Beamforming Design for Wireless Information and Power Transfer Systems: Receive Power-Splitting Versus Transmit Time-Switching

© 1972-2012 IEEE. Information and energy can be transferred over the same radio-frequency channel. In the power-splitting (PS) mode, they are simultaneously transmitted using the same signal by the base station (BS) and later separated at the user (UE)'s receiver by a power splitter. In the time-switching (TS) mode, they are either transmitted separately in time by the BS or received separately in time by the UE. In this paper, the BS transmit beamformers are jointly designed with either the receive PS ratios or the transmit TS ratios in a multicell network that implements wireless information and power transfer (WIPT). Imposing UE-harvested energy constraints, the design objectives include: 1) maximizing the minimum UE rate under the BS transmit power constraint, and 2) minimizing the maximum BS transmit power under the UE data rate constraint. New iterative algorithms of low computational complexity are proposed to efficiently solve the formulated difficult nonconvex optimization problems, where each iteration either solves one simple convex quadratic program or one simple second-order-cone-program. Simulation results show that these algorithms converge quickly after only a few iterations. Notably, the transmit TS-based WIPT system is not only more easily implemented but outperforms the receive PS-based WIPT system as it better exploits the beamforming design at the transmitter side

Applicability of zirconium loaded okara in the removal and recovery of phosphorus from municipal wastewater

© 2019 Published under licence by IOP Publishing Ltd. Recently, there is a new trend to consider wastewater as a precious resource. Since phosphorus is a limited non-renewable element, and MAP (Magnesium Ammonium Phosphate - MgNH4PO4.6H2O) is a valuable slow-release fertilizer, the recovery of phosphorous as MAP has received special attention from scientists all over the world. However, the application of this process with municipal wastewater is still a challenge, due to low concentration of phosphorus and high volume of municipal wastewater. This study investigates the potential of reclaiming MAP from municipal wastewater by combination of adsorption and crystallization. Soybean milk residue (okara) was loaded with Zirconium (Zr) to prepare the adsorbent (ZLO). Adsorption and desorption experiments were conducted in a semi-pilot scale ZLO packed colum system. Effects of P: N: Mg molar ratios, chemical sources and temperature on the formation of MAP were examined in an attempt to identify the optimal crystallization conditions. The attained precipitate was characterized using XRD, SEM, FTIR techniques. It was found that the ZLO packed column adsorption-desorption system could pre-concentrate phosphorus from municipal wastewater up to 28.36 times, fitting well the minimum requirement (50 mg P/L) for the economical MAP recovery. Up to 95.19% of dissolved phosphorus in desorption solution was recovered at pH = 9, Mg: N: P molar ratio = 2:2:1, using a combination of MgCl2.6H2O and NH4Cl. The harvested MAP exhibited high purity (92.59%), high P-availability (89% by mass), and extremely low levels of heavy metals. The results prove that it is viable to recover MAP from municipal wastewater by employing ZLO as adsorbent, followed by crystallization. This paves the way for mining phosphorus from municipal wastewater and reducing okara as an agricultural byproduct in a green way

Comparative study about the performance of three types of modified natural treatment systems for rice noodle wastewater

© 2019 Elsevier Ltd In this study, three semi-pilot scale systems (vertical flow constructed wetland, multi-soil layering, and integrated hybrid systems) for treating real rice noodle wastewater were operated parallelly for the first time in a tropical climate at a loading rate of 50 L/(m2·d) for more than 7 months to determine the optimal conditions and to compare their treatment performance. The results demonstrated that these systems were appropriate for the removal of organics, suspended solids, and total coliform (Tcol). The highest reductions in chemical oxygen demand (CODCr, 73.2%), phosphorus (PO4-P, 54%), and Tcol (4.78 log MPN/100 mL inactivation) were obtained by the integrated hybrid system, while the highest removal efficiencies of ammonium (NH4-N, 60.64%) and suspended solids (80.49%) were achieved in the vertical-flow-constructed wetland and multi-soil layering systems respectively

Stem cell-based therapy for human diseases.

