Investigation of furo[2,3-h]- and pyridazino[3,4-f]cinnolin-3-ol scaffolds as substrates for the development of novel HIV-1 integrase inhibitors

With the aim to develop novel HIV-1 integrase inhibitors, we obtained a set of condensed ring systems based on the furo[2,3-h]cinnolin-3(2H)-one and pyridazino[3,4-f]cinnolin-3-ol scaffolds bearing a potential chelating pharmacophore, which can be involved in the inhibition mechanism of the enzyme. Herein, we report the design, synthesis, structural investigation and preliminary biological results of these heteroaromatic systems

Treatments for COPD

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L'elettrocardiografia endocavitaria per la valutazione della posizione della punta dei cateteri venosi centrali

Abstract non disponibil

Radiomics in cervical and endometrial cancer

Radiomics is an emerging field of research that aims to find associations between quantitative information extracted from imaging examinations and clinical data to support the best clinical decision. In the last few years, some papers have been evaluating the role of radiomics in gynecological malignancies, mainly focusing on ovarian cancer. Nonetheless, cervical cancer is the most frequent gynecological malignancy in developing countries and endometrial cancer is the most common in western countries, The purpose of this narrative review is to give an overview of the latest published papers evaluating the role of radiomics in cervical and endometrial cancer, mostly evaluating association with tumor prognostic factors, with response to therapy and with prediction of recurrence and distant metastasis

Computed tomography–based body composition in patients with ovarian cancer: association with chemotoxicity and prognosis

PurposeTo assess the association between computed tomography (CT)-derived quantitative measures of body composition profiling and chemotherapy-related complications, in terms of dose reduction, premature discontinuation of chemotherapy, and cycle delays in patients with ovarian cancer. Secondary purposes were to evaluate associations between sarcopenia and survival, and to evaluate differences in body composition profiling at baseline and after neoadjuvant chemotherapy. Materials and MethodsThe study population was retrospectively selected from a database of patients with newly diagnosed ovarian cancer (any stage) referred to our Institution between Feb 2011 and Mar 2020. Clinical data were recorded, and CT images at the level of the 3(rd) lumbar vertebra were stored. By using specific software, skeletal muscle area (SMA), subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), and skeletal muscle density (SMD) were extracted. Skeletal muscle index (SMI) was then calculated. Statistical analysis was performed by logistic regression models to identify body composition features predictive of dose reduction, premature end of chemotherapy, and cycle delays. Kaplan-Meier analyses were performed to assess overall survival (OS) and progression-free survival (PFS). The log-rank test was used to determine differences in OS and PFS between sarcopenic and non-sarcopenic patients. Wilcoxon test was performed to compare body composition features before and after neoadjuvant chemotherapy (NACT). ResultsSixty-nine patients were included. A significant association was found between VAT and cycle delays (OR = 1.01, z = 2.01, 95% CI: 1.00-1.02, p < 0.05), between SMA and early discontinuation of chemotherapy (OR = 1.03, z = 2.10, 95% CI: 1.00-1.05, p < 0.05), and between mean SMD and cycle delays (OR = 0.92, z = -2.70, 95%CI: 0.87-0.98, p < 0.01). No significant difference emerged for OS in sarcopenic and non-sarcopenic patients, nor in CT body composition features before and after NACT. ConclusionsIn ovarian cancer patients, CT-derived body composition profiling might predict the risk of chemotoxicity. In particular, VAT and SMD are associated with chemotherapy cycle delays, and SMA with early discontinuation of chemotherapy

Exact Spectral Function of a Tonks-Girardeau Gas in a Lattice

The single-particle spectral function of a strongly correlated system is an essential ingredient to describe its dynamics and transport properties. We develop a method to evaluate exactly the spectral function for a gas of one-dimensional bosons with infinitely strong repulsions valid for any type of external confinement. Focusing on the case of a lattice confinement, we find that the spectral function displays three main singularity lines. One of them is due uniquely to lattice effects, while the two others correspond to the Lieb-I and Lieb-II modes occurring in a uniform fluid. Differently from the dynamical structure factor, in the spectral function the Lieb-II mode shows a divergence, thus providing a route to probe such mode in experiments with ultracold atoms

The American English version of the Juvenile Arthritis Multidimensional Assessment Report (JAMAR)

The Juvenile Arthritis Multidimensional Assessment Report (JAMAR) is a new parent/patient-reported outcome measure that enables a thorough assessment of the disease status in children with juvenile idiopathic arthritis (JIA). We report the results of the cross-cultural adaptation and validation of the parent and patient versions of the JAMAR in the American English language. The reading comprehension of the questionnaire was tested in 10 JIA parents and patients. Each participating centre was asked to collect demographic, clinical data and the JAMAR in 100 consecutive JIA patients or all consecutive patients seen in a 6-month period and to administer the JAMAR to 100 healthy children and their parents. The statistical validation phase explored descriptive statistics and the psychometric issues of the JAMAR: the 3 Likert assumptions, floor/ceiling effects, internal consistency, Cronbach\u2019s alpha, interscale correlations, test\u2013retest reliability, and construct validity (convergent and discriminant validity). A total of 315 JIA patients (5.1% systemic, 31.1% oligoarticular, 34% RF negative polyarthritis, 29.8% other categories) and 98 healthy children, were enrolled in three centres. The JAMAR components discriminated well healthy subjects from JIA patients. All JAMAR components revealed good psychometric performances. In conclusion, the American English version of the JAMAR is a valid tool for the assessment of children with JIA and is suitable for use both in routine clinical practice and clinical research

Prevalence of anti-Leptospira spp. antibodies in cows in the municipalities of Nova Guarita and Nova Santa Helena, Mato Grosso State, Brazil.

