INVESTIGATION OF BIOLOGICAL ACTIVITIES OF 4-HYDROXY-3-(2-HYDROXY-5-METHYLBENZYLIDEAMINO) BENZENESULPHONIC ACID

In this study, the antimicrobial activity, DNA cleavage, DNA binding and antioxidant properties of a sulfonic acid-based imine compound were investigated. The antimicrobial activity of the compound was investigated for minimum inhibitory concentration (MIC) against  some bacteria and yeast cultures.  The DNA cleavage activity of the compound was investigated as hydrolytic and oxidative with the gel electrophoresis method. H2O2 was used as an oxidizing agent for detection of the cleavage activity mechanism. The Ultraviolet-Visible (UV-Vis) field absorption spectroscopy method was used to determine the binding effect to DNA. The sulfonic acid-based imine compound reacted with Calf Thymus DNA (CT-DNA) which was examined by UV-Vis absorption spectroscopy. The free radical scavenging activity was determined using the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) method. The studied compound was found to be effective on yeast and bacteria at different concentrations. The compound was found to be more effective on Staphylococcus aureus ATCC 25923 and Enterococcus faecalis ATCC 29212 bacteria. DNA cleavage study showed that the compound cleaved DNA without any external agents in hydrolytic and oxidative manner. UV-Vis spectroscopy studies of the interactions between the compound and CT-DNA showed that the compound interacts with CT-DNA via electrostatic binding. The compound to be tested was compared with the butylated hydroxytoluene (BHT) solution used as standard. It was found that the compound exhibits good antioxidant activity

Performance analysis with data envelopment analysis on turkish textile industry

Küreselleşme ile birlikte, sosyal ve ekonomik hayatta yaşanan gelişmelere karşı varlığını sürdürebilmek için, tekstil sektörü değişim ve yeniliklere açık olmalıdır. Bu değişim ve yenilikleri gerçekleştirebilmek için öncelikle sektörü tanımak ve bu yüzden de bir performans analizi yapmak gerekmektedir. Bu bakış açısıyla, bu çalışmanın ana konusunu Türk Tekstil Sektöründe performans analizi oluşturmaktadır. Bu çalışmanın amacı, küreselleşmenin beraberinde getirdiği ağır rekabet şartları altında Türk Tekstil Sektörünün performans analizini, 2003-2010 yılları arasını kapsayan verilerle Veri Zarflama Analizi yöntemi yardımıyla gerçekleştirmektir. Bu amaçla, Türk Tekstil Sektörüne ilişkin üç girdi ve bir çıktı bileşeni verileri Türkiye İstatistik Kurumu veri tabanından elde edilerek Veri Zarflama Analizi yöntemi ile analiz gerçekleştirilmiştir. Çalışmanın sonucunda, elde edilen bulgulardan yola çıkarak Türk Tekstil Sektörünün 2003-2010 yılları arası performans durumu analiz edilerek sektör performansının nasıl artırılabileceğine yönelik öneriler sunulmuştur.Due to globalization, Textile Industry, which is a conventional branch of industry, should be open to changes and innovations for maintaining against the rapid improvements at the social and economic life. It is necessary to introduce the industry and also to analyze performance of the industry for carrying out these changes and innovations. With this point of view, performance of the Turkish Textile Industry is the main subject of this study. Under the severe conditions of rivalry brought about by globalization, the purpose of this study is to analyze the performance of Turkish Textile Industry with applying Data Envelopment Analysis between 2003-2010 years. With the data on Turkish Textile Industry about 3 inputs and 1 output is obtained from database of Turkish Statistical Institute. This paper focuses on analyzing the performance by Data Envelopment Analysis method. As a result of the findings about performance analysis, the performance of the Turkish Textile Industry between 2003-2010 years is mentioned and a couple of suggestions about how the performance of textile industry is improved

