Linezolid and dexamethasone experience in a serious case of listeria rhombencephalitis

SummaryListeria rhombencephalitis is a rare cause of brain stem encephalitis. We report a case with a history of immunosupressive therapy due to Takayasu's arteritis that was treated with corticosteroids and linezolid for Listeria rhombencephalitis.A 63-year-old woman was admitted to the hospital with fever, headache, nausea, and vomiting. The patient's body temperature was 38°C, and she had a stiff neck. Listeria monocytogenes was isolated from the cerebrospinal fluid (CSF), and penicillin G and gentamicin treatment was initiated. Linezolid and dexamethasone were added. Due to hematuria and thrombocytopenia, the linezolid was discontinued.In immunocompromised patients with CNS infections, Listeria rhombencephalitis should be suspected. Linezolid can be used in combination with dexamethasone

ISPARTA – GÖLCÜK YÖRESİ YALANCI AKASYA (Robinia pseudoacacia L.) MEŞCERELERİ İÇİN TEK VE ÇİFT GİRİŞLİ AĞAÇ HACİM TABLOSU

Bu çalışma ile Isparta-Gölcük Yöresinde yapay olarak yetiştirilen Yalancı akasya (Robinia pseudoacacia L.) için yöresel tek ve çift girişli ağaç hacım tablosu oluşturulmuştur. Ağaç hacım tablosu oluşturmada regresyon analizi yöntemi kullanılmıştır. Altı tek girişli ve yedi çift girişli olmak üzere toplam 13 adet ağaç hacım modeli denenmiştir. Seçilen Dissescu-Meyer ve Schumacher-Hall modelleri için, korelasyon katsayısı 0,994 ve 0,997; belirtme katsayısı 0,988 ve 0,994 bulunmuştur. Regresyon modellerinin standart hataları 0,036 ve 0,087 m3, toplam hata yüzdeleri –0,255 ve 0,820; ortalama mutlak hata yüzdeleri de 2,426 ve 5,370 bulunmuştur. Bu iki hacım fonksiyonunun bağımsız veri grubu ile uygunluk denetimi yapılmış ve Isparta-Gölcük yöresi Yalancı akasya ağaçlandırma sahaları için %95 güven düzeyi ile uygun oldukları belirlenmiştir. Sonuç olarak, Yalancı akasya tek ve çift girişli hacım tablosu düzenlenmiştir. Anahtar Kelimeler: Yalancı akasya, Robinia pseudoacacia L., Regresyon yöntemi, Tek ve çift girişli ağaç hacım tablosu

Giant arachnoid granulation in a patient with benign intracranial hypertension (2009: 1b)

We report magnetic resonance (MR), computed tomography (CT) and angiographic imaging of an unusual giant arachnoid granulation 7(GAG) in the superior sagittal sinus in a man with headache and vertigo. Intrasinus pressure measurements revealed a significant pressure gradient across the lesion. MR imaging is useful to identify GAG and dural sinus thrombosis, whereas dural sinus pressure measurement in certain cases of GAGs can be used to evaluate the lesion as the cause of the patient's symptoms

Clinical Variability in a Family with Noonan Syndrome with a Homozygous PTPN11 Gene Variant in Two Individuals

INTRODUCTION: Noonan syndrome (NS) is characterized by dysmorphic facial features, short stature, congenital heart defects, and varying levels of developmental delays. It is a genetic, multisystem disorder with autosomal dominant inheritance and is the most common of the RASopathies. In approximately 50% of patients, NS is caused by variants in the Protein Tyrosine Phosphatase Non-Receptor Type 11 (PTPN11) gene. The aim of this study was to evaluate two patients with a previously reported PTPN11 homozygous variant for the first time and seven other kindred members carrying the same heterozygous variant in terms of clinical, biochemical, genetic, and response to treatment. METHODS: Nine patients diagnosed with NS due to the same variants in the PTPN11 gene were included in the study. RESULTS: The median (range) age at diagnosis was 11.5 (6.8-13.9) years and the mean follow-up duration was 4.7 (1-7.6) years. In eight patients (88.9%), short stature was present. The height standard deviation score of the patients on admission was -3.24+-1.15. In six of the patients, growth hormone treatment was initiated. Cardiovascular or bleeding disorders were not detected in any of the patients. Three (33.3%) had hearing loss, two (22.2%) had ocular findings and one (11.1%) had a horseshoe kidney. The mean psychomotor development performance score was 84.03+-17.09 and the verbal score was 82.88+-9.42. Genetic analysis revealed a variant in the PTPN11 gene [c.772G>A; (p.Glu258Lys)] that had been previously described and was detected in all patients. Two patients were homozygous for this variant and short stature was more severe in these two. DISCUSSION AND CONCLUSION: A previously described in PTPN11 affected nine members of the same kindred, two with homozygous inheritance and the remainder being heterozygous. To the best of our knowledge, these are the first homozygous PTPN11 case reports published, coming from two related consanguineous families

