Laptop Technology in Classrooms: How Student Perceptions Shape Learning and Satisfaction

This study is based on perceptions of students regarding the integration of laptops in classroom endeavors. Empirical findings are based on data collected from a sample of 392 students in undergraduate and graduate universities in twelve states of the USA. Three key findings related to the integration of laptop technology into classrooms of higher education are reported. First relates to student perceptions and feelings surrounding laptop use in the classroom. Secondly, we report how these perceptions vary depending on personal characteristics of students. Lastly, we examine the role these perceptions play in student learning, as well as student satisfaction. Traditionally, laptop technology has been viewed as tool for facilitating note taking. However, our findings indicate that the learning experience is equal, and in some instances greater, when laptops are used to develop a more interactive learning environment, increase information gathering during class time, and enhance classroom discussion

Is EuSe a pseudo two-dimensional magnetic system?

We present 77Se NMR measurements in EuSe and review previous 153Eu NMR measurements that show that EuSe displays 2D characteristics at both ends of the magnetization curve. The lowtemperature behavior, in agreement with previous measurements, follows a simple 2D T2 falloff. At the higher temperatures, a critical-exponent fit shows an apparent 2D behavior with ß ~ 0.18 ± 0.02. EuSe has always appeared to be a complicated magnetic system, with a number of co-existing magnetic phases and an alleged first-order magnetic transition. We argue that the multiple magnetic structures are in fact compatible with 2D behavior, and that there is actually no firm evidence of a first-order transition. In the ferromagnetic state of EuSe (obtained under pressure or by an applied field), a ß ~ 0.33 is found, but with a D ~ 1, characteristic of the behavior of the classic 2D magnets K2CuF4 and CrCl3, and not of 3D critical behavior. Additional experiments to verify the 2D nature of EuSe are suggested. The nontrivial implications of the two-dimensionality of EuSe regarding the nature of magnetic interactions in general are also discussed

Bayesian integration of flux tower data into a process-based simulator for quantifying uncertainty in simulated output

Parameters of a process-based forest growth simulator are difficult or impossible to obtain from field observations. Reliable estimates can be obtained using calibration against observations of output and state variables. In this study, we present a Bayesian framework to calibrate the widely used process-based simulator Biome-BGC against estimates of gross primary production (GPP) data. We used GPP partitioned from flux tower measurements of a net ecosystem exchange over a 55-year-old Douglas fir stand as an example. The uncertainties of both the Biome-BGC parameters and the simulated GPP values were estimated. The calibrated parameters leaf and fine root turnover (LFRT), ratio of fine root carbon to leaf carbon (FRC : LC), ratio of carbon to nitrogen in leaf (C : Nleaf), canopy water interception coefficient (Wint), fraction of leaf nitrogen in RuBisCO (FLNR), and effective soil rooting depth (SD) characterize the photosynthesis and carbon and nitrogen allocation in the forest. The calibration improved the root mean square error and enhanced Nash–Sutcliffe efficiency between simulated and flux tower daily GPP compared to the uncalibrated Biome-BGC. Nevertheless, the seasonal cycle for flux tower GPP was not reproduced exactly and some overestimation in spring and underestimation in summer remained after calibration. We hypothesized that the phenology exhibited a seasonal cycle that was not accurately reproduced by the simulator. We investigated this by calibrating the Biome-BGC to each month's flux tower GPP separately. As expected, the simulated GPP improved, but the calibrated parameter values suggested that the seasonal cycle of state variables in the simulator could be improved. It was concluded that the Bayesian framework for calibration can reveal features of the modelled physical processes and identify aspects of the process simulator that are too rigid

A woman with cystic fibrosis, severe hypoxaemia, an atrial thrombus and a patent foramen ovale: a case report

<p>Abstract</p> <p>Introduction</p> <p>Cystic fibrosis is usually associated with chronic pulmonary sepsis and frequent infective exacerbations. We report a very unusual cause of severe hypoxaemia in a woman with cystic fibrosis caused by thrombus formation in the right atrium.</p> <p>Case presentation</p> <p>A 21-year-old Caucasian woman with cystic fibrosis and a totally implantable venous access device presented with severe hypoxaemia. This was initially treated with antibiotics but her oxygen levels did not improve significantly. Subsequently, a transient ischaemic attack occurred. Further investigations, including a contrast echocardiogram and a cardiac magnetic resonance scan, revealed the presence of a large right atrial thrombus and right-to-left intracardiac shunt through a patent foramen ovale.</p> <p>Conclusion</p> <p>This case highlights the need to consider a right-to-left shunt in chronic respiratory diseases when hypoxaemia is out of proportion to the degree of lung function impairment. Totally implantable venous access devices should always be considered as a source of thrombus formation.</p

RBC barcoding allows for the study of erythrocyte population dynamics and P. falciparum merozoite invasion.

