The BIOSIS data base: Evaluation of its indexes and the STRATBLDR, CHEMFILE, STAIRS and DIALOG systems for on-line searching

An IBM-developed program, STAIRS, was selected for performing a search on the BIOSIS file. The evaluation of the hardware and search systems and the strategies used are discussed. The searches are analyzed by type of end user

A unified approach to mapping and clustering of bibliometric networks

In the analysis of bibliometric networks, researchers often use mapping and clustering techniques in a combined fashion. Typically, however, mapping and clustering techniques that are used together rely on very different ideas and assumptions. We propose a unified approach to mapping and clustering of bibliometric networks. We show that the VOS mapping technique and a weighted and parameterized variant of modularity-based clustering can both be derived from the same underlying principle. We illustrate our proposed approach by producing a combined mapping and clustering of the most frequently cited publications that appeared in the field of information science in the period 1999-2008

Radiation back-reaction in relativistically strong and QED-strong laser fields

The emission from an electron in the field of a relativistically strong laser pulse is analyzed. At the pulse intensities of \ge 10^{22} W/cm^2 the emission from counter-propagating electrons is modified by the effects of Quantum ElectroDynamics (QED), as long as the electron energy is sufficiently high: E \ge 1 GeV. The radiation force experienced by an electron is for the first time derived from the QED principles and its applicability range is extended towards the QED-strong fields.Comment: 4 pages, 4 figure

Emission and its back-reaction accompanying electron motion in relativistically strong and QED-strong pulsed laser fields

The emission from an electron in the field of a relativistically strong laser pulse is analyzed. At pulse intensities of J > 2 10^22 W/cm2 the emission from counter-propagating electrons is modified by the effects of Quantum ElectroDynamics (QED), as long as the electron energy is sufficiently high: E > 1 GeV. The radiation force experienced by an electron is for the first time derived from the QED principles and its applicability range is extended towards the QED-strong fields.Comment: 14 pages, 5 figures. Submitted to Phys.Rev.

Frizzled-8 integrates Wnt-11 and transforming growth factor-β signaling in prostate cancer

Wnt-11 promotes cancer cell migration and invasion independently of β-catenin but the receptors involved remain unknown. Here, we provide evidence that FZD8 is a major Wnt-11 receptor in prostate cancer that integrates Wnt-11 and TGF-β signals to promote EMT. FZD8 mRNA is upregulated in multiple prostate cancer datasets and in metastatic cancer cell lines in vitro and in vivo. Analysis of patient samples reveals increased levels of FZD8 in cancer, correlating with Wnt-11. FZD8 co-localizes and co-immunoprecipitates with Wnt-11 and potentiates Wnt-11 activation of ATF2-dependent transcription. FZD8 silencing reduces prostate cancer cell migration, invasion, three-dimensional (3D) organotypic cell growth, expression of EMT-related genes, and TGF-β/Smad-dependent signaling. Mechanistically, FZD8 forms a TGF-β-regulated complex with TGF-β receptors that is mediated by the extracellular domains of FZD8 and TGFBR1. Targeting FZD8 may therefore inhibit aberrant activation of both Wnt and TGF-β signals in prostate cancer

Citation analysis may severely underestimate the impact of clinical research as compared to basic research

Background: Citation analysis has become an important tool for research performance assessment in the medical sciences. However, different areas of medical research may have considerably different citation practices, even within the same medical field. Because of this, it is unclear to what extent citation-based bibliometric indicators allow for valid comparisons between research units active in different areas of medical research. Methodology: A visualization methodology is introduced that reveals differences in citation practices between medical research areas. The methodology extracts terms from the titles and abstracts of a large collection of publications and uses these terms to visualize the structure of a medical field and to indicate how research areas within this field differ from each other in their average citation impact. Results: Visualizations are provided for 32 medical fields, defined based on journal subject categories in the Web of Science database. The analysis focuses on three fields. In each of these fields, there turn out to be large differences in citation practices between research areas. Low-impact research areas tend to focus on clinical intervention research, while high-impact research areas are often more oriented on basic and diagnostic research. Conclusions: Popular bibliometric indicators, such as the h-index and the impact factor, do not correct for differences in citation practices between medical fields. These indicators therefore cannot be used to make accurate between-field comparisons. More sophisticated bibliometric indicators do correct for field differences but still fail to take into account within-field heterogeneity in citation practices. As a consequence, the citation impact of clinical intervention research may be substantially underestimated in comparison with basic and diagnostic research

Relativistic attosecond physics

A study, with particle-in-cell simulations, of relativistic nonlinear optics in the regime of tight focus and ultrashort pulse duration (the λ3λ3 regime) reveals that synchronized attosecond electromagnetic pulses [N. M. Naumova, J. A. Nees, I. V. Sokolov, B. Hou, and G. A. Mourou, Phys. Rev. Lett. 92, 063902 (2004)] and attosecond electron bunches [N. Naumova, I. Sokolov, J. Nees, A. Maksimchuk, V. Yanovsky, and G. Mourou, Phys. Rev. Lett. 93, 195003 (2004)] emerge efficiently from laser interaction with overdense plasmas. The λ3λ3 concept enables a more basic understanding and a more practical implementation of these phenomena because it provides spatial and temporal isolation. The synchronous generation of strong attosecond electromagnetic pulses and dense attosecond electron bunches provides a basis for relativistic attosecond optoelectronics.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/87762/2/056707_1.pd