Correction: Impact of Thermal and Biotechnological Processing on the Bioaccessibility and Allergenic Peptide Profile of White Lupin (Lupinus albus)

Background: White lupin (Lupinus albus) is increasingly recognized as a sustainable, highprotein functional food ingredient, yet its potential allergenicity remains a significant concern for food safety. This study aimed to investigate the impact of thermal and biotechnological processing methods on the bioaccessibility and allergenic peptide profiles of white lupin seeds. Methods: Local lupin seeds were subjected to four distinct processing techniques: boiling, microwave cooking, fermentation, and enzymatic treatment. To evaluate protein stability and allergen release under physiological conditions, the processed samples underwent simulated in vitro gastrointestinal digestion as well as standard protease hydrolysis. The resulting peptide sequences were characterized using liquid chromatography with tandem mass spectrometry (LC-MS/MS) and analyzed via in silico bioinformatics tools to predict potential allergenicity. Results: The results indicated that biotechnological processes, specifically enzymatic treatment and fermentation, generated a higher diversity of detectable peptides and distinct allergenic matches following digestion compared to thermal treatments alone. Furthermore, samples subjected to the simulated gastrointestinal digestion model revealed a broader spectrum of conserved epitope matches in allergen databases compared to standard hydrolysis, suggesting that this model provides a more accurate representation of the allergenic peptides likely to persist in the human digestive tract. Discussion: These findings demonstrate that processing methods significantly modulate the structural integrity and predicted allergenic profile of lupin proteins, providing a molecular basis for selecting appropriate processing strategies in the development of safer lupin-based functional foods

Search for Resonances Decaying to an Anomalous Jet and a Higgs Boson in Proton–Proton Collisions at √s = 13 TeV

This article has 2,419 authors. Abstract This paper presents a search for new physics through the process where a massive particle, X, decays into a Higgs boson and a second particle, Y. The Higgs boson subsequently decays into a bottom quark–antiquark pair, which is reconstructed as a single large-radius jet. The decay products of Y are also assumed to produce a single large-radius jet. The identification of the Y particle is enhanced by computing the anomaly score of its candidate jet using an autoencoder, which measures deviations from typical quark- or gluoninduced jets. This allows a simultaneous search for multiple Y decay scenarios within a single analysis. In the main benchmark process, Y is a scalar particle that decays into a W boson pair. Two other scalar Y decay processes are also considered as benchmarks: decays to a light quark–antiquark pair, and decays to a top quark–antiquark pair. A fourth benchmark process considers Y as a hadronically decaying top quark, arising from the decay of a vector-like quark into a top quark and a Higgs boson. Data recorded by the CMS experiment at a center-of-mass energy of 13 TeV in 2016–2018, corresponding to an integrated luminosity of 138 fb−1 , are analyzed. The search covers X masses between 1.4 and 3.0 TeV and Y masses between 90 and 400 GeV, with all simulated signals produced in the narrow-width approximation. No significant excess above the standard model background expectation is observed. The most stringent upper limits to date are placed on benchmark signal cross sections for various masses of X and Y particle

A Parametric Design Method for the Wooden Turkish Triangle Plated Structure (Barkat) Model

Mimar Sinan’s mosques are celebrated as masterpieces of central-plan mosque design, showcasing exceptional spatial composition and structural form. A previous study designed a novel model by adapting these forms using a catenary curve, folded plates, and Turkish triangles. However, that model established only a static topology. Distinguishing itself by advancing this topology into a dynamic computational framework, this research introduces a novel parametric algorithm that mathematically defines the Turkish triangle. This method allows for both the analytical classification of historical transition zones and the generation of the contemporary ‘Barkat’ mosque model. Using Grasshopper and Python, geometries are defined via wall segmentation/folding (n) and hoop (ring) edge (k) parameters. The analysis confirms that combinations of (n=1–3) and (k=4–8) yield the most balanced forms. The resulting framework offers a dual contribution: a digital reconstruction tool for architectural history and a fabrication-ready design method for folded plate structures

The Relation of Zonulin and Intestinal Fatty Acid-binding Protein with Cognitive Functions in Patients with Bipolar Disorder

