Functional modes of proteins are among the most robust ones

It is shown that a small subset of modes which are likely to be involved in protein functional motions of large amplitude can be determined by retaining the most robust normal modes obtained using different protein models. This result should prove helpful in the context of several applications proposed recently, like for solving difficult molecular replacement problems or for fitting atomic structures into low-resolution electron density maps. Moreover, it may also pave the way for the development of methods allowing to predict such motions accurately.Comment: 4 pages, 5 figure

Опухоль брюшной стенки - грыжа спигелевой линии, содержащая метастатическую карциному с невыявленным первичным очагом

АДЕНОКАРЦИНОМАБРЮШНАЯ СТЕНКАГРЫЖИКАРЦИНОМАКОЛОРЕКТАЛЬНЫЕ НОВООБРАЗОВАНИЯНОВООБРАЗОВАНИЯТОЛСТАЯ КИШК

1 cm2 CH3NH3PbI3 mesoporous solar cells with 17.8% steady-state efficiency by tailoring front FTO electrodes

In this article, we investigate the effects of atmospheric-pressure chemical vapour deposited fluorine doped tin oxide (FTO) thin films as front electrodes for the fabrication of mesoporous perovskite solar cells with an active area of 1 cm2 and compare them with the use of a commonly used commercial transparent conducting oxide. The effects of sheet resistance (Rs) and surface roughness are both closely linked to the film thickness. In order to separate out these effects the characteristics of the deposited FTOs were carefully controlled by changing the fluorine doping levels and the number of passes under the coating head to give films of specific thicknesses or Rs. Under AM 1.5 Sun illumination and maximum power point tracking, the optimised FTOs yielded a steady-state power conversion efficiency of 17.8%, higher than that of the reference cell fabricated from the commercial FTO. We attribute the improved cell efficiency to increased fill factor and a lower series resistance resulting from the lower Rs and increased thickness of these FTO substrates. This low-cost and viable methodology is the first such type of study looking independently at the significance of FTO roughness and resistance for highly efficient mesoporous perovskite solar cells

Nanoscale Analysis by EFTEM and FIB-Tomography for Optimization of Thin-Film Silicon Solar Cells

Extended abstract of a paper presented at Microscopy and Microanalysis 2010 in Portland, Oregon, USA, August 1 - August 5, 201

New Rheumatoid Arthritis Treatments for ‘Old’ Patients : Results of a Systematic Review

Introduction: In the last 20 years, biologic and targeted synthetic disease-modifying antirheumatic drugs (DMARDs) have become available for treating rheumatoid arthritis (RA), and a treat-to-target strategy has been introduced. We hypothesise that these advances should have resulted in changes to the characteristics of patients with RA participating in clinical trials of the newest therapies. This study determined whether the baseline characteristics of patients with RA enrolled in clinical trials have changed in the past decade versus patients participating in earlier RA studies. Methods: This secondary analysis was based on randomised controlled trials (RCTs) identified in a systematic literature review. Baseline characteristics of patients with RA with inadequate response to conventional synthetic DMARDs were compared between RCTs published in 1999\u20132009 and those published in 2010\u20132017 using random-effects meta-analyses. Results: Forty RCTs were analysed: 22 from 1999\u20132009 and 18 from 2010\u20132017. No significant difference between the two timeframes and no obvious trend over time were observed for age, gender, disease duration, rheumatoid factor status, tender and swollen joint counts, physician and patient global assessments of disease activity, and pain scores. Variability between RCTs was high. Similar results were observed for Disease Activity Scores and Health Assessment Questionnaire-Disability Index scores, but with low variability between RCTs. Conclusion: The baseline characteristics of patients with RA participating in RCTs do not appear to have changed in the last decade despite the availability of new treatments and a different treatment approach. Further research should determine the impact of baseline patient characteristics on patients\u2019 response to RA treatments

Qualité microbiologique des fromages artisanaux fabriqués au lait cru en Région wallonne

