Alpha managers - an advantage or disadvantage for the organization

The role of the manager is crucial to the organization. Managers set goals, develop strategies and define tasks of workers, create environment for the development of people and give meaning to their activities. Professional skills are of vital importance to manager’s success. These very skills are the distinguishing characteristics of alpha managers. The aim of the following paper is to present some of the most established ideas in the field of leadership styles, to compare them with the concept of alpha managers and draw some conclusions important to management

Alpha managers - an advantage or disadvantage for the organization

The role of the manager is crucial to the organization. Managers set goals, develop strategies and define tasks of workers, create environment for the development of people and give meaning to their activities. Professional skills are of vital importance to manager’s success. These very skills are the distinguishing characteristics of alpha managers. The aim of the following paper is to present some of the most established ideas in the field of leadership styles, to compare them with the concept of alpha managers and draw some conclusions important to management

The temporal dynamics of Arc expression regulate cognitive flexibility

YesNeuronal activity regulates the transcription and translation of the immediate-early gene Arc/Arg3.1, a key mediator of synaptic plasticity. Proteasomedependent degradation of Arc tightly limits its temporal expression, yet the significance of this regulation remains unknown. We disrupted the temporal control of Arc degradation by creating an Arc knockin mouse (ArcKR) where the predominant Arc ubiquitination sites were mutated. ArcKR mice had intact spatial learning but showed specific deficits in selecting an optimal strategy during reversal learning. This cognitive inflexibility was coupled to changes in Arc mRNA and protein expression resulting in a reduced threshold to induce mGluR-LTD and enhanced mGluR-LTD amplitude. These findings show that the abnormal persistence of Arc protein limits the dynamic range of Arc signaling pathways specifically during reversal learning. Our work illuminates how the precise temporal control of activity-dependent molecules, such as Arc, regulates synaptic plasticity and is crucial for cognition.Open access funded by Biotechnology and Biological Sciences Research Counci