Experimental analysis of 3D flow structures around a floating dike

Floating dikes have several advantages over spur dikes including less influence on riverine sediment transport, bed topography, and ecosystems, and a good adaptability to fluvial conditions. Despite these advantages, floating dikes have not been used in many river regulation schemes due to the limited understanding of the 3D flow structures around floating dikes. In this study, a series of experiments were conducted to investigate the 3D flow structures around floating dikes. Results show that, after installing a floating dike on one side of a flume, the surface water flow is deflected to the opposite side of the flume, and a backflow develops around the outer and downstream side of the dike, where both the vertical turbulent intensity and the absolute magnitude of the Reynolds stress are relatively large. Due to the blocking effect of the dike, the cross-sectional area decreases, causing an increase in velocities below and alongside the dike, as well as a decrease in velocities upstream of the dike. Increasing the submerged depth or length of the dike results in an increase in flow velocity adjacent to the dike, as well as an increase in the vertical or lateral scale of the backflow. On the contrary, increasing the dike thickness leads to a weakening or disappearance of the backflow, along with a decrease in the acceleration rate of flow adjacent to the dike

Approximate Solutions for Ideal Dam-Break Sediment-Laden Flows on Uniform Slopes

Shallow water hydro-sediment-morphodynamic (SHSM) models have been applied increasingly widely in hydraulic engineering and geomorphological studies over the past few decades. Analytical and approximate solutions are usually sought to verify such models and therefore confirm their credibility. Dam-break flows are often evoked because such flows normally feature shock waves and contact discontinuities that warrant refined numerical schemes to solve. While analytical and approximate solutions to clear-water dam-break flows have been available for some time, such solutions are rare for sediment transport in dam-break flows. Here we aim to derive approximate solutions for ideal dam-break sediment-laden flows resulting from the sudden release of a finite volume of frictionless, incompressible water-sediment mixture on a uniform slope. The approximate solutions are presented for three typical sediment transport scenarios, i.e., pure advection, pure sedimentation, and concurrent entrainment and deposition. Although the cases considered in this paper are not real, the approximate solutions derived facilitate suitable benchmark tests for evaluating SHSM models, especially presently when shock waves can be numerically resolved accurately with a suite of finite volume methods, while the accuracy of the numerical solutions of contact discontinuities in sediment transport remains generally poorer

Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults

Background Underweight and obesity are associated with adverse health outcomes throughout the life course. We estimated the individual and combined prevalence of underweight or thinness and obesity, and their changes, from 1990 to 2022 for adults and school-aged children and adolescents in 200 countries and territories. Methods We used data from 3663 population-based studies with 222 million participants that measured height and weight in representative samples of the general population. We used a Bayesian hierarchical model to estimate trends in the prevalence of different BMI categories, separately for adults (age ≥20 years) and school-aged children and adolescents (age 5–19 years), from 1990 to 2022 for 200 countries and territories. For adults, we report the individual and combined prevalence of underweight (BMI <18·5 kg/m2) and obesity (BMI ≥30 kg/m2). For schoolaged children and adolescents, we report thinness (BMI <2 SD below the median of the WHO growth reference) and obesity (BMI >2 SD above the median). Findings From 1990 to 2022, the combined prevalence of underweight and obesity in adults decreased in 11 countries (6%) for women and 17 (9%) for men with a posterior probability of at least 0·80 that the observed changes were true decreases. The combined prevalence increased in 162 countries (81%) for women and 140 countries (70%) for men with a posterior probability of at least 0·80. In 2022, the combined prevalence of underweight and obesity was highest in island nations in the Caribbean and Polynesia and Micronesia, and countries in the Middle East and north Africa. Obesity prevalence was higher than underweight with posterior probability of at least 0·80 in 177 countries (89%) for women and 145 (73%) for men in 2022, whereas the converse was true in 16 countries (8%) for women, and 39 (20%) for men. From 1990 to 2022, the combined prevalence of thinness and obesity decreased among girls in five countries (3%) and among boys in 15 countries (8%) with a posterior probability of at least 0·80, and increased among girls in 140 countries (70%) and boys in 137 countries (69%) with a posterior probability of at least 0·80. The countries with highest combined prevalence of thinness and obesity in school-aged children and adolescents in 2022 were in Polynesia and Micronesia and the Caribbean for both sexes, and Chile and Qatar for boys. Combined prevalence was also high in some countries in south Asia, such as India and Pakistan, where thinness remained prevalent despite having declined. In 2022, obesity in school-aged children and adolescents was more prevalent than thinness with a posterior probability of at least 0·80 among girls in 133 countries (67%) and boys in 125 countries (63%), whereas the converse was true in 35 countries (18%) and 42 countries (21%), respectively. In almost all countries for both adults and school-aged children and adolescents, the increases in double burden were driven by increases in obesity, and decreases in double burden by declining underweight or thinness. Interpretation The combined burden of underweight and obesity has increased in most countries, driven by an increase in obesity, while underweight and thinness remain prevalent in south Asia and parts of Africa. A healthy nutrition transition that enhances access to nutritious foods is needed to address the remaining burden of underweight while curbing and reversing the increase in obesit