Recent advancements in stem cell technology open a new door for patients suffering from diseases and disorders that have yet to be treated. Stem cell-based therapy, including human pluripotent stem cells (hPSCs) and multipotent mesenchymal stem cells (MSCs), has recently emerged as a key player in regenerative medicine. hPSCs are defined as self-renewable cell types conferring the ability to differentiate into various cellular phenotypes of the human body, including three germ layers. MSCs are multipotent progenitor cells possessing self-renewal ability (limited in vitro) and differentiation potential into mesenchymal lineages, according to the International Society for Cell and Gene Therapy (ISCT). This review provides an update on recent clinical applications using either hPSCs or MSCs derived from bone marrow (BM), adipose tissue (AT), or the umbilical cord (UC) for the treatment of human diseases, including neurological disorders, pulmonary dysfunctions, metabolic/endocrine-related diseases, reproductive disorders, skin burns, and cardiovascular conditions. Moreover, we discuss our own clinical trial experiences on targeted therapies using MSCs in a clinical setting, and we propose and discuss the MSC tissue origin concept and how MSC origin may contribute to the role of MSCs in downstream applications, with the ultimate objective of facilitating translational research in regenerative medicine into clinical applications. The mechanisms discussed here support the proposed hypothesis that BM-MSCs are potentially good candidates for brain and spinal cord injury treatment, AT-MSCs are potentially good candidates for reproductive disorder treatment and skin regeneration, and UC-MSCs are potentially good candidates for pulmonary disease and acute respiratory distress syndrome treatment

Mortality patterns in Vietnam, 2006: Findings from a national verbal autopsy survey

<p>Abstract</p> <p>Background</p> <p>Accurate nationally representative statistics on total and cause-specific mortality in Vietnam are lacking due to incomplete capture in government reporting systems. This paper presents total and cause-specific mortality results from a national verbal autopsy survey conducted first time in Vietnam in conjunction with the annual population change survey and discusses methodological and logistical challenges associated with the implementation of a nation-wide assessment of mortality based on surveys.</p> <p>Verbal autopsy interviews, using the WHO standard questionnaire, were conducted with close relatives of the 6798 deaths identified in the 2007 population change survey in Vietnam. Data collectors were health staff recruited from the commune health station who undertook 3-day intensive training on VA interview. The Preston-Coale method assessed the level of completeness of mortality reporting from the population change survey. The number of deaths in each age-sex grouping is inflated according to the estimate of completeness to produce an <it>adjusted </it>number of deaths. Underlying causes of death were aggregated to the International Classification of Diseases Mortality Tabulation List 1. Leading causes of death were tabulated by sex for three broad age groups: 0-14 years; 15-59 years; and 60 years and above.</p> <p>Findings</p> <p>Completeness of mortality reporting was 69% for males and 54% for females with substantial regional variation. The use of VA has resulted in 10% of deaths being classified to ill-defined among males, and 15% among females. More ill-defined deaths were reported among the 60 year or above age group. Incomplete death reporting, wide geographical dispersal of deaths, extensive travel between households, and substantial variation in local responses to VA interviews challenged the implementation of a national mortality and cause of death assessment based on surveys.</p> <p>Conclusions</p> <p>Verbal autopsy can be a viable tool to identify cause of death in Vietnam. However logistical challenges limit its use in conjunction with the national sample survey. Sentinel population clusters for mortality surveillance should be tested to develop an effective and sustainable option for routine mortality and cause of death data collection in Vietnam.</p

Application of Autologous Bone Marrow Derived Mesenchymal Stem Cells to an Ovine Model of Growth Plate Cartilage Injury

Injury to growth plate cartilage in children can lead to bone bridge formation and result in bone growth deformities, a significant clinical problem currently lacking biological treatment. Mesenchymal stem/stromal cells (MSC) offer a promising therapeutic option for regeneration of damaged cartilage, due to their self renewing and multi-lineage differentiation attributes. Although some small animal model studies highlight the therapeutic potential of MSC for growth plate repair, translational research in large animal models, which more closely resemble the human condition, are lacking. Our laboratory has recently characterised MSCs derived from ovine bone marrow, and demonstrated these cells form cartilage-like tissue when transplanted within the gelatin sponge, Gelfoam, in vivo. In the current study, autologous bone marrow MSC were seeded into Gelfoam scaffold containing TGF-β1, and transplanted into a surgically created defect of the proximal ovine tibial growth plate. Examination of implants at 5 week post-operatively revealed transplanted autologous MSC failed to form new cartilage structure at the defect site, but contributed to an increase in formation of a dense fibrous tissue. Importantly, the extent of osteogenesis was diminished, and bone bridge formation was not accelerated due to transplantation of MSCs or the gelatin scaffold. The current study represents the first work that has utilised this ovine large animal model to investigate whether autologous bone marrow derived MSC can be used to initiate regeneration at the injured growth plate

In Vivo Ectopic Implantation Model to Assess Human Mesenchymal Progenitor Cell Potential

