Design and implementation of a wideband sigma delta ADC

Abstract. High-speed and wideband ADCs have become increasingly important in response to the growing demand for high-speed wireless communication services. Continuous time sigma delta modulators (CTƩ∆M), well-known for their oversampling and noise shaping properties, offer a promising solution for low-power and high-speed design in wireless applications. The objective of this thesis is to design and implement a wideband CTƩ∆M for a global navigation satellite system(GNSS) receiver. The targeted modulator architecture is a 3rdorder single-bit CTƩ∆M, specifically designed to operate within a 15 MHz signal bandwidth. With an oversampling ratio of 25, the ADC’s sampling frequency is set at 768 MHz. The design goal is to achieve a theoretical signal to noise ratio (SNR) of 55 dB. This thesis focuses on the design and implementation of the CTƩ∆M, building upon the principles of a discrete time Ʃ∆ modulator, and leveraging system-level simulation and formulations. A detailed explanation of the coefficient calculation procedure specific to CTƩ∆ modulators is provided, along with a "top-down" design approach that ensures the specified requirements are met. MATLAB scripts for coefficient calculation are also included. To overcome the challenges associated with the implementation of CTƩ∆ modulators, particularly excess loop delay and clock jitter sensitivity, this thesis explores two key strategies: the introduction of a delay compensation path and the utilization of a finite impulse response (FIR) feedback DAC. By incorporating a delay compensation path, the stability of the modulator can be ensured and its noise transfer function (NTF) can be restored. Additionally, the integration of an FIR feedback DAC addresses the issue of clock jitter sensitivity, enhancing the overall performance and robustness of the CTƩ∆M. The CTƩ∆Ms employ the cascade of integrators with feed forward (CIFF) and cascade of integrators with feedforward and feedback (CIFF-B) topologies, with a particular emphasis on the CIFF-B configuration using 22nm CMOS technology node and a supply voltage of 0.8 V. Various simulations are performed to validate the modulator’s performance. The simulation results demonstrate an achievable SNR of 55 dB with a power consumption of 1.36 mW. Furthermore, the adoption of NTF zero optimization techniques enhances the SNR to 62 dB.Laajakaistaisen jatkuva-aikaisen sigma delta-AD-muuntimen suunnittelu ja toteutus. Tiivistelmä. Nopeat ja laajakaistaiset AD-muuntimet ovat tulleet entistä tärkeämmiksi nopeiden langattomien kommunikaatiopalvelujen kysynnän kasvaessa. Jatkuva-aikaiset sigma delta -modulaattorit (CTƩ∆M), joissa käytetään ylinäytteistystä ja kohinanmuokkausta, tarjoavat lupaavan ratkaisun matalan tehonkulutuksen ja nopeiden langattomien sovellusten suunnitteluun. Tämän työn tarkoituksena on suunnitella ja toteuttaa laajakaistainen jatkuva -aikainen sigma delta -modulaattori satelliittipaikannusjärjestelmien (GNSS) vastaanottimeen. Arkkitehtuuriltaan modulaattori on kolmannen asteen 1-bittinen CTƩ∆M, jolla on 15MHz:n signaalikaistanleveys. Ylinäytteistyssuhde on 25 ja AD muuntimen näytteistystaajuus 768 MHz. Tavoitteena on saavuttaa teoreettinen 55 dB signaalikohinasuhde (SNR). Tämä työ keskittyy jatkuva-aikaisen sigma delta -modulaattorin suunnitteluun ja toteutukseen, perustuen diskreettiaikaisen Ʃ∆-modulaattorin periaatteisiin ja systeemitason simulointiin ja mallitukseen. Jatkuva-aikaisen sigma delta -modulaattorin kertoimien laskentamenetelmä esitetään yksityiskohtaisesti, ja vaatimusten täyttyminen varmistetaan “top-down” -suunnitteluperiaatteella. Liitteenä on kertoimien laskemiseen käytetty MATLAB-koodi. Jatkuva-aikaisten sigma delta -modulaattoreiden erityishaasteiden, liian pitkän silmukkaviiveen ja kellojitterin herkkyyden, voittamiseksi tutkitaan kahta strategiaa, viiveen kompensointipolkua ja FIR takaisinkytkentä -DA muunninta. Viivekompensointipolkua käyttämällä modulaattorin stabiilisuus ja kohinansuodatusfunktio saadaan varmistettua ja korjattua. Lisäksi FIR takaisinkytkentä -DA-muuntimen käyttö pienentää kellojitteriherkkyyttä, parantaen jatkuva aikaisen sigma delta -modulaattorin kokonaissuorituskykyä ja luotettavuutta. Toteutetuissa jatkuva-aikaisissa sigma delta -modulaattoreissa on kytketty peräkkäin integraattoreita myötäkytkentärakenteella (CIFF) ja toisessa sekä myötä- että takaisinkytkentärakenteella (CIFF-B). Päähuomio on CIFF-B rakenteessa, joka toteutetaan 22nm CMOS prosessissa käyttäen 0.8 voltin käyttöjännitettä. Suorityskyky varmistetaan erilaisilla simuloinneilla, joiden perusteella 55 dB SNR saavutetaan 1.36 mW tehonkulutuksella. Lisäksi kohinanmuokkausfunktion optimoinnilla SNR saadaan nostettua 62 desibeliin

