The Big Pet Diabetes Survey: Perceived Frequency and Triggers for Euthanasia

Current pet diabetes mellitus (DM) treatment necessitates the active daily involvement of owners and can be costly. The current study aimed to investigate the owner population which opts for euthanasia instead of DM treatment. A survey was designed using multiple feedback steps and made available online to veterinarians world-wide. A total of 1192 veterinarians completed the survey and suggested a median one in 10 diabetic pets are euthanased at diagnosis; a further median one in 10 within one year because of lack of success or compliance. Perceived most important motivating factors included “presence concurrent disease” (45% respondents); “costs” (44%); “animal age” (37%); “problems obtaining adequate control” (35%); “pet welfare” (35%); and “impact owner’s lifestyle” (32%). Cats in Canadian (odds ratio (OR) 2.7), Australian (OR 2.3), rural (OR 1.6) and mixed (OR 1.7) practices were more likely to be euthanased because of DM diagnosis, while cats presented to referral/university were less likely to be euthanased (OR 0.6). Dogs were more likely to be euthanased because of DM in Canadian (OR 1.8), rural (OR 1.8) and mixed (OR 1.6) practices. The survey results suggest that benefit exists in improved DM education with emphasis on offering a choice of treatment styles ranging from intense and expensive to hands-off and cheap

Toba Batak Textile Inventions

INTRODUCTION This article focuses on fruits of looms worked by Toba Batak weavers in the Silindung Valley, North Sumatra, Indonesia. Silindung Valley weavings are characteristically bright and fashionable. They are described by the Batak themselves and by visitors from outside as the least traditional of Batak woven goods. They are also surging in popularity throughout all of Toba and increasingly making inroads into the market replacing the old-style textiles which are larger, of coarser yarn, and deeper/sober in colour. It is the modern style of Batak textile which today commands the highest prices locally. Connoisseurs of Indonesian textiles, however, usually will not even consider buying them. To the connoisseur, they are evidence of the decline that is occurring in the once wondrously sophisticated Indonesian textile arts. In this paper I will examine some of the changes that are occurring in Silindung Valley textiles. This Valley of socalled declining textiles is precisely the location of rapid fashion change. The invention of new textiles is not infrequent. I believe that the vitality and dynamism of the Silindung Valley textile tradition forces us to reconsider what is meant by decline as it is used, for example, in the following quotation: To me, antique Batak textiles,especially those from Toba, represent the highest achievement of Indonesian weaving. Hence what now comes from this area is so heart-rending to look at. The contrast between modern and antique products is nowhere else so extreme ... Decline through European influence is especially evident in the imported regular yarn dyed in bright aniline colours... (Visser 1918-1919:21,22). SILINDUNG VALLEY TEXTILE INNOVATIONS To discuss Silindung Valley textile innovations, I will focus on the work of a single weaver/ikat-maker, Nai Ganda (ill 1), who inhabits the village of Hutagalung. She first told me about her textile inventions in 1986, and again in 1990 she showed me several more of her creations, hot off the loom. Each of Nai Ganda\u27s inventions is of a different order, but each exemplifies the modern features for which Silindung Valley textiles are known. I shall briefly review the inventions she introduced me to, both for their innovative features and to indicate the nature of current Silindung Valley textile fashions

Modern agglutinated Foraminifera from the Hovgård Ridge, Fram Strait, west of Spitsbergen: evidence for a deep bottom current

Deep-water agglutinated foraminifera on the crest of the Hovgård Ridge, west of Spitsbergen, consist mostly of large tubular astrorhizids. At a boxcore station collected from the crest of Hovgård Ridge at a water depth of 1169 m, the sediment surface was covered with patches of large (1 mm diameter) tubular forms, belonging mostly to the species Astrorhiza crassatina Brady, with smaller numbers of Saccorhiza, Hyperammina, and Psammosiphonella. Non-tubular species consisted mainly of opportunistic forms, such as Psammosphaera and Reophax. The presence of large suspension-feeding tubular genera as well as opportunistic forms point to the presence of deep currents at this locality that are strong enough to disturb the benthic fauna. This is confirmed by data obtained from sediment echosounding, which exhibit lateral variation in relative sedimentation rates within the Pleistocene sedimentary drape covering the ridge, indicative of winnowing in a south-easterly direction

Using personal statements in college admissions::An investigation of gender bias and the effects of increased structure

Personal statements are among the most commonly used instruments in college admissions procedures. Yet, little research on their reliability, validity, and fairness exists. The first aim of this paper was to investigate hypotheses about adverse impact and underprediction for female applicants, which could result from lower tendencies to use agentic language compared to male applicants. Second, we examined if rating personal statements in a more structured manner would increase reliability and validity. Using personal statements (250 words) from a large cohort of applicants to an undergraduate psychology program at a Dutch University, we found no evidence for adverse impact for female applicants or more agentic language use by male applicants, and no relationship between agentic language use and personal statement ratings. In contrast, we found that personal statements of female applicants were rated slightly more positively than those of males. Exploratory analyses suggest that female applicants’ better writing skills might explain this difference. A more structured approach to rating personal statements yielded higher, but still only ‘moderate’ inter-rater reliability, and virtually identical, negligible predictive validity for first year GPA and dropout

Cell adhesion and mechanics as drivers of tissue organization and differentiation : local cues for large scale organization

Biological patterns emerge through specialization of genetically identical cells to take up distinct fates according to their position within the organism. How initial symmetry is broken to give rise to these patterns remains an intriguing open question. Several theories of patterning have been proposed, most prominently Turing's reaction-diffusion model of a slowly diffusing activator and a fast diffusing inhibitor generating periodic patterns. Although these reaction-diffusion systems can generate diverse patterns, it is becoming increasingly evident that cell shape and tension anisotropies, mediated via cell-cell and/or cell-matrix contacts, also facilitate symmetry breaking and subsequent self-organized tissue patterning. This review will highlight recent studies that implicate local changes in adhesion and/or tension as key drivers of cell rearrangements. We will also discuss recent studies on the role of cadherin and integrin adhesive receptors in mediating and responding to local tissue tension asymmetries to coordinate cell fate, position and behavior essential for tissue self-organization and maintenance.Peer reviewe

A role for the cleaved cytoplasmic domain of E-cadherin in the nucleus

Cell-cell contacts play a vital role in intracellular signaling, although the molecular mechanisms of these signaling pathways are not fully understood. E-cadherin, an important mediator of cell-cell adhesions, has been shown to be cleaved by γ-secretase. This cleavage releases a fragment of E-cadherin, E-cadherin C-terminal fragment 2 (E-cad/CTF2), into the cytosol. Here, we study the fate and function of this fragment. First, we show that coexpression of the cadherin-binding protein, p120 catenin (p120), enhances the nuclear translocation of E-cad/CTF2. By knocking down p120 with short interfering RNA, we also demonstrate that p120 is necessary for the nuclear localization of E-cad/CTF2. Furthermore, p120 enhances and is required for the specific binding of E-cad/CTF2 to DNA. Finally, we show that E-cad/CTF2 can regulate the p120-Kaiso-mediated signaling pathway in the nucleus. These data indicate a novel role for cleaved E-cadherin in the nucleus

A trial studying approach to predict college achievement

We argue that using trial studying is a reliable and valid way to select students for higher education. This method is based on a work sample approach often used in personnel selection contexts. We discuss that this method has predictive validity for study success, has high acceptance by stakeholders, and measures self-regulation in a high-stakes testing context that cannot be measured through self-report questionnaires. We suggest further research to implement this method to select students