Sociodemographic characteristics and diagnoses of individuals referred to a child and adolescent psychiatry outpatient clinic of a university hospital

AMAÇ: Çalışmamızda çocuk ve ergen psikiyatrisi polikliniğine başvuran olguların sosyodemografik özelliklerinin, geliş şikayetlerinin ve aldıkları tanılarının değerlendirilmesi amaçlanmıştır. GEREÇ VE YÖNTEMLER: Adnan Menderes Üniversitesi Çocuk ve Ergen Psikiyatrisi polikliniğine 01 Şubat-31 Temmuz 2014 tarihleri arasında başvuran olguların dosya verileri geriye dönük olarak incelenmiştir. BULGULAR: Çocuk psikiyatrisi polikliniğine altı aylık zaman diliminde başvuran toplam 832 olgunun %41,8’i kız, %58,2’si erkekti. Kızların ve erkeklerin yaş ortalaması sırasıyla 10,8±4,9 ve 8,5±4,7 iken, en sık başvuru 12-18 yaş aralığında idi. Olguların annesi ve babası birlikte olanlar %81,1 iken, yetiştirme yurdundan gelenler %0,8 oranındaydı. Akraba evliliği oranı %13,7 olarak saptandı. Anne ve baba eğitim seviyesi en sık ilkokul mezunu idi (sırası ile %47, %45,6). Annelerin %15,6’sında, babaların %7,6’sında psikiyatrik öykü mevcuttu. Polikliniğe başvuru nedenleri incelendiğinde %21,9’unun sağlık kurulu, %13,8’inin adli değerlendirme ve %11,2’sinin konsültasyon amaçlı başvurduğu, kalan %52,9 olgunun genel poliklinik değerlendirmesi için başvurduğu saptandı. Genel polikliniğe en sık sinirlilik (%15,7), dikkat eksikliği/hareketlilik (%14,8), konuşmada gecikme (%10,5), korkular/kaygılar (%5,9) ve ders başarısızlığı (%5,7) şikayetleri ile başvuruların yapıldığı belirlendi. Hastaların aldıkları tanılar ise en sık olarak dikkat eksikliği hiperaktivite bozukluğu (DEHB) (%20,6), diğer yıkıcı davranış bozuklukları (%12,4) ve anksiyete bozukluğu (%10,2) olarak saptandı. SONUÇ: Çalışmamızda en sık başvuru şikayetinin sinirlilik, en sık alınan tanının ise DEHB olması bu alanda yapılan diğer çalışmalarla benzer niteliktedir. Sonuçlarımıza göre, çocuk psikiyatrisine başvuran ailelerde ebeveynlerde düşük eğitim seviyesi ve yüksek psikiyatrik hastalık yükü mevcuttur. Bu veriler koruyucu ruh sağlığı hizmetlerinin geliştirilmesi için risk faktörleri olarak değerlendirilebilir.OBJECTIVE: The aim of this study is to evaluate the sociodemographic characteristics, complaints, and diagnoses of individuals who were admitted to a child and adolescent psychiatry outpatient clinic. MATERIALS AND METHODS: Medical charts of the patients who were admitted to the child and adolescent psychiatry unit of Adnan Menderes University between February 1st and July 31st, 2014 were retrospectively studied. RESULTS: The rate of girls and boys from a total of 832 cases who were referred to the child and adolescent psychiatry outpatient clinic in the six month period was 41.8% and 58.2%, respectively. The mean age of the girls and boys was 10.8±4.9 and 8.5±4.7 years, respectively. The most common age range was between 12 and 18 years. The proportion of patients who lived with both parents was 81.1%; however, the proportion of individuals brought in by institutional caregivers was 0.8%. The proportion of consanguineous marriages was 13.7%. The education level of mothers and fathers was mostly a primary school degree (47% and 45.6%, respectively). A positive psychiatric history was present in 13.7% of the mothers and 7.6% of the fathers. Reasons for child psychiatric assessments were as follows: 21.9% for disability report, 13.8% for forensic evaluation, 11.2% for consultation, and 52.9% for general psychiatric evaluation. Referral complaints were irritability/anger (15.7%), attention deficit/hyperactivity (14.8%), delay in speech (10.5%), fear/anxiety (5.9%), and poor school performance (5.7%). The diagnoses were as follows: attention deficit hyperactivity disorder (ADHD) (20.6%), other disruptive behaviors (12.4%), and anxiety disorder (10.2%). CONCLUSION: We revealed that the most common referring complaint was irritability/ anger and that the most common diagnosis was ADHD in our patient group, which was similar to previous studies. Our results showed that a low parental educational level and a positive history for parental psychopathology were common in child psychiatry referrals. These data may be considered as risk factors for developing protective mental health service

