Benevolo, G

Cris&#224

D&#8217

Evangelista, A

Ferrero, Dario

Nicolino, B

Pich, Achille

Pirillo, F

Pregno, P

Vitolo, U.

English

Institutional Research Information System University of Turin

    This is an author version of the contribution published on: Questa è la versione dell’autore dell’opera: Haematologica  99(s1): 673-4, 2014 . “In patients with Polycythemia Vera older age is the prognostic factor at highest impact on survival.”  Benevolo G, Nicolino B, Crisà E, Pregno P, Evangelista A, Pirillo F, D’Antico S, Pich A, Ferrero D and Vitolo U    The definitive version is available at: La versione definitiva è disponibile alla URL: http://www.haematologica.org/content/99/supplement_1/1.full-text.pdf+html IN PATIENTS WITH POLYCYTHEMIA VERA OLDER AGE IS THE PROGNOSTIC FACTOR AT HIGHEST IMPACT ON SURVIVAL  Benevolo G1, Nicolino B1, Crisà E2, Pregno P1, Evangelista A3, Pirillo F1, D’Antico S4, Pich A5, Ferrero D2 and Vitolo U   1 SC Hematology, Città della Salute e della Scienza Hospital and University, Torino 2 SC Hematology-U, Città della Salute e della Scienza Hospital and University, Torino 3 Unit of Clinical Epidemiology and CPO Piemonte, Città della Salute e della Scienza Hospital and University, Torino 4 Struttura Complessa Banca del Sangue CPVE, Città della Salute e della Scienza Hospital and University, Torino 5 Anatomia Patologica Generale e Oncogenetica Molecolare-U, Città della Salute e della Scienza Hospital and University, Torino  Background: Life expectancy of Polycythemia Vera (PV) patients is reduced compared with that of the general population mainly due to thrombotic events and evolution into myelofibrotic phase or secondary myelodisplasia/acute leukemia. Recently, in a large study published by IWG-MRT (Tefferi et al, Leukemia 2013) authors developed a widely applicable prognostic model, delineating three different prognostic risk groups by age, leukocyte count and venous thrombosis.   Aims: In this study we tested the IWG-MRT prognostic score in a retrospective group of 204 World Health Organization-defined PV patients, diagnosed from 1974 to 2013 by a single Italian haematological centre (Turin).   Methods: We analysed 204 PV patients. According to the  IWG-MRT score, patients were divided into three groups: adverse points are assigned to age ≥67 years (5 points), age 57–66 years (2 points), leukocyte count ≥15 x109/l (1 point) and venous thrombosis (1 point). In this way patients were divided in low-risk (0 points), intermediate-risk (1 or 2 points) and high-risk (≥3 points) groups. We evaluated overall survival (OS) from diagnosis to death by the Kaplan Meyer method and Hazard Ratio were estimated with the Cox Models. The cumulative incidence of death due to PD was estimated by the method proposed by Gooley et al, accounting for competing events.   Results: Characteristics at diagnosis were as follows: median age was 65 years  (31% were below age 57 years), 104 (51%) were male, constitutional symptoms and palpable splenomegaly were observed in 42 (21%) and 36 (18%) patients, respectively. Twenty-one (10%) patients showed leukocytosis (≥15 x 109/L) whereas thrombocytosis (≥450 x 109/L) was present in 77 (38%) patients. Fifty-three patients had prevoius thrombotic events (40 arterious and 13 venous). As expected, approximately 58% of the patients were positive for JAK2 mutations  (V617F or exon12). At a median follow-up of 93 months we observed 27 (13%) deaths, 26 (13%) myelofibrotic transformations and 7 (3%) leukemic evolution. The incidence of post diagnosis thrombosis arterial vs venous and major hemorrage were 15%, 11% and 9% respectively The overall survival at 10 years was 85.3% (95%CI:77.6-90.5) and the cumulative incidence of death due to PD (leukemic transformation or evolution in myelofibrosis) adjusted for competitive risk event was  9.8% (95%IC: 4.5-15.0).   The prognostic model displayed discrimination between high-risk (n= 91; 10-year survival 68.3%; vs low-risk HR 8.48; 95%CI: 1.94-37.16), intermediate-risk (n= 49; 10-year survival 94.7%; vs low-risk HR 3.23; 95%CI: 0.62-16.68) and low-risk (n=42; 10-year survival 100%) patient groups. The C-statistic was 0.751.  Age was the prognostic factor at highest impact on OS (fig.1); when we consider the older age as a only prognostic factor the discrimination between risk group was similar to those defined by IWG-MRT. The C-statistic was 0.748.  Conclusion: In a retrospective cohort  of PV patients, IWG-MRT prognostic score was confirmed as a good predictor of survival and prognosis. Older age was described with the prognostic factor at highest impact on OS.   Fig1  0.000.250.500.751.0070 66 62 50 43 37 34 24 16 12 10 8 8>70 Years53 51 49 46 43 37 33 30 28 24 18 16 1461-70 Years59 58 55 52 49 46 44 39 35 33 33 29 22<=60 YearsAt risk:0 1 2 3 4 5 6 7 8 9 10 11 12Years<=60 Years61-70 Years>70 YearsOverall Survival     

In patients with Polycythemia Vera older age is the prognostic factor
at highest impact on survival

https://iris.unito.it/bitstream/2318/148685/1/Benevolo%20et%20al%20EHA%20PV%202014_post_print.pdf

In patients with Polycythemia Vera older age is the prognostic factor

at highest impact on survival

In patients with Polycythemia Vera older age is the prognostic factor at highest impact on survival

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