Multilayer motif analysis of brain networks

This work was partially supported by the EU-LASAGNE Project, Contract No. 318132 (STREP)

Flow resistance of flexible vegetation in real-scale drainage channels

The definition of simple and accurate methods to estimate flow resistance in vegetated channels is still a challenging issue in soil bioengineering practices and programming riparian vegetation management to control channel conveyance capacity, sediment deposition, and flooding propensity. In this paper, measurements collected by Errico et al. (2018, 2019) in drainage channels colonized by common reed (Phragmites australis) were used to study the effect of flexible vegetation and its management in flow resistance estimate. At first, a theoretical flow resistance equation, obtained applying dimensional analysis and incomplete self-similarity condition for the velocity distribution of an open channel flow, was briefly summarized. Then, this flow resistance equation was calibrated and tested by open-field hydraulic experiments carried out by Errico et al. (2018, 2019) at the real scale of existing vegetated drainage channels. In particular, the Gamma function of the power velocity profile was empirically related to the slope energy and the flow Froude number by using the available measurements. Taking into account the hydrological regime of the flow in the investigated channels, the original data set was divided into two sub-data sets (calibrating and testing data set) exploring the same range of measured discharges. The calibration and testing of the flow resistance equation were carried out without distinguishing measurements corresponding to different vegetation conditions (full-vegetated, half-vegetated, non-vegetated, central vegetation cut, extensive vegetation cut). The analysis demonstrated that the theoretical flow resistance equation allows an accurate estimate of the Darcy-Weisbach friction factor which is characterized by errors that are always less than 10% and less than or equal to 5% for 90.9% of the investigated cases. The finding of this study also allowed to evaluate the effects of different vegetation management scenarios on flow resistance

Metallothionein gene family in the sea urchin Paracentrotus lividus: Gene structure, differential expression and phylogenetic analysis

Metallothioneins (MT) are small and cysteine-rich proteins that bind metal ions such as zinc, copper, cadmium, and nickel. In order to shed some light on MT gene structure and evolution, we cloned seven Paracentrotus lividus MT genes, comparing them to Echinodermata and Chordata genes. Moreover, we performed a phylogenetic analysis of 32 MTs from different classes of echinoderms and 13 MTs from the most ancient chordates, highlighting the relationships between them. Since MTs have multiple roles in the cells, we performed RT-qPCR and in situ hybridization experiments to understand better MT functions in sea urchin embryos. Results showed that the expression of MTs is regulated throughout development in a cell type-specific manner and in response to various metals. The MT7 transcript is expressed in all tissues, especially in the stomach and in the intestine of the larva, but it is less metal-responsive. In contrast, MT8 is ectodermic and rises only at relatively high metal doses. MT5 and MT6 expression is highly stimulated by metals in the mesenchyme cells. Our results suggest that the P. lividus MT family originated after the speciation events by gene duplications, evolving developmental and environmental sub-functionalization

An intronic cis-regulatory element is crucial for the alpha tubulin Pl-Tuba1a gene activation in the ciliary band and animal pole neurogenic domains during sea urchin development

In sea urchin development, structures derived from neurogenic territory control the swimming and feeding responses of the pluteus as well as the process of metamorphosis. We have previously isolated an alpha tubulin family member of Paracentrotus lividus (Pl-Tuba1a, formerly known as Pl-Talpha2) that is specifically expressed in the ciliary band and animal pole neurogenic domains of the sea urchin embryo. In order to identify cis-regulatory elements controlling its spatio-temporal expression, we conducted gene transfer experiments, transgene deletions and site specific mutagenesis. Thus, a genomic region of about 2.6 Kb of Pl-Tuba1a, containing four Interspecifically Conserved Regions (ICRs), was identified as responsible for proper gene expression. An enhancer role was ascribed to ICR1 and ICR2, while ICR3 exerted a pivotal role in basal expression, restricting Tuba1a expression to the proper territories of the embryo. Additionally, the mutation of the forkhead box consensus sequence binding site in ICR3 prevented Pl-Tuba1a expression

Image-guided laser ablation in the treatment of recurrence of renal tumours : technique and preliminary results

Abdominal recurrences of renal cell carcinoma (RCC) after surgery might represent a challenge for treatment, often requiring difficult surgeries or anticipated systemic therapy. Our aim is to illustrate a novel application of laser ablation for the treatment of abdominal recurrences of RCC. Patients with abdominal recurrences of renal cancer were treated under ultrasound/computed tomography guidance with a diode laser inserted into the lesion through a thin 21-G needle. A fixed 3-W power protocol was used, changing the illumination time according to lesion dimension and shape. Also, technical success, technical efficacy, local tumour progression, and major and minor complications were retrospectively analysed. Three patients were treated with image-guided laser ablation for abdominal recurrences of RCC. In all cases, it was possible to perform ablation as preoperatively planned and all three nodules (size of 6, 8, and 12 mm) were completely ablated with no evidence of residual enhancement after 6 weeks at contrast-enhanced CT. No minor or major complications were observed. No local tumour progression was reported up to 12 months from ablation. Image-guided laser ablation holds the potential to offer a minimally invasive treatment to patients with abdominal recurrence of RCC. Further studies are needed to evaluate the clinical role of this technique