Objective: This study aimed to investigate the relationship between zonulin and intestinal fatty acid-binding protein (I-FABP), biomarkers of intestinal permeability, and cognitive functions in patients with bipolar disorder (BD) compared to healthy controls (HCs). Methods: The study included 40 individuals diagnosed with BD and HCs. Cognitive functions were evaluated using the Stroop Test, Trail Making Test, Öktem Verbal Memory Processes Test, Wisconsin Card Sorting Test, and Digit Span Test. Serum zonulin and I-FABP levels were measured. Results: Zonulin and I-FABP levels were significantly higher in the BD group than in HCs (p < 0.001). After correction for multiple comparisons, significant associations remained between zonulin levels and cognitive performance measures, including the Stroop effect (r = 0.46, p < 0.001), delayed recall (r = -0.41, p < 0.001), and recognition performance (r = 0.42, p < 0.001). No significant correlations were found between I-FABP levels and cognitive test results. Conclusion: The observed associations between zonulin levels and cognitive performance suggests a potential relationship of intestinal barrier integrity and gut microbiota with cognitive functions in BD. These findings should be interpreted as associative rather than causal, and future longitudinal studies are required to explore the direction of these relationships

PAPR Reduction and Performance Enhancement of Optical OFDM Communication Systems via Migrating Birds Optimization-Based SLM Technique

In Intensity-Modulated Direct Detection Optical Orthogonal Frequency Division Multiplexing (IM/DD-OOFDM) communication systems, a lower Peak-to-Average Power Ratio (PAPR) is essential for improving system performance. In order to reduce the high PAPR, a Migrating Birds Optimization(MBO) is integrated with the classical Selective Mapping (SLM) method in IM/DD-OFDM system. This approach successfully optimizes the values of phase factors, minimizes the search numbers, and reduces computational complexity. To evaluate the impact of the MBO-SLM method on PAPR reduction performance, the parameters of the MBO-SLM method play a crucial role in decreasing the PAPR in an IM/DD optical OFDM system. The MBO-SLM method demonstrates improved Bit Error Rate (BER) performance, Power Spectral Density (PSD), and power saving performance compared to other PAPR reduction methods. Numerical results indicate that the proposed PAPR reduction method outperforms other existing methods for optical OFDM signals. Specifically, by implementing this technique in the IM/DD optical OFDM communication system, we achieved a decrease in PAPR from 10.5 dB to 4.95 dB at a Complementary Cumulative Distribution Function(CCDF) of 10–3, resulting in a reduction of 5.55 dB. Additionally, the computational complexity of the MBO-SLM method shows a 91% improvement over the Discrete Elephant Herding Optimization(DEHO) based Partial Transmit Sequence (PTS) method when the search number is set to 512

Adverse Childhood Experiences and Fear of Happiness: Serial Mediation by Belongingness and Dating Anxiety

Adverse childhood experiences (ACEs) constitute the foundation of many problems in an individual’s life. Among theseare a diminished sense of belonging and heightened anxiety, particularly in the context of romantic relationships. Indi-viduals who suffer from anxiety in romantic relationships frequently worry about being rejected or feeling inadequate.Under this emotional strain, people could doubt chances to capture happiness. In this study, the serial mediation effectsof belongingness and dating anxiety were examined in the ACEs - fear of happiness link. The sample consists of 346participants (M = 22.82, SD = 3.37). The mediating role was assessed using the bootstrap method through structural equa-tion modeling (SEM) to verify the presence of mediation. SEM indicated that belongingness and dating anxiety weresignificant mediators in the association between ACEs and fear of happiness. According to the results, ACEs may increasefear of happiness, which may arise as a consequence of low belongingness and high dating anxiety. As a result, happinessmay be hindered by ACEs as well as by poor connection with other people and the degree of anxiety they experienceabout establishing and maintaining romantic relationships. Based on these findings, it is recommended to develop earlyintervention programs and support services for individuals with ACEs. These programs can focus on enhancing feelingsof belongingness and reducing dating anxiety, thereby mitigating fear of happiness

The Evaluation of the Impact of Furniture Layout on Daylight Performance in an Adaptively Reused Library: The Case of Istanbul Ticaret University Küçükyalı Campus

