Os efeitos da pandemia na síndrome de Burnout em profissionais de saúde

A síndrome de Burnout trata-se de um esgotamento psicológico, físico e emocional provocado pelo acúmulo de estresse do trabalho, bastante comum em profissionais da saúde, devido as exigências da profissão. A pandemia do SARS-COV 2 expôs esses profissionais no combate desse novo vírus, resultando em um ambiente de trabalho mais estressante mental e fisicamente, ou seja, tornando-se propicio a Síndrome de Burnout. O estudo objetivou relacionar os efeitos pandêmicos do SARS-COV 2 e a síndrome de Burnout nos profissionais da saúde. Na mini revisão integrativa, aplicou-se os descritores: “: Burnout”, “Profissionais de Saúde” e “Coronavírus” e o operador logístico booleano “AND” entre os descritores nas bases de dados Biblioteca Virtual da Saúde (BVS) e Scientific Electronic Library Online (Scielo). Analisou-se 9 artigos, possuindo como critérios de inclusão: período de 2020 a 2021, tema do estudo e idioma, português e espanhol, sendo, enfim, selecionados 4 artigos. Os participantes da pesquisa com maiores níveis de ansiedade, depressão e stress indicaram o medo de contaminação como fator mais importante, além disso o desrespeito das medidas de saúde favoreceu o adoecimento dos participantes. Fatores sociais como cor de pele, gênero e categoria empregatícia afetam a incidência de casos de depressão e Síndrome de Burnout. Em contrapartida, atividades em grupo e o compartilhamento das questões pessoais e coletivas foram elementos importantes na prevenção de transtornos de ordem psicológica nos profissionais. Vale ressaltar que o cuidado pessoal foi negligenciado pelos profissionais por falta de tempo, instruções e organização no ambiente de trabalho. Conclui-se que a ausência de conhecimentos claros sobre o novo coronavírus, a sobrecarga dos profissionais da saúde, o isolamento social, o risco de contaminação e falta de equipamentos de proteção individual em abundância são efeitos da atual pandemia que corroboram para vulnerabilidade desses profissionais a Síndrome de Burnout, resultando no aumento de doentes

Cobertura Vacinal Infantil No Estado De Goiás: Um Estudo Ecológico

Os imunobiológicos conseguem proteger as pessoas através de uma resposta imune estimulada ou através da imunidade de rebanho. Há existência de estudos que demonstraram queda nas taxas de imunização, e para que se haja êxito na prevenção de doenças imunopreveníveis, é necessário altas taxas de cobertura e administração na idade correta. A fim de obter sucesso, surge o Programa Nacional de Imunização, que através do Sistema Único de Saúde (SUS) disponibiliza os imunizantes, além disso, desenvolve programas e campanhas com intuito de atingir as metas necessárias para desenvolver proteção contra as enfermidades. O presente estudo tem como objetivo descrever a cobertura vacinal, dos imunobiológicos disponíveis no SUS, de crianças e adolescentes, no estado de Goiás entre os anos de 2019 a 2021. Trata-se de um estudo ecológico sobre a cobertura vacinal dos imunobiológicos da caderneta de vacinação da criança. Os dados serão extraídos do Departamento de Informática do Sistema Único de Saúde (DATASUS), utilizando o Sistema de Informações do Programa Nacional de Imunizações. Os dados serão agrupados por município e pela cobertura vacinal de acordo com os imunobiológicos para posteriormente realizar comparações. Dessa maneira, espera-se que o estudo dissemine informações acerca de distribuição, administração e adesão dos imunizantes, pelo público analisado, em caráter de comparação entre os anos de 2019 a 2021, nos municípios goianos