Investigation of the Biological Activities of Colocasia esculenta L. Schott

Throughout history, medicinal plants have been utilized, laying the foundation for contemporary medicine. Plant-derived compounds have been a vital source for developing medications. Colocasia esculenta stands out among traditional crops for its significant nutritional and medicinal potential, surpassing many other tuber crops. In this study, the antioxidant, mutagenicity, and antimutagenicity of four different extracts (hexane, acetone, methanol, and aqueous) of C. esculenta were investigated. Antioxidant activities of C. esculenta extracts were detected with the determination of total phenolic%252Fflavonoid content (TPC%252FTFC), total antioxidant activity (TAC), and DPPH free radical scavenging activity. Acetone extract of C. esculenta exhibited the highest values in all TPC, TFC, TAC, and the DPPH free radical scavenging analyses. The mutagenic and antimutagenic activities of those four extracts were examined with TA98 and TA100 strains of Salmonella typhimurium. In higher concentrations, acetone and methanol extracts showed stronger mutagenic activity than the other extracts in both strains. The highest antimutagenic activity was observed in hexane and acetone in strain TA98

Investigation of the Synthesis and Biological Activity of A New Imine Compound Containing Ferrocene and Benzothiazol

In this study, a new Schiff base containing ferrocene and benzothiazol was synthesized from the reaction of ferrocene-2-carboxialdehyde and 6-methoxybenzo[d]thiazole-2-amine. The structure of the synthesized original imine compound 2-((6-methoxybenzo[d]thiazol-2-ylimino)methyl) ferrocene was illuminated by UV-VIS, FTIR, MS and NMR spectroscopy. The antimicrobial activity of the compound was determined by the minimum inhibition concentration (MIC) method against various bacterial and yeast cultures, and the antioxidant activity was determined by the free radical scavenging activity of 2,2-diphenyl-1-picrilhydrazyl (DPPH). DNA cleavage activity of Schiff base was investigated hydrolytically and oxidatively by agarose gel electrophoresis method, and binding to DNA was investigated by UV-Visible field spectroscopy method. It was found that the studied ferrocene and benzothiazole imine compound had more effect on Pseudomonas aeruginosa (ATCC 27853) and Bacillus subtilis (ATCC 6633) bacteria. The compound was found to exhibit good antioxidant activity compared to the standardized butylated hydroxy toluene (BHT). Agarose gel electrophoresis studies showed that the compound cleaved DNA without any external agent, and UV-Vis spectroscopy studies showed that it interacted electrostatically with CT-DNA

5233 sayılı Terör ve Terörle Mücadeleden Doğan Zararların Karşılanması Hakkında Kanun kapsamında idarenin sorumluluğu

