From ductile to brittle, late- to post-orogenic evolution of the Betic Cordillera: Structural insights from the northeastern Internal zones

International audienceRelations between Alpine detachment-bounded metamorphic domes, crustal-scale strike-slip fault zones and sedimentary basins in the Internal zones of the Betic cordillera are still matter of debate. Current tectonic interpretations of these basins vary from late-orogenic extensional structures to compressional ones associated with strike-slip motions along major still active faults. Structural investigations including new field mapping, meso-scale faults recognition, palaeostress analysis of brittle small-scale faults systems were performed in the sedimentary cover of the Almanzora corridor and the Huércal-Overa basins, located either in the hanging wall unit of the Filabres extensional shear zone or at the termination of the Alhama de Murcia sinistral fault zone. In parallel, a detailed study of the ductile and the ductile-brittle deformation was carried out in the footwall unit of the Filabres extensional shear zone, in the Nevado-Fílabride complex. Three main brittle events were recognised in the basin cover including two extensional events that occurred prior to a weak tectonic inversion of the basin during a third, still active event. The first one, D1b is characterized by the development a first stress regime consistent with ~NW-SE extensional tectonics. Besides, the consistency between the latest ductile and the brittle kinematics for the Filabres extensional shear zone and the activity of meso-scale fault systems that primarily control the main SW-NE depocentres allow concluding to a top-to-the-NW continuum of strain during the final exhumation of the Nevado-Filábride complex. The resulting overall half-graben architecture of the basins is then related to the combination of the formation of the metamorphic domes that added a local control superimposed on the regional deformation. Indeed, after a consistent top-to-the-west shearing prevailing during most of the Nevado-Filábride exhumation, final exhumation stages were in turn, characterised by important kinematics changes with a subordinate top-to-the-NW sense of shear (D1b). The onset of sedimentation in the basins occurred shortly after the crossing of the ductile-brittle transition in the underlying metamorphic domes at ca. 14 Ma into SW-NE fault-bounded troughs. Tectonic subsidence was then maintained during D2b while extensional kinematics changed to N-S or even locally to SSW-NNE. Extensional tectonics then lasted most of the Tortonian during the final tectonic denudation increments of the Sierra de los Filabres achieved at ca. 9-8 Ma. Intramontane basins are therefore genuinely extensional and clearly related to the latest exhumation stages of the Nevado-Filábride complex in the back-arc domain. Conversely, at ca. 8 Ma, basins started to record a ~N-S to NNW-SSE compressional stress regime (D3b) and ceased to be active depocentres while shortening within the Internal zones then recorded only the Iberia/Africa convergence. The weak inversion of the basins however resulted either in the reactivation of originally extensional faults such as the Alhama de Murcia fault or the basin individualisation and a progressive water exchange reduction with the Atlantic ocean and is thus proposed to be directly responsible for the Late Miocene salinity crises

Illite crystallinity patterns in the Anti-Atlas of Morocco

The low-grade metamorphism of the sedimentary cover of the Moroccan Anti-Atlas is investigated using Illite crystallinity (IC) method. More than 200 samples from three key areas (southwestern, central and eastern Anti-Atlas) have been taken from a maximum of different stratigraphic levels and have been analysed. The metamorphism is of low to very low degree throughout the southern flank of the Anti-Atlas. It increases from northeast to southwest. Whereas in the eastern Anti-Atlas diagenetic and anchizonal IC-values are predominant, in the western and central Anti-Atlas also epizonal IC-values are found. In every respective area the IC improves with stratigraphic age. At the scale of the entire Palaeozoic Anti-Atlas basin the IC correlates best with estimated paleo-overburden. However, burial metamorphism cannot be the cause even though considering missing sedimentary pile of Late Carboniferous age. The ‘abnormal' paleo-geothermal gradient of 43-35 °C/km we evidenced for the Carboniferous is a true one, and has to be related to a basement sequence enriched in heat producing elements such as series of the West African Crato

Thermal structure and metamorphic evolution of the Piemont-Ligurian metasediments in the northern Western Alps

