Digital Health’s Impact on Integrated Care, Carer Empowerment and Patient-Centeredness for Persons Living With Dementia

E-health or digital health technologies endeavour to connect key stakeholders and thereby lay the foundation for better integrated as well as potentially more patient-centered care. However, despite the promise of empowerment, efficiency and value, digital health has yet to become part of the daily lives of the people who care for persons living with dementi

Learning with/from others : teachers' perceptions of peer collaboration and group work in the OBE classroom.

Post 1994 the South African education system has focused on creating education for all under a single core syllabus. It also stressed the need for a shift from the traditional teacher-centred approach to a learner-centred approach. As a result, the shift was made from an aims-and-objectives education to Outcomes Based Education (OBE). OBE has placed a different set of demands on teachers and the way in which they assess. Specifically teachers are required to use peer collaboration to bring about learning and simultaneously assess that learning has transpired. However, many teachers are left feeling uncertain about the efficacy of OBE. This report reviews the relevant literature as well as theories needed to understand the process learning. The objective of this research report is to establish teacher’s current perceptions are of OBE. More so, the research aimed to ascertain how useful peer collaboration is in facilitating learning. The results from this study show that teachers are uncertain about the efficacy of OBE. Although a significant number of teachers strongly agree with the underlying principles of OBE they feel that implementation as intended by policy makers is idealistic. Furthermore, they are conflicted about the notion that peer collaboration can sufficiently facilitate learning. Lastly, the findings of this study suggest that in implementing peer collaboration successfully, tenets from social psychology such as group dynamics need to be considered

Curatorial Practice as Production of Visual & Spatial Knowledge: Panel Discussion, October 4, 2014

The following is a transcription of a conversation between curators of art, science, and digital data about how their practice creates knowledge in their respective fields. Drawn from Pittsburgh’s rich institutional resources, the panelists include Dan Byers, (then) Richard Armstrong Curator of Contemporary Art, Carnegie Museum of Art; Dr. Alison Langmead, Director, Visual Media Workshop, Department of History of Art and Architecture, and Assistant Professor, School of Information Scienes, University of Pittsburgh; Dr. Cynthia Morton, Associate Curator of Botany, Carnegie Museum of Natural History; and Dr. Terry Smith, Andrew W. Mellon Professor of Contemporary Art History and Theory, University of Pittsburgh. Moderated by Nicole Scalissi, PhD candidate, Department of History of Art and Architecture, University of Pittsburgh. The panel took place as a part of Debating Visual Knowledge, a symposium organized by graduate students in Information Science and History of Art and Architecture at the University of Pittsburgh, October 3-5, 2014. The transcription has been edited for clarity.Curatorial Practice as Production of Visual &amp; Spatial Knowledge</jats:p

Wall-associated kinase 1 (WAK1) is crosslinked in endomembranes, and transport to the cell surface requires correct cell-wall synthesis

The Arabidopsis thaliana wall-associated kinases (WAKs) bind to pectin with an extracellular domain and also contain a cytoplasmic protein kinase domain. WAKs are required for cell elongation and modulate sugar metabolism. This work shows that in leaf protoplasts a WAK1-GFP fusion protein accumulates in a cytoplasmic compartment that contains pectin. The WAK compartment contains markers for the Golgi, the site of pectin synthesis. The migration of WAK1-GFP to the cell surface is far slower than that of a cell surface receptor not associated with the cell wall, is influenced by the presence of fucose side chains on one or more unidentified molecules that might include pectin, and is dependent upon cellulose synthesis on the plasma membrane. WAK is crosslinked into a detergent-insoluble complex within the cytoplasmic compartment before it appears on the cell surface, and this is independent of fucose modification or cellulose synthesis. Thus, the assembly and crosslinking of WAKs may begin at an early stage within a cytoplasmic compartment rather than in the cell wall itself, and is coordinated with synthesis of surface cellulose

TH9 cells are required for tissue mast cell accumulation during allergic inflammation

BACKGROUND: IL-9 is important for the growth and survival of mast cells. IL-9 is produced by T cells, natural killer T cells, mast cells, eosinophils, and innate lymphoid cells, although the cells required for mast cell accumulation during allergic inflammation remain undefined. OBJECTIVE: We sought to elucidate the role of TH9 cells in promoting mast cell accumulation in models of allergic lung inflammation. METHODS: Adoptive transfer of ovalbumin-specific TH2 and TH9 cells was used to assess the ability of each subset to mediate mast cell accumulation in tissues. Mast cell accumulation was assessed in wild-type mice and mice with PU.1-deficient T cells subjected to acute and chronic models of allergic inflammation. RESULTS: Adoptive transfer experiments demonstrated that recipients of TH9 cells had significantly higher mast cell accumulation and expression of mast cell proteases compared with control or TH2 recipients. Mast cell accumulation was dependent on IL-9, but not IL-13, a cytokine required for many aspects of allergic inflammation. In models of acute and chronic allergic inflammation, decreased IL-9 levels in mice with PU.1-deficient T cells corresponded to diminished tissue mast cell numbers and expression of mast cell proteases. Mice with PU.1-deficient T cells have defects in IL-9 production from CD4(+) T cells, but not natural killer T cells or innate lymphoid cells, suggesting a TH cell-dependent phenotype. Rag1(-/-) mice subjected to a chronic model of allergic inflammation displayed reduced mast cell infiltration comparable with accumulation in mice with PU.1-deficient T cells, emphasizing the importance of IL-9 produced by T cells in mast cell recruitment. CONCLUSION: TH9 cells are a major source of IL-9 in models of allergic inflammation and play an important role in mast cell accumulation and activation

