Self modulated dynamics of a relativistic charged particle beam in plasma wake field excitation

Self modulated dynamics of a relativistic charged particle beam is reviewed within the context of the theory of plasma wake field excitation. The self-consistent description of the beam dynamics is provided by coupling the Vlasov equation with a Poisson-type equation relating the plasma wake potential to the beam density. An analysis of the beam envelope self-modulation is then carried out and the criteria for the occurrence of the instability are discussed thereby.Comment: This is a 10 pages manuscript which contain 4 figures. This manuscript is recently submitted in 'Nuclear Instruments and Methods in Physics Research Section A' as a proceeding of the conference 'EAAC 2015

The impact of diurnal variations of air traffic on contrail radiative forcing

We combined high resolution aircraft flight data from the EU Fifth Framework Programme project AERO2k with analysis data from the ECMWF's integrated forecast system to calculate diurnally resolved 3-D contrail cover. We scaled the contrail cover in order to match observational data for the Bakan area (eastern-Atlantic/western-Europe). <br><br> We found that less than 40% of the global distance travelled by aircraft is due to flights during local night time. Yet, due to the cancellation of shortwave and longwave effects during daytime, night time flights contribute a disproportional 60% to the global annual mean forcing. Under clear sky conditions the night flights contribute even more disproportionally at 76%. There are pronounced regional variations in night flying and the associated radiative forcing. Over parts of the North Atlantic flight corridor 75% of air traffic and 84% of the forcing occurs during local night, whereas only 35% of flights are during local night in South-East Asia, yet these contribute 68% of the radiative forcing. In general, regions with a significant local contrail radiative forcing are also regions for which night time flights amount to less than half of the daily total of flights. Therefore, neglecting diurnal variations in air traffic/contrail cover by assuming a diurnal mean contrail cover can over-estimate the global mean radiative forcing by up to 30%

Classical and Quantum-like approaches to Charged-Particle Fluids in a Quadrupole

A classical description of the dynamics of a dissipative charged-particle fluid in a quadrupole-like device is developed. It is shown that the set of the classical fluid equations contains the same information as a complex function satisfying a Schrodinger-like equation in which Planck's constant is replaced by the time-varying emittance, which is related to the time-varying temperature of the fluid. The squared modulus and the gradient of the phase of this complex function are proportional to the fluid density and to the current velocity, respectively. Within this framework, the dynamics of an electron bunch in a storage ring in the presence of radiation damping and quantum-excitation is recovered. Furthermore, both standard and generalized (including dissipation) coherent states that may be associated with the classical particle fluids are fully described in terms of the above formalism.Comment: LaTex, to appear in Physica Script

Towards a Formal Verification Methodology for Collective Robotic Systems

We introduce a UML-based notation for graphically modeling systems’ security aspects in a simple and intuitive way and a model-driven process that transforms graphical specifications of access control policies in XACML. These XACML policies are then translated in FACPL, a policy language with a formal semantics, and the resulting policies are evaluated by means of a Java-based software tool

Stochastic collective dynamics of charged-particle beams in the stability regime

We introduce a description of the collective transverse dynamics of charged (proton) beams in the stability regime by suitable classical stochastic fluctuations. In this scheme, the collective beam dynamics is described by time--reversal invariant diffusion processes deduced by stochastic variational principles (Nelson processes). By general arguments, we show that the diffusion coefficient, expressed in units of length, is given by $\lambda_c\sqrt{N}$, where $N$ is the number of particles in the beam and $\lambda_c$ the Compton wavelength of a single constituent. This diffusion coefficient represents an effective unit of beam emittance. The hydrodynamic equations of the stochastic dynamics can be easily recast in the form of a Schr\"odinger equation, with the unit of emittance replacing the Planck action constant. This fact provides a natural connection to the so--called ``quantum--like approaches'' to beam dynamics. The transition probabilities associated to Nelson processes can be exploited to model evolutions suitable to control the transverse beam dynamics. In particular we show how to control, in the quadrupole approximation to the beam--field interaction, both the focusing and the transverse oscillations of the beam, either together or independently

