Creep-fatigue crack growth testing and analysis of pre-strained 316H stainless steel

Material pre-straining is known to have significant effects of the mechanical response and crack growth behaviour of steels. In this paper, the influence of material pre-straining on the subsequent creep-fatigue crack growth behaviour of Type 316H stainless steel at 550 °C has been examined by performing tests on compact tension specimens that were extracted from blocks uniformly pre-compressed at room temperature. Creep-fatigue crack growth tests on pre-compressed material were performed at the frequency of 0.01 Hz and R-ratio of 0.1. The crack growth data obtained from these experiments have been correlated with the C* and K fracture mechanics parameters and the results are compared with the existing creep crack growth data on the pre-compressed and as-received material at 550 °C. The results obtained have also been compared with the creep-fatigue data from experiments on weldments where the crack tip was located in the heat affected zone (HAZ). The crack growth behaviour in creep-fatigue tests on pre-compressed material has been found similar to that of HAZ material and are higher than that of the as-received material. Moreover, depending on the loading condition and frequency the crack growth data obtained from creep-fatigue tests on pre-compressed material may be characterized using C* or ΔK fracture mechanics parameters

An investigation of irregular crack path effects on fracture mechanics parameters using a grain microstructure meshing technique

Electronic version of an article published as Journal of Multiscale Modeling, Vol. 4, Iss. 1, atricle 1250001, 2012, http://dx.doi.org/10.1142/S1756973712500011 © World Scientific Publishing Company, http://www.worldscientific.com/worldscinet/jmmA sub-grain size finite element modelling approach is presented in this paper to investigate variations in fracture mechanics parameters for irregular crack paths. The results can be used when modelling intergranular and transgranular crack growth where creep and fatigue are the dominant failure mechanisms and their crack paths are irregular. A novel method for sub-grain scale finite element mesh consisting of multiple elements encased in ~50–150 μm-sized grains has been developed and implemented in a compact tension, C(T), mesh structure. The replicated shapes and dimensions were derived from an isotropic metallic grain structure using representative random sized grain shapes repeated in sequence ahead of the crack tip. In this way the effects of crack tip angle ahead of the main crack path can be considered in a more realistic manner. A comprehensive sensitivity analysis has been performed for elastic and elastic-plastic materials using ABAQUS and the stress distributions, the stress intensity factor and the J-integral have been evaluated for irregular crack paths and compared to those of obtained from analytical solutions. To examine the local and macroscopic graph path effects on fracture mechanics parameters, a few extreme cases with various crack-tip angles have been modelled by keeping the macroscopic crack path parallel to the axis of symmetry. The numerical solutions from these granular mesh structures have been found in relatively good agreement with analytical solutions

Plastic pre-compression and creep damage effects on the fracture toughness behaviour of Type 316H stainless steel

The influence of inelastic damage in the form of plastic pre-strain and creep damage, on fracture toughness of Type 316H stainless steel has been examined. Creep damage has been introduced into the 8% pre-compressed material by interrupting creep crack growth tests. Comparisons have been made between the fracture toughness test results from the as-received, pre-compressed and creep damaged materials. Furthermore, the effects of creep crack discontinuities on the crack tip strain fields have been examined by digital image correlation measurements. Inelastic damage was found to reduce the fracture toughness of the material, with creep damage having more severe effects than pre-strain

Immunomodulatory effects of human umbilical cord wharton's Jelly-Derived mesenchymal stem cells on differentiation, maturation and endocytosis of monocyte-derived dendritic cells

The Wharton's jelly of the umbilical cord is believed to be a source of mesenchymal stem cells (MSCs) which can be therapeutically applied in degenerative diseases. In this study, we investigated the immunomodulatory effect of umbilical cord derivedmesenchymal stem cells (UC-MSCs) and bone marrow-derived-mesenchymal stem cells (BM-MSCs) on differentiation, maturation, and endocytosis of monocyte-derived dendritic cells in a transwell culture system under laboratory conditions. Monocytes were differentiated into immature dendritic cells (iDCs) in the presence of GM-CSF and IL-4 for 6 days and then differentiated into mature dendritic cells (mDCs) in the presence of TNF-for 2 days. In every stage of differentiation, immature and mature dendritic cells were separately cocultured with UC-MSCs and BM-MSCs. The findings showed that UC-MSCs and BM-MSCs inhibited strongly differentiation and maturation of dendritic cells at higher dilution ratios (1:1). The BM-MSCs and UC-MSCs showed more inhibitory effect on CD1a, CD83, CD86 expression, and dendritic cell endocytic activity, respectively. On the other hand, these cells severely up-regulated CD14 marker expression. We concluded that UC-MSCs and BM-MSCs could inhibit differentiation, maturation and endocytosis in monocyte-derived DCs through the secreted factors and free of any cellcell contacts under laboratory conditions. As DCs are believed to be the main antigen presenting cells for naive T cells in triggering immune responses, it would be logical that their inhibitory effect on differentiation, maturation and function can decrease or modulate immune and inflammatory responses. Copyright © Spring 2013, Iran J Allergy Asthma Immunol. All rights reserved