30 research outputs found
Health-related quality of life of pediatric renal transplant recipients and their parents: the role of associated factors and clinical counseling
Background/aim: This study evaluates the health-related quality of life
(HRQoL) of pediatric renal transplant recipients and their parents and
investigates the effects of clinical, socioeconomic, and psychological
factors as well as continuous counseling on the HRQoL.
Materials and methods: Patients aged 8-17 years (mean: 14.9 +/- 2.9)
were enrolled. Clinical and demographic data were noted. The Beck
Depression Inventory (BDI), Rosenberg Self-Esteem Scale (RSES), and
Turkish version of the Kinder Lebensqualitat Fragebogen (KINDL)
questionnaire for children and the BDI, RSES, parent-proxy version of
KINDL, and Short-Form 36 (SF-36) for parents were applied (step 1).
Following a 1-year counseling program, the tests were repeated (step 2).
Results: Child-self and parent-proxy KINDL scores were optimal with no
difference between periods (for child-self and parent-proxy scores, P >
0.05). Parent SF-36 scores indicated optimal results. Parent RSES scores
decreased in step 2 (P < 0.05). The BDI scores were higher in parents
than children in both periods (P < 0.05 for step 1 and P < 0.01 for step
2). Higher creatinine levels, lower monthly income, and urological
comorbidities modified the HRQoL negatively in step 1.
Conclusion: Continuous education with psychosocial counseling carries
importance in improving HRQoL in the posttransplant period
Whole blood viscosity and cerebral blood flow velocities in obese hypertensive or obese normotensive adolescents.
Abstract
Background: Obesity affects all major organ systems and leads to increased morbidity and mortality. Whole blood
viscosity is an important independent regulator of cerebral blood flow. The aim of the present study was to evaluate the
effect of whole blood viscosity on cerebral artery blood flow velocities using transcranial Doppler ultrasound in pediatric patients with obesity compared to healthy controls and analyze the effect of whole blood viscosity and blood pressure status to the cerebral artery blood flow velocities.
Methods: Sixty patients with obesity diagnosed according to their body mass index (BMI) percentiles aged 13–18 years old were prospectively enrolled. They were grouped as hypertensive or normotensive according to their ambulatory blood pressure monitoring. Whole blood viscosity and middle cerebral artery velocities by transcranial Doppler ultrasound were studied and compared to 20 healthy same aged controls.
Results: Whole blood viscosity values in hypertensive (0.0619 ± 0.0077 poise) and normotensive (0.0607 ± 0.0071
poise) groups were higher than controls (0.0616 ± 0.0064 poise), with no significance. Middle cerebral artery
blood flow velocities were higher in the obese hypertensive (73.9 ± 15.0 cm/s) and obese normotensive groups (75.2 ± 13.5 cm/s) than controls (66.4 ± 11.5 cm/s), but with no statistical significance.
Conclusions: Physiological changes in blood viscosity and changes in blood pressure did not seem to have any direct
effect on cerebral blood flow velocities, the reason might be that the cerebral circulation is capable of adaptively
modulating itself to changes to maintain a uniform cerebral blood flow.
Keywords: adolescents; cerebral blood flow; children; hypertension; obesity; whole blood viscosity
Serum levels of insulin-like growth factor-I and insulin-like growth factor binding protein-3 in children with insulin-dependent diabetes mellitus
Pubertal development has recently been evaluated from the standpoint of changes in insulinlike growth factor (IGF)-I and IGF-binding protein-3 (IGFBP-3) levels in healthy children, We studied puberty related changes in serum IGF-I and IGFBP-3 levels in 24 patients (11 prepubertal) with insulin dependent diabetes mellitus (IDDM) and 26 healthy subjects (14 prepubertal), Serum IGF-I and IGFBP-3 levels were assayed using immunoradiometric assays and radioimmunoassays, respectively, Serum IGF-I and IGFBP-3 levels in diabetics did not increase during puberty, as opposed to those in healthy children, Serum IGF-I and IGFBP-3 levels of diabetic patients were found to be lower than those of control subjects during puberty (p<0.0001 and p<0.05, respectively), Proteolysis is believed to be a general mechanism to increase IGF bioavailability in the presence of IGFBPs, Increased IGFBP-3 protease activity has been shown in sera of children with IDDM as well as a decrease in this activity in response to insulin therapy, Our data displaying low IGFBP-3 levels in diabetic children may be due to increased proteolysis, which also causes a shift in IGF-I to its lower molecular weight forms. Higher rate of clearance of the latter may be the reason for the low IGF-I levels we observed in children with IDDM. The moderate correlation between insulin dose and IGFBP-3 levels (r=0.5, p<0.01) may suggest insulin to be a contributing factor in the regulation of IGFBP-3 levels, We conclude that regulation of IGF-I and IGFBP-3 concentrations is disturbed in children with IDDM, in particular during adolescence
What triggered massive hemoptysis in Goodpasture syndrome with isolated pulmonary involvement in a 14-year-old boy?
Şişmanlar-Eyüboğlu T, Aslan AT, Gezgin-Yıldırım D, Buyan N, Emeksiz S, Kalkan G. What triggered massive hemoptysis in Goodpasture syndrome with isolated pulmonary involvement in a 14-year-old boy? Turk J Pediatr 2019; 61: 611-614. Goodpasture syndrome is a rare, autoimmune disease associated with the development of antibodies against a specific antigen both in glomerular basement membrane and alveolar basement membrane. It is very rare in childhood and its incidence is not known. Although the mechanism of the disease is the same in lung as in the kidney, sometimes it presents with involvement of only one organ. Pulmonary involvement may be lifethreatening in patients with massive hemoptysis. Herein we report a 14-yearold boy with isolated lung involvement. He had massive hemoptysis following bronchoscopy and recovered succesfully with treatment
Successful treatment of a childhood synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome with subcutaneous methotrexate: A case report.
