760 research outputs found
The Mechanics and Statistics of Active Matter
Active particles contain internal degrees of freedom with the ability to take
in and dissipate energy and, in the process, execute systematic movement.
Examples include all living organisms and their motile constituents such as
molecular motors. This article reviews recent progress in applying the
principles of nonequilibrium statistical mechanics and hydrodynamics to form a
systematic theory of the behaviour of collections of active particles -- active
matter -- with only minimal regard to microscopic details. A unified view of
the many kinds of active matter is presented, encompassing not only living
systems but inanimate analogues. Theory and experiment are discussed side by
side.Comment: This review is to appear in volume 1 of the Annual Review of
Condensed Matter Physics in July 2010 and is posted here with permission from
that journa
Validation of six years of SCIAMACHY carbon monoxide observations using MOZAIC CO profile measurements
This paper presents a validation study of SCanning Imaging Absorption SpectroMeter for Atmospheric CartograpHY (SCIAMACHY) carbon monoxide (CO) total column measurements from the Iterative Maximum Likelihood Method (IMLM) algorithm using vertically integrated profile aircraft measurements obtained within the MOZAIC project for the six year time period of 2003-2008. Overall we find a good agreement between SCIAMACHY and airborne measurements for both mean values also on a year-to-year basis as well as seasonal variations. Several locations show large biases that are attributed to local effects like orography and proximity of large emission sources. Differences were detected for individual years: 2003, 2004 and 2006 have larger biases than 2005, 2007 and 2008, which appear to be related to SCIAMACHY instrumental issues but require more research. Results from this study are consistent with, and complementary to, findings from a previous validation study using ground-based measurements (de Laat et al., 2010b). According to this study, the SCIAMACHY data, if individual measurements are of sufficient quality-good signal-to-noise, can be used to determine the spatial distribution and seasonal cycles of CO total columns over clean areas. Biases found over areas with strong emissions (Africa, China) could be explained by low sensitivity of the instrument in the boundary layer and users are recommended to avoid using the SCIAMACHY data while trying to quantify CO burden and/or retrieve CO emissions in such areas. © 2012 Author(s)
Enhanced reaction kinetics in biological cells
The cell cytoskeleton is a striking example of "active" medium driven
out-of-equilibrium by ATP hydrolysis. Such activity has been shown recently to
have a spectacular impact on the mechanical and rheological properties of the
cellular medium, as well as on its transport properties : a generic tracer
particle freely diffuses as in a standard equilibrium medium, but also
intermittently binds with random interaction times to motor proteins, which
perform active ballistic excursions along cytoskeletal filaments. Here, we
propose for the first time an analytical model of transport limited reactions
in active media, and show quantitatively how active transport can enhance
reactivity for large enough tracers like vesicles. We derive analytically the
average interaction time with motor proteins which optimizes the reaction rate,
and reveal remarkable universal features of the optimal configuration. We
discuss why active transport may be beneficial in various biological examples:
cell cytoskeleton, membranes and lamellipodia, and tubular structures like
axons.Comment: 10 pages, 2 figure
Dynamic concentration of motors in microtubule arrays
We present experimental and theoretical studies of the dynamics of molecular
motors in microtubule arrays and asters. By solving a convection-diffusion
equation we find that the density profile of motors in a two-dimensional aster
is characterized by continuously varying exponents. Simulations are used to
verify the assumptions of the continuum model. We observe the concentration
profiles of kinesin moving in quasi two-dimensional artificial asters by
fluorescent microscopy and compare with our theoretical results.Comment: 4pages, 4 figures revte
Validation of Aura Microwave Limb Sounder O-3 and CO observations in the upper troposphere and lower stratosphere
International audienceGlobal satellite observations of ozone and carbon monoxide from the Microwave Limb Sounder (MLS) on the EOS Aura spacecraft are discussed with emphasis on those observations in the 215–100 hPa region (the upper troposphere and lower stratosphere). The precision, resolution and accuracy of the data produced by the MLS “version 2.2” processing algorithms are discussed and quantified. O3 accuracy is estimated at ~40 ppbv +5% (~20 ppbv +20% at 215 hPa) while the CO accuracy is estimated at ~30 ppbv +30% for pressures of 147 hPa and less. Comparisons with expectations and other observations show good agreements for the O3 product, generally consistent with the systematic errors quoted above. In the case of CO, a persistent factor of ~2 high bias is seen at 215 hPa. However, the morphology is shown to be realistic, consistent with raw MLS radiance data, and useful for scientific study. The MLS CO data at higher altitudes are shown to be consistent with other observations