Clinical interest on human mesenchymal progenitor cells (hMPC) relies on their potential applicability in cell-based therapies. An in vitro characterization is usually performed in order to define MPC potency. However, in vitro predictions not always correlate with in vivo results and thus there is no consensus in how to really assess cell potency. Our goal was to provide an in vivo testing method to define cell behavior before therapeutic usage, especially for bone tissue engineering applications. In this context, we wondered whether bone marrow stromal cells (hBMSC) would proceed in an osteogenic microenvironment. Based on previous approaches, we developed a fibrin/ceramic/BMP-2/hBMSCs compound. We implanted the compound during only 2 weeks in NOD-SCID mice, either orthotopically to assess its osteoinductive property or subcutaneously to analyze its adequacy as a cell potency testing method. Using fluorescent cell labeling and immunohistochemistry techniques, we could ascertain cell differentiation to bone, bone marrow, cartilage, adipocyte and fibrous tissue. We observed differences in cell potential among different batches of hBMSCs, which did not strictly correlate with in vitro analyses. Our data indicate that the method we have developed is reliable, rapid and reproducible to define cell potency, and may be useful for testing cells destined to bone tissue engineering purposes. Additionally, results obtained with hMPCs from other sources indicate that our method is suitable for testing any potentially implantable mesenchymal cell. Finally, we propose that this model could successfully be employed for bone marrow niche and bone tumor studies. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s12015-013-9464-1) contains supplementary material, which is available to authorized users

Cell-Free Massive MIMO in the Short Blocklength Regime for URLLC

This paper considers cell-free massive MIMO (cfm-MIMO) for downlink ultra reliable and low-latency communication (URLLC). At the time of writing, cfm-MIMO has only been considered for communication in the long blocklength regime (LBR), whose throughput is determined by the Shannon capacity with the interference treated as Gaussian noise. Conjugate beamforming (CB) is often used as it requires only local channel state information (CSI) for implementation but its design is based on a large-scale nonconvex problem, which is computationally intractable. The rate function in URLLC is much more complex than the Shannon rate function. The paper proposes a special class of CB, which admits a low-scale optimization formulation for computational tractability. Accordingly, a new path-following algorithm, which generates a sequence of better feasible points and converges at least to a locally optimal solution, is developed for optimizing URLLC rates and cfm-MIMO energy efficiency. Furthermore, the paper also develops improper Gaussian signaling to improve both the Shannon rate and URLLC rate

Joint Load Balancing and Interference Management for Small-Cell Heterogeneous Networks with Limited Backhaul Capacity

© 2016 IEEE. In this paper, new strategies are devised for joint load balancing and interference management in the downlink of a heterogeneous network, where small cells are densely deployed within the coverage area of a traditional macrocell. Unlike existing work, the limited backhaul capacity at each base station (BS) is taken into account. Here, users (UEs) cannot be offloaded to any arbitrary BS, but only to ones with sufficient backhaul capacity remaining. Jointly designed with traffic offload, transmit power allocation mitigates the intercell interference to further support the quality of service of each UE. The objective here is either: 1) to maximize the network sum rate subject to minimum throughput requirements at individual UEs, or 2) to maximize the minimum UE throughput. Both formulated problems belong to the difficult class of mixed-integer nonconvex optimization problems. The inherently binary BS-UE association variables are strongly coupled with the transmit power variables, making the problems even more challenging to solve. New iterative algorithms are developed based on an exact penalty method combined with successive convex programming, where the binary BS-UE association problem and the nonconvex power allocation problem are dealt with one at a time. At each iteration of the proposed algorithms, only two simple convex problems need to be solved at the same time scale. It is proven that the algorithms improve the objective functions at each iteration and converge eventually. Numerical results demonstrate the efficiency of the proposed algorithms in both traffic offloading and interference mitigation

Cell-free massive MIMO networks: Optimal power control against active eavesdropping

© 1972-2012 IEEE. This paper studies the security aspect of a recently introduced 'cell-free massive MIMO' network under a pilot spoofing attack. First, a simple method to recognize the presence of this type of an active eavesdropping attack to a particular user is shown. In order to deal with this attack, we consider the problem of maximizing the achievable data rate of the attacked user or its achievable secrecy rate. The corresponding problems of minimizing the power consumption subject to security constraints are also considered in parallel. Path-following algorithms are developed to solve the posed optimization problems under different power allocation to access points (APs). Under equip-power allocation to APs, these optimization problems admit closed-form solutions. Numerical results show their efficiency