Editorial: What’s in a Name? Distinguishing forced labour, trafficking and slavery

Over the last fifteen years the parameters of anti-trafficking have shifted considerably. This shift has not been immediate or seismic. It has been a gradual shift, and what was once advocated for as a specific practice of trafficking is now associated with, and at times used interchangeably with, slavery and forced labour

Fusion of the NUP98 gene with the LEDGF/p52 gene defines a recurrent acute myeloid leukemia translocation

BACKGROUND: The NUP98 gene is involved in multiple rearrangements in haematological malignancy. The leukemic cells in an acute myeloid leukemia (AML) patient with a t(9;11)(p22;p15) were recently shown to have a fusion between the NUP98 gene and the LEDGF gene but it was not demonstrated that this fusion was recurrent in other leukaemia patients with the same translocation. RESULTS: We used RT-PCR to analyse the leukemic cells from an AML patient who presented with a cytogenetically identical translocation as the sole chromosomal abnormality. A NUP98-LEDGF fusion transcript was observed and confirmed by sequencing. The reciprocal transcript was also observed. The fusion transcript was not detectable during remission and recurred at relapse. The breakpoints in the NUP98 and LEDGF genes were different to those previously reported. The NUP98 breakpoint occurs in the intron between exons 8 and 9. It is the most 5' breakpoint reported in a translocation involving the NUP98 gene. All of the LEDGF gene is included in the fusion except for exon 1 which codes for the first 24 amino terminal amino acids. CONCLUSIONS: Our results show that fusion of the NUP98 and LEDGF genes is a new recurrent translocation in AML

Qualitative research: exploring the multiple perspectives of osteopathy

This paper is offered as an introduction to qualitative research, with the hope that it informs and stimulates osteopaths and researchers who are unfamiliar with this area of research. This paper discusses the potential contribution of qualitative research in exploring the complex and multiple aspects of osteopathy and how the findings of qualitative studies may contribute to the knowledge base of osteopathy. A definition of qualitative research is provided, and a number of different methodologies are discussed. Finally it suggests examples of how the findings of qualitative research could potentially help inform osteopathic practice. © 2011 Elsevier Ltd

Does latent inhibition underpin creativity, positive schizotypy and anomalous cognition?

This paper presents two experiments in which an experimental paradigm developed to examine the efficacy of filtering mechanisms of attention, Latent Inhibition (LI), was adapted to include a psi component. LI assesses the processing of irrelevant stimuli, thus we tested whether a psi-stimulus might be processed akin to the irrelevant stimulus. Because the processing of the irrelevant stimulus has been shown to be moderated by creativity and positive schizotypy, we hypothesized that these same variables would also moderate the processing of any psi effect. In Experiment 1, a significant LI effect was observed but no psi effect. However, non-linear cognition in the creative process (NLCC) (e.g., intuition and hypnagogia) was significantly associated with a psi-LI-like effect. In Experiment 2 there was a significant psi effect that seemed to operate under the same conditions as LI (being attenuated with a high attentional load). However, creativity and positive schizotypy did not moderate the strength of this psi-LI-like effect. The LI effect was significantly enhanced by NLCC and attenuated by originality

WSES classification and guidelines for liver trauma

The severity of liver injuries has been universally classified according to the American Association for the Surgery of Trauma (AAST) grading scale. In determining the optimal treatment strategy, however, the haemodynamic status and associated injuries should be considered. Thus the management of liver trauma is ultimately based on the anatomy of the injury and the physiology of the patient. This paper presents the World Society of Emergency Surgery (WSES) classification of liver trauma and the management Guidelines

Promoting students’ safety and wellbeing : Ethical practice in schools

Although ‘child safety’ is now a national policy priority in Australia, there is little research exploring the practices in schools that contribute to children and young people’s felt sense of safety and wellbeing. Drawing on a mixed-method Australian Research Council (ARC) Discovery project, this article presents findings from interviews with school staff (N = 10), leaders (N = 5) and nine focus groups with students (N = 58), in primary and secondary schools in three Australian states (New South Wales, Victoria and South Australia). We employ relational ethics, recognition theory and the theory of practice architectures to explore practices at school that support student wellbeing and safety. The findings contribute significantly to understanding the ‘bundled’ nature of current practices and the conditions that enable and constrain these. Close attention to these findings is critical as schools seek to operationalise the National Child Safe Principles and refine ongoing safeguarding procedures. The findings have informed the development of an online survey that is currently testing, on a much larger scale, which elements of ethical practice are most positively associated with students’ safety, wellbeing and recognition at school