6th Central European Symposium on Building Physics, CESBP 2025 / Editors:Balázs Nagy, Zsuzsa Szalay -- Springer -- ISBN:978-303214018-0 -- 2026.This study comparatively evaluates the effects of eleven alternative furniture layouts developed parametrically with the current layout on the natural lighting performance of Istanbul Ticaret University Küçükyalı Campus Library. Within the scope of the study, spatial models created with AutoCAD and SketchUp software were integrated into the Rhino–Grasshopper platform; daylight analyses were performed using the Honeybee plugin. In accordance with international standards, sDA (Spatial Daylight Autonomy), ASE (Annual Sunlight Exposure) and UDI (Useful Daylight Illuminance) metrics were adopted as basic performance criteria. According to the analysis results, in the current layout, positioning the stacks directly in front of glass surfaces limits the homogeneous distribution of daylight throughout the interior with a performance of sDA 60.21%, UDI 74.57% and ASE 5.63%. In alternative layout scenarios, significant increases in sDA and UDI values were observed in arrangements where the shelves were moved away from the facades and the work areas were brought closer to natural light sources. The highest sDA value was obtained in scenario number 7 with 75.20%, while the lowest ASE value was obtained in the current layout with 5.35%. The results show that furniture placement is a decisive design input not only in terms of functional circulation and aesthetic continuity, but also in terms of daylight performance and optimization of user-oriented visual comfort. Furthermore, the daylight assessment was conducted in line with EN 17037, ensuring the study’s consistency with internationally recognized standards for daylight provision

In Search of a New Social Contract: Polarization over the Aims of Higher Education in Türkiye and the Promise of Comparative Political Theory

To address the negative effects of political polarization on social cohesion, trust, and democratic deliberation, this article tackles the dispute between conservative and non-conservative groups in Türkiye over the aims of higher education and examines the possibility of reaching common ground between these polarized groups to create a new social contract. The article contends that comparative political theory, when viewed as a component of liberal education, offers ideas that can serve as a constructive framework for restructuring university curricula and academics’ teaching practices. Such a liberal vision of comparative political theory can incorporate non-Western political ideas into university curricula without sacrificing liberal concerns about the cultivation of individual autonomy. While this approach may not appeal to those who seek to shape education according to their worldview, it offers a shared framework for those genuinely concerned about the harmful effects of polarization

Geometric Reconstruction of Ribbed Domes Covering the Ishrat-Khana Mausoleum in Samarkand

Ishrat-Khana Mausoleum in Samarkand, a Timurid artifact, represents a significant example of the 15th century with its ribbed domes, opening a new era in the region's architecture. However, it was surveyed only once by hand drawing and has been standing in ruins due to its geometric complexity. Subsequent restoration attempts, on the other hand, contain serious faults. This study is about the geometric reconstruction of Ishrat-Khana's superstructure to contribute to possible restorations. The study offers one of the first comprehensive studies on ribbed domes in Transoxania, filling a significant gap in the literature. The geometry of the ribbed domes has been analyzed according to some design parameters inspired by historical drawings. The analyses revealed that restorations in the central hall and the masjid contain methodical errors, while the restitution drawings are also incorrect for the southern hall and the basement. As a result, a specific formulation for drawing a potential comprehensive restoration has been proposed

Nexus of Whey Proteins, Gut Dysbiosis, and Colonic Health

The gut microbiota is essential for colonic health, and its imbalance (dysbiosis) is linked to conditions like inflammatory boweldisease and metabolic disorders. Whey proteins (WPs), including β-lactoglobulin, α-lactalbumin, glycomacropeptide, and lacto-ferrin, possess antimicrobial, immunomodulatory, and prebiotic-like properties that may help restore microbial balance. Beyondmodulating the microbiome, WPs play a significant role in reinforcing intestinal barrier integrity and regulating host metabo-lism. This review summarizes evidence from in vitro, in vivo, and clinical studies showing WPs can enhance beneficial bacteria(e.g., Bifidobacterium, Lactobacillus) while suppressing harmful ones. Furthermore, WP supplementation has been shown toalleviate dysbiosis-related conditions such as colitis, obesity, and allergies by improving microbial diversity, enhancing short-chain fatty acid production, strengthening the mucosal barrier, and modulating immune responses. However, the effects varydepending on WP composition, processing, and individual microbiota. Despite encouraging results, knowledge gaps remainregarding optimal dosing and long-term impacts. Overall, WPs show promise as functional food components and potential ther-apeutic agents for promoting colonic health, metabolic homeostasis, and gut barrier function, but more research is needed torefine their clinical applicatio