189 research outputs found
Liouville Vortex And Kink Solutions Of The Seiberg--Witten Equations
The Seiberg--Witten equations, when dimensionally reduced to \bf R^{2}\mit,
naturally yield the Liouville equation, whose solutions are parametrized by an
arbitrary analytic function . The magnetic flux is the integral of
a singular Kaehler form involving ; for an appropriate choice of ,
coaxial or separated vortex configurations with are
obtained when the integral is regularized. The regularized connection in the
\bf R^{1}\mit case coincides with the kink solution of theory.Comment: 14 pages, Late
On non- solutions to the Seiberg-Witten equations
We show that a previous paper of Freund describing a solution to the
Seiberg-Witten equations has a sign error rendering it a solution to a related
but different set of equations. The non- nature of Freund's solution is
discussed and clarified and we also construct a whole class of solutions to the
Seiberg-Witten equations.Comment: 8 pages, Te
Towards trajectory anonymization: A generalization-based approach
Trajectory datasets are becoming,popular,due,to the massive,usage,of GPS and,location- based services. In this paper, we address privacy issues regarding the identification of individuals in static trajectory datasets. We first adopt the notion of k-anonymity,to trajectories and propose,a novel generalization-based approach,for anonymization,of trajectories. We further show,that releasing anonymized,trajectories may,still have,some,privacy,leaks. Therefore we propose,a randomization based,reconstruction,algorithm,for releasing anonymized,trajectory data and,also present how,the underlying,techniques,can be adapted,to other anonymity,standards. The experimental,results on real and,synthetic trajectory datasets show,the effectiveness of the proposed,techniques
Stabilizing role of platelet P2Y(12) receptors in shear-dependent thrombus formation on ruptured plaques
Background: In most models of experimental thrombosis, healthy blood vessels are damaged. This results in the formation of a platelet thrombus that is stabilized by ADP signaling via P2Y(12) receptors. However, such models do not predict involvement of P2Y(12) in the clinically relevant situation of thrombosis upon rupture of atherosclerotic plaques. We investigated the role of P2Y(12) in thrombus formation on (collagen-containing) atherosclerotic plaques in vitro and in vivo, by using a novel mouse model of atherothrombosis.
Methodology: Plaques in the carotid arteries from Apoe(-/-) mice were acutely ruptured by ultrasound treatment, and the thrombotic process was monitored via intravital fluorescence microscopy. Thrombus formation in vitro was assessed in mouse and human blood perfused over collagen or plaque material under variable conditions of shear rate and coagulation. Effects of two reversible P2Y(12) blockers, ticagrelor (AZD6140) and cangrelor (AR-C69931MX), were investigated.
Principal Findings: Acute plaque rupture by ultrasound treatment provoked rapid formation of non-occlusive thrombi, which were smaller in size and unstable in the presence of P2Y(12) blockers. In vitro, when mouse or human blood was perfused over collagen or atherosclerotic plaque material, blockage or deficiency of P2Y(12) reduced the thrombi and increased embolization events. These P2Y(12) effects were present at shear rates >500 s(-1), and they persisted in the presence of coagulation. P2Y(12)-dependent thrombus stabilization was accompanied by increased fibrin(ogen) binding.
Conclusions/Significance: Platelet P2Y(12) receptors play a crucial role in the stabilization of thrombi formed on atherosclerotic plaques. This P2Y(12) function is restricted to high shear flow conditions, and is preserved in the presence of coagulation
A Quasiperiodic Gibbons--Hawking Metric and Spacetime Foam
We present a quasiperiodic self-dual metric of the Gibbons--Hawking type with
one gravitational instanton per spacetime cell. The solution, based on an
adaptation of Weierstrassian and functions to three
dimensions, conforms to a definition of spacetime foam given by Hawking.Comment: 14 pages, Late
N=2 Supersymmetric Model with Dirac-Kahler Fermions from Generalized Gauge Theory in Two Dimensions
We investigate the generalized gauge theory which has been proposed
previously and show that in two dimensions the instanton gauge fixing of the
generalized topological Yang-Mills action leads to a twisted N=2 supersymmetric
action. We have found that the R-symmetry of N=2 supersymmetry can be
identified with the flavour symmetry of Dirac-Kahler fermion formulation. Thus
the procedure of twist allows topological ghost fields to be interpreted as the
Dirac-Kahler matter fermions.Comment: 22 pages, LaTe
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Systematic Exploration of Synergistic Drug Pairs
Drug synergy allows a therapeutic effect to be achieved with lower doses of component drugs. Drug synergy can result when drugs target the products of genes that act in parallel pathways (âspeciïŹc synergyâ). Such cases of drug synergy should tend to correspond to synergistic genetic interaction between the corresponding target genes. Alternatively, âpromiscuous synergyâ can arise when one drug non-speciïŹcally increases the effects of many other drugs, for example, by increased bioavailability. To assess the relative abundance of these drug synergy types, we examined 200 pairs of antifungal drugs in S. cerevisiae. We found 38 antifungal synergies, 37 of which were novel. While 14 cases of drug synergy corresponded to genetic interaction, 92% of the synergies we discovered involved only six frequently synergistic drugs. Although promiscuity of four drugs can be explained under the bioavailability model, the promiscuity of Tacrolimus and Pentamidine was completely unexpected. While many drug synergies correspond to genetic interactions, the majority of drug synergies appear to result from non-speciïŹc promiscuous synergy
Potentiation of thrombus instability: a contributory mechanism to the effectiveness of antithrombotic medications
© The Author(s) 2018The stability of an arterial thrombus, determined by its structure and ability to resist endogenous fibrinolysis, is a major determinant of the extent of infarction that results from coronary or cerebrovascular thrombosis. There is ample evidence from both laboratory and clinical studies to suggest that in addition to inhibiting platelet aggregation, antithrombotic medications have shear-dependent effects, potentiating thrombus fragility and/or enhancing endogenous fibrinolysis. Such shear-dependent effects, potentiating the fragility of the growing thrombus and/or enhancing endogenous thrombolytic activity, likely contribute to the clinical effectiveness of such medications. It is not clear how much these effects relate to the measured inhibition of platelet aggregation in response to specific agonists. These effects are observable only with techniques that subject the growing thrombus to arterial flow and shear conditions. The effects of antithrombotic medications on thrombus stability and ways of assessing this are reviewed herein, and it is proposed that thrombus stability could become a new target for pharmacological intervention.Peer reviewedFinal Published versio
A Large Hadron Electron Collider at CERN
This document provides a brief overview of the recently published report on
the design of the Large Hadron Electron Collider (LHeC), which comprises its
physics programme, accelerator physics, technology and main detector concepts.
The LHeC exploits and develops challenging, though principally existing,
accelerator and detector technologies. This summary is complemented by brief
illustrations of some of the highlights of the physics programme, which relies
on a vastly extended kinematic range, luminosity and unprecedented precision in
deep inelastic scattering. Illustrations are provided regarding high precision
QCD, new physics (Higgs, SUSY) and electron-ion physics. The LHeC is designed
to run synchronously with the LHC in the twenties and to achieve an integrated
luminosity of O(100) fb. It will become the cleanest high resolution
microscope of mankind and will substantially extend as well as complement the
investigation of the physics of the TeV energy scale, which has been enabled by
the LHC
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