Sulfur-oxygen processes on Io

Laboratory studies of irradiated sulfur dioxide frost have found that sulfur trioxide should be formed as a consequence of the irradiation process. The spectral reflectance of solid sulfur trioxide was measured in the laboratory and it was found that the compound has strong absorption features at 3.37 and 3.70 microns. These features are not present in the spectral geometric albedo of Io. This is interpreted as an indication that sulfur trioxide may exist in such limited abundance that it is undetectable in disk averaged spectrophotometry. It is suggested that the Near-Infrared Mapping Spectrometer on the Galileo spacecraft should be able to identify condensed sulfur trioxide on Io particularly in regions bordering the sulfur dioxide deposits. The presence of elemental sulfur on Io's surface has been questioned on several grounds, most notably the suggested production process (quenched molten sulfur extrusions) and the effect of radiation (particularly X-rays) on some of the allotropes. Mixtures of sulfur allotropes were produced in the laboratory by quenching molten sulfur and it was found that the spectra indicate the presence of certain red-colored allotropes which are preserved upon quenching. The color of the sulfur glass produced is redder when the temperature of the original melt is higher. This is consistent with the suggestion that Io's spectral geometric albedo can be partly explained by the presence of quenched sulfur glasses

Breaking down the delta wing vortex: The role of vorticity in the breakdown process

Experimental x-wire measurements of the flowfield above a 70 and 75 deg flat plate delta wing were performed at a Reynolds number of 250,000. Grids were taken normal to the wing at various chordwise locations for angles of attack of 20 and 30 deg. Axial and azimuthal vorticity distributions were derived from the velocity fields. The dependence of circulation on distance from the vortex core and on chordwise location was also examined. The effects of nondimensionalization in comparison with other experimental data is made. The results indicate that the circulation distribution scales with the local semispan and grows in a nearly linear fashion in the chordwise direction. The spanwise distribution of axial vorticity is severely altered through the breakdown. The axial vorticity components with a negative sense, such as that found in the secondary vortex, seem to remain unaffected by changes in wind sweep or angle of attack, in direct contrast to the positive components. In addition, the inclusion of the local wing geometry into a previously derived correlation parameter allows the circulation of growing leading edge vortex flows to be reduced into a single curve

Aberrant Radiocarbon Dates on an Inuit Arrowhead

Apparently aberrant radiocarbon dates on a Thule culture antler artefact lead to the conclusion that this tool was made of material that was already ancient at the time of manufacture. This finding documents a potential problem in the interpretation of radiocarbon dates on Arctic cultural materials.Des datations au radiocarbone apparemment aberrantes effectuées sur un objet de la culture Thulé fabriqué en bois d'animal permettent de conclure que cet outil a été fait d'un matériau qui était déjà ancien à l'époque de sa fabrication. Ces résultats documentent un problème potentiel dans l'interprétation de la datation au radiocarbone sur des matériaux culturels de l'Arctique

The stoichiometry of P2X2/6 receptor heteromers depends on relative subunit expression levels

Fast synaptic transmission involves the operation of ionotropic receptors, which are often composed of at least two types of subunit. We have developed a method, based on atomic force microscopy imaging to determine the stoichiometry and subunit arrangement within ionotropic receptors. We showed recently that the P2X(2) receptor for ATP is expressed as a trimer but that the P2X(6) subunit is unable to oligomerize. In this study we addressed the subunit stoichiometry of heteromers containing both P2X(2) and P2X(6) subunits. We transfected tsA 201 cells with both P2X(2) and P2X(6) subunits, bearing different epitope tags. We manipulated the transfection conditions so that either P2X(2) or P2X(6) was the predominant subunit expressed. By atomic force microscopy imaging of isolated receptors decorated with antiepitope antibodies, we demonstrate that when expression of the P2X(2) subunit predominates, the receptors contain primarily 2 x P2X(2) subunits and 1 x P2X(6) subunit. In contrast, when the P2X(6) subunit predominates, the subunit stoichiometry of the receptors is reversed. Our results show that the composition of P2X receptor heteromers is plastic and dependent on the relative subunit expression levels. We suggest that this property of receptor assembly might introduce an additional layer of subtlety into P2X receptor signaling

The Impact of Publicly Owned Hotels on Competing Properties

Substantial public subsidies, and even outright public ownership, of hotels have become common in the United States as communities target tourism as an integral economic development tool. A critical question that is increasingly being raised about the public sector entering the hotel business is, are these government-funded facilities unfair competition to properties developed by the private sector? The common reply to these concerns is that the publicly owned hotel is critical to growing demand for lodging accommodation and that once it opens, the new hotel will attract enough new business that all hotels will benefit. We use an event study to test this hypothesis across all of the 100% publicly developed hotels for which there are sufficient data to conduct the analysis. In looking at these 21 hotels, we found strong evidence that the performance of neighboring hotels worsens after the introduction of a publicly owned hotel

