Correlations of CO2 levels

This project looks at the correlation between CO2 levels and human influences as well as the correlation between CO2 levels and global temperatures

Hour-level Resolution on Consumption Pattern of Substance Abuse

Conventional survey-based approaches of determining the consumption statistics of drugs in communities are suffered from non-response biases, and typically underestimate the actual consumption. Time and cost-intensive conventional approaches, therefore, can’t be utilized to determine high-resolution temporal variability in drug consumption. In this study, the temporal trend of consumption of 10 illicit and 26 prescribed neuropsychiatric drugs was determined at hour-level resolution utilizing wastewater-based epidemiology. The hourly composite raw wastewater (every 10 minutes) samples were collected for three consecutive days in a typical week (total of 72 samples), analyzed for target drug residues using UPLC-MS/MS, and back-calculated the consumption rate of drugs in a community. Typical 24 h-composite samples and grab samples were also analyzed and compared to the hourly composite samples. Time-sensitive consumption pattern of drugs can be critical information for authorities to combat drug abuse and addiction

Leslie Matrices and Women Population in the United States of America

This research tests the accuracy of the Leslie matrix, which is a discrete age-structured method that uses fertility and survival rates, as a tool for predicting women population. Based on available data for the year 2000, we have constructed a Leslie matrix that predicts female population in the United States for every five years from the years 2000 to 2020. To test the accuracy of this method, we compare the aforementioned obtained projected data for the year 2010 with the actual data for women population in the United States obtained by the 2010 U.S. Census

Antifungal activity of novel compound EIPE-1 against Cryptococcus neoformans

Cryptococcus neoformans is an opportunistic fungal pathogen of the respiratory tract, which is responsible for over 200,000 deaths annually. Antifungal drugs have been used to treat fungal infections for many decades; however, due to similarities between fungal and mammalian cells, these drugs are often toxic. In these last few decades, the fungi have also become resistant to the antifungal drugs. EIPE-1 was synthesized from vanillin, and was shown to have activity against methicillin resistant S. aureus (MRSA), and other gram-positive bacterial pathogens. We hypothesized that EIPE-1 could be used to kill fungal pathogens. For this study, we tested EIPE-1 against C. neoformans using a minimum inhibitory concentration (MIC) assay and an in vitro model of intracellular macrophage growth using RAW macrophages. EIPE-1 has antifungal activity in our MIC assay, with an MIC value of 1.749 ug/ml. In addition, after incubation of C. neoformans with RAW macrophages and EIPE-1, treatment with EIPE-1 had significant antifungal effects on C. neoformans compared to C. neoformans alone and compared to C. neoformans with RAW macrophages. In further studies, we will examine the mechanism of EIPE-1 anti-fungal activity, and we will also test EIPE-1 against other fungal pathogens including Candida albicans.Oklahoma Louis Stokes Alliance for Minority Participation ProgramNational Science Foundation (U.S.)Oklahoma State University. StartupCowboy TechnologiesMicrobiology and Molecular GeneticsChemistr

Exploration of Grit and Emotional Intelligence and Success in a Doctor of Physical Therapy Program

Background: Higher education programs that admit students to sequential curricula incur a substantial financial loss when an enrolled student fails to continue in the program for whatever reason. In many instances, the seat cannot be filled, and valuable tuition dollars often over $90,000 per student is lost to the institution. In addition to financial loss, Doctor of Physical Therapy (DPT) programs are required to report and explain rates to the Commission for Accreditation of Physical Therapy Education (CAPTE). Admission committees at Doctor of Physical Therapy programs seek candidates that will be successful in the program and pass the National Physical Therapy Examination (NPTE). Purpose: The purpose of this study was to explore relationships of non-cognitive characteristics (grit and emotional intelligence) and Grade Point Average (GPA) in the first year of a DPT program with the intent to potentially identify students who might benefit from remediation/intervention to prevent attrition. Methods: Forty-two students in the first year of a Doctor of Physical Therapy program completed the Grit scale and the Mayers-Salovey Emotional Intelligence test early in the fall semester of year one. Results: There were no significant relationships between grit or emotional intelligence and academic success in the first year of a DPT program. Conclusions: The current study provides preliminary information related to non-cognitive factors of grit and emotional intelligence and success in a Doctor of Physical Therapy program

Calcification of the Planktonic Foraminiferaglobigerinabulloidesand Carbonate Ion Concentration Resultsfrom the Santa Barbara Basin

