Fantastic Patterns and Where Not to Find Them

Interesting patterns are everywhere we look, but what happens when we try to avoid patterns? A permutation is a list of numbers in a specific order. When we avoid a pattern, we try not to order those numbers in certain ways. For example, the permutation 45312 avoids the 123 pattern because no three elements in the permutation are in an increasing order. In our work, we studied the permutations that avoid two different patterns of length three. We focused on the distribution of peaks, valleys, double ascents, and double descents over these sets of permutations

Citizen science for cuneiform studies

This paper examines the potential applications of Citizen Science and Open Linked Data within a critical Web Science framework. Described here is a work-inprocess concerning an interdisciplinary, multiinstitutional project for the digitization, annotation and online dissemination of a large corpus of written material from ancient Mesopotamia. The paper includes an outline of the problems presented by a large, heterogeneous and incomplete dataset, as well as a discussion of the potential of Citizen Science as a potential solution, combining both technical and social aspects. Drawing inspiration from other successful Citizen Science projects, the current paper suggests a process for capturing and enriching the data in ways which can address not only the challenges of the current data set, but also similar issues arising elsewhere on the wider Web

Government Performance, Identity, and Support for Further Devolution in Europe

Over the past three decades, Europe has witnessed a growing trend of devolution, or the transfer of power from states to their regions. Much of the previous scholarship has examined the causes of initial devolution, and found that the creation of regional institutions is linked to unique regional identities. This thesis examines whether these identities still matters to voters when making decisions about further devolution. Working from the premise that voters can assess the material utility of devolution after regional governments have been established, and that voters will weigh considerations of material utility more strongly than assessments of expressive utility (identity), this thesis tests whether voters\u27 policy and affective satisfaction with regional government displaces identity as the determining factor of support for further devolution. This study uses polling data from two European case studies, Wales and Catalonia, and finds that while satisfaction does displace identity in both cases, the nature and meaning of identity affects its role in voters decision-making

Increasing Capacity for Innovation through an Inquiry Approach to Instruction

The requirements of a 21st century society are described particularly as they relate to the needs of individuals. Developmental theories are compared and reviewed in light of educational practice and goals. Assumptions regarding mankind\u27s needs for inquiry are reflected in the processes of the human mind. The pathways are described through which cognitive processes are developed in students. This summary paints a portrait of humans as natural innovators deriving much of their meaning in life from solutions to challenges. The literature, by comparing the innovative needs of society with natural inquisitiveness in individuals, makes a compelling case necessitating reform in public instructional practice. With this in mind, the research here calls on practitioners in education to embrace the natural workings of the human mind through inquiry-based curricula in order to align goals with the future needs of society and the fundamental purpose innate in the human brain

Current trends in glioblastoma multiforme treatment: radiation therapy and immune checkpoint inhibitors.

Glioblastoma multiforme (GBM) is the most common primary brain cancer. Even with aggressive combination therapy, the median life expectancy for patients with GBM remains approximately 14 months. In order to improve the outcomes of patients with GBM, the development of newer treatments is critical. The concept of using the immune system as a therapeutic option has been suggested for several decades; by harnessing the body's adaptive immune mechanisms, immunotherapy could provide a durable and targeted treatment against cancer. However, many cancers, including GBM, have developed mechanisms that protect tumor cells from being recognized and eliminated by the immune system. For new immunotherapeutic regimens to be successful, overcoming immunosuppression via immune checkpoint signaling should be taken into consideration

Limit of many molecules dynamics with rigorous macroscopic results

The thesis builds on recent ideas that combine work by C.B. Morrey (1955) and D.W. Jepsen & D. ter Haar (1962) with more recent analytic techniques: measure disintegration, PDEs for measures, etc. (M.I. Vishik & A.V. Fursikov 1988, L. Ambrosio et. al. 2005). In particular, it is shown that sufficient assumptions for rigorous, non phenomenological, macroscopic equations for mass and momentum as the limit of Hamiltonian dynamics are indeed satisfied by a class of initial conditions and rescalings of interaction potentials, including all 1=rp, p > 3 potentials. The total energy equation is also obtained. The averages naturally defined by this method are shown to be abstract Reynolds averages in the sense of Kampe' de Feriet, Rota, and Moy, both in terms of abstract Reynolds properties and as conditional expectations with respect to the correct σ-algebra. Further, a close examination of the disintegration theorem provides justification for Reynolds's insistence on space averages. Finally, a certain approximation of the non-linear velocity term, close to equilibrium and in terms of Hermite polynomials, satisfi es Landau-Lifschitz type formulas, ostensibly leaving room for non-thermal fluctuations. With an eye to applications and insisting on space averages, the thesis avoids Gibbs ensembles and the Liouville equation, as well as the Boltzmann equation. The approach is entirely not quantum and non-relativistic