Analysis of segregated boundary-domain integral equations for mixed variable-coefficient BVPs in exterior domains
This is the post-print version of the Article. The official published version can be accessed from the link below - Copyright @ 2011 Birkhäuser Boston.Some direct segregated systems of boundary–domain integral equations (LBDIEs) associated with the mixed boundary value problems for scalar PDEs with variable coefficients in exterior domains are formulated and analyzed in the paper. The LBDIE equivalence to the original boundary value problems and the invertibility of the corresponding boundary–domain integral operators are proved in weighted Sobolev spaces suitable for exterior domains. This extends the results obtained by the authors for interior domains in non-weighted Sobolev spaces.The work was supported by the grant EP/H020497/1 ”Mathematical analysis of localised boundary-domain integral equations for BVPs with variable coefficients” of the EPSRC, UK
Anomalous fluctuations of active polar filaments
Using a simple model, we study the fluctuating dynamics of inextensible,
semiflexible polar filaments interacting with active and directed force
generating centres such as molecular motors. Taking into account the fact that
the activity occurs on time-scales comparable to the filament relaxation time,
we obtain some unexpected differences between both the steady-state and
dynamical behaviour of active as compared to passive filaments. For the
statics, the filaments have a {novel} length-scale dependent rigidity.
Dynamically, we find strongly enhanced anomalous diffusion.Comment: 5 pages, 3 figure
Maternal and infant prediction of the child BMI trajectories; studies across two generations of Northern Finland birth cohorts
Background/objective Children BMI is a longitudinal phenotype, developing through interplays between genetic and environmental factors. Whilst childhood obesity is escalating, we require a better understanding of its early origins and variation across generations to prevent it. Subjects/methods We designed a cross-cohort study including 12,040 Finnish children from the Northern Finland Birth Cohorts 1966 and 1986 (NFBC1966 and NFBC1986) born before or at the start of the obesity epidemic. We used group-based trajectory modelling to identify BMI trajectories from 2 to 20 years. We subsequently tested their associations with early determinants (mother and child) and the possible difference between generations, adjusted for relevant biological and socioeconomic confounders. Results We identified four BMI trajectories, ‘stable-low’ (34.8%), ‘normal’ (44.0%), ‘stable-high’ (17.5%) and ‘early-increase’ (3.7%). The ‘early-increase’ trajectory represented the highest risk for obesity. We analysed a dose-response association of maternal pre-pregnancy BMI and smoking with BMI trajectories. The directions of effect were consistent across generations and the effect sizes tended to increase from earlier generation to later. Respectively for NFBC1966 and NFBC1986, the adjusted risk ratios of being in the early-increase group were 1.08 (1.06–1.10) and 1.12 (1.09–1.15) per unit of pre-pregnancy BMI and 1.44 (1.05–1.96) and 1.48 (1.17–1.87) in offspring of smoking mothers compared to non-smokers. We observed similar relations with infant factors including birthweight for gestational age and peak weight velocity. In contrast, the age at adiposity peak in infancy was associated with the BMI trajectories in NFBC1966 but did not replicate in NFBC1986. Conclusions Exposures to adverse maternal predictors were associated with a higher risk obesity trajectory and were consistent across generations. However, we found a discordant association for the timing of adiposity peak over a 20-year period. This suggests the role of residual environmental factors, such as nutrition, and warrants additional research to understand the underlying gene–environment interplay
BMI in childhood and adolescence is associated with impaired reproductive function-a population-based cohort study from birth to age 50 years
Peer reviewe
The monoclinic phase of PZT ceramics: Raman and phenomenological theory studies
This work reports on the first Raman detection of the tetragonal to
monoclinic phase transition in PZT ceramics near morphotropic phase boundary at
low temperatures. The transition is characterized by changes in the frequency
of lattice modes with the temperature. The results presented here confirm the
previous one recently reported by Noheda et al. using high-resolution
synchrotron X-ray powder diffraction technique and dielectric measurements. The
stability of the new phase is discussed within the framework of
phenomenological Landau-Devonshire Theory.Comment: 6 pages including 4 figures, Latex, submitted to Applied Physics
Letter
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