Molecular and functional characterization of gap junctions in the avian inner ear.

To analyze the fundamental role of gap junctions in the vertebrate inner ear, we examined molecular and functional characteristics of gap junctional communication (GJC) in the auditory and vestibular system of the chicken. By screening inner ear tissues for connexin isoforms using degenerate reverse transcription-PCR, we identified, in addition to chicken Cx43 (cCx43) and the inner-ear-specific cCx30, an as yet uncharacterized connexin predicted to be the ortholog of the mammalian Cx26. In situ hybridization indicated that cCx30 and cCx26 transcripts were both widely expressed in the cochlear duct and utricle in an overlapping pattern, suggesting coexpression of these isoforms similar to that in the mammalian inner ear. Immunohistochemistry demonstrated that cCx43 was present in gap junctions connecting supporting cells of the basilar papilla, in which its immunofluorescence colocalized with that of cCx30. However, cCx43 was absent from supporting cell gap junctions of the utricular macula. This variation in the molecular composition of gap junction plaques coincided with differences in the functional properties of GJC between the auditory and vestibular sensory epithelia. Fluorescence recovery after photobleaching, adapted to examine the diffusion of calcein in inner ear explants, revealed asymmetric communication pathways among supporting cells in the basilar papilla but not in the utricular macula. This study supports the hypothesis that the coexpression of Cx26/Cx30 is unique to gap junctions in the vertebrate inner ear. Furthermore, it demonstrates asymmetric GJC within the supporting cell population of the auditory sensory epithelium, which might mediate potassium cycling and/or intercellular signaling

Extended Scaling for the high dimension and square lattice Ising Ferromagnets

In the high dimension (mean field) limit the susceptibility and the second moment correlation length of the Ising ferromagnet depend on temperature as chi(T)=tau^{-1} and xi(T)=T^{-1/2}tau^{-1/2} exactly over the entire temperature range above the critical temperature T_c, with the scaling variable tau=(T-T_c)/T. For finite dimension ferromagnets temperature dependent effective exponents can be defined over all T using the same expressions. For the canonical two dimensional square lattice Ising ferromagnet it is shown that compact "extended scaling" expressions analogous to the high dimensional limit forms give accurate approximations to the true temperature dependencies, again over the entire temperature range from T_c to infinity. Within this approach there is no cross-over temperature in finite dimensions above which mean-field-like behavior sets in.Comment: 6 pages, 6 figure

On the non-abelian Brumer-Stark conjecture and the equivariant Iwasawa main conjecture

We show that for an odd prime p, the p-primary parts of refinements of the (imprimitive) non-abelian Brumer and Brumer-Stark conjectures are implied by the equivariant Iwasawa main conjecture (EIMC) for totally real fields. Crucially, this result does not depend on the vanishing of the relevant Iwasawa mu-invariant. In combination with the authors' previous work on the EIMC, this leads to unconditional proofs of the non-abelian Brumer and Brumer-Stark conjectures in many new cases.Comment: 33 pages; to appear in Mathematische Zeitschrift; v3 many minor updates including new title; v2 some cohomological arguments simplified; v1 is a revised version of the second half of arXiv:1408.4934v

Experimental mathematics on the magnetic susceptibility of the square lattice Ising model

We calculate very long low- and high-temperature series for the susceptibility $\chi$ of the square lattice Ising model as well as very long series for the five-particle contribution $\chi^{(5)}$ and six-particle contribution $\chi^{(6)}$. These calculations have been made possible by the use of highly optimized polynomial time modular algorithms and a total of more than 150000 CPU hours on computer clusters. For $\chi^{(5)}$ 10000 terms of the series are calculated {\it modulo} a single prime, and have been used to find the linear ODE satisfied by $\chi^{(5)}$ {\it modulo} a prime. A diff-Pad\'e analysis of 2000 terms series for $\chi^{(5)}$ and $\chi^{(6)}$ confirms to a very high degree of confidence previous conjectures about the location and strength of the singularities of the $n$-particle components of the susceptibility, up to a small set of ``additional'' singularities. We find the presence of singularities at $w=1/2$ for the linear ODE of $\chi^{(5)}$, and $w^2= 1/8$ for the ODE of $\chi^{(6)}$, which are {\it not} singularities of the ``physical'' $\chi^{(5)}$ and $\chi^{(6)},$ that is to say the series-solutions of the ODE's which are analytic at $w =0$. Furthermore, analysis of the long series for $\chi^{(5)}$ (and $\chi^{(6)}$) combined with the corresponding long series for the full susceptibility $\chi$ yields previously conjectured singularities in some $\chi^{(n)}$, $n \ge 7$. We also present a mechanism of resummation of the logarithmic singularities of the $\chi^{(n)}$ leading to the known power-law critical behaviour occurring in the full $\chi$, and perform a power spectrum analysis giving strong arguments in favor of the existence of a natural boundary for the full susceptibility $\chi$.Comment: 54 pages, 2 figure

