Modelling health and economic impact of nutrition interventions: a systematic review

Diet related non-communicable diseases (NCDs), as well as micronutrient deficiencies, are of widespread and growing importance to public health. Authorities are developing programs to improve nutrient intakes via foods. To estimate the potential health and economic impact of these programs there is a wide variety of models. The aim of this review is to evaluate existing models to estimate the health and/or economic impact of nutrition interventions with a focus on reducing salt and sugar intake and increasing vitamin D, iron, and folate/folic acid intake. The protocol of this systematic review has been registered with the International Prospective Register of Systematic Reviews (PROSPERO: CRD42016050873). The final search was conducted on PubMed and Scopus electronic databases and search strings were developed for salt/sodium, sugar, vitamin D, iron, and folic acid intake. Predefined criteria related to scientific quality, applicability, and funding/interest were used to evaluate the publications. In total 122 publications were included for a critical appraisal: 45 for salt/sodium, 61 for sugar, 4 for vitamin D, 9 for folic acid, and 3 for iron. The complexity of modelling the health and economic impact of nutrition interventions is dependent on the purpose and data availability. Although most of the models have the potential to provide projections of future impact, the methodological challenges are considerable. There is a substantial need for more guidance and standardization for future modelling, to compare results of different studies and draw conclusions about the health and economic impact of nutrition interventions. © 2022, The Author(s)

Stabilizing role of platelet P2Y(12) receptors in shear-dependent thrombus formation on ruptured plaques

Background: In most models of experimental thrombosis, healthy blood vessels are damaged. This results in the formation of a platelet thrombus that is stabilized by ADP signaling via P2Y(12) receptors. However, such models do not predict involvement of P2Y(12) in the clinically relevant situation of thrombosis upon rupture of atherosclerotic plaques. We investigated the role of P2Y(12) in thrombus formation on (collagen-containing) atherosclerotic plaques in vitro and in vivo, by using a novel mouse model of atherothrombosis. Methodology: Plaques in the carotid arteries from Apoe(-/-) mice were acutely ruptured by ultrasound treatment, and the thrombotic process was monitored via intravital fluorescence microscopy. Thrombus formation in vitro was assessed in mouse and human blood perfused over collagen or plaque material under variable conditions of shear rate and coagulation. Effects of two reversible P2Y(12) blockers, ticagrelor (AZD6140) and cangrelor (AR-C69931MX), were investigated. Principal Findings: Acute plaque rupture by ultrasound treatment provoked rapid formation of non-occlusive thrombi, which were smaller in size and unstable in the presence of P2Y(12) blockers. In vitro, when mouse or human blood was perfused over collagen or atherosclerotic plaque material, blockage or deficiency of P2Y(12) reduced the thrombi and increased embolization events. These P2Y(12) effects were present at shear rates >500 s(-1), and they persisted in the presence of coagulation. P2Y(12)-dependent thrombus stabilization was accompanied by increased fibrin(ogen) binding. Conclusions/Significance: Platelet P2Y(12) receptors play a crucial role in the stabilization of thrombi formed on atherosclerotic plaques. This P2Y(12) function is restricted to high shear flow conditions, and is preserved in the presence of coagulation

İnsülin Direnci, Beslenme ve Yağlı Yeme İsteği ile CD36 Reseptörü İlişkisi

Global olarak beslenme gibi yaşam tarzındaki hızlı değişim ile birlikte insülin direnci ve diyabet prevalansı hızla artış göstermiş ve günümüzde Tip II diabetes mellitus (Tip II DM) epidemik bir sorun haline gelmiştir. Yaşam tarzı müdahalelerinden en önemlisi olan diyetin düzenlenmesi ise tip II DM’nin ortaya çıkmasının engellenmesinde, geciktirilmesinde, komplikasyonların oluşmasında ve önlenmesinde önemli bir role sahiptir. Son yıllarda yapılan çalışmalarda Tip II DM gelişimine neden olan patolojik faktörler arasında yer alan insülin aktivitesi ve insülin sekresyonunun diyabet nedenini belirlemek açısından tek başına yetersiz kaldığı ele alınmaktadır. Buna ek olarak diyabet etiyolojisinde multi-faktöriyel nedenlerin, insülinin yanı sıra farklı reseptörlerin yer aldığı ve bu durumu genetik çalışmaların desteklediği bilinmektedir. Bu reseptörlerden biri olan CD36 reseptörü ise, kardiyovasküler sağlık ve hastalıklar, kanser, diyabet, insülin direnci, tat alma duyusu ve besin seçiminde önemli rol oynamaktadır. Yapılan çalışmalarda yüksek kan CD36 düzeylerinin tip II DM patogenezinde yeni bir belirteç olarak katkı sağlayabileceği yer almaktadır. Ayrıca güncel veriler CD36 reseptörünün yağlı besin seçimi açısından farklı tat ve kokularda görev alabildiğini göstermektedir. Bu derlemede CD36 reseptörü ile insülin direnci ve diyette yağlı besin seçimi arasında ilişki incelenmiştir

The Effects Of Dietary High Fructose And Saturated Fatty Acids On Chronic Low Grade Inflammation In The Perspective Of Chronic Diseases

