908 research outputs found
Alpha-stat acid-base regulation during cardiopulmonary bypass improves neuropsychologic outcome in patients undergoing coronary artery bypass grafting
AbstractNeuropsychologic impairment in patients undergoing cardiopulmonary bypass may be associated with cerebral blood flow changes arising from different management protocols for carbon dioxide tension during bypass. Seventy patients having coronary artery bypass grafting were randomized to either pH-stat or alpha-stat acid-base management during cardiopulmonary bypass with a membrane oxygenator. In each patient, cerebral blood flow (xenon 133 clearance), middle cerebral artery blood flow velocity (transcranial Doppler sonography), and cerebral oxygen metabolism (cerebral metabolic rate and cerebral extraction ratio) were measured during four phases of the operation: before bypass, during bypass (at hypothermia and at normothermia), and after bypass. A battery of neuropsychologic tests were also conducted before and 6 weeks after the operation. During hypothermic (28º C) bypass, cerebral blood flow was significantly (p < 0.001) greater in the pH-stat group (41 ml•100 gm -1 •min -1 ; 95% confidence interval 39 to 43 ml•100 gm -1 •min -1 ) than in the alpha-stat group (24 ml•100 gm -1 •min -1 ; confidence interval 22 to 26 ml•100 gm -1 •min -1 ) at constant pressure and flow. Arterial carbon dioxide tensions were 41 mm Hg (40 to 41 mm Hg) and 26 mm Hg (25 to 27 mm Hg), respectively; pH was 7.36 (7.34 to 7.38) and 7.53 (7.51 to 7.55), respectively. Middle cerebral artery flow velocity was significantly (p < 0.05) reduced in the alpha-stat group to 87% (77% to 96%) of the prebypass value, whereas it was significantly (p < 0.05) increased (152%; 141% to 162%) in the pH-stat group. Cerebral extraction ratio for oxygen demonstrated relative cerebral hyperemia during hypothermic (28º C) bypass in both the pH-stat and alpha-stat groups (0.12 [0.11 to 0.14] and 0.25 [0.22 to 0.28], respectively); however, hyperemia was significantly more pronounced in the pH-stat group, indicating greater disruption in cerebral autoregulation. Neuropsychologic impairment criteria of deterioration in results of three or more tests revealed that a significantly (Fisher's exact test, p = 0.02) higher proportion of patients in the pH-stat group fared poorly than in the alpha-stat group at 6 weeks (17/35, 48.6% [32% to 65.1%], and 7/35, 20% [6.7% to 33.2.2%], respectively). In conclusion, patients receiving alpha-stat management had less disruption of cerebral autoregulation during cardiopulmonary bypass, accompanied by a reduced incidence of postoperative cerebral dysfunction. (J THORAC CARDIOVASC SURG 1996;111:1267-79
Pattern densities in fluid dimer models
In this paper, we introduce a family of observables for the dimer model on a
bi-periodic bipartite planar graph, called pattern density fields. We study the
scaling limit of these objects for liquid and gaseous Gibbs measures of the
dimer model, and prove that they converge to a linear combination of a
derivative of the Gaussian massless free field and an independent white noise.Comment: 38 pages, 3 figure
Unravelling the size distribution of social groups with information theory on complex networks
The minimization of Fisher's information (MFI) approach of Frieden et al.
[Phys. Rev. E {\bf 60} 48 (1999)] is applied to the study of size distributions
in social groups on the basis of a recently established analogy between scale
invariant systems and classical gases [arXiv:0908.0504]. Going beyond the ideal
gas scenario is seen to be tantamount to simulating the interactions taking
place in a network's competitive cluster growth process. We find a scaling rule
that allows to classify the final cluster-size distributions using only one
parameter that we call the competitiveness. Empirical city-size distributions
and electoral results can be thus reproduced and classified according to this
competitiveness, which also allows to correctly predict well-established
assessments such as the "six-degrees of separation", which is shown here to be
a direct consequence of the maximum number of stable social relationships that
one person can maintain, known as Dunbar's number. Finally, we show that scaled
city-size distributions of large countries follow the same universal
distribution
Fracture model with variable range of interaction
We introduce a fiber bundle model where the interaction among fibers is
modeled by an adjustable stress-transfer function which can interpolate between
the two limiting cases of load redistribution, the global and the local load
sharing schemes. By varying the range of interaction several features of the
model are numerically studied and a crossover from mean field to short range
behavior is obtained. The properties of the two regimes and the emergence of
the crossover in between are explored by numerically studying the dependence of
the ultimate strength of the material on the system size, the distribution of
avalanches of breakings, and of the cluster sizes of broken fibers. Finally, we
analyze the moments of the cluster size distributions to accurately determine
the value at which the crossover is observed.Comment: 8 pages, 8 figures. Two columns revtex format. Final version to be
published in Phys. Rev.
Rotating metrics admitting non-perfect fluids in General Relativity
In this paper, by applying Newman-Janis algorithm in spherical symmetric
metrics, a class of embedded rotating solutions of field equations is
presented. These solutions admit non-perfect fluidsComment: LaTex, 39 page
Semantic disambiguation and contextualisation of social tags
The final publication is available at Springer via http://dx.doi.org/10.1007/978-3-642-28509-7_18This manuscript is an extended version of the paper ‘cTag: Semantic Contextualisation of Social Tags’, presented at the 6th International Workshop on Semantic Adaptive Social Web (SASWeb 2011).We present an algorithmic framework to accurately and efficiently identify the semantic meanings and contexts of social tags within a particular folksonomy. The framework is used for building contextualised tag-based user and item profiles. We also present its implementation in a system called cTag, with which we preliminary analyse semantic meanings and contexts of tags belonging to Delicious and MovieLens folksonomies. The analysis includes a comparison between semantic similarities obtained for pairs of tags in Delicious folksonomy, and their semantic distances in the whole Web, according to co-occurrence based metrics computed with results of a Web search engine.This work was supported by the Spanish Ministry of Science
and Innovation (TIN2008-06566-C04-02), and Universidad Autónoma de Madrid
(CCG10-UAM/TIC-5877
Time evolution of damage under variable ranges of load transfer
We study the time evolution of damage in a fiber bundle model in which the
range of interaction of fibers varies through an adjustable stress transfer
function recently introduced. We find that the lifetime of the material
exhibits a crossover from mean field to short range behavior as in the static
case. Numerical calculations showed that the value at which the transition
takes place depends on the system's disorder. Finally, we have performed a
microscopic analysis of the failure process. Our results confirm that the
growth dynamics of the largest crack is radically different in the two limiting
regimes of load transfer during the first stages of breaking.Comment: 8 pages, 7 figures, revtex4 styl
Variational Principle underlying Scale Invariant Social Systems
MaxEnt's variational principle, in conjunction with Shannon's logarithmic
information measure, yields only exponential functional forms in
straightforward fashion. In this communication we show how to overcome this
limitation via the incorporation, into the variational process, of suitable
dynamical information. As a consequence, we are able to formulate a somewhat
generalized Shannonian Maximum Entropy approach which provides a unifying
"thermodynamic-like" explanation for the scale-invariant phenomena observed in
social contexts, as city-population distributions. We confirm the MaxEnt
predictions by means of numerical experiments with random walkers, and compare
them with some empirical data
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