An Overview of Stepped Hull Performance Evaluation: Sea Trial Data vs Full-Scale CFD Simulation

It is well known that the dynamic of the stepped hull in real scale is rather complex and it’s not easy to predict that using empirical or mathematical approaches, and by the numerical and experimental way as well. Moreover, there is a huge lack in the literature of data related to sea trials of the stepped hull. Furthermore, the reliability of full-scale CFD simulations is not widely proven and validated especially for high speed and planing hull. For these several reasons, in this paper, the authors are focused on the comparison of the results carried out from model experimental tests performed in the model basin, full-scale CFD simulations, and sea trial tests. The performed simulations in full-scale have been compared to the extrapolated experimental tests and the sea-trial results. Moreover, the dynamic trim angle and the dynamic wetted surface have been taken into account to assess the reliability of the full-scale simulation performed. The stepped hull considered is a Mito 31 outboard Rigid Inflatable Boat (RIB) built by MV Marine Srl Company

Preface of MEPDaW 2022: Managing the Evolution and Preservation of the Data Web

[no abstract available

Comparison of the neuroprotective effects of aspirin, atorvastatin, captopril and metformin in diabetes mellitus

Objective: The aim of this study was to investigate the effect of combined intake of a high dose of aspirin, atorvastatin, captopril and metformin on oxidative stress in the brain cortex and hippocampus of streptozotocin (STZ)-induced diabetic rats. Material and methods: Rats were randomly divided into the following 11 groups: control and diabetic (D), as well as 9 groups that were treated with metformin (M, 300 mg/kg) or aspirin (ASA, 120 mg/kg) alone or in different combinations with captopril (C, 50 mg/kg) and/or atorvastatin (AT, 40 mg/kg) as follows: (D + M), (D + ASA), (D + M + ASA), (D + M + C), (D + M + AT), (D + M + C + ASA), (D + M + C + AT), (D + M + AT + ASA) and (D + M + C + AT + ASA). The rats in treatment groups received drugs by gavage daily for six weeks. Serum lipid profile and levels of oxidative markers in the brain cortex and hippocampus tissues were evaluated. Results: The levels of malondialdehyde in the brain cortex and hippocampus in all the treated groups decreased significantly (p < 0.05). There was a significant increase in the total thiol concentration as well as catalase activity in treated rats in (M + AT), (M + C + ASA), (M + C + AT), (M + AT + ASA) and (M + C + AT + ASA) groups in cortex and hippocampus in comparison with the diabetic rats (p < 0.05). Also, the superoxide dismutase activity in all treated rats with medications was significantly increased compared to the diabetic rats (p < 0.05–0.01). Conclusion: Our findings showed that the combined use of high-dose aspirin, metformin, captopril and atorvastatin potentiated their antioxidant effects on the brain, and hence could potentially improve cognitive function with their neuroprotective effects on hippocampus

Experimental and numerical study of elasto-inertial focusing in straight channels.

Elasto-inertial microfluidics has drawn significant attention in recent years due to its enhanced capabilities compared to pure inertial systems in control of small microparticles. Previous investigations have focused mainly on the applications of elasto-inertial sorting, rather than studying its fundamentals. This is because of the complexity of simulation and analysis, due to the presence of viscoelastic force. There have been some investigative efforts on the mechanisms of elasto-inertial focusing in straight channels; however, these studies were limited to simple rectangular channels and neglected the effects of geometry and flow rates on focusing positions. Herein, for the first time, we experimentally and numerically explore the effects of elasticity accompanying channel cross-sectional geometry and sample flow rates on the focusing phenomenon in elasto-inertial systems. The results reveal that increasing the aspect ratio weakens the elastic force more than inertial force, causing a transition from one focusing position to two. In addition, they show that increasing the angle of a channel corner causes the elastic force to push the particles more efficiently toward the center over a larger area of the channel cross section. Following on from this, we proposed a new complex straight channel which demonstrates a tighter focusing band compared to other channel geometries. Finally, we focused Saccharomyces cerevisiae cells (3-5 μm) in the complex channel to showcase its capability in focusing small-size particles. We believe that this research work improves the understanding of focusing mechanisms in viscoelastic solutions and provides useful insights into the design of elasto-inertial microfluidic devices

