305 research outputs found

    The importance of subclasses of chitin synthase enzymes with myosin-like domains for the fitness of fungi

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    Acknowledgements TG and CF are funded by FEDER funds through the Operational Programme Competitiveness Factors – COMPETE and national funds by FCT – Foundation for Science and Technology under the strategic project UID/NEU/04539/2013. C.F. is a recipient of a postdoctoral fellowship from FCT-Fundação para a CiΓͺncia e Tecnologia (SFRH/BPD/63733/2009). NG is funded by The Wellcome Trust (080088, 086827, 075470, 099215 & 097377), the FungiBrain Marie Curie Network and the Medical Research Council (UK).Peer reviewedPostprin

    Caspofungin Treatment of Aspergillus fumigatus Results in ChsG-Dependent Upregulation of Chitin Synthesis and the Formation of Chitin-Rich Microcolonies

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    Date of Acceptance: 23/07/2015 We thank Gillian Milne for help with electron microscopy, Sophie M. SchΓ€fer for pilot experiments, and Emilia Mellado for strains. All authors acknowledge financial support of Gilead Sciences through Ph.D. studentships for L.A.W. and K.K.L. We also acknowledge research grants from the Wellcome Trust (080088, 086827, 075470, 099215, and 097377) and the British Society for Antimicrobial Chemotherapy.Peer reviewedPublisher PD

    Dissection of the Candida albicans class I chitin synthase promoters

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    We acknowledge financial support from the Biotechnology and Biological Sciences Research Council (10161), Medical Research Council (New Investigator Award to C.A.M.), the European Community FUNGALWALL and SIGNALPATH initiatives and the Wellcome Trust.Peer reviewedPublisher PD

    Macrophage Migration Is Impaired within Candida albicans Biofilms

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    Acknowledgments: We thank the Microscopy and Histology Core Facility at the University of Aberdeen. This work was funded by NHS Grampian Endowments (grant RG10191); the Wellcome Trust Strategic Award in Medical Mycology and Fungal Immunology (grant 097377); the Wellcome Trust Investigator award (grants 101873, 086827, 075470, & 200208) and the Medical Research Council Centre for Medical Mycology (grant MR/N006364/1).Peer reviewedPublisher PD

    Rab14 regulates the maturation of macrophage phagosomes containing the fungal pathogen Candida albicans and the outcome of the host-pathogen interaction

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    Date of Acceptance: 02/02/2015 Copyright Β© 2015, American Society for Microbiology. All Rights Reserved.Peer reviewedPublisher PD

    Metabolism impacts upon Candida immunogenicity and pathogenicity at multiple levels

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    Copyright Β© 2014 The Authors. Published by Elsevier Ltd.. All rights reserved. Open Access funded by Wellcome TrustNon peer reviewedPublisher PD

    Titan cell production in Cryptococcus neoformans reshapes the cell wall and capsule composition during infection

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    This work was supported by the National Institutes of Health (R01AI080275 and R21AI22352), the NIH Fogarty International Center (R25TW009345), the University of Minnesota Center for Translational Science Institute (UL1TR000114), Wellcome Trust (086827, 075470, 097377, 101873 & 200208) and MRC Centre for Medical Mycology (N006364/1). The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.Peer reviewedPublisher PD
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