NEOTROPICAL CARNIVORES: a data set on carnivore distribution in the Neotropics

Mammalian carnivores are considered a key group in maintaining ecological health and can indicate potential ecological integrity in landscapes where they occur. Carnivores also hold high conservation value and their habitat requirements can guide management and conservation plans. The order Carnivora has 84 species from 8 families in the Neotropical region: Canidae; Felidae; Mephitidae; Mustelidae; Otariidae; Phocidae; Procyonidae; and Ursidae. Herein, we include published and unpublished data on native terrestrial Neotropical carnivores (Canidae; Felidae; Mephitidae; Mustelidae; Procyonidae; and Ursidae). NEOTROPICAL CARNIVORES is a publicly available data set that includes 99,605 data entries from 35,511 unique georeferenced coordinates. Detection/non-detection and quantitative data were obtained from 1818 to 2018 by researchers, governmental agencies, non-governmental organizations, and private consultants. Data were collected using several methods including camera trapping, museum collections, roadkill, line transect, and opportunistic records. Literature (peer-reviewed and grey literature) from Portuguese, Spanish and English were incorporated in this compilation. Most of the data set consists of detection data entries (n = 79,343; 79.7%) but also includes non-detection data (n = 20,262; 20.3%). Of those, 43.3% also include count data (n = 43,151). The information available in NEOTROPICAL CARNIVORES will contribute to macroecological, ecological, and conservation questions in multiple spatio-temporal perspectives. As carnivores play key roles in trophic interactions, a better understanding of their distribution and habitat requirements are essential to establish conservation management plans and safeguard the future ecological health of Neotropical ecosystems. Our data paper, combined with other large-scale data sets, has great potential to clarify species distribution and related ecological processes within the Neotropics. There are no copyright restrictions and no restriction for using data from this data paper, as long as the data paper is cited as the source of the information used. We also request that users inform us of how they intend to use the data

Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries

Background Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks. Methods The internationally intended protocol, iteratively co-developed by a multistage Delphi process, comprised an online educational module introducing risk stratification, an intraoperative checklist, and harmonized surgical techniques. Clusters (hospital teams) were randomized to one of three arms with varied sequences of intervention/data collection by a derived stepped-wedge batch design (at least 18 hospital teams per batch). Patients were blinded to the study allocation. Low- and middle-income country enrolment was encouraged. The primary outcome (assessed by intention to treat) was anastomotic leak rate, and subgroup analyses by module completion (at least 80 per cent of surgeons, high engagement; less than 50 per cent, low engagement) were preplanned. Results A total 355 hospital teams registered, with 332 from 64 countries (39.2 per cent low and middle income) included in the final analysis. The online modules were completed by half of the surgeons (2143 of 4411). The primary analysis included 3039 of the 3268 patients recruited (206 patients had no anastomosis and 23 were lost to follow-up), with anastomotic leaks arising before and after the intervention in 10.1 and 9.6 per cent respectively (adjusted OR 0.87, 95 per cent c.i. 0.59 to 1.30; P = 0.498). The proportion of surgeons completing the educational modules was an influence: the leak rate decreased from 12.2 per cent (61 of 500) before intervention to 5.1 per cent (24 of 473) after intervention in high-engagement centres (adjusted OR 0.36, 0.20 to 0.64; P < 0.001), but this was not observed in low-engagement hospitals (8.3 per cent (59 of 714) and 13.8 per cent (61 of 443) respectively; adjusted OR 2.09, 1.31 to 3.31). Conclusion Completion of globally available digital training by engaged teams can alter anastomotic leak rates. Registration number: NCT04270721 (http://www.clinicaltrials.gov)

The value of open-source clinical science in pandemic response: lessons from ISARIC

International audienc

ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

The International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) COVID-19 dataset is one of the largest international databases of prospectively collected clinical data on people hospitalized with COVID-19. This dataset was compiled during the COVID-19 pandemic by a network of hospitals that collect data using the ISARIC-World Health Organization Clinical Characterization Protocol and data tools. The database includes data from more than 705,000 patients, collected in more than 60 countries and 1,500 centres worldwide. Patient data are available from acute hospital admissions with COVID-19 and outpatient follow-ups. The data include signs and symptoms, pre-existing comorbidities, vital signs, chronic and acute treatments, complications, dates of hospitalization and discharge, mortality, viral strains, vaccination status, and other data. Here, we present the dataset characteristics, explain its architecture and how to gain access, and provide tools to facilitate its use

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field