In recent years, the role of chronic low grade inflammation in the emergence of chronic diseases has been emphasized. Chronic low grade inflammation is a metabolic process characterized by systemic circulation and increased inflammatory mediators and some proinflammatory cytokines in various tissues. C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1), interleukin-4 (IL-4), interleukin-6 (IL-6), toll like receptor-4 (TLR-4) are some proinflammatory molecules that play a role in the chronic low grade inflammation. Recent studies have shown that fructose and saturated fatty acids, which are consumed with increased consumption of processed foods in the current diet, might trigger chronic low grade inflammation. In this review, the effects of dietary high fructose and saturated fatty acids on development of chronic low grade inflammation through some proinflammatory mediators were examined.Wo

Fatty Acid Transport Receptor Soluble Cd36 And Dietary Fatty Acid Pattern In Type 2 Diabetic Patients: A Comparative Study

Recently, it has been remarked that dietary fatty acids and fatty acid receptors might be involved in the aetiology of diabetes. Therefore, this study was conducted to determine the relationship between dietary fatty acid pattern, fatty food preferences and soluble CD36 (sCD36) and insulin resistance in type 2 diabetes mellitus (DM). The study was carried out with thirty-eight newly diagnosed type 2 DM patients and thirty-seven healthy volunteers, aged 30-65 years. In the study, socio-demographic characteristics, dietary fat type and fatty acid pattern of individuals were recorded. After anthropometric measurements were taken, blood CD36, glucose, TAG and insulin levels were analysed. The results showed that although the type of fatty acid intake did not differ between the groups (P>0.05), the consumption of olive oil in the type 2 DM group was lower than the control group (P0.05). Crucially, elevated sCD36 levels increased the type 2 DM risk (OR 1.21, P<0.05). In conclusion, sCD36 level may be a possible biomarker, independent from the dietary fatty acid pattern, for type 2 DM owing to its higher levels in these patients. Therefore, the new insights make CD36 attractive as a therapeutic target for diabetes.WoSScopu

How Does Food Addiction Influence Dietary Intake Profile?

This study aimed to investigate whether there was any difference in eating pattern, abnormal eating behaviour, obesity and the number of food addiction symptoms according to food addiction presence. A total sample of 851 healthy subjects living in Ankara (n = 360 male, n = 491 female) aged 19–65 years were included in this cross-sectional survey. Data on demographic information, 24-hour dietary recalls, Yale Food Addiction Scale (YFAS), Eating Attitudes Test-26 (EAT-26), and anthropometric measurements were collected through face-to-face interviews. Overall, 11.4% of participants were identified as “food addicted” (F: 13.0%; M: 9.2%). Subjects meeting criteria for ‘food addiction' had higher body mass index (35.1% were obese and 3.1% were underweight), compared to subjects without food addiction (13.1% were obese and 10.2% were underweight) (p<0.05). Abnormal eating attitudes estimated with EAT-26 were determined as 45.5% in males, 37.5% in females and 40.2% in total, among subjects with food addiction. Daily energy, protein and fat intakes were significantly higher in food addicted females, compared to non-addicted females (p<0.05). Participants with food addiction reported significantly more problems with foods, which contain high amounts of fat and sugar, compared to the participants without food addiction. Food addiction behaviour should be considered as a part of efforts towards reducing food related problems involving obesity.PubMedWoSScopu

Key role of integrin alpha(IIb)beta(3) signaling to Syk kinase in tissue factor-induced thrombin generation

The fibrin(ogen) receptor, integrin α(IIb)β(3), has a well-established role in platelet spreading, aggregation and clot retraction. How α(IIb)β(3) contributes to platelet-dependent coagulation is less well resolved. Here, we demonstrate that the potent suppressing effect of clinically used α(IIb)β(3) blockers on tissue factor-induced thrombin generation is linked to diminished platelet Ca(2+) responses and phosphatidylserine (PS) exposure. The same blockers suppress these responses in platelets stimulated with collagen and thrombin receptor agonists, whereas added fibrinogen potentiates these responses. In platelets spreading on fibrinogen, outside-in α(IIb)β(3) signaling similarly enhances thrombin-induced Ca(2+) rises and PS exposure. These responses are reduced in α(IIb)β(3)-deficient platelets from patients with Glanzmann’s thrombasthenia. Furthermore, the contribution of α(IIb)β(3) to tissue factor-induced platelet Ca(2+) rises, PS exposure and thrombin generation in plasma are fully dependent on Syk kinase activity. Tyrosine phosphorylation analysis confirms a key role of Syk activation, which is largely but not exclusively dependent on α(IIb)β(3) activation. It is concluded that the majority of tissue factor-induced procoagulant activity of platelets relies on Syk activation and ensuing Ca(2+) signal generation, and furthermore that a considerable part of Syk activation relies on α(IIb)β(3) signaling. These results hence point to a novel role of Syk in integrin-dependent thrombin generation. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00018-012-1033-2) contains supplementary material, which is available to authorized users

Anthropometric measurements categorized by presence of food addiction by gender.

<p>Anthropometric measurements categorized by presence of food addiction by gender.</p