tissue and inflamed GT of 10 systemically healthy non‐smokers with chronic periodontitis. Tissue levels of immunoregulatory molecules were determined by qPCR and Gingival Crevicular Fluid (GCF) levels by ELISA. Subgingival plaque levels of periodontal pathogens were determined by qPCR Results: Cells with MSC‐properties were isolated from both inflamed GT and healthy gingival (G) tissue. A pro‐inflammatory process predominated in GT which was partly reflected in GCF and putative periodontal pathogens were higher at diseased sites. However, there was no significant difference in surface levels of mesenchymal (CD90, CD73, CD146, CD271, STRO‐1), endothelial (CD105, CD106), hematopoietic (CD34, CD45) and embryonic (SSEA‐4) stem cell markers between MSCs isolated from GT and G tissue. Conclusion: Periodontal lesions, albeit inflamed, retain healing potential as inferred by the presence of MSC‐like cells with similar immunophenotypic characteristics to those found in healthy periodontal tissue. Therefore, there might be merits for healing in preserving sufficient GT in‐situ during periodontal surgery

Importance of historical cases in learning of chemistry in university students

La historia de la Química constituye un instrumento valioso para su enseñanza, principalmente en la educación científica universitaria, pues permite a los alumnos una mejor comprensión de la disciplina científica, obtener concepciones y representaciones más acabadas, así como entender las diferentes implicancias de su conocimiento en los ámbitos profesionales y socio-culturales. Objetivos: indagar cuáles son las opiniones e importancia que le otorgan los alumnos a la historia de la Química como estrategia para su aprendizaje, en el contexto de las carreras de Farmacia y Bioquímica de la UMaza

Understanding of chemistry as science in university students of pharmacy and biochemistry

El contexto de investigación es la Facultad de Farmacia y Bioquímica, respondiendo a los inconvenientes de los alumnos para comprender la Química como ciencia, la generación de los conocimientos disciplinares, la relevancia en la formación profesional y afrontar el proceso aprendizaje-enseñanza

University pharmacy and biochemistry student’s views, beliefs and attitudes of nature of science and technology

La investigación se realizó en la Facultad de Farmacia y Bioquímica, en atención a los interrogantes evidenciados en los alumnos acerca de la química como ciencia, su aprendizaje y las profesiones. Los diagnósticos dejaban entrever concepciones (visiones) distorsionadas y no adecuadas acerca de la Naturaleza de la Ciencia y Tecnología (NdCyT), por lo que la problemática se centró en estudiar cuál es la comprensión y significación que le otorgan dichos alumnos

COTS vision system, radiation sensor and 6 DoF robot for use in identifying radiologically uncharacterised objects

A novel, semi-autonomous radiological scanning system for inspecting uncharacterised objects is presented. The research utilises commercially available off-the-shelf (COTS) electronic components, intended for use in relatively low radioactive dose environments. To illustrate the concept, a Microsoft Kinect, a Universal Robots UR3 (6 degree of freedom) manipulator and a Kromek RadAngel gamma radiation spectrometer are utilised. The new control software allows the remote operator to select the required object, before the robot arm autonomously scans it, enabling the generation of various radiological spectra shapes. These data inform the operator of any likely radioisotopes present and where they are located in the object

Evolving Discourses on Water Resource Management and Climate Change in the Equatorial Nile Basin

