Bone Involvement in Hyperphosphatemic Familial Tumoral Calcinosis: A New Phenotypic Presentation

Mutations in FGF23, KL, and GALNT3 have been identified as the cause for the development of hyperphosphatemic familial tumoral calcinosis (HFTC). Patients with HFTC typically present in childhood or adolescence with periarticular soft tissue deposits that eventually progress to disrupt normal joint articulation. Mutations in the GALNT3 gene were shown to account for the hyperphosphatemic state in both HFTC and hyperostosis-hyperphosphatemia syndrome (HHS), the latter characterized by bone involvement. We present the case of a patient of a Druze ethnic origin with known HFTC that presented to our department with the first documented case of pathologic fracture occurring secondary to the disease. Our report introduces this new phenotypic presentation, suggests a potential role for prophylactic bone screening, and highlights the need for preconception genetic screening in selected populations

Simplest cosmological model with the scalar field II. Influence of cosmological constant

Continuing the investigation of the simplest cosmological model with the massive real scalar non-interacting inflaton field minimally coupled to gravity we study an influence of the cosmological constant on the behaviour of trajectories in closed minisuperspace Friedmann-Robertson-Walker model. The transition from chaotic to regular behaviour for large values of cosmological constant is discussed. Combining numerical calculations with qualitative analysis both in configuration and phase space we present a convenient classification of trajectories.Comment: 12 pages with 2 gif figures and 2 eps figures, mprocl.sty, To appear in International Journal of Modern Physics

Scale-free static and dynamical correlations in melts of monodisperse and Flory-distributed homopolymers: A review of recent bond-fluctuation model studies

It has been assumed until very recently that all long-range correlations are screened in three-dimensional melts of linear homopolymers on distances beyond the correlation length $\xi$ characterizing the decay of the density fluctuations. Summarizing simulation results obtained by means of a variant of the bond-fluctuation model with finite monomer excluded volume interactions and topology violating local and global Monte Carlo moves, we show that due to an interplay of the chain connectivity and the incompressibility constraint, both static and dynamical correlations arise on distances $r \gg \xi$. These correlations are scale-free and, surprisingly, do not depend explicitly on the compressibility of the solution. Both monodisperse and (essentially) Flory-distributed equilibrium polymers are considered.Comment: 60 pages, 49 figure

Exercises in Futility: Postwar Automobile-Trade Negotiations Between Japan and the United States

This article traces the history of the failed automobile-trade negotiations between Japan and the United States from the 1970s to the mid-1990s. It attributes the failure of those negotiations to a lack of understanding on both sides of not only what was motivating the other side, but also the unalterable cultural, social, and economic constraints under which the other side operated.