In the Western Alps, the Piemont-Ligurian oceanic domain records blueschist to eclogite metamorphic conditions during the Alpine orogeny. This domain is classically divided into two "zones” (Combin and Zermatt-Saas), with contrasting metamorphic evolution, and separated tectonically by the Combin fault. This study presents new metamorphic and temperature (RSCM thermometry) data obtained in Piemont-Ligurian metasediments and proposes a reevaluation of the P-T evolution of this domain. In the upper unit (or "Combin zone”) temperatures are in the range of 420-530°C, with an increase of temperature from upper to lower structural levels. Petrological evidences show that these temperatures are related to the retrograde path and to deformation at greenschist metamorphic conditions. This highlights heating during exhumation of HP metamorphic rocks. In the lower unit (or "Zermatt-Saas zone”), temperatures are very homogeneous in the range of 500-540°C. This shows almost continuous downward temperature increase in the Piemont-Ligurian domain. The observed thermal structure is interpreted as the result of the upper and lower unit juxtaposition along shear zones at a temperature of ~500°C during the Middle Eocene. This juxtaposition probably occurred at shallow crustal levels (~15-20km) within a subduction channel. We finally propose that the Piemont-Ligurian Domain should not be viewed as two distinct "zones”, but rather as a stack of several tectonic slice

A genetic validation study reveals a role of vitamin D metabolism in the response to interferon-alfa-based therapy of chronic hepatitis C

Background: To perform a comprehensive study on the relationship between vitamin D metabolism and the response to interferon-α-based therapy of chronic hepatitis C. Methodology/Principal Findings: Associations between a functionally relevant polymorphism in the gene encoding the vitamin D 1α-hydroxylase (CYP27B1-1260 rs10877012) and the response to treatment with pegylated interferon-α (PEG-IFN-α) and ribavirin were determined in 701 patients with chronic hepatitis C. In addition, associations between serum concentrations of 25-hydroxyvitamin D3 (25[OH]D3) and treatment outcome were analysed. CYP27B1-1260 rs10877012 was found to be an independent predictor of sustained virologic response (SVR) in patients with poor-response IL28B genotypes (15% difference in SVR for rs10877012 genotype AA vs. CC, p = 0.02, OR = 1.52, 95% CI = 1.061–2.188), but not in patients with favourable IL28B genotype. Patients with chronic hepatitis C showed a high prevalence of vitamin D insufficiency (25[OH]D3<20 ng/mL) during all seasons, but 25(OH)D3 serum levels were not associated with treatment outcome. Conclusions/Significance: Our study suggests a role of bioactive vitamin D (1,25[OH]2D3, calcitriol) in the response to treatment of chronic hepatitis C. However, serum concentration of the calcitriol precursor 25(OH)D3 is not a suitable predictor of treatment outcome

Mir-21 Suppression Promotes Mouse Hepatocarcinogenesis.

The microRNA 21 (miR-21) is upregulated in almost all known human cancers and is considered a highly potent oncogene and potential therapeutic target for cancer treatment. In the liver, miR-21 was reported to promote hepatic steatosis and inflammation, but whether miR-21 also drives hepatocarcinogenesis remains poorly investigated in vivo. Here we show using both carcinogen (Diethylnitrosamine, DEN) or genetically (PTEN deficiency)-induced mouse models of hepatocellular carcinoma (HCC), total or hepatocyte-specific genetic deletion of this microRNA fosters HCC development-contrasting the expected oncogenic role of miR-21. Gene and protein expression analyses of mouse liver tissues further indicate that total or hepatocyte-specific miR-21 deficiency is associated with an increased expression of oncogenes such as Cdc25a, subtle deregulations of the MAPK, HiPPO, and STAT3 signaling pathways, as well as alterations of the inflammatory/immune anti-tumoral responses in the liver. Together, our data show that miR-21 deficiency promotes a pro-tumoral microenvironment, which over time fosters HCC development via pleiotropic and complex mechanisms. These results question the current dogma of miR-21 being a potent oncomiR in the liver and call for cautiousness when considering miR-21 inhibition for therapeutic purposes in HCC

Elementos de filosofía

Sign.: []2, 1-504.La secuencia de la sign. tipografica de los cuadernos se expresa en números arábigos seguido del exponente correspondiente

Elementos de filosofía

Sign.: []2, [asterisco]4, 2[asterisco]2, 1-574.La secuencia de la sign. tipografica de los cuadernos se expresa en números arábigos seguido del exponente correspondiente.Las h. de grab. calc.: "Cipriano Maré lo grabo à de 1795", representan figuras de física