Transboundary water resources management in the Equatorial Nile Basin (EQNB) is a politically contested issue. There is a growing body of literature examining water-related discourses which identifies the ability of powerful actors and institutions to influence policy. Concern about the effects of future climate change has featured strongly in research on the Nile River for several decades. It is therefore timely to consider whether and how these concerns are reflected in regional policy documents and policy discourse. This study analyzes discourse framings of water resources management and climate change in policy documents (27, published between 2001 and 2013) and as elicited in interviews (38) with water managers in the EQNB. Three main discursive framings are identified which are present in the discourses on both subjects: a problem-oriented environmental risk frame and two solution-oriented frames, on governance and infrastructure development. Climate change discourse only emerges as a common topic around 2007. The framings found in the water resources management discourse and the climate change discourse are almost identical, suggesting that discursive framings were adopted from the former for use in the latter. We infer that the climate change discourse may have offered a less politically sensitive route to circumvent political sensitivities around water allocation and distribution between riparian countries in the EQNB. However, the climate change discourse does not offer a lasting solution to the more fundamental political dispute over water allocation. Moreover, in cases where the climate change discourse is subsumed within a water resources management discourse, there are dangers that it will not fully address the needs of effective adaptation

A Low-Cost and Semi-Autonomous Robotic Scanning System for Characterising Radiological Waste

A novel, semi-autonomous radiological scanning system for inspecting irregularly shaped and radiologically uncharacterised objects in various orientations is presented. The system utilises relatively low cost, commercial-off-the-shelf (COTS) electronic components, and is intended for use within relatively low to medium radioactive dose environments. To illustrate the generic concepts, the combination of a low-cost COTS vision system, a six DoF manipulator and a gam-ma radiation spectrometer are investigated. Three modes of vision have been developed, al-lowing a remote operator to choose the most appropriate algorithm for the task. The robot arm subsequently scans autonomously across the selected object, determines the scan positions and enables the generation of radiological spectra using the gamma spectrometer. These data inform the operator of any likely radioisotopes present, where in the object they are located and thus whether the object should be treated as LLW, ILW or HLW

The alpha 7 nicotinic receptor agonist PHA-543613 hydrochloride inhibits <i>Porphyromonas gingivalis</i>-induced expression of interleukin-8 by oral keratinocytes

Objective: The alpha 7 nicotinic receptor (α7nAChR) is expressed by oral keratinocytes. α7nAChR activation mediates anti-inflammatory responses. The objective of this study was to determine if α7nAChR activation inhibited pathogen-induced interleukin-8 (IL-8) expression by oral keratinocytes.&lt;p&gt;&lt;/p&gt; Materials and methods: Periodontal tissue expression of α7nAChR was determined by real-time PCR. OKF6/TERT-2 oral keratinocytes were exposed to &lt;i&gt;Porphyromonas gingivalis&lt;/i&gt; in the presence and absence of a α7nAChR agonist (PHA-543613 hydrochloride) alone or after pre-exposure to a specific α7nAChR antagonist (α-bungarotoxin). Interleukin-8 (IL-8) expression was measured by ELISA and real-time PCR. Phosphorylation of the NF-κB p65 subunit was determined using an NF-κB p65 profiler assay and STAT-3 activation by STAT-3 in-cell ELISA. The release of ACh from oral keratinocytes in response to &lt;i&gt;P. gingivalis&lt;/i&gt; lipopolysaccharide was determined using a GeneBLAzer M3 CHO-K1-blacell reporter assay.&lt;p&gt;&lt;/p&gt; Results: Expression of α7nAChR mRNA was elevated in diseased periodontal tissue. PHA-543613 hydrochloride inhibited &lt;i&gt;P. Gingivalis&lt;/i&gt;-induced expression of IL-8 at the transcriptional level. This effect was abolished when cells were pre-exposed to a specific α7nAChR antagonist, α-bungarotoxin. PHA-543613 hydrochloride downregulated NF-κB signalling through reduced phosphorylation of the NF-κB p65-subunit. In addition, PHA-543613 hydrochloride promoted STAT-3 signalling by maintenance of phosphorylation. Furthermore, oral keratinocytes upregulated ACh release in response to &lt;i&gt;P. Gingivalis&lt;/i&gt; lipopolysaccharide.&lt;p&gt;&lt;/p&gt; Conclusion: These data suggest that α7nAChR plays a role in regulating the innate immune responses of oral keratinocytes.&lt;p&gt;&lt;/p&gt