Türkiye'nin uzun süreden beri gündemini meşgul eden ve gerek maddi ve gerekse de manevi yönden büyük sorunlara yol açan terör faaliyetleri nedeniyle bireylerin uğramış olduğu zararların tazmini sosyal bir hukuk devleti olan ülkemiz açısından oldukça öneme sahiptir. Devlet tarafından, terör faaliyetlerinin önlenmesi amacıyla büyük bir çaba sarf edilmekte ise de, ne yazık ki bunu engellemek her zaman mümkün olmamaktadır. Bu nedenle terörist eylemlerin en az zararla atlatılması için çeşitli düzenlemeler yapılmış ve çözüm yolları geliştirilmiştir. Terörle Mücadele Kanunu'nun kabul edilmesiyle başlayan bu süreç, 5233 sayılı Terör ve Terörle Mücadeleden Doğan Zararların Karşılanması Hakkında Kanun ile devam etmiş ve bu hususta ki uyuşmazlıkların öncelikli olarak dostane yollarla çözüme kavuşturulması amaçlanmıştır. Bu kapsamda, 5233 sayılı Kanun'un önemli bir getirisi olan "sulh yolu" uyuşmazlığın çözümü noktasında önemli ve etkili bir idari başvuru usulü olarak düzenlenmiştir. Bu çalışmamızda, terör eylemleri ve terörle mücadeleden kaynaklanan faaliyetler sonucunda bireylerin uğramış olduğu zararların tazmininde, 5233 sayılı Kanun'un kabulü öncesi dönemde çözümüne ilişkin süreç ile 5233 sayılı Kanun kapsamında getirilen yenilikler, bir idari başvuru makamı olarak düzenlenen Zarar Tespit Komisyonlarının oluşumu, komisyon kararlarının niteliği ve bu kararlara karşı izlenecek yöntemler ve son olarak da yargısal süreçteki yansımalarına yönelik çeşitli tespit ve değerlendirilmelere yargı kararları ışığında yer verilmiştir. Yer verilen tespit ve değerlendirmeler ışığında, 5233 sayılı Kanun'un, uygulanması noktasında bir takım eksiklikler ve çelişkilere sebebiyet verdiği görülmekle birlikte uyuşmazlıkların sulh yolu ile çözüme kavuşturulması ve yargıya intikal eden uyuşmazlıklar noktasında da yol gösterici olması adına, etkili ve işlevsel bir başvuru yolu olduğu sonucuna varılmıştır.Compensation for damages suffered by individuals because of terrorist activities be made busy Turkey's agenda for a long time and caused material and spiritual big problems are quite important for our country, which is a social state of law.Even though there is a great effort to prevent terrorism by the government, unfortunately, preventing it don't always possible, therefore minimalized terrorism has been made some regulations and developed solutions.This process, which started with the acceptance of the Fight Against Terrorism Law, continued with Law No. 5233 on Terrorism and Compensation for Damages Arising from the Fight Against Terrorism. Also, it was aimed to resolve disputes on this matter primarily through friendly means. In this context, the peace remedy, which is a significant benefit of Law No. 5233, has been regulated as an important and effective administrative application procedure at the point of resolution of the dispute.In this study, the process regarding the settlement of disputes in the period before the adoption of Law No. 5233 and the innovations brought within the scope of Law No 5233, the formation of Damage Assessment Commissions organized as an administrative appeal authority, the nature of the commission's decisions and the methods to be followed against these decisions finally, various determinations and evaluations regarding their reflections in the judicial process are included in the light of judicial decisions.Consequently, in the light of the determinations and evaluations included, Law No. 5233 has caused some deficiencies and contradictions in its implementation, but it is an effective and functional remedy for the settlement of disputes amicably and for guiding the disagreements submitted to the judiciary

Being a female domestic worker during the pandemic period from the hope perspective

Pandemic processes are important factors triggering the changes in the psychological and sociological structure of society. The COVID-19 outbreak has embodied many variables affecting people's lives in several terms in Turkey as in the whole world. People have appeared to face many psychosocial and economic difficulties due to the social and economic conditions changing with the pandemic period. During this period, domestic workers are the first people who experience these problems in multiple ways. Hope is an important concept in terms of protecting and improving the well-being of domestic worker women who have serious problems in terms of social security, social relations and economic income. Therefore, this research aims at examining the hope mechanisms developed by female domestic workers against the difficulties they experience during the pandemic period between March-June 2020. As it known, hope increases the well-being of people. 15 female domestic workers participated in the research, which was designed in a descriptive phenomenological pattern. The analyses obtained as a result of the interviews held with the female domestic workers revealed that the findings were related to the themes of sources of hope and adaptation process during the pandemic. When the sources of motivation in the structuring of hope are reviewed, it is noteworthy that they are divided into the subthemes of social and inner sources. Considering the relationship of hope with the adaptation to the pandemic period, on the other hand, the subthemes of efforts on reducing concerns, rearrangement of the financial life and view of the future come to the fore

Looking at Anxiety from the Eyes of Domestic Workers: The Covid-19 Pandemic of 2020 Experience in Istanbul