EN-US: Frequently, leptospirosis is related to reproductive problems in livestock, such as abortion, increased embryonic mortality and stillbirths. Unfortunately, there are few reports addressing the prevalence of the disease in cattle in the North of Mato Grosso State (MT), Brazil. The aim of the present study was to determine the presence of anti-Leptospira spp. antibodies in cattle in the municipalities of Nova Guarita and Nova Santa Helena, MT. Nine hundred and eighty blood samples were taken from cows aged ≥24 months from 49 farms slaughtered in Sinop, MT. Microscopic Agglutination Test was used for the detection of anti-Leptospira spp. antibodies. The animal prevalence was 17.9% (95% CI = 15.6-20.5%). The prevalence observed in the municipalities Nova Guarita and Nova Santa Helena was 13.4% (95% CI = 12.8-14.1%) and 23.2% (95% CI = 22.0-24.3%), respectively. The herd prevalence was 83.6% (95% CI = 79.4-87.8%). The most frequent serovar was Wolffi (47.7%), followed by Hardjo (16.1%), Hardjo - Bolivia sample (11.0%), Australis (7.4%), Grippotyphosa (4.6%), Pomona (3.4%), Batavie (3.4%), Autumnalis (1.7%), Icterohaemorrhagiae (1.7%), Hebdomadis (1.1%), Hardjo-bovis (1.1%), and Castellonis (0.5%). Infection by Leptospira spp. is endemic in both municipalities, reinforcing the need for new epidemiological studies to subsidize the control of the disease in Mato Grosso. | PT-BR: A leptospirose está frequentemente relacionada a problemas reprodutivos em rebanhos bovinos, como abortamentos, aumento da mortalidade embrionária e nascimento de bezerros fracos. Infelizmente, existem poucos estudos envolvendo a prevalência da enfermidade em bovinos na região norte do Estado de Mato Grosso, Brasil. O presente estudo teve como objetivo determinar a presença de anticorpos anti-Leptospira spp. em rebanhos bovinos dos municípios de Nova Guarita e Nova Santa Helena, Mato Grosso. No total, 980 amostras de sangue foram coletadas de fêmeas bovinas oriundas de 49 propriedades, todas com idade ≥ 24 a meses abatidas em abatedouro frigorifico localizado no município de Sinop, MT. O teste de Soroaglutinação Microscópica foi utilizado para a detecção de anticorpos anti-Leptospira spp. A prevalência animal foi de 17,9 % (95% IC = 15,6?20,5%). A prevalência observada entre os municípios de Nova Guarita e Nova Santa Helena foi de 13,4% (95% IC = 12,8?14,1%) e 23,2% (95% IC = 22,0?24,3%), respectivamente. A prevalência de propriedades foco foi de 83,6% (95% IC = 79,4?87,8%). A sorovariedade mais frequente foi a Wolffi (47,7%), seguido pelas sorovariedades Hardjo (16,1%); Hardjo amostra Bolívia (11,0%); Australis (7,4%); Grippotyphosa (4,6%); Pomona (3,4%); Batavie (3,4%); Autumnalis (1,7%); Icterohaemorrhagiae (1,7%); Hebdomadis (1,1%); Hardjobovis (1,1%) e Castellonis (0,5%). Concluiu-se que a infecção por Leptospira spp. é endêmica nos dois os municípios, reiterando a necessidade de novos estudos epidemiológicos para subsidiar o controle da doença em Mato Grosso

The Flemish version of the Juvenile Arthritis Multidimensional Assessment Report (JAMAR)

The Juvenile Arthritis Multidimensional Assessment Report (JAMAR) is a new parent/patient reported outcome measure that enables a thorough assessment of the disease status in children with juvenile idiopathic arthritis (JIA). We report the results of the cross-cultural adaptation and validation of the parent and patient versions of the JAMAR in the Flemish language. The reading comprehension of the questionnaire was tested in 10 JIA parents and patients. Each participating centre was asked to collect demographic, clinical data and the JAMAR in 100 consecutive JIA patients or all consecutive patients seen in a 6-month period and to administer the JAMAR to 100 healthy children and their parents. The statistical validation phase explored descriptive statistics and the psychometric issues of the JAMAR: the 3 Likert assumptions, floor/ceiling effects, internal consistency, Cronbach's alpha, interscale correlations, test-retest reliability, and construct validity (convergent and discriminant validity). A total of 100 JIA patients (8% systemic, 33% oligoarticular, 24% RF negative polyarthritis, 35% other categories) and 99 healthy children, were enrolled in two centres. The JAMAR components discriminated well healthy subjects from JIA patients. All JAMAR components revealed good psychometric performances. In conclusion, the Flemish version of the JAMAR is a valid tool for the assessment of children with JIA and is suitable for use both in routine clinical practice and clinical research