Evaluate the effectiveness of various diagnostic criteria and treatment outcomes in colposcopy screening for cervical cancer in a tertiary care medical college and hospital

Background: Cervical cancer is a significant health concern, particularly in developing countries like Bangladesh. This study aimed to evaluate the efficacy of diagnostic criteria and treatment outcomes in cervical cancer screening using colposcopy. Methods: A retrospective study was conducted at Holy Family Red Crescent Medical College and Hospital, involving 110 female participants from January 2016 to December 2018. Inclusion criteria included women with symptoms such as vaginal discharge or postcoital bleeding, an unhealthy cervix or cervical erosion, abnormal Pap smear results, or positive VIA tests. Exclusion criteria were applied to ensure the integrity of the study. Results: The study included participants ranging from 20 to 60 years old. Among the age groups, individuals aged 31-40 were the most represented, accounting for 43% of the total population. The second largest group was those aged 20-30, comprising 29% of the participants. The mean and SD of the population is 27.5±14.36. The most prevalent reasons for referral were an unhealthy cervix (31%), white discharge (26%), and cervical erosion (18%). Other indications included post-coital bleeding (9%), abnormal Pap smear results (11%), positive results for VIA (3%) and HPV DNA (2%). LLETZ was performed in 6% of cases for the treatment of abnormal cervical cells, while EC was conducted in 18% of cases to collect tissue samples from the endocervical canal. Conclusions: The study highlights the importance of colposcopy in the screening process for cervical cancer, allowing for the detection of abnormalities and subsequent interventions. The findings contribute to the understanding of diagnostic criteria, treatment outcomes, and the need for early detection and prevention of cervical cancer.

Development of methods for managing energy consumption and energy efficiency in a common system

The work aims to analyze and examine renewable energy sources (RES) to develop interconnected energy efficiency and energy consumption management system by integrating the software-defined machine-to-machine (M2M) communication. The article’s objectives include analysis of using RES as alternative raw materials for electricity production, the study of intelligent technologies for integrating RES into monitoring and control systems, research of devices and methods for monitoring energy production and consumption, analysis of sensor application for automation of control systems in the energy sector, a study of data transmission and information processing rates. The study results showed that the data transfer rate was delayed by 6 seconds to process 1,000 MB of information. It has been proven that wind energy can be used most efficiently within a 12-hour daily cycle, in contrast to tidal energy and solar energy. It is shown that due to the cyclical nature of obtaining energy from renewable sources, they do not fully provide energy to a large city, on the basis of which it is necessary to additionally use other energy sources. Three different types of power generation facilities were examined and compared. Wind farms were found to have the highest potential for electricity generation, amounting to 1,600-1,700 kW

Brown-pigmented Mycobacterium mageritense as a cause of prosthetic valve endocarditis and bloodstream infection

Mycobacterium spp. are a rare cause of endocarditis. Herein, we describe a case of Mycobacterium mageritense prosthetic valve endocarditis. This organism produced an unusual brown pigment on solid media. Cultures of valve tissue for acid-fast bacilli might be considered in some cases of apparently culture-negative prosthetic valve endocarditis

gUML: Reasoning about Energy at Design Time by Extending UML Deployment Diagrams with Data Centre Contextual Information

With the rising energy demand in ICT services and its associated environmental impact, the need for energy efficient Enterprise ICT solutions is growing. As data centres account for a large part of energy consumption in ICT, data centre operators strive to create opportunities to put more emphasis on reducing energy consumption. However, creating ICT Systems that are energy efficient by design remains a key challenge. In this paper, we identify and map contextual energy information about data centre operations in order to model their power related components. This contextual modelling is then mapped to deployment diagram where we introduce greenUML (gUML), an extension to UML diagrams to improve energy efficiency through energy analysis at design time. gUML will allow system architects to reason about the energy footprint of their applications at design time

Numerical analysis of microwave heating cavity: Combining electromagnetic energy, heat transfer and fluid dynamics for a NaY zeolite fixed-bed

[EN] Three-dimensional mathematical model was developed for a rectangular TE10n microwave heating cavity system, working at 2.45 GHz. Energy/heat, momentum equations were solved together with Maxwell's electromagnetic field equations using comm. MULTIPHYSICS (R) simulation environment. The dielectric properties, epsilon' and epsilon '', of NaY zeolite (Si/Al = 2.5) were evaluated as a function of temperature. Considering these values, the microwave heating of a porous fixed-bed made of dry NaY zeolite was simulated. Electric field distribution, axial and radial temperature profiles and temperature evolution with time were obtained. The zeolite fixed bed was heated up to 180 degrees C in 5 min, with 30 W power. The fixed-bed temperature evolution under non-steady state conditions showed the same trend as the one observed experimentally with only an average deviation of 10.3%. The model was used to predict microwave heating of other materials improving energy efficiency of the microwave cavity. Furthermore, the developed model was able to predict thermal runaway for zeolites.Financial support from the European Research Council ERC-Advanced Grant HECTOR-267626 is gratefully acknowledged. Hakan Nigar acknowledges financial support from the Spanish Ministry of Education for the FPU grant (Formacion del Profesorado Universitario - FPU12/06864), and also for the academic short stay grant (Estancia Breve - FPU2016) at the Delft University of Technology, Delft, The Netherlands.Nigar, H.; Sturm, GSJ.; García-Baños, B.; Penaranda-Foix, FL.; Catalá Civera, JM.; Mallada, R.; Stankiewicz, A.... (2019). Numerical analysis of microwave heating cavity: Combining electromagnetic energy, heat transfer and fluid dynamics for a NaY zeolite fixed-bed. Applied Thermal Engineering. 155:226-238. https://doi.org/10.1016/j.applthermaleng.2019.03.117S22623815

