Association of Type 1 Diabetes vs Type 2 Diabetes Diagnosed During Childhood and Adolescence With Complications During Teenage Years and Young Adulthood

The burden and determinants of complications and comorbidities in contemporary youth-onset diabetes are unknown

The James Webb Space Telescope Mission

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figure

The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance

INTRODUCTION Investment in Africa over the past year with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing has led to a massive increase in the number of sequences, which, to date, exceeds 100,000 sequences generated to track the pandemic on the continent. These sequences have profoundly affected how public health officials in Africa have navigated the COVID-19 pandemic. RATIONALE We demonstrate how the first 100,000 SARS-CoV-2 sequences from Africa have helped monitor the epidemic on the continent, how genomic surveillance expanded over the course of the pandemic, and how we adapted our sequencing methods to deal with an evolving virus. Finally, we also examine how viral lineages have spread across the continent in a phylogeographic framework to gain insights into the underlying temporal and spatial transmission dynamics for several variants of concern (VOCs). RESULTS Our results indicate that the number of countries in Africa that can sequence the virus within their own borders is growing and that this is coupled with a shorter turnaround time from the time of sampling to sequence submission. Ongoing evolution necessitated the continual updating of primer sets, and, as a result, eight primer sets were designed in tandem with viral evolution and used to ensure effective sequencing of the virus. The pandemic unfolded through multiple waves of infection that were each driven by distinct genetic lineages, with B.1-like ancestral strains associated with the first pandemic wave of infections in 2020. Successive waves on the continent were fueled by different VOCs, with Alpha and Beta cocirculating in distinct spatial patterns during the second wave and Delta and Omicron affecting the whole continent during the third and fourth waves, respectively. Phylogeographic reconstruction points toward distinct differences in viral importation and exportation patterns associated with the Alpha, Beta, Delta, and Omicron variants and subvariants, when considering both Africa versus the rest of the world and viral dissemination within the continent. Our epidemiological and phylogenetic inferences therefore underscore the heterogeneous nature of the pandemic on the continent and highlight key insights and challenges, for instance, recognizing the limitations of low testing proportions. We also highlight the early warning capacity that genomic surveillance in Africa has had for the rest of the world with the detection of new lineages and variants, the most recent being the characterization of various Omicron subvariants. CONCLUSION Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve. This is important not only to help combat SARS-CoV-2 on the continent but also because it can be used as a platform to help address the many emerging and reemerging infectious disease threats in Africa. In particular, capacity building for local sequencing within countries or within the continent should be prioritized because this is generally associated with shorter turnaround times, providing the most benefit to local public health authorities tasked with pandemic response and mitigation and allowing for the fastest reaction to localized outbreaks. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century

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This is a pre-registration poster for the 2022 XPRAG conference in Pavia, IT</p

Graphics, Visualization, and Usability Center

Graphics, Visualization, and Usability (GVU) is an interdisciplinary area which draws its intellectual foundations from Computer Science, Psychology, Industrial and Systems Engineering, and Computer Engineering, and which has application to any use of computers to graphically convey information to users. Typical applications are computer aided design, scientific and business data visualization, multimedia, computer-supported cooperative work, computer-based teaching, image understanding, medical imaging, and user interface design. The GVU Center has three missions: education, service, and research. In our educational role, we teach the principles and methods of computer graphics, visualization, and usability to members of the academic community ranging from undergraduate students to graduate students and faculty. Center members teach dozens of courses and seminars among the wide offering of relevant courses listed in Section F. A set of continuing education short courses (Section G) are provided to assist practitioners to stay abreast of current developments. Our service mission is carried out through the Scientific Visualization Lab, a joint undertaking with Information Technology (the campus-wide computer service), to provide state of the art computer graphics hardware and software capabilities to the entire Georgia Tech Community. Over 150 faculty, graduate students and staff use the visualization lab's facilities. Our research, described in Section B, spans the areas of realistic imagery, computer-supported collaborative work, algorithm animation, medical imaging, image understanding, scientific data visualization, animation, user interface software, usability, adaptive user interfaces, multimedia, stereo graphics, virtual environments, image quality, and expert systems in graphics and user interfaces. The twenty faculty and staff who are actively developing the lab's programs are drawn from Psychology, Mechanical Engineering, Office of Interdisciplinary Programs, Physics, Mathematics, Information Technology, and the College of Computing. An active seminar series and brown-bag lunches brings us together every week to discuss current research topics. By integrating these three missions together in a single unit, the Center is developing a highly interactive and collaborative environment where researchers unfamiliar with computer graphics can come for help in integrating scientific visualization into their research work, graphics experts and graduate students can share thier knowledge with one another and find new and interesting problems on which to work, and students can learn in a melting pot of closely-related ideas and collaborations between researchers from multiple disciplines. This intellectually-stimulating environment, complemented by over 40 workstations and other pieces of equipment and over 3000 square feet of newly-renovated lab space, provides a paradigm for the use of interactive computer graphics systems which will be necessary for engineering and scientific research in the 21st century

Acoustic regularities in infant-directed speech and song across cultures

National audienceWhen interacting with infants, humans often alter their speech and song in ways thought to support communication. Theories of human child-rearing, informed by data on vocal signalling across species, predict that such alterations should appear globally. Here, we show acoustic differences between infant-directed and adult-directed vocalizations across cultures. We collected 1,615 recordings of infant- and adult-directed speech and song produced by 410 people in 21 urban, rural and small-scale societies. Infant-directedness was reliably classified from acoustic features only, with acoustic profiles of infant-directedness differing across language and music but in consistent fashions. We then studied listener sensitivity to these acoustic features. We played the recordings to 51,065 people from 187 countries, recruited via an English-language website, who guessed whether each vocalization was infant-directed. Their intuitions were more accurate than chance, predictable in part by common sets of acoustic features and robust to the effects of linguistic relatedness between vocalizer and listener. These findings inform hypotheses of the psychological functions and evolution of human communication