Numerical Study on Fluid-Structure Interaction in a Patient-Specific Abdominal Aortic Aneurysm for Evaluating Wall Heterogeneity and Material Model Effects on its Rupture

Abdominal Aortic Aneurysm (AAA) is one of the main cardiovascular diseases, which threats human’s health while it appears, develops and in crucial cases ruptures and leads to hemorrhage. In the current work, we aim to investigate numerically the transient blood flow in a patient-specific AAA model, while effects of wall compliance is considered by employing the fluid-structure interaction method. The AAA model is reconstructed from acquired CT angiographic data of a patient diagnosed with AAA and an intraluminal thrombus (ILT). For the comparison purposes two different material models, i.e. isotropic and anisotropic are considered. Additionally, to have a better estimation, wall thickness variability is compared with simpler uniform wall thickness model. In this study Navier-Stokes equations along with elastodynamics equation are coupled through Arbitrary Lagrangian-Eulerian formulation method and solved numerically. Findings demonstrate that the isotropic material model with uniform wall thickness significantly underestimates wall stresses as compared to the anisotropic material model with variable wall thickness. Indeed, results emphasize that considering vessel wall as an anisotropic, heterogeneous (variable thickness) structure estimates much higher wall stresses comparing with isotropic, uniform thickness model. Therefore, given realistic vessel wall structure and the fact that the anisotropic, variable wall thickness model predicts higher wall stresses, it could be a more reliable model to give an accurate estimation to physicians to diagnose the stage of a disease and choosing an appropriate therapeutic procedure

Fabrication of unconventional inertial microfluidic channels using wax 3D printing.

Inertial microfluidics has emerged over the past decade as a powerful tool to accurately control cells and microparticles for diverse biological and medical applications. Many approaches have been proposed to date in order to increase the efficiency and accuracy of inertial microfluidic systems. However, the effects of channel cross-section and solution properties (Newtonian or non-Newtonian) have not been fully explored, primarily due to limitations in current microfabrication methods. In this study, we overcome many of these limitations using wax 3D printing technology and soft lithography through a novel workflow, which eliminates the need for the use of silicon lithography and polydimethylsiloxane (PDMS) bonding. We have shown that by adding dummy structures to reinforce the main channels, optimizing the gap between the dummy and main structures, and dissolving the support wax on a PDMS slab to minimize the additional handling steps, one can make various non-conventional microchannels. These substantially improve upon previous wax printed microfluidic devices where the working area falls into the realm of macrofluidics rather than microfluidics. Results revealed a surface roughness of 1.75 μm for the printed channels, which does not affect the performance of inertial microfluidic devices used in this study. Channels with complex cross-sections were fabricated and then analyzed to investigate the effects of viscoelasticity and superposition on the lateral migration of the particles. Finally, as a proof of concept, microcarriers were separated from human mesenchymal stem cells using an optimized channel with maximum cell-holding capacity, demonstrating the suitability of these microchannels in the bioprocessing industry

Slip-Flow and Heat Transfer in Isoflux Rectangular Microchannels with Thermal Creep Effects

A control-volume numerical approach has been used to study rarefaction effects in simultaneously hydrodynamically and thermally developing flow in rectangular microchannels with a prescribed uniform wall heat flux in the slip-flow regime (10-3 ≤ Kn ≤ 10-1). The effects of velocity slip and thermal creep on the key flow parameters are examined in detail. Low Reynolds number flows (Re ≤ 1) for different channel aspect ratios (0 ≤ α* ≤ 1) are considered. The effects of rarefaction on the global features of the flow and thermal development in the entrance region are examined. Dramatic reductions in the friction coefficient are observed in the entrance region due to rarefaction effects, which are enhanced by thermal creep. For the fluid heating cases considered here, thermal creep increases slip at the wall and thereby further reduces the friction coefficient and slightly enhances heat transfer at a given Reynolds number. For an identical heat flux applied to the microchannel walls, thermal creep effects become much more pronounced at lower Reynolds numbers since it results in higher axial temperature gradients

Calm-water performance of a boat with two swept steps at high-speeds: Laboratory measurements and mathematical modeling

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