Albert Camus' de mutluluk arayışı

Anlamsızlığın, ayrılığın, yalnızlığın ve ölümün egemen olduğu mutsuzluklarla dolu, acılı yaşamı sürdürmek durumunda olan Camus'nün insanlarının tek amacı mutluluğu gerçekleştirmektir. Ayırımsız, kahramanlarının hepsini, bir mutluluk arayışı içerisinde görmekteyiz. Pierre-Henri Simon, Sartre ve Camus arasındaki ayrılığa değinirken, Noces yazarının mutluluk fikrine ne denli bağlı olduğunu şöyle belirtir: "L'appel vers les hommes et ces rares jaillissements de tendresse qui parfois irriguent le désert sartrien de l'amour, on les retrouve chez Camus, mais plus fréquents et plus forts

Camus'nün yapıtlarında ölüm

Kuşkusuz ölüm, kesin bir son olarak, insanoğlunun değişmeyen tek alınya zisi olarak çoğu yazarların en önde gelen temalarından birini oluşturmuştur. Bunların içerisinde Camus kadar ölüm fikriyle yoğrulanını bulmak güçtür. Ayi rimsiz Camus'nün bütün yapıtlarında ölüm teması, bazen ön planda bazen de geri planda, ama kesinlikle yer alır. Camus'nün bütün insanlarını ölümle savaş halinde görürüz Claude Treil'in de belirttiği gibi, bu savaş, ölümü yenme ya da verdiği korku ve nefrete egemen olabilme isteğinden kaynaklanmaktadır.: "Ces oeuvres (les oeuvres de Camus) ont toutes la mort comme thème principal et dans chacune d'elles l'indifférence est une éthique qui permet de mieux mourir ou de mieux tucr. De toutes façons, il s'agit, pour les personnages ultras, de dominer la mort, et de combattre la peur, l'angoisse ou la haine qu'elle provoque"

Pesticide binding and urea-induced controlled release applications with calixarene naphthalimide molecules by host-guest complexation

WOS:000457090700004PubMed:29842827Three novel calix[4]arene molecule-based 1,8 naphthalimide fluoroionophore for the selective determination of kesoxim-methyl were synthesized and used in pesticide binding studies. The possible interaction between pesticides and fluorescent calix[4]arene molecules was monitored by UV/Vis absorption and fluorescence spectroscopy. When compared the studied pesticides, kesoxim-methyl was strongly quenched the fluorescence intensity of upper rim-modified calix[4]arene. UV and fluorescence titration experiments were also studied to determine both the quenching mechanism and stoichiometric ratio consisted in complex formation. Furthermore, pesticide release experiments were also performed with a fertilizing agent as urea by using fluorescence spectroscopy technique.Karamanoglu Mehmetbey University Research FoundationKaramanoglu Mehmetbey University; Scientific and Technological Research Application Center (BILTEM)We thank Karamanoglu Mehmetbey University Research Foundation and The Scientific and Technological Research Application Center (BILTEM) for the financial and technical supports

Evaluation of The Open Course Ware Initiatives Within The Scope of Digital Literacy Skills: Turkish Open Course Ware Consortium Case

AbstractThis study aims to evaluate the Turkish Open Course Ware (OCW) initiative in terms of digital literacy skills required for effective usage for new learners. The study also finds out how universities, lecturers/academics and other institutions contribute to this initiative. For the purpose of the study, the descriptive method was used and a check-list which evaluates the OER for the digital literacy skills was created according to the literature review. Findings show that the Turkish OCW initiative has some different point of views in terms of content creation approaches and directions. However, it has interactive learning management system capabilities. The results indicated that the points can be developed for effective course interaction environments. It is also expected that the results will inform the communities about developing OERs and encourage them for further discussions and researches

Modeling and Measurement of Micro End Mill Dynamics Using Inverse Stability Approach

Micro-milling applications require high precision and dimensional accuracy. Chatter vibrations arising from unstable cutting conditions cause poor surface finish and damage to the cutting tools. Tool point frequency response functions (FRF); needed to generate stability diagrams, cannot be determined experimentally due to very small tool size. In this study an analytical model for tool point FRF of micro end mills is presented. An inverse algorithm is proposed to correct geometric representation and damping of the tool. The model and the correction methodology presented improve productivity and part quality in micro-milling through accurate prediction of chatter stability limits, enabling better cutting parameter selection. (C) 2016 The Authors. Published by Elsevier B.