FORMULATION DEVELOPMENT AND EVALUATION OF NIOSOMAL GEL OF COLLECTIVE ANTI-FUNGAL AGENTS

Objectives: Tea tree oil (TTO) and Eucalyptus oil (EO) are essential oils derived from the leaves and terminal branches of Melaleuca alternifolia and Eucalyptus globulus. Both oils have narrative topical antifungal agents. Niosomal vesicles were chosen for Tea tree and EO dispersion in this investigation because of their ability to protect enclosed drugs, reduce drug dose amount, target drug delivery, increase residence time and penetration. Methods: TTO and EO containing niosomes were made using a modified thin-film hydration process and Carbopol 934 as a gelling agent to produce a smooth antifungal niosomal gel. Results: TTO and EO entrapment efficiency was found to be 84.89±0.19% and 86.86±0.57%, respectively, and percent cumulative drug diffusion of TTO and EO was found to be 84.21% and 85.22% in the prepared optimized batch [N9]. Transmission electron microscopy revealed vesicular, spherical particles in the nano range with a smooth surface. The optimum batch [N9] of niosomal gel was made with 1% w/w carbopol 934. TTO 84.9% and EO 86.89%, respectively, were found to have prolonged drug release in an in vitro release investigation utilizing the dialysis bag method. The G9 batch niosomal gel was found to be stable by performing an accelerated stability study for 3 months. Conclusion: It was concluded that the best formulation batch G9 shows better-sustained release, enhanced residence time, and stability

Dissolution Rate Enhancement of Lansoprazole Tablet in Hydrophilic Carrier Solid Dispersions by Solvent Evaporation Methods

Solid dispersion technique has been developed for improving solubility of water-insoluble drugs, aiming to achieve a better oral bioavailability. The objectives of present investigation is to improve the solubility and rate of dissolution of poorly aqueous soluble drug lansoprazole by preparing solid dispersion with hydrophilic carrier Poly Ethylene Glycol 6000, hydroxy propyl methyl cellulose, Polyvinyl pyrrolidone by using solvent evaporation method and selecting the best solid dispersion. The drug and excipient compatibility study of selected solid dispersion was performed by FTIR and DSC. This study showed no interaction in drug and carrier. The designed granulation method was employed to prepare solid dispersion tablets and the formulation was optimized through investigating the dissolution behaviours. The results indicated PEG and Polyvinyl pyrrolidone in combination of solid dispersion showed the best effect both on physical characterizations and dissolution studies. Furthermore, all type of solid dispersions significantly improved the dissolution rates when compared to pure drug and its corresponding physical mixture (PM). All the evaluations were performed and complies with the pharmacopoeial standards. The formulation F7 showed 98.88% of cumulative drug release within 8 min with zero order release pattern. The solid dispersion tablets prepared in simplified tableting method exhibited better operability, stability and dissolution behaviour than the tablets prepared in traditional ways, which brought more opportunities to solid dispersion technique for industrial productio

Quantum Dots: Method of Preparation and Biological Application

Quantum dots are inorganic semiconductor crystal of nanometer size which having distinctive conductive property depend on its size & shape. After administration of quantum dots parentally they identify target and bound them. Also quantum dots having light emitting property depend on size & shape. Quantum dots are prepared by chemical synthesis method include both organic & water phase synthesis & also by top- bottom approach. Tumor cell targeting & detection of pathogen & toxin are the main application of quantum dots & also in targeting drug delivery system. This review provides the overview of method of preparation of quantum dots & its biological application. Keywords: Quantum dot, targeting drug delivery, biological applicatio

Design and Performance Evaluation of Resource Allocation Mechanisms in Optical Data Center Networks

A datacenter hosts hundreds of thousands of servers and a huge amount of bandwidth is required to accommodate communication between thousands of servers. Several packet switched based datacenter architectures are proposed to cater the high bandwidth requirement using multilayer network topologies, however at the cost of increased network complexity and high power consumption. In recent years, the focus has shifted from packet switching to optical circuit switching to build the data center networks as it can support on demand connectivity and high bit rates with low power consumption. On the other hand, with the advent of Software Defined Networking (SDN) and Network Function Virtualization (NFV), the role of datacenters has become more crucial. It has increased the need of dynamicity and flexibility within a datacenter adding more complexity to datacenter networking. With NFV, service chaining can be achieved in a datacenter where virtualized network functions (VNFs) running on commodity servers in a datacenter are instantiated/terminated dynamically. A datacenter also needs to cater large capacity requirement as service chaining involves steering of large aggregated flows. Use of optical circuit switching in data center networks is quite promising to meet such dynamic and high capacity traffic requirements. In this thesis work, a novel and modular optical data center network (DCN) architecture that uses multi-directional wavelength switches (MD-WSS) is introduced. VNF service chaining use case is considered for evaluation of this DCN and the end-to-end service chaining problem is formulated as three inter-connected sub-problems: multiplexing of VNF service chains, VNFs placement in the datacenter and routing and wavelength assignment. This thesis presents integer linear programming (ILP) formulation and heuristics for solving these problems, and numerically evaluate them.Ett datacenter inrymmer hundratusentals servrar och en stor mängd bandbredd krävs för att skicka data mellan tusentals servrar. Flera datacenter baserade på paketförmedlande arkitekturer föreslås för att tillgodose kravet på hög bandbredd med hjälp av flerskiktsnätverkstopologier, men på bekostnad av ökad komplexitet i nätverken och hög energiförbrukning. Under de senaste åren har fokus skiftat från paketförmedling till optisk kretsomkoppling for att bygga datacenternätverk som kan stödja på-begäran-anslutningar och höga bithastigheter med låg strömförbrukning. Å andra sidan, med tillkomsten av Software Defined Networking (SDN) och nätverksfunktionen Virtualisering (NFV), har betydelsen av datacenter blivit mer avgörande. Det har ökat behovet av dynamik och flexibilitet inom ett datacenter, vilket leder till storre komplexitet i datacenternätverken. Med NFV kan tjänstekedjor åstadkommas i ett datacenter, där virtualiserade nätverksfunktioner (VNFs) som körs på servrar i ett datacenter kan instansieras och avslutas dynamiskt. Ett datacenter måste också tillgodose kravet på stor kapacitet eftersom tjänstekedjan innebär styrning av stora aggregerade flöden. Användningen av optisk kretsomkoppling i datacenternätverk ser ganska lovande ut for att uppfylla sådana trafikkrav dynamik och hög kapacitet. I detta examensarbete, har en ny och modulär optisk datacenternätverksarkitektur (DCN) som använder flerriktningvåglängdsswitchar (MD-WSS) införs. Ett användningsfall av VNF-tjänstekedjor noga övervägd för utvärdering av denna DCN och end-to-end-servicekedjans problem formuleras som tre sammankopplade delproblem: multiplexering av VNF-servicekedjor, VNF placering i datacentret och routing och våglängd uppdrag. Denna avhandling presenterar heltalsprogrammering (ILP) formulering och heuristik för att lösa dessa problem och numeriskt utvärdera dem