Tectonics and fluvial dynamism affecting the Tiber River in prehistoric Rome

Open access funding provided by Istituto Nazionale di Geofisica e Vulcanologia within the CRUI-CARE Agreement. Research funding was provided by Loeb Classical Library Foundation, Gerda Henkel Foundation, American Philosophical Society, Etruscan Foundation, Fondazione Lemmermann, University of Michigan, University of St Andrews, and the Leverhulme Trust.Geomorphological investigations in Rome’s river valley are revealing the dynamism of the prehistoric landscape. It is becoming increasingly apparent that paleogeographic conditions that defined Rome in the historical era are the product of changes since the Bronze Age, which may be the result of local fault activity in addition to fluvial dynamism. Through a dedicated borehole chronostratigraphic study, integrated by 14C and archaeological dates, and paleomagnetic investigations, we offer here new evidence for fault displacement since ca. 4500 years/BP. We present the failure of the sedimentary fabric of a clay horizon caused by liquefaction processes commonly linked with seismic shaking, interpreting an (ca. 4 m) offset to signify the existence of a fault line located at the foot of the Capitoline Hill. In addition, we show evidence for another (ca. 1 m) offset affecting a stratigraphic horizon in the river channel, occurring along another hypothesized fault line crossing through the Tiber Valley. Movement along this fault may have contributed to a documented phase of fast overflooding dated to the sixth century BCE which eventually led to the birth of the Tiber Island. The most plausible scenario implies progressive deformation, with an average tectonic rate of 2 mm/year, along these inferred fault lines. This process was likely punctuated with moderate earthquakes, but no large event necessarily occurred. Together, the available evidence suggests that during the early centuries of sedentary habitation at the site of Rome, active fault lines contributed to significant changes to the Tiber River valley, capable of challenging lowland activities.Publisher PDFPeer reviewe

Plot investigation on rill flow resistance due to path tortuosity

The path tortuosity t is an indicator of rill morphology accounting for the deviation of the thalweg from a straight alignment. The effect of t on flow resistance has been little investigated for rills. This paper reports the results of a plot investigation aimed to establish the suitable accuracy of the rill thalweg measurement to determine the tortuosity parameter and to test the reliability of a theoretical flow resistance law. Four rills were incised in clay soil (CS) and clay-loam soil (LS) and shaped by a clear flow discharge. The three-dimensional Digital Terrain Models were created by the Structure from Motion technique. For rills on LS, an approximate thalweg was tracked by photo-interpretation, and a specific calculation routine was applied to identify the cross sections with a constant spacing d. The actual rill thalweg was obtained as the line joining the lowest points of these cross-sections. Among the different tested d values, d = 0.075 m was chosen to determine t. For both CS and LS, the Darcy-Weisbach friction factor f featured a non-monotonic relation with t, which was explained as the result of three additive components due to bed roughness, sediment transport, and localized energy losses due to curves. The effect of the former two components on f contrasts that of the third, resulting in a linearly decreasing f-t relationship and constant flow velocity for the three lowest tortuosity values, and an increased friction factor and reduced flow velocity for the highest tortuosity value. The flow resistance law was positively tested, and the predicted friction factor was dependent on t

Irreducibility of multilayer network dynamics: the case of the voter model

10 pages, 6 figuresThis work has been supported by the Spanish MINECO and FEDER under projects INTENSE@COSYP (FIS2012-30634), and by the EU Commission through the project LASAGNE (FP7-ICT-318132). VL also acknowledges support from EPSRC project GALE (EP/K020633/1

Cross-Language Question Re-Ranking

We study how to find relevant questions in community forums when the language of the new questions is different from that of the existing questions in the forum. In particular, we explore the Arabic-English language pair. We compare a kernel-based system with a feed-forward neural network in a scenario where a large parallel corpus is available for training a machine translation system, bilingual dictionaries, and cross-language word embeddings. We observe that both approaches degrade the performance of the system when working on the translated text, especially the kernel-based system, which depends heavily on a syntactic kernel. We address this issue using a cross-language tree kernel, which compares the original Arabic tree to the English trees of the related questions. We show that this kernel almost closes the performance gap with respect to the monolingual system. On the neural network side, we use the parallel corpus to train cross-language embeddings, which we then use to represent the Arabic input and the English related questions in the same space. The results also improve to close to those of the monolingual neural network. Overall, the kernel system shows a better performance compared to the neural network in all cases.Comment: SIGIR-2017; Community Question Answering; Cross-language Approaches; Question Retrieval; Kernel-based Methods; Neural Networks; Distributed Representation