Plasmodium falciparum invasion of host erythrocytes is essential for the propagation of the blood stage of malaria infection. Additionally, the brief extracellular merozoite stage of P. falciparum represents one of the rare windows during which the parasite is directly exposed to the host immune response. Therefore, efficient invasion of the host erythrocyte is necessary not only for productive host erythrocyte infection, but also for evasion of the immune response. Host traits, such as hemoglobinopathies and differential expression of erythrocyte invasion ligands, can protect individuals from malaria by impeding parasite erythrocyte invasion. Here we combine RBC barcoding with flow cytometry to study P. falciparum invasion. This novel high-throughput method allows for the (i) direct comparison of P. falciparum invasion into different erythrocyte populations and (ii) assessment of the impact of changing erythrocyte population dynamics on P. falciparum invasion

Patient perception of telephone follow-up after resection for colorectal cancer: Is it time for an alternative to the out-patient clinic?

The economic reality of modern healthcare provides a timely reminder to clinicians of their duty to provide outstanding and cost-effective care. Although multiple guidelines outline investigation, management and surveillance of colorectal cancer, none advocate a particular delivery method. Nurse-led telephone follow-up in multiple specialties has demonstrated equivalent clinical outcomes and patient satisfaction when compared to traditional outpatient department follow-up. This paper aims to compare nurse-led telephone and outpatient follow-up, following surgical resection of colorectal cancer (CRC), focusing on patient perceptions. This cross-sectional study distributed adapted patient satisfaction questionnaire (PS-Q 18) to patients undergoing surveillance following CRC resection via either nurse-led telephone clinics (TC) or standard outpatient department appointments (OPD). 161 questionnaires were distributed (100 OPD, 61 TC); the response rate was 70% for the OPD group, and 87% for the TC group (p=0.02). There was no statistically significant difference between patient reported satisfaction or in preference for healthcare delivery system between groups. More patients in the TC group had serum CEA measured than OPD group. This survey demonstrates high patient satisfaction with telephone follow-up. Owing to the financial benefits on both a patient and healthcare provider level, as well as improved screening uptake (CEA) in our study, a role for this innovative specialist nurse-led telephone clinic clearly exists. The benefits of telephone follow-up in terms of health economics, health equity and adherence to screening protocols support its exclusive role in long-term CRC surveillance

Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity.

Breast cancer arises from breast epithelial cells that acquire genetic alterations leading to subsequent loss of tissue homeostasis. Several distinct epithelial subpopulations have been proposed, but complete understanding of the spectrum of heterogeneity and differentiation hierarchy in the human breast remains elusive. Here, we use single-cell mRNA sequencing (scRNAseq) to profile the transcriptomes of 25,790 primary human breast epithelial cells isolated from reduction mammoplasties of seven individuals. Unbiased clustering analysis reveals the existence of three distinct epithelial cell populations, one basal and two luminal cell types, which we identify as secretory L1- and hormone-responsive L2-type cells. Pseudotemporal reconstruction of differentiation trajectories produces one continuous lineage hierarchy that closely connects the basal lineage to the two differentiated luminal branches. Our comprehensive cell atlas provides insights into&nbsp;the cellular blueprint of the human breast epithelium and will form the foundation to understand how the system goes awry during breast cancer

Nutrition as the Foundation for Good Health: Evaluating the Impact of Food Programs on Health

Introduction. Previous studies have demonstrated a link between food insecurity and childhood behavioral problems, particularly internal problems such as anxiety and depression. Burlington Children’s Space (BCS), a local preschool and daycare in Burlington, VT, has created a healthy and nutritious meal program for their children, many of whom cannot afford enough to eat well at home.https://scholarworks.uvm.edu/comphp_gallery/1194/thumbnail.jp

Faecal Microbiota Transplantation plus selected use of antibiotics for severe-complicated Clostridium difficile infection: description of a protocol with high success rate

Background Severe and severe/complicated Clostridium difficile infection (CDI) can result in ICU admission, sepsis, toxic megacolon and death. In this setting, colectomy is the standard of care but it is associated with a 50% mortality. Aim To evaluate safety and efficacy of a sequential faecal microbiota transplantation (FMT) and antibiotic protocol in severe and severe/complicated CDI patients who are at high risk for colectomy. Methods All patients with severe and severe/complicated CDI refractory to oral vancomycin ± rectal vancomycin and intravenous metronidazole therapy were offered FMT. Treatment consisted of sequential FMTs via colonoscopy with the need for repeat FMT and continued vancomycin guided by clinical response and pseudomembranes at colonoscopy. Results A total of 29 patients underwent FMT between July 2013 and August 2014. The overall treatment response of endoscopic sequential FMT was 93% (27/29), with 100% (10/10) for severe CDI and 89% (17/19) for severe/complicated CDI. A single FMT was performed in 62%, two FMTs were performed in 31% and three FMTs in 7% of patients. The use of non-CDI antibiotics predicted repeat FMT (odds ratio = 17.5). The 30-day all-cause mortality after FMT was 7%, and the cumulative 3-month survival was 76%. Of the two patients who died within 30 days, one underwent colectomy and succumbed to sepsis; the other died from septic shock related to CDI. Conclusion The success of a treatment protocol for severe and severe/complicated involving faecal microbiota transplantation and continued vancomycin in selected patients was high, and it warrants further evaluation