Microbiological quality of craft raw milk cheeses produced in Wallonia. The main objective of this study was to evaluatethe bacteriological quality of raw milk cheeses produced in the southern part of Belgium (Wallonia) and to compare withsamples coming from other European countries. Results from bacteriological analyses of 153 cheese samples have beencompared with regard to food microbial standards (92/46 EC Directive). It can be concluded from this work that 69% of thesamples may be considered as acceptable, while 31% showed coliforms and Staplylococcus aureus counts exceeding thestandard values. As far as pathogens were concerned, 0.7% and 7.2% of the samples have were found unsatifactory with thecriteria related to Salmonella and Listeria monocytogenes, respectively. Enterobacteriaceae contamination has also beenevaluated and demonstrated an average log count of about 3.78 cfu/g. Cheeses produced from ewe milk showed anoutstanding microbiological quality since all samples turned out to be acceptable regarding the S. aureus counts and devoidof Salmonella and L. monocytogenes contamination. Although no seasonal effect on the bacteriological quality could beobserved, the microbial quality decreased after the production stage, i.e. mainly during the storage and the distribution.Cheese made by small producers seems to be better than those originating from industrial enterprises. By comparing theseresults with those obtained on cheese samples produced in some other European countries, it appears that the mean qualitylevel of Walloon raw milk cheeses is quite satifactory

Growth model of MOCVD polycrystalline ZnO

A growth model for the low pressure chemical vapor deposition (LPCVD) of polycrystalline ZnO thin films is proposed. This model is based on experimental observations of the surface morphology and crystallographic orientations of the layers at different thicknesses and growth temperatures. It is shown that the films preferred orientation evolves from c-axis to aaxis as the growth temperature is increased from 110 to 220 Cand then goes back to c-axis at 380 C. At the same time, when the film thickness increases, the surface morphology evolves from small rounded grains to large pyramids at a growth temperature of 150 C. The selection of various preferential orientations under different deposition conditions is attributed to growth competition between clusters initially formed with different crystallographic orientations

Enhanced mobility of hydrogenated MO-LPCVD ZnO contacts for high performances thin film silicon solar cells

In this contribution, we study the increase in metalorganic-low pressure chemical vapor deposited (MO-LPCVD) ZnO thin films conductivity by hydrogen plasma post-treatment. We show that this improvement is linked to defect passivation at grain boundaries, decreasing the electron traps density and resulting in the almost complete suppression of the electron scattering at grain boundaries. For a 2 μm thick non-intentionally doped ZnO layer, electron mobility reaches after treatment values close to 60 cm2V-1s-1 (corresponding to an increase of 100%), with a carrier density still as low as 3 x1019 cm-3 (+1.5 x1019 cm-3). Such layers have an absorbance below 2-3% in the range of 400 to 1100 nm making them among the most transparent and conductive materials reported so far. In addition, we demonstrate that hydrogen plasma posttreated ZnO layers can be used as front electrode for producing highly transparent and conductive electrodes. Eventually, it is shown that hydrogen plasma treatment can also be used on the complete thin film solar cell stack (back contact and silicon device) to improve the cell performances.PV-LABIMT-NE Number: 68

A Cluster of Legionnaires' Disease and Associated Pontiac Fever Morbidity in Office Workers, Dublin, June-July 2008

In June and July 2008, two office workers were admitted to a Dublin hospital with Legionnaires' disease. Investigations showed that cooling towers in the basement car park were the most likely source of infection. However, positive results from cooling tower samples by polymerase chain reaction (PCR) did not correlate with subsequent culture results. Also, many employees reported Pontiac fever-like morbidity following notification of the second case of Legionnaires' disease. In total, 54 employees attended their general practitioner or emergency department with symptoms of Legionnaires' disease or Pontiac fever. However, all laboratory tests for Legionnaires' disease or Pontiac fever were negative. In this investigation, email was used extensively for active case finding and provision of time information to employees and medical colleagues. We recommend clarification of the role of PCR in the diagnosis of legionellosis and also advocate for a specific laboratory test for the diagnosis of the milder form of legionellosis as in Pontiac fever