Geographies and politics of localism: the localism of the United Kingdom's Coalition Government

There has always been a localist element to British politics. But recently, a particular version of localism has been moved to the foreground by the 2011 Localism Act. This paper identifies various uses and meanings of localism, maps their geographical assumptions and effects, and critiques their politics. It does this using the localism of the United Kingdom’s Coalition Government as a case study of localism in practice. The rationalities, mentalities, programmes, and technologies of this localism are established from Ministerial speeches and press releases, along with Parliamentary Acts, Bills, White Papers, Green Papers, and Statements – all published between May 2010 when the Coalition Government was formed, and November 2011 when the Localism Act became law. We argue that localism may be conceptualised as spatial liberalism, is never straightforwardly local, and can be anti-politica

Analysis of a typical railway turnout sleeper system using grillage beam analogy

A simplified grillage beam analogy was performed to investigate the behaviour of railway turnout sleeper system with a low value of elastic modulus on different support moduli. This study aimed at determining an optimum modulus of elasticity for an emerging technology for railway turnout application - fibre composites sleeper. The finite element simulation suggests that the changes in modulus of elasticity of sleeper, Esleeper and the sleeper support modulus, Us have a significant influence on the behaviour of turnout sleepers. The increase in Us from 10 to 40 MPa resulted in a 15% reduction in the bending moment while the increase in Esleeper from 1 GPa to 10 GPa has resulted in almost 75% increase in the bending moment. The shear forces in turnout sleepers is not sensitive to both the changes of the Esleeper and Us while the sleeper with low Esleeper tend to undergo greater settlement into the ballast. An Esleeper of 4 GPa was found optimal for an alternative fibre composite turnout sleeper provided that the Us is at least 20 MPa from the consideration of sleeper ballast pressure and maximum vertical deflection. It was established that the turnout sleeper has a maximum bending moment of 19 kN-m and a shear force of 158 kN under service conditions

Linking genetics with biology in disease research: an interview with Nick Hastie

Professor Nick Hastie is Director of the MRC Human Genetics Unit in Edinburgh, a centre originally famous for early studies of chromosome biology. He is also Director of the newly formed Institute of Genetics and Molecular Medicine, which includes the Human Genetics Unit. In addition to overseeing the work on cancer and developmental genetics in his own lab, he is involved in a number of large-scale genetic studies aimed at uncovering genetic risk factors for various human diseases

The Wider Social Impacts of Changes in the Structure of Agricultural Businesses

Agricultural restructuring is not a new phenomenon. Indeed, recent decades have seen substantial changes, not only to the number and types of farmers and farm businesses, but also to ownership structures and to the relationship between land holding and management control. The Department of Food, Environment and Rural Affairs (Defra), together with the UK Countryside Agencies, has commissioned a body of research in recent years which, taken together, offer important insights into the nature, speed and extent of restructuring in the UK and of the potential for further, accelerated change in the years to come. From this body of work it is clear that a prolonged and difficult process of disengagement from agriculture as a mainstream income source is beginning to take place, with evidence of both adaptation and resistance to change by a land management community which is becoming increasingly diverse in its social composition and behaviour. The adjustment to farming practice, living standards and lifestyles which all of this implies is not without personal cost and, while claims of an agricultural crisis may be exaggerated, it is clear that large numbers of farmers are finding they have to make difficult adjustments against a shifting background of policy reform and market change. Moreover, given the traditional centrality of farmers in rural communities, both as employers and as participants in many of the key institutions of rural life, there may be wider social implications of agricultural restructuring which now deserve to be more closely investigated. What, for example is the nature, extent and wider significance of the personal costs and social implications of agricultural restructuring.Agribusiness, Industrial Organization,

Cholesteatoma and family history: An international survey

Objective To explore the relative frequency of a family history of cholesteatoma in patients with known cholesteatoma, and whether bilateral disease or earlier diagnosis is more likely in those with a family history. Associations between cleft lip or palate and bilateral disease and age of diagnosis were also explored. Design An online survey of patients with diagnosed cholesteatoma was conducted between October 2017 and April 2019. Participants The sample consisted of patients recruited from two UK clinics and self‐selected respondents recruited internationally via social media. Main outcome measures Side of cholesteatoma, whether respondents had any family history of cholesteatoma, age of diagnosis and personal or family history of cleft lip or palate were recorded. Results Of 857 respondents, 89 (10.4%) reported a positive family history of cholesteatoma. Respondents with a family history of cholesteatoma were more likely to have bilateral cholesteatoma (P = .001, odds ratio (OR) 2.15, 95% confidence interval (CI) 1.35‐3.43), but there was no difference in the age of diagnosis (P = .23). Those with a history of cleft lip or palate were not more likely to have bilateral disease (P = .051, OR 2.71, CI 1.00‐7.38), and there was no difference in age of diagnosis (P = .11). Conclusion The relatively high proportion of respondents that reported a family history of cholesteatoma offers supporting evidence of heritability in cholesteatoma. The use of social media to recruit respondents to this survey means that the results cannot be generalised to other populations with cholesteatoma. Further population‐based research is suggested to determine the heritability of cholesteatoma

Frequency of glucose-6-phosphate dehydrogenase deficiency in malaria patients from six African countries enrolled in two randomized anti-malarial clinical trials

