Insight on Effectiveness of Frequently Exercised PQ Classification Techniques

The growing demands of global consumer market in green energy system have opened the doors for many technologies as well as various sophisticated electrical devices for both commercial and domestic usage. However, with the increasing demands of energy and better quality of services, there is a significant increase in non-linearity in load distribution causing potential effect on the Power Quality (PQ). The harmful effects on PQ are various events e.g. sag, swell, harmonics etc that causes significant amount of system degradation. Therefore, this paper discusses various significant research techniques pertaining to the PQ disturbance classification system introduced by the authors in the past and analyzes its effectiveness scale in terms of research gap. The paper discusses some of the frequently exercised PQ classification techniques from the most relevant literatures in order to have more insights of the techniques

The mazEF toxin-antitoxin system as a novel antibacterial target in Acinetobacter baumannii

Although analysis of toxin-antitoxin (TA) systems can be instructive, to date, there is no information on the prevalence and identity of TA systems based on a large panel of Acinetobacter baumannii clinical isolates. The aim of the current study was to screen for functional TA systems among clinical isolates of A. baumannii and to identify the systems' locations. For this purpose, we screened 85 A. baumannii isolates collected from different clinical sources for the presence of the mazEF, relBE and higBA TA genes. The results revealed that the genes coding for the mazEF TA system were commonly present in all clinical isolates of A. baumannii. Reverse transcriptase-polymerase chain reaction analysis showed that transcripts were produced in the clinical isolates. Our findings showed that TA genes are prevalent, harboured by chromosomes and transcribed within A. baumannii. Hence, activation of the toxin proteins in the mazEF TA system should be investigated further as an effective antibacterial strategy against this bacterium

A Clinical Study on Siddha Diagnostic Methodology, Line of Treatment and Dietary Regimen of Urathapithavatham

Yugi has described a number of diseases in Siddha system of medicine. Urathapithavatham is one of the pitha diseases recited by this siddhar in his ‘Yugi Vaithiya Cinthamani’. The symptoms mentioned in Urathapithavatham may be correlated with those of Hypertension. In the Modern Medicine, Hypertension as a clinical entity really came into being in 1896 with the invention of the cuff-based sphygmomanometer by scipione Riva-Rocci, in 1896 which is only before 120 yrs. Whereas the siddhar Yugi has described the symptoms of the disease, now called as Hypertension, even before 10000 yrs. The author has taken Urathapithavatham (Hypertension) as her dissertation topic because hypertension is an “iceberg” disease. According to WHO, globally, the overall prevalence of raised blood pressure in adults aged 25 and over was around 40% in 2008. Worldwide, raised blood pressure is estimated to cause 7.5 million deaths, about 12.8% of the total of all deaths. Early diagnosis using Ennvagai Thervu and treatment in Siddha system would definitely help in preventing the mortality and morbidity due to complications of hypertension. The following page of this study contains detailed reports of the analysis that were made upon careful observation of the Siddha literature that elaborates various aspects of the disease. AIM : To conduct a study on Urathapithavatham and there by to document the symptoms and signs of Urathapithavatham using Siddha Diagnostic Methodology. OBJECTIVE : PRIMARY OBJECTIVE : To elucidate Siddha diagnostic methodology for causes and clinical methods in the Urathapithavatham. SECONDARY OBJECTIVE : • To collect literary evidences about Urathapithavatham. • To study the detailed etiological factors of Urathapithavatham. • To analyze the signs and symptoms of Urathapithavatham. • To find out the changes of Udal thathu and Uyir thathu. • To correlate the symptoms of Urathapithavatham with that of closely resembling conditions in modern medical literature. • To have an idea of incidence of the Urathapithavatham with reference to sex, age, habit. • To standardize the line of treatment for Urathapithavatham. • To recommend a dietary regimen for Urathapithavatham. CONCLUSION : The disease URATHAPITHAVATHAM was taken for my clinical study with reference in Yugi Vaithiya Cinthamani – 800. The study of Urathapithavatham was carried out in this dissertation giving importance to the changes in the Uyir thathukkal and Udal thathukkal. The changes in the Uyir thathukkal and Udal thathukkal were assessed by Siddha parameters like Ennvagai Thervu, Manikkadai Nool and Yakkai Ilakkanam. A paralleled modern diagnosis was derived through blood pressure monitoring and 40 cases were observed clinically in the outpatient division. From this study, the following data were concluded. • Maximum incidence of age was between 34 – 66 years ie. Pitha kaalam. • Males were affected more than females. • The aetiological factors like increased intake of salt, sour and pungent tastes in food, stress sleep deprivation and hot environment were strongly associated with the prevalence of the disease. • 100% of cases were from neithal nilam. • 100% were prone to anger, 62.5% had confusion, 62.5% had headache and 92.5% had insomnia. • Praanan, Samaanan and Devadhathan were affected in all the cases. • Ranjagam and Sathagam were affected in all the cases. • Tharpagam is affected in 67.5% of the cases. • This observational study reveals i. In Ennvagai Thervu, Naadi – 65% revealed Pithavatha naadi Neerkuri – 67.5% had pale yellow colour urine Neikkuri – 47.5% showed irregular pattern of spreading ii. In manikkadai nool 50% of the patients had 9 ¼ fbs iii. In Yakkai 57.5% were pithavatha thegi The symptoms of Urathapithavatham may be correlated with Hypertension in modern medium