Planktonic foraminiferal calcification intensity, reflected by shell wall thickness, has been hypothesized to covary with the carbonate chemistry of seawater. Here we use both sediment trap and box core samples from the Santa Barbara Basin to evaluate the relationship between the calcification intensity of the planktonic foraminifera species Globigerina bulloides, measured by area density (µg/µm2), and the carbonate ion concentration of seawater ([CO32−]). We also evaluate the influence of both temperature and nutrient concentration ([PO43−]) on foraminiferal calcification and growth. The presence of two G. bulloides morphospecies with systematically different calcification properties and offset stable isotopic compositions was identified within sampling populations using distinguishing morphometric characteristics. The calcification temperature and by extension calcification depth of the more abundant “normal” G. bulloides morphospecies was determined using δ18O temperature estimates. Calcification depths vary seasonally with upwelling and were used to select the appropriate [CO32−], temperature, and [PO43−] depth measurements for comparison with area density. Seasonal upwelling in the study region also results in collinearity between independent variables complicating a straightforward statistical analysis. To address this issue, we use additional statistical diagnostics and a down core record to disentangle the respective roles of each parameter on G. bulloides calcification. Our results indicate that [CO32−] is the primary variable controlling calcification intensity while temperature influences shell size. We report a modern calibration for the normal G. bulloides morphospecies that can be used in down core studies of well‐preserved sediments to estimate past [CO32−]

Impact of Metazooplankton Filter Feeding on \u3ci\u3eEscherichia coli\u3c/i\u3e under Variable Environmental Conditions

The fecal indicator bacterial species Escherichia coli is an important measure of water quality and a leading cause of impaired surface waters. We investigated the impact of the filter-feeding metazooplankton Daphnia magna on the inactivation of E. coli. The E. coli clearance rates of these daphnids were calculated from a series of batch experiments conducted under variable environmental conditions. Batch system experiments of 24 to 48 h in duration were completed to test the impacts of bacterial concentration, organism density, temperature, and water type. The maximum clearance rate for adult D. magna organisms was 2 ml h1 organism1. Less than 5% of E. coli removed from water by daphnids was recoverable from excretions. Sorption of E. coli on daphnid carapaces was not observed. As a comparison, the clearance rates of the freshwater rotifer Branchionus calyciflorus were also calculated for select conditions. The maximum clearance rate for B. calyciflorus was 6 104 ml h1 organism1. This research furthers our understanding of the impacts of metazooplankton predation on E. coli inactivation and the effects of environmental variables on filter feeding. Based on our results, metazooplankton can play an important role in the reduction of E. coli in natural treatment systems under environmentally relevant condition

Brain arteriolosclerosis

Brain arteriolosclerosis (B-ASC), characterized by pathologic arteriolar wall thickening, is a common finding at autopsy in aged persons and is associated with cognitive impairment. Hypertension and diabetes are widely recognized as risk factors for B-ASC. Recent research indicates other and more complex risk factors and pathogenetic mechanisms. Here we describe aspects of the unique architecture of brain arterioles, histomorphologic features of B-ASC, relevant neuroimaging findings, epidemiology and association with aging, established genetic risk factors, and the co-occurrence of B-ASC with other neuropathologic conditions such as Alzheimer’s disease and limbic-predominant age-related TDP-43 encephalopathy (LATE). There may also be complex physiologic interactions between metabolic syndrome (e.g. hypertension and inflammation) and brain arteriolar pathology. Although there is no universally applied diagnostic methodology, several classification schemes and neuroimaging techniques are used to diagnose and categorize cerebral small vessel disease pathologies that include B-ASC, microinfarcts, microbleeds, lacunar infarcts, and cerebral amyloid angiopathy (CAA). In clinical-pathologic studies that include consideration of comorbid diseases, B-ASC is independently associated with impairments in global cognition, episodic memory, working memory, and perceptual speed, and has been linked to autonomic dysfunction and motor symptoms including parkinsonism. We conclude by discussing critical knowledge gaps related to B-ASC and suggest that there are probably subcategories of B-ASC that differ in pathogenesis. Observed in over 80% of autopsied individuals beyond 80 years of age, B-ASC is a complex and under-studied contributor to neurologic disability

Model Lessons to Use With The Student Atlas of Oregon

Model lessons for teachers to use with The Student Atlas of Oregon.https://pdxscholar.library.pdx.edu/geographyed_instructional/1001/thumbnail.jp