687 research outputs found
The BIOSIS data base: Evaluation of its indexes and the STRATBLDR, CHEMFILE, STAIRS and DIALOG systems for on-line searching
An IBM-developed program, STAIRS, was selected for performing a search on the BIOSIS file. The evaluation of the hardware and search systems and the strategies used are discussed. The searches are analyzed by type of end user
A unified approach to mapping and clustering of bibliometric networks
In the analysis of bibliometric networks, researchers often use mapping and
clustering techniques in a combined fashion. Typically, however, mapping and
clustering techniques that are used together rely on very different ideas and
assumptions. We propose a unified approach to mapping and clustering of
bibliometric networks. We show that the VOS mapping technique and a weighted
and parameterized variant of modularity-based clustering can both be derived
from the same underlying principle. We illustrate our proposed approach by
producing a combined mapping and clustering of the most frequently cited
publications that appeared in the field of information science in the period
1999-2008
Radiation back-reaction in relativistically strong and QED-strong laser fields
The emission from an electron in the field of a relativistically strong laser
pulse is analyzed. At the pulse intensities of \ge 10^{22} W/cm^2 the emission
from counter-propagating electrons is modified by the effects of Quantum
ElectroDynamics (QED), as long as the electron energy is sufficiently high: E
\ge 1 GeV. The radiation force experienced by an electron is for the first time
derived from the QED principles and its applicability range is extended towards
the QED-strong fields.Comment: 4 pages, 4 figure
Emission and its back-reaction accompanying electron motion in relativistically strong and QED-strong pulsed laser fields
The emission from an electron in the field of a relativistically strong laser
pulse is analyzed. At pulse intensities of J > 2 10^22 W/cm2 the emission from
counter-propagating electrons is modified by the effects of Quantum
ElectroDynamics (QED), as long as the electron energy is sufficiently high: E >
1 GeV. The radiation force experienced by an electron is for the first time
derived from the QED principles and its applicability range is extended towards
the QED-strong fields.Comment: 14 pages, 5 figures. Submitted to Phys.Rev.
Frizzled-8 integrates Wnt-11 and transforming growth factor-β signaling in prostate cancer
Wnt-11 promotes cancer cell migration and invasion independently of β-catenin but the receptors involved remain unknown. Here, we provide evidence that FZD8 is a major Wnt-11 receptor in prostate cancer that integrates Wnt-11 and TGF-β signals to promote EMT. FZD8 mRNA is upregulated in multiple prostate cancer datasets and in metastatic cancer cell lines in vitro and in vivo. Analysis of patient samples reveals increased levels of FZD8 in cancer, correlating with Wnt-11. FZD8 co-localizes and co-immunoprecipitates with Wnt-11 and potentiates Wnt-11 activation of ATF2-dependent transcription. FZD8 silencing reduces prostate cancer cell migration, invasion, three-dimensional (3D) organotypic cell growth, expression of EMT-related genes, and TGF-β/Smad-dependent signaling. Mechanistically, FZD8 forms a TGF-β-regulated complex with TGF-β receptors that is mediated by the extracellular domains of FZD8 and TGFBR1. Targeting FZD8 may therefore inhibit aberrant activation of both Wnt and TGF-β signals in prostate cancer
Inhibition of PAF-induced aggregation of human PMNs and platelets by adenosine: in vitro investigations using a newly developed blood filtration system
Citation analysis may severely underestimate the impact of clinical research as compared to basic research
Background: Citation analysis has become an important tool for research
performance assessment in the medical sciences. However, different areas of
medical research may have considerably different citation practices, even
within the same medical field. Because of this, it is unclear to what extent
citation-based bibliometric indicators allow for valid comparisons between
research units active in different areas of medical research.
Methodology: A visualization methodology is introduced that reveals
differences in citation practices between medical research areas. The
methodology extracts terms from the titles and abstracts of a large collection
of publications and uses these terms to visualize the structure of a medical
field and to indicate how research areas within this field differ from each
other in their average citation impact.
Results: Visualizations are provided for 32 medical fields, defined based on
journal subject categories in the Web of Science database. The analysis focuses
on three fields. In each of these fields, there turn out to be large
differences in citation practices between research areas. Low-impact research
areas tend to focus on clinical intervention research, while high-impact
research areas are often more oriented on basic and diagnostic research.
Conclusions: Popular bibliometric indicators, such as the h-index and the
impact factor, do not correct for differences in citation practices between
medical fields. These indicators therefore cannot be used to make accurate
between-field comparisons. More sophisticated bibliometric indicators do
correct for field differences but still fail to take into account within-field
heterogeneity in citation practices. As a consequence, the citation impact of
clinical intervention research may be substantially underestimated in
comparison with basic and diagnostic research
Is energy excess the initial trigger of carbon overflow metabolism? Transcriptional network response of carbon-limited Escherichia coli to transient carbon excess
Relativistic attosecond physics
A study, with particle-in-cell simulations, of relativistic nonlinear optics in the regime of tight focus and ultrashort pulse duration (the λ3λ3 regime) reveals that synchronized attosecond electromagnetic pulses [N. M. Naumova, J. A. Nees, I. V. Sokolov, B. Hou, and G. A. Mourou, Phys. Rev. Lett. 92, 063902 (2004)] and attosecond electron bunches [N. Naumova, I. Sokolov, J. Nees, A. Maksimchuk, V. Yanovsky, and G. Mourou, Phys. Rev. Lett. 93, 195003 (2004)] emerge efficiently from laser interaction with overdense plasmas. The λ3λ3 concept enables a more basic understanding and a more practical implementation of these phenomena because it provides spatial and temporal isolation. The synchronous generation of strong attosecond electromagnetic pulses and dense attosecond electron bunches provides a basis for relativistic attosecond optoelectronics.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/87762/2/056707_1.pd
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