Akçaboy M, Bakkaloğlu-Ezgü SA, Büyükkaragöz B, Isıyel E, Kandur Y, Hasanoğlu E, Buyan N. Successful treatment of a childhood synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome with subcutaneous methotrexate: A case report. Turk J Pediatr 2017; 59: 184-188. SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis and osteitis) is defined as a syndrome that is related to various osteoarticular manifestations and chronic dermatological conditions especially severe acne. SAPHO syndrome is a rare and unusual clinical entity in childhood and treatment choices are variable. We report an 11-year-old girl who suffered from SAPHO syndrome and successfully treated with subcutaneous methotrexate. We report our case in order to take attention to this rare clinical condition in evaluating patients and also to point out that treatment options beyond biologic agents should be the first line treatment in childhood
Effects of whole blood viscosity and plasma NOx on cardiac function and cerebral blood flow in children with chronic kidney disease
Background/aim: The aim of the study was to investigate the effects of whole blood viscosity and plasma nitric oxide on cerebral and cardiovascular risks associated with chronic kidney disease. Materials and methods: The study group consisted of 40 pediatric patients and 21 healthy control subjects. Hematologic and biochemical variables, viscosity and plasma nitric oxide levels, echocardiographic findings, and middle cerebral artery blood flow velocity were examined. Results: Viscosity values of patients were significantly lower than those of the control group. Lower values of hematocrit, total protein, and albumin and higher values of ferritin in all patient groups resulted in significantly low viscosity levels. Plasma nitric oxide levels were higher in all patient groups than those in the controls. No statistically significant difference was present in middle cerebral artery blood flow velocity between the patient and control groups. Even when systolic functions were normal, the patient group had significant deterioration in diastolic functions, suggesting morbidity and mortality risks. Conclusions: Cerebral blood flow velocities were not affected by viscosity and nitric oxide levels, suggesting that cerebral circulation has the ability to make adaptive modulation. The metabolism of nitric oxide levels needs further investigation and studies in patients with chronic renal disease
What triggered massive hemoptysis in Goodpasture syndrome with isolated pulmonary involvement in a 14-year-old boy?
Goodpasture syndrome is a rare, autoimmune disease associated with the
development of antibodies against a specific antigen both in glomerular
basement membrane and alveolar basement membrane. It is very rare in
childhood and its incidence is not known. Although the mechanism of the
disease is the same in lung as in the kidney, sometimes it presents with
involvement of only one organ. Pulmonary involvement may be
life-threatening in patients with massive hemoptysis. Herein we report a
14-year-old boy with isolated lung involvement. He had massive
hemoptysis following bronchoscopy and recovered succesfully with
treatment
Cerebral Vasculitis in Henoch-Schönlein Purpura: A Case Report.
Henoch-Schönlein purpura is a common form of systemic small vessel vasculitis in childhood. Although headache and behavioral changes have been described in a significant proportion of children with Henoch-Schönlein purpura, severe neurological complications are rare. In this article, we report a case of central vasculitis in a four-year-old boy who presented with hemiplegia and aphasia. The treatment options for cerebral vasculitis of Henoch-Schönlein purpura are numerous but controversial in pediatric patients. Our patient was successfully treated by pulse methylprednisolone and pulse cyclophosphamide. The patient was followed-up for four years without any sequel
Successful treatment of a childhood synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome with subcutaneous methotrexate: A case report
SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis and osteitis)
is defined as a syndrome that is related to various osteoarticular
manifestations and chronic dermatological conditions especially severe
acne. SAPHO syndrome is a rare and unusual clinical entity in childhood
and treatment choices are variable. We report an 11-year-old girl who
suffered from SAPHO syndrome and successfully treated with subcutaneous
methotrexate. We report our case in order to take attention to this rare
clinical condition in evaluating patients and also to point out that
treatment options beyond biologic agents should be the first line
treatment in childhood
Post-transplant glucose status in 61 pediatric renal transplant recipients: Preliminary results of five Turkish pediatric nephrology centers
To assess the incidence, risk factors and outcomes of PTDM, a total of 61 non-diabetic children (24 girls, 37 boys, age: 14.5 +/- 2.1 yr) were examined after their first kidney transplantation (37.3 +/- 21.6 months) with an OGTT. At baseline, 16 (26.2%) patients had IGT, 45 (73.8%) had NGT, and no patient had PTDM. No significant difference was shown between TAC- and CSA-treated patients in terms of IGT. Higher BMI z-scores (p = 0.011), LDL-cholesterol (p < 0.05) and triglyceride levels (p < 0.01), HOMA-IR (p = 0.013) and lower HOMA-%beta (p = 0.011) were significantly associated with IGT. Fifty-four patients were re-evaluated after six months; eight patients with baseline IGT (50%) improved to NGT, three (19%) developed PTDM requiring insulin therapy, five (31%) remained with IGT, and four patients progressed from NGT to either IGT (two) or PTDM (two). These 12 progressive patients had significantly higher total cholesterol (p < 0.05), triglycerides (p < 0.05), HOMA-IR (p < 0.01) and lower HOMA-%beta (p < 0.0) than non-progressive patients at baseline. We can conclude that post-transplantation glucose abnormalities are common in Turkish pediatric kidney recipients, and higher BMI z-scores and triglyceride concentrations are the main risk factors. Considering that the progressive patients are significantly more insulin resistant at baseline, we suggest that the utility of both HOMA-IR and HOMA-%beta in predicting future risk of PTDM and/or IGT should be evaluated in children