Emerg Infect Dis

Pathogens in the gastrointestinal tract exist within a vast population of microbes. We examined associations between pathogens and composition of gut microbiota as they relate to Shigella spp./enteroinvasive Escherichia coli infection. We analyzed 3,035 stool specimens (1,735 nondiarrheal and 1,300 moderate-to-severe diarrheal) from the Global Enteric Multicenter Study for 9 enteropathogens. Diarrheal specimens had a higher number of enteropathogens (diarrheal mean\uc2\ua01.4, nondiarrheal mean\uc2\ua00.95; p<0.0001). Rotavirus showed a negative association with Shigella spp. in cases of diarrhea (odds ratio 0.31, 95% CI 0.17-0.55) and had a large combined effect on moderate-to-severe diarrhea (odds ratio 29, 95% CI 3.8-220). In 4 Lactobacillus taxa identified by 16S rRNA gene sequencing, the association between pathogen and disease was decreased, which is consistent with the possibility that Lactobacillus spp. are protective against Shigella spp.-induced diarrhea. Bacterial diversity of gut microbiota was associated with diarrhea status, not high levels of the Shigella spp. ipaH gene

Multiple bilateral supernumerary mandibular premolars in a non-syndromic patient with associated orthokeratised odontogenic cyst- A case report and review of literature

Multiple supernumerary teeth are very rare, accounting for less than 1% of cases. They are commonly associated with syndromes like Gardner′s syndrome and cleidocranial dysostosis and cleft lip and palate. Non-syndromic multiple supernumerary teeth have a predilection to occur in the mandibular premolar region. Orthokeratinized odontogenic cyst (OOC) is a relatively uncommon developmental cyst comprising about 10% of the cases that had been previously implied as odontogenic keratocysts. More than half of the cases of OOC are associated with impacted tooth; but not a single case of OOC associated with supernumerary teeth is reported. Hence, the purpose of this article is to report the first case of multiple supernumerary mandibular premolars associated with OOC in a 35-year-old male and to review the literature associated with multiple bilateral supernumerary mandibular premolars

Benign fibrous histiocytoma of the maxilla: A case report and review of literature

Benign fibrous histiocytoma (BFH) is a mesenchymal tumor which commonly affects the skin of extremities. Histologically, BFH of soft tissues and bone shows similar features, but BFH of the bone is rare with less than 100 cases reported worldwide and usually it involves tibia, femur, and pelvic bone. As far as the oral cavity is concerned, majority of the BFHs are found in the soft tissues of the buccal mucosa, gingiva, lower and upper lips, soft palate, and floor of the mouth. Occurrence of this tumor in the jaw bones is extremely rare as only one case of the maxilla and six cases of the mandible have been reported so far . Hence, the purpose of this article is to report the second case of BFH of the maxilla in a 23-year-old female patient and to review the literature of this entity affecting the jaws

ProHSO4: An efficient catalyst for solvent-free synthesis of bis(indolyl)methanes and their in silico screening for potential biological activity

A simple, mild, and efficient protocol has been developed for the synthesis of 3,3′-bis(indolyl)methanes (BIMs) using prolinium hydrogen sulfate (ProHSO4) as a catalyst under solvent-free and support-free conditions. This mechanochemical method undergoes electrophilic substitution reaction of indole with diverse aldehydes to afford the desired BIMs in high yields at room temperature. Due to diverse pharmacological utility, the synthesized BIMs were subjected to in silico studies. The structure activity analysis of BIMs revealed their ability to bind Eg5 kinesin, Human p38 α MAP Kinase, and Human 3 alpha HSD type 3 as a potential protein target for anticancer activity. The compounds exhibited higher binding affinities with Eg5 kinesin having hydrophobic interactions with α2, α3 helices and loop5 amino acid residues. Moreover, molecular docking with Human p38 α MAP Kinase protein depicted compounds as ATP-competitive molecules interacting with hydrophobic region I, II and allosteric DFG motif. A total of 13 derivatives were synthesized and subjected for in silico screening for predicting potential biological activity. Among them, 3b, 3d, 3f, 3 g, 3i, 3j, and 3 k compounds were identified as potential inhibitors of Eg5 kinesin, Human p38 α MAP Kinase, and Human 3 alpha HSD type 3, and their evaluation in the biological experimental system is warranted