254 research outputs found
A latent class analysis of parental bipolar disorder: examining associations with offspring psychopathology
Bipolar disorder (BD) is highly heterogeneous, and course variations are associated with patient outcomes. This diagnostic complexity challenges identification of patients in greatest need of intervention. Additionally, course variations have implications for offspring risk. First, latent class analysis (LCA) categorized parents with BD based on salient illness characteristics: BD type, onset age, polarity of index episode, pole of majority of episodes, rapid cycling, psychosis, anxiety comorbidity, and substance dependence. Fit indices favored three parental classes with some substantively meaningful patterns. Two classes, labeled “Earlier-Onset Bipolar-I” (EO-I) and “Earlier-Onset Bipolar-II” (EO-II), comprised parents who had a mean onset age in mid-adolescence, with EO-I primarily BD-I parents and EO-II entirely BD-II parents. The third class, labeled “Later-Onset BD” (LO) had an average onset age in adulthood. Classes also varied on probability of anxiety comorbidity, substance dependence, psychosis, rapid cycling, and pole of majority of episodes. Second, we examined rates of disorders in offspring (ages 4–33, Mage=13.46) based on parental latent class membership. Differences emerged for offspring anxiety disorders only such that offspring of EO-I and EO-II parents had higher rates, compared to offspring of LO parents, particularly for daughters. Findings may enhance understanding of BD and its nosologyThis study was funded by two Brain & Behavior Research Foundation (formerly NARSAD) Independent Investigator Awards (PI: Nierenberg), a Brain & Behavior Research Foundation Young Investigator Award (PI: Henin) generously supported in part by the SHINE Initiative, and an MGH Claflin Award (PI: Henin). We thank David A. Langer, Ph.D., Thomas M. Olino, Ph.D., and Meredith Lotz Wallace, Ph.D. for their consultation. (Brain & Behavior Research Foundation; Brain & Behavior Research Foundation Young Investigator Award; SHINE Initiative; MGH Claflin Award)Accepted manuscrip
Luminous Satellites II: Spatial Distribution, Luminosity Function and Cosmic Evolution
We infer the normalization and the radial and angular distributions of the
number density of satellites of massive galaxies
() between redshifts 0.1 and 0.8 as a function
of host stellar mass, redshift, morphology and satellite luminosity. Exploiting
the depth and resolution of the COSMOS HST images, we detect satellites up to
eight magnitudes fainter than the host galaxies and as close as 0.3 (1.4)
arcseconds (kpc). Describing the number density profile of satellite galaxies
to be a projected power law such that P(R)\propto R^{\rpower}, we find
\rpower=-1.1\pm 0.3. We find no dependency of \rpower on host stellar mass,
redshift, morphology or satellite luminosity. Satellites of early-type hosts
have angular distributions that are more flattened than the host light profile
and are aligned with its major axis. No significant average alignment is
detected for satellites of late-type hosts. The number of satellites within a
fixed magnitude contrast from a host galaxy is dependent on its stellar mass,
with more massive galaxies hosting significantly more satellites. Furthermore,
high-mass late-type hosts have significantly fewer satellites than early-type
galaxies of the same stellar mass, likely a result of environmental
differences. No significant evolution in the number of satellites per host is
detected. The cumulative luminosity function of satellites is qualitatively in
good agreement with that predicted using subhalo abundance matching techniques.
However, there are significant residual discrepancies in the absolute
normalization, suggesting that properties other than the host galaxy luminosity
or stellar mass determine the number of satellites.Comment: 23 pages, 12 figures, Accepted for publication in the Astrophysical
Journa
Cultivating equality: delivering just and sustainable food systems in a changing climate
T
oday, the world faces a greater challenge perhaps than ever before:
tackling hunger and malnutrition in the face of climate change
and increasing natural resource scarcity. Civil society, governments,
researchers, donors, and the private sector are simultaneously debating
and collaborating to find solutions. But the dialogue is over-emphasizing
food production.