Levy-Student Distributions for Halos in Accelerator Beams

We describe the transverse beam distribution in particle accelerators within the controlled, stochastic dynamical scheme of the Stochastic Mechanics (SM) which produces time reversal invariant diffusion processes. This leads to a linearized theory summarized in a Shchr\"odinger--like (\Sl) equation. The space charge effects have been introduced in a recent paper~\cite{prstab} by coupling this \Sl equation with the Maxwell equations. We analyze the space charge effects to understand how the dynamics produces the actual beam distributions, and in particular we show how the stationary, self--consistent solutions are related to the (external, and space--charge) potentials both when we suppose that the external field is harmonic (\emph{constant focusing}), and when we \emph{a priori} prescribe the shape of the stationary solution. We then proceed to discuss a few new ideas~\cite{epac04} by introducing the generalized Student distributions, namely non--Gaussian, L\'evy \emph{infinitely divisible} (but not \emph{stable}) distributions. We will discuss this idea from two different standpoints: (a) first by supposing that the stationary distribution of our (Wiener powered) SM model is a Student distribution; (b) by supposing that our model is based on a (non--Gaussian) L\'evy process whose increments are Student distributed. We show that in the case (a) the longer tails of the power decay of the Student laws, and in the case (b) the discontinuities of the L\'evy--Student process can well account for the rare escape of particles from the beam core, and hence for the formation of a halo in intense beams

Laparoscopic hyperthermic isolated limb perfusion a new minimally invasive approach for HILP

Hyperthermic isolated limb perfusion (HILP) represents a limb-sparing treatment for unresectable soft tissue sarcoma (STS) of the extremities with substantial complete response rates. HILP often provides good functional limb preservation, hence a significant improvement also in terms of quality of life of the patient. Notwithstanding these clear advantages, the traditional technique is still hindered by relatively high post-operative morbidity.We treated a 78-year-old female with unresectable angiosarcoma of the left leg using a new surgical approach: an entirely laparoscopic HILP.No conversion from laparoscopic to "open" surgery was necessary. Since no abdominal muscle section was performed, post-operative pain was low and easily manageable; early mobilisation and early discharge were achieved. Patient developed moderate toxicity, which resolved spontaneously within 3-4 weeks, with complete return to normal daily activities after 30 d. Complete clinical response with preservation of leg function was obtained.We describe for the first time an entirely laparoscopic HILP. Demonstration of this technique's efficacy and safety on a large series of patients is clearly necessary but its therapeutic efficacy appears to be comparable to the standard technique. Furthermore, laparoscopic HILP has shown low post-operative morbidity: no wound complications, mild and easily manageable post-operative pain and early discharge from the hospital and early resuming of daily activities

In vitro selection of resistance in Streptococcus pneumoniae at in vivo fluoroquinolone concentrations

Methods: Twenty strains of S. pneumoniae susceptible to fluoroquinolones were used. The frequencies of spontaneous single-step mutations at plasma and epithelial lining fluid (ELF) peak and trough antibiotic concentrations were calculated. Multi-step selection of resistance was evaluated by performing 10 serial subcultures on agar plates containing a linear gradient from peak to trough antimicrobial concentrations, followed by 10 subcultures on antibiotic-free agar. Resistant strains selected after multi-step selection were characterized for DNA mutations by sequencing gyrA, gyrB, parC and parE genes. Results: Levofloxacin and moxifloxacin showed the lowest frequencies of mutations (median <10 211 ) at plasma peak and at ELF concentrations, while medians ranging from 10 28 to 10 26 were observed for ciprofloxacin and prulifloxacin. In a multi-step selection assay, ciprofloxacin and prulifloxacin selected for the highest number of resistant strains (19 and 31, respectively). No selection of resistance was observed for levofloxacin at ELF concentrations and for moxifloxacin at plasma and ELF concentrations. Mutations in parC, parE and gyrA genes were found in ciprofloxacin- and prulifloxacinresistant strains, while only parC mutations were found for levofloxacin. Conclusions: Levofloxacin and moxifloxacin are characterized by a lower propensity to select in vitro for resistance in S. pneumoniae than ciprofloxacin and prulifloxacin, when tested at plasma and lung concentrations