Geodynamical framework and hydrocarbon plays of a salt giant: the North Western Mediterranean Basin

The North Western Mediterranean Basin developed during the Oligocene-Miocene rifting of the Eastern Iberian-European magma-poor continental margin. The margin developed as a result of back-arc extension associated with the roll-back of the retreating Calabrian-Tethys subduction zone. Reinterpretation of 2D regional seismic reflection data suggests that rifting took place by hyperextension of the Iberian-European lithosphere. This process led to the seaward arrangement of distinct crustal domains, namely proximal, necking and distal. The late post-rift Messinian Salinity Crisis (MSC) gave place to significant margin erosion and canyon incision whose lowstand sedimentary by-products were largely deposited prior to the Messinian evaporitic sequences. Mesozoic-Cenozoic and Messinian to recent salt tectonics events have been recognized. A regional hydrocarbon play concept is here proposed for shelf to deep waters settings, including pre-salt, Messinian and post-salt plays

Long-Term Drug Survival and Effectiveness of Secukinumab in Patients with Moderate to Severe Chronic Plaque Psoriasis: 42-Month Results from the SUPREME 2.0 Study

Purpose: SUPREME, a phase IIIb study conducted in Italy, demonstrated safety and high efficacy of secukinumab for up to 72 weeks in patients with moderate-to-severe plaque-type psoriasis. SUPREME 2.0 study aimed to provide real-world data on the long-term drug survival and effectiveness of secukinumab beyond 72 weeks. Patients and Methods: SUPREME 2.0 is a retrospective observational chart review study conducted in patients previously enrolled in SUPREME study. After the end of the SUPREME study, eligible patients continued treatment as per clinical practice, and their effectiveness and drug survival data were retrieved from medical charts. Results: Of the 415 patients enrolled in the SUPREME study, 297 were included in SUPREME 2.0; of which, 210 (70.7%) continued secukinumab treatment throughout the 42-month observation period. Patients in the biologic-naïve cohort had higher drug survival than those in the biologic-experienced cohort (74.9% vs 61.7%), while HLA-Cw6–positive and HLA-Cw6–negative patients showed similar drug survival (69.3% and 71.9%). After 42 months, Psoriasis Area and Severity Index (PASI) 90 was achieved by 79.6% of patients overall; with a similar proportion of biologic-naïve and biologic-experienced patients achieving PASI90 (79.8% and 79.1%). The mean absolute PASI score reduced from 21.94 to 1.38 in the overall population, 21.90 to 1.24 in biologic-naïve and 22.03 to 1.77 in biologic-experienced patients after 42 months. The decrease in the absolute PASI score was comparable between HLACw6–positive and HLA–Cw6-negative patients. The baseline Dermatology Life Quality Index scores also decreased in the overall patients (10.5 to 2.32) and across all study sub-groups after 42 months. Safety was consistent with the known profile of secukinumab, with no new findings. Conclusion: In this real-world cohort study, secukinumab showed consistently high long-term drug survival and effectiveness with a favourable safety profile

Analisi verticale del concetto di pendenza: dalla scuola secondaria di primo grado all’università

Si studia l’analisi in verticale degli errori ricorrenti effettuati da studenti di diversi livelli scolastici relativi al concetto di pendenza, dalla scuola secondaria di I grado all’inizio della carriera universitaria. Tale analisi è basata sullo studio dei risultati delle valutazioni standardizzate INVALSI di Matematica effettuate a livello 8 e a livello 10 e su alcuni risultati di domande dei pretest del livello 13 somministrate a un campione di matricole universitarie. Tra le domande con una bassa percentuale di risposte corrette, si sono individuate caratteristiche comuni che forniscono una buona chiave di lettura per alcuni concetti chiave di didattica della Matematica. In particolare, dalla ricerca sono emerse difficoltà in verticale relative alla gestione dei diversi registri di rappresentazione degli oggetti matematici in questione. I risultati della ricerca mostrano che il problema permane anche con passaggi di livelli scolastici e porta, a livello universitario, a una misconcezione del concetto di derivata

Geodynamical framework and hydrocarbon plays of a salt giant: the NW Mediterranean Basin

