18 research outputs found
Vascular Remodeling in Health and Disease
The term vascular remodeling is commonly used to define the structural changes in blood vessel geometry that occur in response to long-term physiologic alterations in blood flow or in response to vessel wall injury brought about by trauma or underlying cardiovascular diseases.1, 2, 3, 4 The process of remodeling, which begins as an adaptive response to long-term hemodynamic alterations such as elevated shear stress or increased intravascular pressure, may eventually become maladaptive, leading to impaired vascular function. The vascular endothelium, owing to its location lining the lumen of blood vessels, plays a pivotal role in regulation of all aspects of vascular function and homeostasis.5 Thus, not surprisingly, endothelial dysfunction has been recognized as the harbinger of all major cardiovascular diseases such as hypertension, atherosclerosis, and diabetes.6, 7, 8 The endothelium elaborates a variety of substances that influence vascular tone and protect the vessel wall against inflammatory cell adhesion, thrombus formation, and vascular cell proliferation.8, 9, 10 Among the primary biologic mediators emanating from the endothelium is nitric oxide (NO) and the arachidonic acid metabolite prostacyclin [prostaglandin I2 (PGI2)], which exert powerful vasodilatory, antiadhesive, and antiproliferative effects in the vessel wall
Recent results on modelling the spatial and temporal structure of the Earth's gravity field
Sea-Level Rise by 2100
ISI Document Delivery No.: 274ZI Times Cited: 0 Cited Reference Count: 0 Church, John A. Clark, Peter U. Cazenave, Anny Gregory, Jonathan M. Jevrejeva, Svetlana Levermann, Anders Merrifield, Mark A. Milne, Glenn A. Nerem, R. Steven Nunn, Patrick D. Payne, Antony J. Pfeffer, W. Tad Stammer, Detlef Unnikrishnan, Alakkat S. payne, antony/A-8916-2008; Church, John/A-1541-2012 payne, antony/0000-0001-8825-8425; Church, John/0000-0002-7037-8194 0 AMER ASSOC ADVANCEMENT SCIENCE WASHINGTON SCIENC