The location of the UK cotton textiles industry in 1838 : a quantitative analysis

We examine the geography of cotton textiles in Britain in 1838 to test claims about why the industry came to be so heavily concentrated in Lancashire. Our analysis considers both first and second nature aspects of geography including the availability of water power, humidity, coal prices, market access and sunk costs. We show that some of these characteristics have substantial explanatory power. Moreover, we exploit the change from water to steam power to show that the persistent effect of first nature characteristics on industry location can be explained by a combination of sunk costs and agglomeration effects

Import pathways of precursor proteins into mitochondria

The precursor of porin, a mitochondrial outer membrane protein, competes for the import of precursors destined for the three other mitochondrial compartments, including the Fe/S protein of the bc1- complex (intermembrane space), the ADP/ATP carrier (inner membrane), subunit 9 of the F0-ATPase (inner membrane), and subunit beta of the F1- ATPase (matrix). Competition occurs at the level of a common site at which precursors are inserted into the outer membrane. Protease- sensitive binding sites, which act before the common insertion site, appear to be responsible for the specificity and selectivity of mitochondrial protein uptake. We suggest that distinct receptor proteins on the mitochondrial surface specifically recognize precursor proteins and transfer them to a general insertion protein component (GIP) in the outer membrane. Beyond GIP, the import pathways diverge, either to the outer membrane or to translocation contact-sites, and then subsequently to the other mitochondrial compartments

What do you mean with “direction”? Local and global cues to biological motion perception in pigeons

AbstractBiological motion point-light displays are a rich and versatile instrument to study perceptual organization. Humans are able to retrieve information from biological motion through at least two different channels: The global articulated structure as revealed by the non-rigid, yet highly constrained deformation of the dot pattern, and the characteristics of local motion trajectories of individual dots. Here, we tested eight pigeons on a task in which they had to discriminate a left-facing from a right-facing biological motion point-light figure. Since the two stimuli were mirror-flipped versions of each other, we were not sure if the birds would be able to solve the task at all. However, all birds learned the discrimination quickly and performed at high accuracy. We then challenged them with a number of test trials introduced into the sequence of the normal training trials. Tested on backwards moving walkers, the majority of the birds indicated that they used local motion cues to solve the training task, while the remaining birds obviously used global, configural cues. Testing the pigeons on different versions of scrambled biological motion confirmed that each individual bird had made a clear decision for one of the two potentially available strategies. While we confirm a previously described local precedence in processing visual patterns, the fact that some birds used global features suggests that even the birds who relied on local cues probably dispose of the perceptual abilities to use global structure, but “chose” to not use them

Measurement of calcium isotopes (δ44Ca) using a multicollector TIMS technique

We propose a new“multicollector technique” for the thermal ionization mass spectrometer (TIMS) measurement of calcium (Ca) isotope ratios improving average internal statistical uncertainty of the 44Ca/40Ca measurements by a factor of 2–4 and average sample throughput relative to the commonly used “peak jumping method” by a factor of 3. Isobaric interferences with potassium (40K+) and titanium (48Ti+) or positively charged molecules like 24Mg19F+, 25Mg19F+, 24Mg16O+ and 27Al16O+ can either be corrected or are negligible. Similar, peak shape defects introduced by the large dispersion of the whole Ca isotope mass range from 40–48 atomic mass units (amu) do not influence Ca-isotope ratios. We use a 43Ca/48Ca double spike with an iterative double spike correction algorithm for precise isotope measurement

Proposal for International Agreement on Ca Notation resulting from discussion at workshops on stable isotope measurement held in Davos (Goldschmidt 2002) and Nice (EGS-AGU-EUG 2003)

A proposal is made to standardise the reporting of Ca isotope data to the δ44Ca/40Ca notation (or δ44Ca/42Ca) and to adopt NIST SRM 915a as the reference standard

Import of ADP/ATP carrier into mitochondria

We have identified the yeast homologue of Neurospora crassa MOM72, the mitochondrial import receptor for the ADP/ATP carrier (AAC), by functional studies and by cDNA sequencing. Mitochondria of a yeast mutant in which the gene for MOM72 was disrupted were impaired in specific binding and import of AAC. Unexpectedly, we found a residual, yet significant import of AAC into mitochondria lacking MOM72 that occurred via the receptor MOM19. We conclude that both MOM72 and MOM19 can direct AAC into mitochondria, albeit with different efficiency. Moreover, the precursor of MOM72 apparently does not require a positively charged sequence at the extreme amino terminus for targeting to mitochondria

Does anxiety induced by social interaction influence the perception of bistable biological motion?

When observing point light walkers orthographically projected onto a frontoparallel plane, the direction in which they are walking is ambiguous. Nevertheless, observers more often perceive them as facing towards than as facing away from them. This phenomenon is known as the "facing-the-viewer bias" (FTV). Two interpretations of the facing-the-viewer bias exist in the literature: a top-down and a bottom-up interpretation. Support for the top-down interpretation comes from evidence that social anxiety correlates with the FTV bias. However, the direction of the relationship between the FTV bias and social anxiety is inconsistent across studies and evidence for a correlation has mostly been obtained with relatively small samples. Therefore, the first aim of the current study was to provide a strong test of the hypothesized relationship between social anxiety and the facing-the-viewer bias in a large sample of 200 participants recruited online. In addition, a second aim was to further extend top-down accounts by investigating if the FTV bias is also related to autistic traits. Our results replicate the FTV bias, showing that people indeed tend to perceive orthographically projected point light walkers as facing towards them. However, no correlation between the FTV bias and social interaction anxiety (tau = -0.01, p = .86, BF = 0.18) or autistic traits (tau = -0.0039, p = .45, BF = 0.18) was found. As such, our data cannot confirm the top-down interpretation of the facing-the-viewer bias

The Effect of Looming and Receding Sounds on the Perceived In-Depth Orientation of Depth-Ambiguous Biological Motion Figures

BACKGROUND: The focus in the research on biological motion perception traditionally has been restricted to the visual modality. Recent neurophysiological and behavioural evidence, however, supports the idea that actions are not represented merely visually but rather audiovisually. The goal of the present study was to test whether the perceived in-depth orientation of depth-ambiguous point-light walkers (plws) is affected by the presentation of looming or receding sounds synchronized with the footsteps. METHODOLOGY/PRINCIPAL FINDINGS: In Experiment 1 orthographic frontal/back projections of plws were presented either without sound or with sounds of which the intensity level was rising (looming), falling (receding) or stationary. Despite instructions to ignore the sounds and to only report the visually perceived in-depth orientation, plws accompanied with looming sounds were more often judged to be facing the viewer whereas plws paired with receding sounds were more often judged to be facing away from the viewer. To test whether the effects observed in Experiment 1 act at a perceptual level rather than at the decisional level, in Experiment 2 observers perceptually compared orthographic plws without sound or paired with either looming or receding sounds to plws without sound but with perspective cues making them objectively either facing towards or facing away from the viewer. Judging whether either an orthographic plw or a plw with looming (receding) perspective cues is visually most looming becomes harder (easier) when the orthographic plw is paired with looming sounds. CONCLUSIONS/SIGNIFICANCE: The present results suggest that looming and receding sounds alter the judgements of the in-depth orientation of depth-ambiguous point-light walkers. While looming sounds are demonstrated to act at a perceptual level and make plws look more looming, it remains a challenge for future research to clarify at what level in the processing hierarchy receding sounds affect how observers judge the in-depth perception of plws