Synergistic Positive Feedback Mechanisms Underlying Seizure Initiation

Investigations into seizure initiation, in recent years, have focused almost entirely upon alterations of interneuronal function, chloride homeostasis, and extracellular potassium levels. In contrast, little attention has been directed toward a possible role of dendritic plateau potentials in the actual ictogenic transition, despite a substantial literature dating back 40 years regarding its importance generally in epilepsy. Here, we argue that an increase in dendritic excitability, coordinated across the population of pyramidal cells, is a key stage in ictogenesis

Clinicoepidemiological study of fixed drug eruption in tertiary care hospital

Background: Adverse cutaneous drug reactions pose diagnostic difficulties due to a varied clinical manifestations and broad categories of causative agents. Fixed drug eruptions (FDE) are one of them. Present study aims i) to record various clinical features of FDE, their causative agents and ii) to study the pattern of morbidity in patients with FDE in a tertiary care hospital, Rajkot, Gujarat, India.Methods: The 88 patients with FDEs attending department of dermatology, venereology and leprosy at PDU govt. medical college and hospital, Rajkot, Gujarat from September 2018 to September 2020 were included after informed consent. After taking thorough history, complete blood count and biochemical tests were done. HIV testing was done in severe reactions with generalised involvement. Appropriate treatment was given with counselling regarding the offending drug for prevention of reaction in future.Results: The male patients were more affected than female patients with M: F ratio of 1.3:1. The most common age group affected was 21-30 years (22.7%). Antimicrobials were the most common offending drugs (43.2%). None of the patients were HIV reactive in our study. No mortality was reported in our study.Conclusions: The patterns of FDE and the causative drugs are remarkably different in our study. Knowledge of patterns and the causative agents helps in prevention of same reactions in future in patients

Comparison of Methods for Purification of DNA From Rice

Three techniques were employed to purify genomic DNA from deomstic rice (Oryza sativa L). Following extraction, the DNA was electrophoresed through agarose to determine its integrity. We determined that spooling yielded better quality, through lower quantity DNA than either of the other two techniques

Growth of TiO<SUB>2</SUB> nanoparticles in thermally evaporated fatty amine thin films by a method of ion entrapment

The synthesis of titania nanoparticles within thermally evaporated octadecylamine (ODA) thin films is described. Synthesis of the nanoparticles was achieved by electrostatically entrapping TiF62&#8722; ions in thin films of the fatty amine by a simple immersion technique followed by in-situ hydrolysis of the metal ions. Without any further heat treatment, it was observed that titania nanoparticles of the brookite polymorph were formed within the film. By this simple procedure, uniformly distributed fairly monodisperse titania nanoparticles of ca. 4 nm diameter were synthesized within the lipid matrix and investigated using a host of techniques

Investigating emotion regulation and social information processing as mechanisms linking adverse childhood experiences with psychosocial functioning in young swiss adults: the FACE epidemiological accelerated cohort study.