Improving yields is important, particularly in places where there is not
enough food or where food producers live in poverty. But simply producing
more is not enough to tackle hunger. Furthermore, acknowledging that
lack of food is not the sole cause of hunger is important. Inequality
shapes who has access to food and the resources to grow it and buy it.
It governs who eats first and who eats worst. Inequality determines who
can adapt more readily to a changing climate. Hunger and poverty are
not an accident – they are the result of social and economic injustice and
inequality at all levels, from household to global. The reality of inequality
is no truer for anyone than it is for women – half the world’s population,
with far less than their fair share of the world’s resources.
If we are to achieve the new Sustainable Development Goal of ending
hunger by 2030, we must address the underlying inequalities in food
systems. In a changing climate, agriculture and food systems must be
sustainable and productive – but our efforts cannot end there. They
must be profitable for those for whom it is a livelihood; they must be
equitable, to facilitate a level playing field in the market, to secure rights
to resources for food producers, and to ensure access to nutritious food for
all; they must be resilient to build the capacity of populations vulnerable
to economic shocks, political instability, and increasing, climate-induced
natural hazards to recover and still lift themselves out of poverty
The Lick AGN Monitoring Project 2011: Reverberation Mapping of Markarian 50
The Lick AGN Monitoring Project 2011 observing campaign was carried out over
the course of 11 weeks in Spring 2011. Here we present the first results from
this program, a measurement of the broad-line reverberation lag in the Seyfert
1 galaxy Mrk 50. Combining our data with supplemental observations obtained
prior to the start of the main observing campaign, our dataset covers a total
duration of 4.5 months. During this time, Mrk 50 was highly variable,
exhibiting a maximum variability amplitude of a factor of 4 in the U-band
continuum and a factor of 2 in the H-beta line. Using standard
cross-correlation techniques, we find that H-beta and H-gamma lag the V-band
continuum by tau_cen = 10.64(-0.93,+0.82) and 8.43(-1.28,+1.30) days,
respectively, while the lag of He II 4686 is unresolved. The H-beta line
exhibits a symmetric velocity-resolved reverberation signature with shorter
lags in the high-velocity wings than in the line core, consistent with an
origin in a broad-line region dominated by orbital motion rather than infall or
outflow. Assuming a virial normalization factor of f=5.25, the virial estimate
of the black hole mass is (3.2+-0.5)*10^7 solar masses. These observations
demonstrate that Mrk 50 is among the most promising nearby active galaxies for
detailed investigations of broad-line region structure and dynamics.Comment: Accepted for publication in ApJ Letters. 6 pages, 4 figure
The Lick AGN Monitoring Project 2011: Spectroscopic Campaign and Emission-Line Light Curves
In the Spring of 2011 we carried out a 2.5 month reverberation mapping
campaign using the 3 m Shane telescope at Lick Observatory, monitoring 15
low-redshift Seyfert 1 galaxies. This paper describes the observations,
reductions and measurements, and data products from the spectroscopic campaign.