In vivo assessment of diet-induced rat hepatic steatosis development by percutaneous single-fiber spectroscopy detects scattering spectral changes due to fatty infiltration

This study explores percutaneous single-fiber spectroscopy (SfS) of rat livers undergoing fatty infiltration. Eight test rats were fed a methionine-choline-deficient (MCD) diet, and four control rats were fed a normal diet. Two test rats and one control rat were euthanized on days 12, 28, 49, and 77 following initiation of the diet, after percutaneous SfS of the liver under transabdominal ultrasound guidance. Histology of each set of the two euthanized test rats showed mild and mild hepatic lipid accumulations on day 12, moderate and severe on day 28, severe and mild on day 49, and moderate and mild on day 77. Livers with moderate or higher lipid accumulation generally presented higher spectral reflectance intensity when compared to lean livers. Livers of the eight test rats on day 12, two of which had mild lipid accumulation, revealed an average scattering power of 0.37±0.14 in comparison to 0.07±0.14 for the four control rats (p<0.01). When livers of the test rats with various levels of fatty infiltration were combined, the average scattering power was 0.36±0.15 in comparison to 0.14±0.24 of the control rats (0.05<p<0.1). Increasing lipid accumulation in concentration and size seemed to cause an increase of the scattering power prior to increasing total spectral reflectance.Electrical and Computer EngineeringVeterinary Clinical Science

In vivo percutaneous reflectance spectroscopy of fatty liver development in rats suggests that the elevation of the scattering power is an early indicator of hepatic steatosis

This study assessed whether there was a scattering spectral marker quantifiable by reflectance measurements that could indicate early development of hepatic steatosis in rats for potential applications to pre-procurement organ evaluation. Sixteen rats were fed a methionine-choline-deficient (MCD) diet and eight rats were fed a normal diet. Direct assessment of the liver parenchyma of rats in vivo was performed by percutaneous reflectance spectroscopy using a single fiber probe at the beginning of diet-intake and arbitrary post-diet-intake times up to 11 weeks to render longitudinal comparison. Histological sampling of the liver over the duration of diet administration was performed on two MCD-diet treated rats and one control rat euthanized after reflectance spectroscopy measurement. The images of hematoxylin/eosin-stained liver specimens were analyzed morphometrically to evaluate the lipid size changes associated with the level of steatosis. The MCD-diet-treated group (n=16) had mild steatosis in seven rats, moderate in three rats, severe in six rats, and no other significant pathology. No control rats (n=8) developed hepatic steatosis. Among the parameters retrieved from per-SfS, only the scattering power (can be either positive or negative) appeared to be statistically different between MCD-treated and control livers. The scattering power for the 16 MCD-diet-treated livers at the time of euthanasia and presenting various levels of steatosis was 0.33±0.21, in comparison to 0.036±0.25 of the eight control livers (p=0.0189). When evaluated at days 12 and 13 combined, the scattering power of the 16 MCD-diet-treated livers was 0.32±0.17, in comparison to 0.10±0.11 of the eight control livers (p=0.0017). All of four MCD-treated livers harvested at days 12 and 13 presented mild steatosis with sub-micron size lipid droplets, even though none of the MCD-treated livers were sonographically remarkable for fatty changes. The elevation of the scattering power may be a valuable marker indicating early hepatic steatosis before the steatosis is sonographically detectable.Electrical and Computer EngineeringVeterinary Clinical Science

Rules versus Discretion in Committee Decision Making: An Application to the 2001 RAE for UK Economics Departments

The question of rules versus discretion has generated a great deal of debate in many areas of the social sciences. Recently, much of the discussion among academics and stakeholders about the assessment of research in UK higher education institutions has focused on the means that should be used to determine research quality. We present a model of committee decision-making when both rules and discretion are available. Some of the predictions of the model are tested empirically using the UK RAE 2001 results

Anion-Sensitive Regions of L-Type CaV1.2 Calcium Channels Expressed in HEK293 Cells

L-type calcium currents (ICa) are influenced by changes in extracellular chloride, but sites of anion effects have not been identified. Our experiments showed that CaV1.2 currents expressed in HEK293 cells are strongly inhibited by replacing extracellular chloride with gluconate or perchlorate. Variance-mean analysis of ICa and cell-attached patch single channel recordings indicate that gluconate-induced inhibition is due to intracellular anion effects on Ca2+ channel open probability, not conductance. Inhibition of CaV1.2 currents produced by replacing chloride with gluconate was reduced from ∼75%–80% to ∼50% by omitting β subunits but unaffected by omitting α2δ subunits. Similarly, gluconate inhibition was reduced to ∼50% by deleting an α1 subunit N-terminal region of 15 residues critical for β subunit interactions regulating open probability. Omitting β subunits with this mutant α1 subunit did not further diminish inhibition. Gluconate inhibition was unchanged with expression of different β subunits. Truncating the C terminus at AA1665 reduced gluconate inhibition from ∼75%–80% to ∼50% whereas truncating it at AA1700 had no effect. Neutralizing arginines at AA1696 and 1697 by replacement with glutamines reduced gluconate inhibition to ∼60% indicating these residues are particularly important for anion effects. Expressing CaV1.2 channels that lacked both N and C termini reduced gluconate inhibition to ∼25% consistent with additive interactions between the two tail regions. Our results suggest that modest changes in intracellular anion concentration can produce significant effects on CaV1.2 currents mediated by changes in channel open probability involving β subunit interactions with the N terminus and a short C terminal region