In vitro inhibition of Helicobacter pylori urease with non and semi fermented Camellia sinensis

Purpose: Helicobacter pylori is the etiological agent in duodenal and peptic ulcers. The growing problem of antibiotic resistance by the organism demands the search for novel compounds, especially from natural sources. This study was conducted to evaluate the effect of Camellia sinensis extracts on the urease enzyme that is a major colonization factor for H. pylori. Methods: Minimum inhibitory concentrations of nonfermented and semifermented C. sinensis methanol: water extracts were assessed by broth dilution method. Examination of the urease function was performed by Mc Laren method, and urease production was detected on 12% SDS polyacrylamide gel electrophoresis from whole cell and membrane bound proteins. Results: Both extracts had inhibitory effects against H. pylori and urease production. At a concentration of 2.5 mg/ml of nonfermented extract and 3.5 mg/ml of semifermented extract the production of Ure A and Ure B subunits of the urease enzyme were inhibited completely. A concentration of 4 mg/ml of nonfermented and 5.5 mg/ml of semifermented extract were bactericidal for H. pylori. Conclusions: C. sinensis extracts, especially the nonfermented, could reduce H. pylori population and inhibit urease production at lower concentrations. The superior effect of nonfermented extract is due to its rich polyphenolic compounds and catechin contents

Graphite furnace atomic absorption spectrometric determination of cadmium after solid-liquid extraction with dithizone

A method for the determination of trace amount of cadmium ion after preconcentration by extracting its dithizone complex into molten naphthalene was developed. Several experimental conditions such as pH of the solution, stirring time, the amounts of naphthalene, standing time and volume of the solution were optimized. Trace amount of cadmium ion in aqueous solution of sample was chelated with 5 mL of 0.001 M dithizone at pH 8. After addition of 0.15 g naphthalene, the solution was heated to about 85 oC and stirred (800rpm) for 2 min to reproduce the microcrystalline naphthalene. Cadmium ion was determined by a graphite furnace atomic absorption spectrometer. The interfering effects of diverse concomitant ions (cations and anions) wereinvestigated. Artificial sea water and a standard reference material (SRM) were analyzed by this method. The sensitivity and detection limit of 1.2 ngL-1 and 1.5 ng L-1 were found, respectively

Vasopressin attenuates ischemia-reperfusion injury via reduction of oxidative stress and inhibition of mitochondrial permeability transition pore opening in rat hearts