Mathematical modeling of shallow-water flows on steep slopes

A 2D hydrodynamic (labeled as CAR) model has been proposed in a rectangular Cartesian coordinate system with two axes within the horizontal plane and one axis along the vertical direction (global coordinates), considering the effects of bed slope on both pressure distribution and bed shear stresses. The CAR model satisfactorily reproduces the analytical solutions of dam-break flow over a steep slope, while the traditional Saint-Venant Equations (labeled as SVE) significantly overestimate the flow velocity. For flood events with long duration and large mean slope, the CAR and the SVE models present distinguishable discrepancies. Therefore, the proposed CAR model is recommended for applications to real floods for its facility of extending from 1D to 2D version and ability to model shallow-water flows on steep slopes

Experimental Analysis of 3D Flow Structures around a Floating Dike

Floating dikes have several advantages over spur dikes including less influence on riverine sediment transport, bed topography, and ecosystems, and a good adaptability to fluvial conditions. Despite these advantages, floating dikes have not been used in many river regulation schemes due to the limited understanding of the 3D flow structures around floating dikes. In this study, a series of experiments were conducted to investigate the 3D flow structures around floating dikes. Results show that, after installing a floating dike on one side of a flume, the surface water flow is deflected to the opposite side of the flume, and a backflow develops around the outer and downstream side of the dike, where both the vertical turbulent intensity and the absolute magnitude of the Reynolds stress are relatively large. Due to the blocking effect of the dike, the cross-sectional area decreases, causing an increase in velocities below and alongside the dike, as well as a decrease in velocities upstream of the dike. Increasing the submerged depth or length of the dike results in an increase in flow velocity adjacent to the dike, as well as an increase in the vertical or lateral scale of the backflow. On the contrary, increasing the dike thickness leads to a weakening or disappearance of the backflow, along with a decrease in the acceleration rate of flow adjacent to the dike

Experimental analysis of 3D flow structures around a floating dike

Floating dikes have several advantages over spur dikes including less influence on riverine sediment transport, bed topography, and ecosystems, and a good adaptability to fluvial conditions. Despite these advantages, floating dikes have not been used in many river regulation schemes due to the limited understanding of the 3D flow structures around floating dikes. In this study, a series of experiments were conducted to investigate the 3D flow structures around floating dikes. Results show that, after installing a floating dike on one side of a flume, the surface water flow is deflected to the opposite side of the flume, and a backflow develops around the outer and downstream side of the dike, where both the vertical turbulent intensity and the absolute magnitude of the Reynolds stress are relatively large. Due to the blocking effect of the dike, the cross-sectional area decreases, causing an increase in velocities below and alongside the dike, as well as a decrease in velocities upstream of the dike. Increasing the submerged depth or length of the dike results in an increase in flow velocity adjacent to the dike, as well as an increase in the vertical or lateral scale of the backflow. On the contrary, increasing the dike thickness leads to a weakening or disappearance of the backflow, along with a decrease in the acceleration rate of flow adjacent to the dike

A New Flash Flood Warning Scheme Based on Hydrodynamic Modelling

Flash flooding is one of the most severe natural hazards and commonly occurs in mountainous and hilly areas. Due to the rapid onset of flash floods, early warnings are critical for disaster mitigation and adaptation. In this paper, a flash flood warning scheme is proposed based on hydrodynamic modelling and critical rainfall. Hydrodynamic modelling considers different rainfall and initial soil moisture conditions. The critical rainfall is calculated from the critical hazard, which is based on the flood flow depth and velocity. After the critical rainfall is calculated for each cell in the catchment, a critical rainfall database is built for flash flood warning. Finally, a case study is presented to show the operating procedure of the new flash flood warning scheme

Overexpression of a Malus baccata WRKY transcription factor gene (MbWRKY5) increases drought and salt tolerance in transgenic tobacco