An Arabidopsis cell wall-associated kinase required for invertase activity and cell growth

The wall-associated kinases (WAK), a family of five proteins that contain extracellular domains that can be linked to pectin molecules of the cell wall, span the plasma membrane and have a cytoplasmic serine/threonine kinase domain. Previous work has shown that a reduction in WAK protein levels leads to a loss of cell expansion, indicating that these receptor-like proteins have a role in cell shape formation. Here it is shown that a single wak2 mutation exhibits a dependence on sugars and salts for seedling growth. This mutation also reduces the expression and activity of vacuolar invertase, often a key factor in turgor and expansion. WAKs may thus provide a molecular mechanism linking cell wall sensing (via pectin attachment) to regulation of solute metabolism, which in turn is known to be involved in turgor maintenance in growing cells. © 2006 The Authors

Development and characterization of microsatellite loci for the haploid–diploid red seaweed Gracilaria vermiculophylla

Microsatellite loci are popular molecular markers due to their resolution in distinguishing individual genotypes. However, they have rarely been used to explore the population dynamics in species with biphasic life cycles in which both haploid and diploid stages develop into independent, functional organisms. We developed microsatellite loci for the haploid–diploid red seaweed Gracilaria vermiculophylla, a widespread non-native species in coastal estuaries of the Northern hemisphere. Forty-two loci were screened for amplification and polymorphism. Nine of these loci were polymorphic across four populations of the extant range with two to eleven alleles observed. Mean observed and expected heterozygosities ranged from 0.265 to 0.527 and 0.317 to 0.387, respectively. Overall, these markers will aid in the study of the invasive history of this seaweed and further studies on the population dynamics of this important haploid–diploid primary producer

Th17 cells demonstrate stable cytokine production in a proallergic environment

Th17 cells are critical for the clearance of extracellular bacteria and fungi, but also contribute to the pathology of autoimmune diseases and allergic inflammation. After exposure to an appropriate cytokine environment, Th17 cells can acquire a Th1-like phenotype, but less is known about their ability to adopt Th2 and Th9 effector programs. To explore this in more detail, we used an IL-17F lineage tracer mouse strain that allows tracking of cells that formerly expressed IL-17F. In vitro-derived Th17 cells adopted signature cytokine and transcription factor expression when cultured under Th1-, Th2-, or Th9-polarizing conditions. In contrast, using two models of allergic airway disease, Th17 cells from the lungs of diseased mice did not adopt Th1, Th2, or Th9 effector programs, but remained stable IL-17 secretors. Although in vitro-derived Th17 cells expressed IL-4Rα, those induced in vivo during allergic airway disease did not, possibly rendering them unresponsive to IL-4-induced signals. However, in vitro-derived, Ag-specific Th17 cells transferred in vivo to OVA and aluminum hydroxide-sensitized mice also maintained IL-17 secretion and did not produce alternative cytokines upon subsequent OVA challenge. Thus, although Th17 cells can adopt new phenotypes in response to some inflammatory environments, our data suggest that in allergic inflammation, Th17 cells are comparatively stable and retain the potential to produce IL-17. This might reflect a cytokine environment that promotes Th17 stability, and allow a broader immune response at tissue barriers that are susceptible to allergic inflammation

Hydrologic and isotopic modeling of Alpine Lake Waiau, Mauna Kea, Hawai'i

Analysis of hydrologic, meteorologic, and isotopic data collected over 3 yr quantifies and explains the enormous variability and isotopic enrichment (δ18O = +16.9, δD = +50.0) of alpine Lake Waiau, a culturally and ecologically significant perched lake near the summit of Mauna Kea, Hawai'i. Further, a simple one-dimensional hydrologic model was developed that couples standard water budget modeling with modeling of δD and δ18O isotopic composition to provide daily predictions of lake volume and chemistry. Data analysis and modeling show that winter storms are the primary source of water for the lake, adding a distinctively light isotopic signature appropriate for high-altitude precipitation. Evaporation at the windy, dry summit is the primary loss mechanism for most of the year, greatly enriching the lake in heavy isotopes

Koinonia

Best Practices FeaturesStudents of Concern Committee: Coordinating Care, Connie Horton and Mark Davis Want to Change Student Culture on Your Campus? Do the CORE!, Eric Lowdermilk Spotlight FeaturesYou Only Get 1 Up, Justin Heth and Caleb Farmer The Season, Sharon Virkler Book ReviewsThe Future of Christian Learning: An Evangelical and Catholic Dialogue (by Mark Noll and James Turner), reviewed by Philip D. Byers Restoring Rebecca: A Story of Traumatic Stress, Caregiving and the Unmasking of a Superhero (by Christopher Marchand), reviewed by David M. Johnstone A Review of Culture Making: Recovering our Creative Calling (by Andy Crouch), reviewed by Jeff Rioux Revisiting How Minority Students Experience College: Implications for Planning and Policy (by LKemuel Watson, Melvin Terrell, Doris Wright, Fred Bonner II, Michael Cuyjet, James Gold, Donna Rudy and Dawn Person), reviewed by Joshua Canada Excerpts from Breathe: Finding Freedom to Thrive in Relationships after Childhood Sexual Abuse, Nicole Braddock Bromley ReflectionsMy Journey into Student Affairs, Kim Stave FeaturesThe President\u27s Corner Editor\u27s Deskhttps://pillars.taylor.edu/acsd_koinonia/1079/thumbnail.jp