Aim of this study was to investigate the involvement of the mitochondrial permeability transition pore (MPTP) and oxidative stress in the cardioprotective effect of vasopressin (AVP) on ischemia/reperfusion (I/R) injury. Anesthetized male wistar rats were subjected to regional 30 min ischemia and 120 min reperfusion and randomly divided into nine groups: (1) Control; saline was administered intravenously before ischemia, (2) vasopressin was administrated 10 min prior to ischemia, (3, 4) Atractyloside as MPTP opener, was injected 5 min prior to reperfusion without and with vasopressin, (5, 6) Cyclosporine A as a MPTP closer, was injected 5 min prior to reperfusion without and with vasopressin, (7) mitochondria were isolated from control group and CaCl2 was added as MPTP opener and swelling inducer, (8) isolated mitochondria from Control hearts was incubated with Cyclosporine A before adding the CaCl2 (9) CaCl2 was added to isolated mitochondria from vasopressin group. Infusion of vasopressin decreased infarct size (18.6±1.7% vs. control group 37.6±2.4%), biochemical parameters [LDH (Lactate Dehydrogenase), CK-MB (Creatine Kinase-MB) and MDA (Malondialdehyde) plasma levels, PAB (Prooxidant-antioxidant balance)] compared to control group. Atactyloside suppressed the cardioprotective effect of vasopressin (32.5±1.9% vs. 18.6±1.7%) but administration of the Cyclosporine A without and with vasopressin significantly reduced infarct size to 17.7±4% (P<0.001) and 22.7±3% (P<0.01) respectively, vs. 37.6±2.4% in control group. Also, vasopressin, similar to Cyclosporine A, led to decrease in CaCl2-induced swelling. It seems that vasopressin through antioxidant effect and MPTP inhibition has created a cardioprotection against ischemia/reperfusion injuries. © 2015 Elsevier B.V. All rights reserved

Analysis of development levels in the cities of Tehran province regarding health infrastructural index: The strategy of standardized score and Morris' inequality index

Background: One of the main indexes of development is health index or the degree to which a society enjoys health and therapeutic services. The present study was done with the aim to analyze development levels in cities in Tehran regarding health infrastructural index using the standardized score and Morris' model. Methods: This is a descriptive and pragmatic study which ranks 14 cities in Tehran province using the standardized score and Morris' models based on 10 selected health indexes. The required data were gathered using a researcher-made information list and the information gathered from the Statistics Center and Tehran University of Medical Sciences. The data were analyzed using Excel software. Results: The development coefficient in the studied cities varies from 0.595 to -0.379 so that Rey city has the highest level of development and Pishva city has the lowest level of development among the studied cities. The more number of the cities (43) was among the rather undeveloped group and none of the cities (0) was in the rather developed group. Conclusion: Regarding the findings, there is a big gap and difference regarding enjoying health and therapeutic infrastructural indexes among the cities in Tehran province. Therefore, it is suggested that development-oriented plans consistentent with development levels should be implemented in these cities

Predicting compressive strength of different geopolymers by artificial neural networks

In the present study,six different models based on artificial neural networks have been developed to predict the compressive strength of different types of geopolymers.The differences between the models were in the number of neurons in hidden layers and in the method of finalizing the models.Seven independent input parameters that cover the curing time,Ca(OH)2 content, the amount of superplasticizer, NaOH concentration,mold type,geopolymer type and H2O/Na2O molar ratio were considered.For each set of these input variables,the compressive strength of geopolymers was obtained.A total number of 399 input-target pairs were collected from the literature, randomly divided into 279,60 and 60data and were trained,validated and tested, respectively. The best performance model was obtained through a network with two hidden layers and absolute fraction of variance of 0.9916, the absolute percentage error of 2.2102 and the root mean square error of 1.4867 in training phase. Additionally,the entire trained,validated and tested network showed a strong potential for predicting the compressives trength of geopolymers with a reasonable performance in the considered range