<p>Abstract</p> <p>Background</p> <p>Glucose-6-phosphate dehydrogenase (G6PD) deficiency is common in populations living in malaria endemic areas. G6PD genotype and phenotype were determined for malaria patients enrolled in the chlorproguanil-dapsone-artesunate (CDA) phase III clinical trial programme.</p> <p>Methods</p> <p>Study participants, aged > 1 year, with microscopically confirmed uncomplicated <it>Plasmodium falciparum </it>malaria, and haemoglobin ≥ 70 g/L or haematocrit ≥ 25%, were recruited into two clinical trials conducted in six African countries (Burkina Faso, Ghana, Kenya, Nigeria, Tanzania, Mali). G6PD genotype of the three most common African forms, G6PD*B, G6PD*A (A376G), and G6PD*A- (G202A, A542T, G680T and T968C), were determined and used for frequency estimation. G6PD phenotype was assessed qualitatively using the NADPH fluorescence test. Exploratory analyses investigated the effect of G6PD status on baseline haemoglobin concentration, temperature, asexual parasitaemia and anti-malarial efficacy after treatment with CDA 2/2.5/4 mg/kg or chlorproguanil-dapsone 2/2.5 mg/kg (both given once daily for three days) or six-dose artemether-lumefantrine.</p> <p>Results</p> <p>Of 2264 malaria patients enrolled, 2045 had G6PD genotype available and comprised the primary analysis population (1018 males, 1027 females). G6PD deficiency prevalence was 9.0% (184/2045; 7.2% [N = 147] male hemizygous plus 1.8% [N = 37] female homozygous), 13.3% (273/2045) of patients were heterozygous females, 77.7% (1588/2045) were G6PD normal. All deficient G6PD*A- genotypes were A376G/G202A. G6PD phenotype was available for 64.5% (1319/2045) of patients: 10.2% (134/1319) were G6PD deficient, 9.6% (127/1319) intermediate, and 80.2% (1058/1319) normal. Phenotype test specificity in detecting hemizygous males was 70.7% (70/99) and 48.0% (12/25) for homozygous females. Logistic regression found no significant effect of G6PD genotype on adjusted mean baseline haemoglobin (p = 0.154), adjusted mean baseline temperature (p = 0.9617), or adjusted log mean baseline parasitaemia (p = 0.365). There was no effect of G6PD genotype (p = 0.490) or phenotype (p = 0.391) on the rate of malaria recrudescence, or reinfection (p = 0.134 and p = 0.354, respectively).</p> <p>Conclusions</p> <p>G6PD deficiency is common in African patients with malaria and until a reliable and simple G6PD test is available, the use of 8-aminoquinolines will remain problematic. G6PD status did not impact baseline haemoglobin, parasitaemia or temperature or the outcomes of anti-malarial therapy.</p> <p>Trial registration</p> <p>Clinicaltrials.gov: <a href="http://www.clinicaltrials.gov/ct2/show/NCT00344006">NCT00344006</a> and <a href="http://www.clinicaltrials.gov/ct2/show/NCT00371735">NCT00371735</a>.</p

Dynamic changes in depositional patterns and glaciotectonic deformations revealed by high-resolution 3D seismic data in the Northern North Sea.

Kurjanski, B., Lee, N., MacKay, A., Powell, B., and Oukili, J.: Dynamic changes in depositional patterns and glaciotectonic deformations revealed by high-resolution 3D seismic data in the Northern North Sea., EGU General Assembly 2024, Vienna, Austria, 14–19 Apr 2024, EGU24-1121, https://doi.org/10.5194/egusphere-egu24-1121, 2024.Peer reviewe

Self-reported quality of care for older adults from 2004 to 2011: a cohort study

Background: little is known about changes in the quality of medical care for older adults over time. Objective: to assess changes in technical quality of care over 6 years, and associations with participants' characteristics. Design: a national cohort survey covering RAND Corporation-derived quality indicators (QIs) in face-to-face structured interviews in participants' households. Participants: a total of 5,114 people aged 50 or more in four waves of the English Longitudinal Study of Ageing. Methods: the percentage achievement of 24 QIs in 10 general medical and geriatric clinical conditions was calculated for each time point, and associations with participants' characteristics were estimated using logistic regression. Results: participants were eligible for 21,220 QIs. QI achievement for geriatric conditions (cataract, falls, osteoarthritis and osteoporosis) was 41% [95% confidence interval (CI): 38–44] in 2004–05 and 38% (36–39) in 2010–11. Achievement for general medical conditions (depression, diabetes mellitus, hypertension, ischaemic heart disease, pain and cerebrovascular disease) improved from 75% (73–77) in 2004–05 to 80% (79–82) in 2010–11. Achievement ranged from 89% for cerebrovascular disease to 34% for osteoarthritis. Overall achievement was lower for participants who were men, wealthier, infrequent alcohol drinkers, not obese and living alone. Conclusion: substantial system-level shortfalls in quality of care for geriatric conditions persisted over 6 years, with relatively small and inconsistent variations in quality by participants' characteristics. The relative lack of variation by participants' characteristics suggests that quality improvement interventions may be more effective when directed at healthcare delivery systems rather than individuals

DNA methylation affects nuclear organization, histone modifications, and linker histone binding but not chromatin compaction

DNA methylation has been implicated in chromatin condensation and nuclear organization, especially at sites of constitutive heterochromatin. How this is mediated has not been clear. In this study, using mutant mouse embryonic stem cells completely lacking in DNA methylation, we show that DNA methylation affects nuclear organization and nucleosome structure but not chromatin compaction. In the absence of DNA methylation, there is increased nuclear clustering of pericentric heterochromatin and extensive changes in primary chromatin structure. Global levels of histone H3 methylation and acetylation are altered, and there is a decrease in the mobility of linker histones. However, the compaction of both bulk chromatin and heterochromatin, as assayed by nuclease digestion and sucrose gradient sedimentation, is unaltered by the loss of DNA methylation. This study shows how the complete loss of a major epigenetic mark can have an impact on unexpected levels of chromatin structure and nuclear organization and provides evidence for a novel link between DNA methylation and linker histones in the regulation of chromatin structure