The dynamic interaction of order flows and the CAD/USD exchange rate

We explore the relationship between disaggregated order flow, the Canada/U.S. dollar (CAD/USD) market and U.S. macroeconomic announcements. Three types of CAD order flow and the CAD/USD are cointegrated. Financial order flow appears to contemporaneously drive the CAD/USD while commercial order flow seems to contemporaneously respond to exchange rate movements. Past order flow and lagged exchange rates strongly explain most types of order flow. Despite this predictability and the contemporaneous correlation of order flow with exchange rate returns, exchange rate returns are not predictable by either statistical or economic criteria (trading rule). This negative finding contrasts with that of Rime et al (2007), who use a different data set. There is strong evidence of structural breaks in the order-flow-exchange rate systems in 1994, 1996-1997 and 1999-2000.Foreign exchange rates

Intrusion detection methods and apparatus that use a building\u27s infrastructure as part of a sensor

Intrusion detection methods and apparatus exploit the infrastructure of the building itself. The preferred embodiments use the existing power line infrastructure to provide power, data, and sensor observables to a monitoring system which is simply connected at one point, namely, the connection of the building to the city power grid. Computer network interfaces may also be used. In terms of sensors, impedance, capacitive, inductive, electric field and Radar modalities may be used.https://digitalcommons.mtu.edu/patents/1026/thumbnail.jp

Patientenverfügungen als Ausdruck individualistischer Selbstbestimmung?: Die Rolle der Angehörigen in Patientenverfügungsformularen

Zusammenfassung : Patientenverfügungen werden häufig als Ausdruck eines Bestrebens verstanden, ausschließlich selbst über die eigene Behandlung am Lebensende oder in anderen medizinisch kritischen Situationen entscheiden zu wollen. Kritische Stimmen wenden sich gegen eine Marginalisierung von Angehörigen oder ein verkürztes Verständnis von Autonomie, welches von der Relationalität als Grundgegebenheit menschlicher Existenz abstrahiert. Im vorliegenden Beitrag wird zunächst der rechtliche Rahmen beschrieben, der die Praxis bezüglich Patientenverfügungen und Stellvertretern in der Schweiz bestimmt. Zudem werden in der Schweiz verfügbare Patientenverfügungsformulare hinsichtlich der darin vorgesehenen Rolle von Angehörigen bzw. nahe stehenden Personen analysiert. Abschließend soll gefragt werden, ob Patientenverfügungen, wie sie derzeit im Schweizer Kontext genutzt werden, wirklich als Instrumente rein individualistischer Selbstbestimmung verstanden werden könne

Reduced complexity of activity patterns in patients with Chronic Fatigue Syndrome: a case control study

ABSTRACT: BACKGROUND: Chronic fatigue syndrome (CFS) is an illness characterised by pervasive physical and mental fatigue without specific identified pathological changes. Many patients with CFS show reduced physical activity which, though quantifiable, has yielded little information to date. Nonlinear dynamic analysis of physiological data can be used to measure complexity in terms of dissimilarity within timescales and similarity across timescales. A reduction in these objective measures has been associated with disease and ageing. We aimed to test the hypothesis that activity patterns of patients with CFS would show reduced complexity compared to healthy controls. METHODS: We analysed continuous activity data over 12 days from 42 patients with CFS and 21 matched healthy controls. We estimated complexity in two ways, measuring dissimilarity within timescales by calculating entropy after a symbolic dynamic transformation of the data and similarity across timescales by calculating the fractal dimension using allometric aggregation. RESULTS: CFS cases showed reduced complexity compared to controls, as evidenced by reduced dissimilarity within timescales (mean (SD) Renyi(3) entropy 4.05 (0.21) vs. 4.30 (0.09), t = -6.6, p < 0.001) and reduced similarity across timescales (fractal dimension 1.19 (0.04) vs. 1.14 (0.04), t = 4.2, p < 0.001). This reduction in complexity persisted after adjustment for total activity. CONCLUSION: Patients with CFS show evidence of reduced complexity of activity patterns. Measures of complexity applied to activity have potential value as objective indicators for CFS

Dynamic-ADAPT-QAOA: An algorithm with shallow and noise-resilient circuits

The quantum approximate optimization algorithm (QAOA) is an appealing proposal to solve NP problems on noisy intermediate-scale quantum (NISQ) hardware. Making NISQ implementations of the QAOA resilient to noise requires short ansatz circuits with as few CNOT gates as possible. Here, we present Dynamic-ADAPT-QAOA. Our algorithm significantly reduces the circuit depth and the CNOT count of standard ADAPT-QAOA, a leading proposal for near-term implementations of the QAOA. Throughout our algorithm, the decision to apply CNOT-intensive operations is made dynamically, based on algorithmic benefits. Using density-matrix simulations, we benchmark the noise resilience of ADAPT-QAOA and Dynamic-ADAPT-QAOA. We compute the gate-error probability $p_\text{gate}^\star$ below which these algorithms provide, on average, more accurate solutions than the classical, polynomial-time approximation algorithm by Goemans and Williamson. For small systems with $6-10$ qubits, we show that $p_{\text{gate}}^\star>10^{-3}$ for Dynamic-ADAPT-QAOA. Compared to standard ADAPT-QAOA, this constitutes an order-of-magnitude improvement in noise resilience. This improvement should make Dynamic-ADAPT-QAOA viable for implementations on superconducting NISQ hardware, even in the absence of error mitigation.Comment: 15 pages, 9 figure

Occupational therapy predischarge home visits for patients with a stroke (HOVIS): results of a feasibility randomized controlled trial

Objective: To assess the feasibility of conducting a randomized controlled trial of occupational therapy predischarge home visits for people after stroke. Design: Randomized controlled trial and cohort study. We randomized eligible patients for whom there was clinical uncertainty about the need to conduct a home visit to a randomized controlled trial; patients for whom a visit was judged ‘essential’ were enrolled into a cohort study. Setting: Stroke rehabilitation unit of teaching hospital. Participants: One hundred and twenty-six participants hospitalized following recent stroke. Interventions: Predischarge home visit or structured, hospital-based interview. Main outcome measures: The primary objective was to collect information on the feasibility of a randomized controlled trial, including eligibility, control intervention and outcome assessments. The primary outcome measure was the Nottingham Extended Activities of Daily Living Scale at one month after discharge from hospital. Secondary outcomes included mood, quality of life and costs at one week and one month following discharge. Results: Ninety-three people were allocated to the randomized controlled trial; 47 were randomized to intervention and 46 to control. Thirty-three were enrolled into the cohort study. More people were allocated to the randomized controlled trial as the study progressed. One hundred and thirteen people (90%) received the proposed intervention, although there was a need for stricter protocol adherence. Follow-up was good: at one month 114 (90%) were assessed. There were no significant differences between the groups in the randomized controlled trial for the primary outcome measure at one month. The average cost of a home visit was £208. Conclusion: A trial is feasible and warranted given the resource implications of predischarge occupational therapy home visits