Multiple jumps and vacancy diffusion in a face-centered cubic metal

The diffusion of monovacancies in gold has been studied by computer simulation. Multiple jumps have been found to play a central role in the atomic dynamics at high temperature, and have been shown to be responsible for an upward curvature in the Arrhenius plot of the diffusion coefficient. Appropriate saddle points on the potential energy surface have been found, supporting the interpretation of vacancy multiple jumps as distinct migration mechanisms.Comment: 16 page

Honey bee colony losses

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Optimal Covariant Measurement of Momentum on a Half Line in Quantum Mechanics

We cannot perform the projective measurement of a momentum on a half line since it is not an observable. Nevertheless, we would like to obtain some physical information of the momentum on a half line. We define an optimality for measurement as minimizing the variance between an inferred outcome of the measured system before a measuring process and a measurement outcome of the probe system after the measuring process, restricting our attention to the covariant measurement studied by Holevo. Extending the domain of the momentum operator on a half line by introducing a two dimensional Hilbert space to be tensored, we make it self-adjoint and explicitly construct a model Hamiltonian for the measured and probe systems. By taking the partial trace over the newly introduced Hilbert space, the optimal covariant positive operator valued measure (POVM) of a momentum on a half line is reproduced. We physically describe the measuring process to optimally evaluate the momentum of a particle on a half line.Comment: 12 pages, 3 figure

Regularized covariance estimation for weighted maximum likelihood policy search methods

Many episode-based (or direct) policy search algorithms, maintain a multivariate Gaussian distribution as search distribution over the parameter space of some objective function. One class of algorithms, such as episodic REPS, PoWER or PI2 uses, a weighted maximum likelihood estimate (WMLE) to update the mean and covariance matrix of this distribution in each iteration. However, due to high dimensionality of covariance matrices and limited number of samples, the WMLE is an unreliable estimator. The use of WMLE leads to over-fitted covariance estimates, and, hence the variance/entropy of the search distribution decreases too quickly, which may cause premature convergence. In order to alleviate this problem, the estimated covariance matrix can be regularized in different ways, for example by using a convex combination of the diagonal covariance estimate and the sample covariance estimate. In this paper, we propose a new covariance matrix regularization technique for policy search methods that uses the convex combination of the sample covariance matrix and the old covariance matrix used in last iteration. The combination weighting is determined by specifying the desired entropy of the new search distribution. With this mechanism, the entropy of the search distribution can be gradually decreased without damage from the maximum likelihood estimate

Global access to affordable direct oral anticoagulants

Poor control of cardiovascular disease accounts for a substantial proportion of the disease burden in developing countries, but often essential anticoagulant medicines for preventing strokes and embolisms are not widely available. In 2019, direct oral anticoagulants were added to the World Health Organization's WHO Model list of essential medicines. The aims of this paper are to summarize the benefits of direct oral anticoagulants for patients with cardiovascular disease and to discuss ways of increasing their usage internationally. Although the cost of direct oral anticoagulants has provoked debate, the affordability of introducing these drugs into clinical practice could be increased by: price negotiation; pooled procurement; competitive tendering; the use of patent pools; and expanded use of generics. In 2017, only 14 of 137 countries that had adopted national essential medicines lists included a direct oral anticoagulant on their lists. This number could increase rapidly if problems with availability and affordability can be tackled. Once the types of patient likely to benefit from direct oral anticoagulants have been clearly defined in clinical practice guidelines, coverage can be more accurately determined and associated costs can be better managed. Government action is required to ensure that direct oral anticoagulants are covered by national budgets because the absence of reimbursement remains an impediment to achieving universal coverage. Tackling cardiovascular disease with the aid of direct oral anticoagulants is an essential component of efforts to achieve the World Health Organization's target of reducing premature deaths due to noncommunicable disease by 25% by 2025

Effective Theories for Circuits and Automata

Abstracting an effective theory from a complicated process is central to the study of complexity. Even when the underlying mechanisms are understood, or at least measurable, the presence of dissipation and irreversibility in biological, computational and social systems makes the problem harder. Here we demonstrate the construction of effective theories in the presence of both irreversibility and noise, in a dynamical model with underlying feedback. We use the Krohn-Rhodes theorem to show how the composition of underlying mechanisms can lead to innovations in the emergent effective theory. We show how dissipation and irreversibility fundamentally limit the lifetimes of these emergent structures, even though, on short timescales, the group properties may be enriched compared to their noiseless counterparts.Comment: 11 pages, 9 figure

South-West extension of the hard X-ray emission from the Coma cluster

We explore the morphology of hard (18-30 keV) X-ray emission from the Coma cluster of galaxies. We analyze a deep (1.1 Ms) observation of the Coma cluster with the ISGRI imager on board the \emph{INTEGRAL} satellite. We show that the source extension in the North-East to South-West (SW) direction ($\sim 17'$) significantly exceeds the size of the point spread function of ISGRI, and that the centroid of the image of the source in the 18-30 keV band is displaced in the SW direction compared to the centroid in the 1-10 keV band. To test the nature of the SW extension we fit the data assuming different models of source morphology. The best fit is achieved with a diffuse source of elliptical shape, although an acceptable fit can be achieved assuming an additional point source SW of the cluster core. In the case of an elliptical source, the direction of extension of the source coincides with the direction toward the subcluster falling onto the Coma cluster. If the SW excess is due to the presence of a point source with a hard spectrum, we show that there is no obvious X-ray counterpart for this additional source, and that the closest X-ray source is the quasar EXO 1256+281, which is located $6.1'$ from the centroid of the excess. The observed morphology of the hard X-ray emission clarifies the nature of the hard X-ray "excess" emission from the Coma cluster, which is due to the presence of an extended hard X-ray source SW of the cluster core.Comment: 7pages, 10 figure