The reduced spectra were fitted with a multicomponent model in order to isolate
the contributions of various continuum and emission-line components. We present
light curves of broad emission lines and the AGN continuum, and measurements of
the broad H-beta line widths in mean and root-mean square (rms) spectra. For
the most highly variable AGNs we also measured broad H-beta line widths and
velocity centroids from the nightly spectra. In four AGNs exhibiting the
highest variability amplitudes, we detect anticorrelations between broad H-beta
width and luminosity, demonstrating that the broad-line region "breathes" on
short timescales of days to weeks in response to continuum variations. We also
find that broad H-beta velocity centroids can undergo substantial changes in
response to continuum variations; in NGC 4593 the broad H-beta velocity shifted
by ~250 km/s over a one-month duration. This reverberation-induced velocity
shift effect is likely to contribute a significant source of confusion noise to
binary black hole searches that use multi-epoch quasar spectroscopy to detect
binary orbital motion. We also present results from simulations that examine
biases that can occur in measurement of broad-line widths from rms spectra due
to the contributions of continuum variations and photon-counting noise.Comment: 33 pages, 28 figures, accepted for publication in ApJ Supplement
Serie
Luminous Satellites of Early-Type Galaxies I: Spatial Distribution
We study the spatial distribution of faint satellites of intermediate
redshift (0.1<z<0.8), early-type galaxies, selected from the GOODS fields. We
combine high resolution HST images and state-of-the-art host subtraction
techniques to detect satellites of unprecedented faintness and proximity to
intermediate redshift host galaxies (up to 5.5 magnitudes fainter and as close
as 0."5/2.5 kpc to the host centers). We model the spatial distribution of
objects near the hosts as a combination of an isotropic, homogenous
background/foreground population and a satellite population with a power law
radial profile and an elliptical angular distribution. We detect a significant
population of satellites, Ns =1.7 (+0.9,-0.8) that is comparable to the number
of Milky Way satellites with similar host-satellite contrast.The average
projected radial profile of the satellite distribution is isothermal, gamma_p=
-1.0(+0.3,-0.4), which is consistent with the observed central mass density
profile of massive early-type galaxies. Furthermore, the satellite distribution
is highly anisotropic (isotropy is ruled out at a >99.99% confidence level).
Defining phi to be the offset between the major axis of the satellite spatial
distribution and the major axis of the host light profile, we find a maximum
posterior probability of phi = 0 and |phi| less than 42 degrees at the 68%
confidence level. The alignment of the satellite distribution with the light of
the host is consistent with simulations, assuming that light traces mass for
the host galaxy as observed for lens galaxies. The anisotropy of the satellite
population enhances its ability to produce the flux ratio anomalies observed in
gravitationally lensed quasars.Comment: 21 pages, 16 figures, Accepted for publication in Ap
Differences between patients' and clinicians' report of sleep disturbance: a field study in mental health care in Norway
<p>Abstract</p> <p>Background</p> <p>The aims of the study was to assess the prevalence of diagnosed insomnia and the agreement between patient- and clinician-reported sleep disturbance and use of prescribed hypnotic medication in patients in treatment for mental disorders.</p> <p>Methods</p> <p>We used three cross-sectional, multicenter data-sets from 2002, 2005, and 2008. Data-set 1 included diagnostic codes from 93% of all patients receiving treatment in mental health care in Norway (<it>N </it>= 40261). Data-sets 2 (<it>N </it>= 1065) and 3 (<it>N </it>= 1181) included diagnostic codes, patient- and clinician-reported sleep disturbance, and use of prescribed hypnotic medication from patients in 8 mental health care centers covering 10% of the Norwegian population.</p> <p>Results</p> <p>34 patients in data-set 1 and none in data-sets 2 and 3 had a diagnosis of insomnia as a primary or comorbid diagnosis. In data-sets 2 and 3, 42% and 40% of the patients reported sleep disturbance, whereas 24% and 13% had clinician-reported sleep disturbance, and 7% and 9% used hypnotics. Patients and clinicians agreed in 29% and 15% of the cases where the patient or the clinician or both had reported sleep disturbance. Positive predictive value (PPV) of clinicians' evaluations of patient sleep disturbance was 62% and 53%. When the patient reported sleep disturbance as one of their most prominent problems PPV was 36% and 37%. Of the patients who received hypnotic medication, 23% and 29% had neither patient nor clinician-rated sleep disturbance.</p> <p>Conclusion</p> <p>When patients meet the criteria for a mental disorder, insomnia is almost never diagnosed, and sleep disturbance is imprecisely recognized relative to the patients' experience of sleep disturbance.</p
Age at onset, course of illness and response to psychotherapy in bipolar disorder: Results from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)
Background. The course of bipolar disorder progressively worsens in some patients. Although responses to pharmacotherapy appear to diminish with greater chronicity, less is known about whether patients\u27 prior courses of illness are related to responses to psychotherapy
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