Relationship of Black Walnut Wood Color to Soil Properties and Site

This investigation is the first to provide information for any species on the magnitude of quantitative wood color differences between individual trees and between groups of trees at specified locations. It is also the first to report on the effects of specific environmental factors on wood color. Larger differences were found between black walnut (Juglans nigra L.) trees in heartwood luminance (lightness) than in dominant wavelength (hue) or purity (percentage of principal hue). Indiana-grown walnut heartwood had higher luminance than Missouri-grown. The relationship of heartwood color to soil properties was greater than it was either to tree age or to diameter-growth rate (rings per inch)

Polarization of macrophages toward M2 phenotype is favored by reduction in iPLA2β (group VIA phospholipase A2)*

Macrophages are important in innate and adaptive immunity. Macrophage participation in inflammation or tissue repair is directed by various extracellular signals and mediated by multiple intracellular pathways. Activation of group VIA phospholipase A2 (iPLA2β) causes accumulation of arachidonic acid, lysophospholipids, and eicosanoids that can promote inflammation and pathologic states. We examined the role of iPLA2β in peritoneal macrophage immune function by comparing wild type (WT) and iPLA2β−/− mouse macrophages. Compared with WT, iPLA2β−/− macrophages exhibited reduced proinflammatory M1 markers when classically activated. In contrast, anti-inflammatory M2 markers were elevated under naïve conditions and induced to higher levels by alternative activation in iPLA2β−/− macrophages compared with WT. Induction of eicosanoid (12-lipoxygenase (12-LO) and cyclooxygenase 2 (COX2))- and reactive oxygen species (NADPH oxidase 4 (NOX4))-generating enzymes by classical activation pathways was also blunted in iPLA2β−/− macrophages compared with WT. The effects of inhibitors of iPLA2β, COX2, or 12-LO to reduce M1 polarization were greater than those to enhance M2 polarization. Certain lipids (lysophosphatidylcholine, lysophosphatidic acid, and prostaglandin E2) recapitulated M1 phenotype in iPLA2β−/− macrophages, but none tested promoted M2 phenotype. These findings suggest that (a) lipids generated by iPLA2β and subsequently oxidized by cyclooxygenase and 12-LO favor macrophage inflammatory M1 polarization, and (b) the absence of iPLA2β promotes macrophage M2 polarization. Reducing macrophage iPLA2β activity and thereby attenuating macrophage M1 polarization might cause a shift from an inflammatory to a recovery/repair milieu

Maternal thyroid function and child educational attainment: prospective cohort study

Objective: To determine if first trimester maternal thyroid dysfunction is a critical determinant of child scholastic performance and overall educational attainment. Design: Prospective cohort study. Setting: Avon Longitudinal Study of Parents and Children cohort in the UK. Participants: 4615 mother-child pairs with an available first trimester sample (median 10 weeks gestation, interquartile range 8-12). Exposures: Free thyroxine, thyroid stimulating hormone, and thyroid peroxidase antibodies assessed as continuous measures and the seven clinical categories of maternal thyroid function. Main outcome measures: Five age-specific national curriculum assessments in 3580 children at entry stage assessment at 54 months, increasing up to 4461 children at their final school assessment at age 15. Results: No strong evidence of clinically meaningful associations of first trimester free thyroxine and thyroid stimulating hormone levels with entry stage assessment score or Standard Assessment Test scores at any of the key stages was found. Associations of maternal free thyroxine or thyroid stimulating hormone with the total number of General Certificates of Secondary Education (GCSEs) passed (range 0-16) were all close to the null: free thyroxine, rate ratio per pmol/L 1.00 (95% confidence interval 1.00 to 1.01); and thyroid stimulating hormone, rate ratio 0.98 (0.94 to 1.02). No important relationship was observed when more detailed capped scores of GCSEs allowing for both the number and grade of pass or when language, mathematics, and science performance were examined individually or when all educational assessments undertaken by an individual from school entry to leaving were considered. 200 (4.3%) mothers were newly identified as having hypothyroidism or subclinical hypothyroidism and 97 (2.1%) subclinical hyperthyroidism or hyperthyroidism. Children of mothers with thyroid dysfunction attained an equivalent number of GCSEs and equivalent grades as children of mothers with euthyroidism. Conclusions: Maternal thyroid dysfunction in early pregnancy does not have a clinically important association with impaired child performance at school or educational achievement