WRKY transcription factors are widely involved in abiotic stress responses in plants. However, their roles in abiotic stresses of Malus plants are still not well known. In this study, a WRKY gene is isolated from Malus baccata (L.) Borkh and designated as MbWRKY5. MbWRKY5 contains two WRKY domains and one Cys2-His2 (C2H2) zinc-finger motif, and was localized in nucleus. The expression levels of MbWRKY5 were up-regulated by salinity, heat, cold, drought and abscisic acid (ABA) treatments in M. baccata seedlings. When MbWRKY5 was introduced into tobacco, an improvement in tolerance to drought and salt was achieved in transgenic plants. Under drought and salt treatments, the transgenic plants had higher contents of chlorophyll, proline, glutathione (GSH) and Ascorbate (AsA), and increased activities of peroxidase (POD), superoxide dismutase (SOD), and catalase (CAT) than wild type (WT) tobaccos. Compared to WT plants, over-expression of MbWRKY5 in transgenic tobacco also led to decreased levels of malondialdehyde (MDA) and hydrogen peroxide (H2O2) under drought and salt stresses. Moreover, the MbWRKY5-OE tobaccos increased the expression levels of stress-related genes involved in oxidative stress response (NtPOD, NtSOD and NtCAT) and membrane protection (NtLEA5, NtERD10D and NtP5CS), especially under drought and salt stresses. These results suggest that MbWRKY5 gene plays a positive regulatory role in drought and salt stress responses.The accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author

RfxCas13d-mediated inhibition of Circ1647 alleviates renal fibrosis via PI3K/AKT signaling pathway

Background Circular RNAs (CircRNAs) have been shown to be involved in the development of chronic kidney disease (CKD). This study aimed to investigate the role of Circ1647 in renal fibrosis, which is a hallmark of CKD.Methods In this study, we established a unilateral ureteral obstruction (UUO) model and delivered Circ1647 RfxCas13d knockdown plasmid into renal parenchymal cells via retrograde injection through the ureter followed by electroporation. After that, the pathological changes were determined by Hematoxylin and Eosin. Meanwhile, Immunohistochemistry, qRT-PCR and Western blot were conducted to assess the degree of fibrosis. In addition, overexpressing of Circ1647 in renal tubular epithelial cells (TCMK1) was performed to investigate the underlying mechanisms of Circ1647.Results Our results displayed that electroporation-mediated knockdown of Circ1647 by RfxCas13d knockdown plasmid significantly inhibited renal fibrosis in UUO mice as evidenced by reduced expression of fibronectin and α-SMA (alpha-smooth muscle actin). Conversely, overexpression of Circ1647 in TCMK1 cells promoted the fibrosis. In terms of mechanism, Circ1647 may mediate the PI3K/AKT Signaling Pathway as demonstrated by the balance of the phosphorylation of PI3K and AKT in vivo and the aggravated phosphorylation of PI3K and AKT in vitro. These observations were corroborated by the effects of the PI3K inhibitor LY294002, which mitigated fibrosis post Circ1647 overexpression.Conclusion Our study suggests that Circ1647 plays a significant role in renal fibrosis by mediating the PI3K/AKT signaling pathway. RfxCas13d-mediated inhibition of Circ1647 may serve as a therapeutic target for renal fibrosis in CKD

Mesoporous Silica Nanoparticles/Hydroxyapatite Composite Coated Implants to Locally Inhibit Osteoclastic Activity

In an attempt to improve implant-bone integration and accelerate bone fracture healing from resisting osteoclastic resorption point of view, we have employed a novel procedure to develop a mesoporous silica nanoparticles/hydroxyapatite (MSNs/HA) composite coating onto stainless Kirschner wire substrate. Characterizations of the surface microstructures indicated enlarged specific surface area compared to HA-coated wires as control, thus the MSNs/HA composite coated implants are endowed with abilities to locally deliver biomedical substances and enhance fracture healing. Herein, zoledronic acid (ZOL) as a model drug, different doses of which were immobilized in the mesoporous coating toward decreasing osteoclastic resorption activity. The loading capacities of ZOL increased almost eight-folds to that of pure HA coating, and the introduction of MSNs obviously retarded ZOL release to achieve a more sustained release profile. After certain periods of osteoclast like cells co-culturing with ZOL contained wires, tartrat-resistant acid phosphatases (TRAP) staining of polynucleated cells and a pit formation assay were performed to investigate the ZOL dose-dependent anti-resorption activity. The promoted local effect on osteoclasts will be of clinical benefit to support implant integration and bone repair