Renormalised four-point coupling constant in the three-dimensional O(N) model with N=0

We simulate self-avoiding walks on a cubic lattice and determine the second virial coefficient for walks of different lengths. This allows us to determine the critical value of the renormalized four-point coupling constant in the three-dimensional N-vector universality class for N=0. We obtain g* = 1.4005(5), where g is normalized so that the three-dimensional field-theoretical beta-function behaves as \beta(g) = - g + g^2 for small g. As a byproduct, we also obtain precise estimates of the interpenetration ratio Psi*, Psi* = 0.24685(11), and of the exponent \nu, \nu = 0.5876(2).Comment: 16 page

Color-superconductivity in the strong-coupling regime of Landau gauge QCD

The chirally unbroken and the superconducting 2SC and CFL phases are investigated in the chiral limit within a Dyson-Schwinger approach for the quark propagator in QCD. The hierarchy of Green's functions is truncated such that at vanishing density known results for the vacuum and at asymptotically high densities the corresponding weak-coupling expressions are recovered. The anomalous dimensions of the gap functions are analytically calculated. Based on the quark propagator the phase structure is studied, and results for the gap functions, occupation numbers, coherence lengths and pressure differences are given and compared with the corresponding expressions in the weak-coupling regime. At moderate chemical potentials the quasiparticle pairing gaps are several times larger than the extrapolated weak-coupling results.Comment: 14 pages, 9 figures; v2: one reference adde

The diagonal Ising susceptibility

We use the recently derived form factor expansions of the diagonal two-point correlation function of the square Ising model to study the susceptibility for a magnetic field applied only to one diagonal of the lattice, for the isotropic Ising model. We exactly evaluate the one and two particle contributions $\chi_{d}^{(1)}$ and $\chi_{d}^{(2)}$ of the corresponding susceptibility, and obtain linear differential equations for the three and four particle contributions, as well as the five particle contribution ${\chi}^{(5)}_d(t)$, but only modulo a given prime. We use these exact linear differential equations to show that, not only the russian-doll structure, but also the direct sum structure on the linear differential operators for the $n$-particle contributions $\chi_{d}^{(n)}$ are quite directly inherited from the direct sum structure on the form factors $f^{(n)}$. We show that the $n^{th}$ particle contributions $\chi_{d}^{(n)}$ have their singularities at roots of unity. These singularities become dense on the unit circle $|\sinh2E_v/kT \sinh 2E_h/kT|=1$ as $n\to \infty$.Comment: 18 page

Quantum statistics in complex networks

In this work we discuss the symmetric construction of bosonic and fermionic networks and we present a case of a network showing a mixed quantum statistics. This model takes into account the different nature of nodes, described by a random parameter that we call energy, and includes rewiring of the links. The system described by the mixed statistics is an inhomogemeous system formed by two class of nodes. In fact there is a threshold energy $\epsilon_s$ such that nodes with lower energy $(\epsilon<\epsilon_s)$ increase their connectivity while nodes with higher energy $(\epsilon>\epsilon_s)$ decrease their connectivity in time.Comment: 5 pages, 2 figure

Identification of cis-acting determinants mediating the unconventional secretion of tau.

The deposition of tau aggregates throughout the brain is a pathological characteristic within a group of neurodegenerative diseases collectively termed tauopathies, which includes Alzheimer's disease. While recent findings suggest the involvement of unconventional secretory pathways driving tau into the extracellular space and mediating the propagation of the disease-associated pathology, many of the mechanistic details governing this process remain elusive. In the current study, we provide an in-depth characterization of the unconventional secretory pathway of tau and identify novel molecular determinants that are required for this process. Here, using Drosophila models of tauopathy, we correlate the hyperphosphorylation and aggregation state of tau with the disease-related neurotoxicity. These newly established systems recapitulate all the previously identified hallmarks of tau secretion, including the contribution of tau hyperphosphorylation as well as the requirement for PI(4,5)P2 triggering the direct translocation of tau. Using a series of cellular assays, we demonstrate that both the sulfated proteoglycans on the cell surface and the correct orientation of the protein at the inner plasma membrane leaflet are critical determinants of this process. Finally, we identify two cysteine residues within the microtubule binding repeat domain as novel cis-elements that are important for both unconventional secretion and trans-cellular propagation of tau