BACKGROUND Adverse childhood experiences increase the risk for psychological disorders and lower psychosocial functioning across the lifespan. However, less is known about the processes through which ACE are linked to multiple negative outcomes. The aim of the FACE epidemiological study is to investigate emotion regulation (emotional reactivity, perseverative thinking and self-efficacy for managing emotions) and social information processing (rejection sensitivity, interpretation biases and social understanding) as potential mechanisms linking adverse childhood experiences and psychosocial functioning in a large population sample of young adults. It is embedded in a larger project that also includes an ecological momentary assessment of emotion regulation and social information processing and informs the development and evaluation of an online self-help intervention for young adults with a history of ACE. METHODS The study plans to recruit 5000 young adults aged 18 to 21 from the German-speaking Swiss population. Addresses are provided by Swiss Federal Statistical Office and participants are invited by mail to complete a self-report online survey. If the targeted sample size will not be reached, a second additional sample will be recruited via educational facilities such as universities or teacher training colleges or military training schools. Three follow-ups are planned after 1 year, 2 years and 3 years, resulting in ages 18-24 being covered. The main exposure variable is self-reported adverse childhood experiences before the age of 18, measured at the baseline. Primary outcomes are psychosocial functioning across the study period. Secondary outcomes are social information processing, emotion regulation and health care service use. Statistical analyses include a range of latent variable models to identify patterns of adverse childhood experiences and patterns and trajectories of psychosocial adaptation. DISCUSSION The results will contribute to the understanding of the underlying mechanisms that link ACE with psychosocial functioning which is crucial for an improved insight into risk and resilience processes and for tailoring interventions. Furthermore, the identification of factors that facilitate or hinder service use among young adults with ACE informs healthcare policies and the provision of appropriate healthcare services. TRIAL REGISTRATION NUMBER NCT05122988. The study was reviewed and authorized by the ethical committee of Northwestern and Central Switzerland (BASEC number 2021-01204)

Humoral immune consequences of Staphylococcus aureus ST239-associated bacteremia

The humoral immune responses against 46 different staphylococcal antigens in 27 bacteremia patients infected by clonally related methicillin-resistant Staphylococcus aureus (MRSA) strains of a single sequence type (ST) 239 were investigated. A group of non-infected patients (n = 31) hospitalized for different reasons served as controls. All strains were confirmed as ST 239 by S. aureus and mecA-specific PCR, spa, and multi-locus sequence typing (MLST). In each bacteremia patient, a unique pattern of S. aureus antigen-specific immune responses after infection was observed. Antibody levels among bacteremia patients were significantly higher than controls for HlgB (P = 0.001), LukD (P = 0.009), LukF (P = 0.0001), SEA (P = 0.0001), SEB (P = 0.011), SEC (P = 0.010), SEQ (P = 0.049), IsaA (P = 0.043), IsdA (P = 0.038), IsdH (P = 0.01), SdrD (P = 0.001), SdrE (P = 0.046), EsxA (P = 0.0001), and SA0104 (P = 0.0001). On the other hand, the antibody levels were significantly higher among controls for SSL3 (P = 0.009), SSL9 (P = 0.002), and SSL10 (P = 0.007) when the IgG level on the day of infection was compared with that measured on the day of admission. Diversity was observed in the immune response against the antigens. However, a set of antigens (IsaA, IsdA, IsdH, SdrD, and HlgB) triggered a similar type of immune response in different individuals. We suggest that these antigens could be considered when developing a multi-component (passive) vaccine. SEA and/or its specific antibodies seem to play a critical role during ST239 MRSA bacteremia and SEA-targeted therapy may be a strategy to be considered