Thematic set: The Messinian salinity crisis.-- 13 pages, 8 figures, 2 tablesThe NW Mediterranean Basin developed during the Oligocene-Miocene rifting of the Eastern Iberian-European magma-poor continental margin. The margin developed as a result of back-arc extension associated with the rollback of the retreating Calabrian-Tethys subduction zone. Reinterpretation of 2D regional seismic reflection data suggests that rifting took place by hyperextension of the Iberian-European lithosphere. This process led to the seawards arrangement of distinct crustal domains: namely, proximal, necking and distal. The late post-rift Messinian salinity crisis (MSC) gave rise to significant margin erosion and canyon incision, the lowstand sedimentary by-products of which were largely deposited prior to the Messinian evaporitic sequences. Mesozoic-Cenozoic and Messinian-Recent salt tectonics events have been recognized. A regional hydrocarbon play concept is proposed here for shelf-deep-water settings, including pre-salt, Messinian and post-salt playsThis is a contribution of the Institut de Recerca Geomodels and the Geodinàmica i Analisi de Conques research group (2014SGR467SGR) from the Agencia de Gestió d’Ajuts Universitaris i de Recerca (AGAUR) and the Secretaria d’Universitats i Recerca del Departament d’Economia i Coneixement de la Generalitat de Catalunya. P.G. acknowledges the financial support from ENEL Trade SpA (Project FBG307360) and from the ‘Grup de Recerca de Geodinàmica i Anàlisi de Conques’, 2009 SGR 1198 of the Comissionat d’Universitats i Recerca de la Generalitat de Catalunya. This work also benefited from the financial support of the SALCRETES (CGL2014–54118-C2–1-R) and EDINSED3D (CTM2007–64880/MAR) projects. This article is based on work from COST Action MEDSALT (CA15103), supported by COST (European Cooperation in Science and Technology)Peer Reviewe

Sieroepidemiologia delle infezioni da Toxoplasma gondii, virus della Rosolia e Citomegalovirus in una coorte di gravide

Toxoplasma gondii, Rubella virus and Citomegalovirus are responsible for maternal-fetal infections that can cause severe consequences in fetus. The surveillance of these infections in pregnancy is made by specific antibodies detection and when necessary by demostrating the presence of the infectious agent in body fluids. We have evaluated the seroprevalence of antibodies in a cohort of 1100 pregnant women against Toxoplasma gondii, Rubella virus and Citomegalovirus. Our data show a low seroprevalence against Toxoplasma gondii, a suboptimal immunitary coverage against Rubella virus and a significative increase of incidence in Citomegalovirus infection. The study suggests the need of a multiprofessional and multidisciplinary approach for the right management of these maternal-fetal infections and underlines the pivot role played by Clinical Pathologists

Recommendations for the rehabilitation of children with cerebral palsy

The SINPIA-SIMFER(Italian Society of Child and Adolescent Neuropsychiatry-Italian Society of Physical Medicine and Rehabilitation) Intersociety Commission was set up in December 2000 and is composed of members from both scientific societies, who are experts in the field of rehabilitation of patients with cerebral palsy (CP). In accordance with the indications of the Italian Health Ministry's Planning Department, in 1999 this Commission was entrusted with the task of drawing up "Guidelines for the Rehabilitation of Children Affected by Cerebral Palsy", and to successively revise and update it every five years. The present document is a summary of the latest update, drawn up through meetings of the Intersociety Commission, held in 2012 and 2013, and discussed and approved at the annual SINPIA-SIMFERmeeting held in Brindisi in October 2013. The current version of the Recommendations extends and updates the previous one, also addressing new areas of intervention and adding some in-depth analysis. The document as a whole is not so much a proposal for treatment updated on the basis of advancing knowledge in the field of rehabilitation of CP, as a presentation of the method that should be applied by professionals seeking to define the most appropriate intervention and treatment strategies. The text is the offspring of a process of careful exchanges, which have been conducted in a collegial and collaborative fashion among professionals working in different fields (rehabilitation medicine and child neuropsychiatry) and in healthcare settings at different levels (ranging from first-level local settings to third-level national ones) and of different types (affiliated outpatient clinics and centers, local health authorities, hospitals, "IRCCS" research hospitals, universities)

Sleep and sleep disorders during pregnancy and postpartum: The Life-ON study.

OBJECTIVE to prospectively assess sleep and sleep disorders during pregnancy and postpartum in a large cohort of women. METHODS multicenter prospective Life-ON study, recruiting consecutive pregnant women at a gestational age between 10 and 15 weeks, from the local gynecological departments. The study included home polysomnography performed between the 23rd and 25th week of pregnancy and sleep-related questionnaires at 9 points in time during pregnancy and 6 months postpartum. RESULTS 439 pregnant women (mean age 33.7 ± 4.2 yrs) were enrolled. Poor quality of sleep was reported by 34% of women in the first trimester of pregnancy, by 46% of women in the third trimester, and by as many as 71% of women in the first month after delivery. A similar trend was seen for insomnia. Excessive daytime sleepiness peaked in the first trimester (30% of women), and decreased in the third trimester, to 22% of women. Prevalence of restless legs syndrome was 25%, with a peak in the third trimester of pregnancy. Polysomnographic data, available for 353 women, revealed that 24% of women slept less than 6 h, and 30.6% of women had a sleep efficiency below 80%. Sleep-disordered breathing (RDI≥5) had a prevalence of 4.2% and correlated positively with BMI. CONCLUSIONS The Life-ON study provides the largest polysomnographic dataset coupled with longitudinal subjective assessments of sleep quality in pregnant women to date. Sleep disorders are highly frequent and distributed differently during pregnancy and postpartum. Routine assessment of sleep disturbances in the perinatal period is necessary to improve early detection and clinical management