In this phenomenological study, it was attempted to carry out an in-depth investigation of the anxiety experiences of domestic workers, who were working as housekeepers but could not continue their work life during the COVID-19 outbreak. Through this, it was aimed to reveal their experiences regarding the anxiety they experienced during the pandemic process. In this study, in which the criterion sampling method was used, semi-structured interviews were conducted with 16 domestic worker women between the ages of 30-42. The 4-step data analysis process in Giorgi's descriptive phenomenology pattern was used in the analyses. The descriptive phenomenological analysis revealed five main themes that describe the participants' experiences: i) anxiety symptoms, ii) financial difficulties, iii) interfamilial relationships, iv) uncertainty and v) emotions that accompany anxiety. The main themes obtained by this research were similar to the sources of anxiety, its components and the emotions accompanying anxiety mentioned in the literature. During the quarantine days, it was seen that the most intense emotion experienced by domestic workers was anxiety. Although the lockdown and unemployment experiences of each participant is unique, it was determined that the most important determinants of this were economic problems due to the lack of job security

Analysis Of Annual, Seasonal And Monthly Trends Of Climatic Data: A Case Study Of Samsun

Climate change impacts are perceived today asbeing very noticeable; determination of precipitation, wind, flow, evaporationand temperature trends has become essential for water resources and engineeringprojects in management and planning. Nowadays there is a lot of studies havebeen made in progress on global and regional climate changes in literature. Inthis study, monthly, annual and seasonal trends in average temperature, totalprecipitation, and average wind speed data calculated by Mann-Kendall, lineartrend and Sen’s trend tests. The gauge station is located in Samsun, which isthe largest city of the Turkey’s Black Sea region. The data sets are obtainedfor the period 1980 to 2015. According to the results, at the levels ofsignificance of 5 and 10, Mann-Kendall's statistical results were found to begenerally similar to those of trend analysis methods.Nature SciencesNature Science

Investigation of The Effect of Concentration of Lawsonia inermis on the Adsorption of Activated Calcium Bentonite in aqueous solution

How does concentration of Lawsonia inermis (2.00%, 4.00%, 6.00%, 8.00%, 10.00%) affect the swelling of activated calcium bentonite in aqueous solution at 23.00°C under 100 kPa by measuring conductivity by conductivity probe(siemens/m)

Meteorological Drought Analysis And Regional Frequency Analysis In The Kizilirmak Basin: Creating A Framework For Sustainable Water Resources Management

Drought research is needed to understand the complex nature of drought phenomena and to develop effective management and mitigation strategies accordingly. This study presents a comprehensive regional frequency analysis (RFA) of 12-month meteorological droughts in the K & imath;z & imath;l & imath;rmak Basin of Turkey using the L-moments approach. For this purpose, monthly precipitation data from 1960 to 2020 obtained from 22 meteorological stations in the basin are used. In the drought analysis, the Standard Precipitation Index (SPI), Z-Score Index (ZSI), China-Z Index (CZI) and Modified China-Z Index (MCZI), which are widely used precipitation-based indices in the literature, are employed. Here, the main objectives of this study are (i) to determine homogeneous regions based on drought, (ii) to identify the best-fit regional frequency distributions, (iii) to estimate the maximum drought intensities for return periods ranging from 5 to 1000 years, and (iv) to obtain drought maps for the selected return periods. The homogeneity test results show that the basin consists of a single homogeneous region according to the drought indices considered here. The best-fit regional frequency distributions for the selected drought indices are identified using L-moment ratio diagrams and ZDIST goodness-of-fit tests. According to the results, the best-fit regional distributions are the Pearson-Type 3 (PE3) for the SPI and ZSI, generalized extreme value (GEV) for the CZI, and generalized logistic distribution (GLO) for the MCZI. The drought maps obtained here can be utilized as a useful tool for estimating the probability of drought at any location across the basin, even without enough data for hydrological research.WATE