Extending the Real-Time Maude Semantics of Ptolemy to Hierarchical DE Models

This paper extends our Real-Time Maude formalization of the semantics of flat Ptolemy II discrete-event (DE) models to hierarchical models, including modal models. This is a challenging task that requires combining synchronous fixed-point computations with hierarchical structure. The synthesis of a Real-Time Maude verification model from a Ptolemy II DE model, and the formal verification of the synthesized model in Real-Time Maude, have been integrated into Ptolemy II, enabling a model-engineering process that combines the convenience of Ptolemy II DE modeling and simulation with formal verification in Real-Time Maude.Comment: In Proceedings RTRTS 2010, arXiv:1009.398

Enterprise Architecture as Strategic Enabler in ESG Transition and Resilience

This study positions Enterprise Architecture (EA) as a strategic enabler for harmonizing organizational strategies, processes, and technologies with Environmental, Social, and Governance (ESG) goals for organizational resilience amid fragmented initiatives that often lead to systemic risks and inefficiencies. Grounded in stakeholder theory, institutional theory, and the resource-based view, we propose a framework where EA maturity enhances ESG performance through adaptive governance and stakeholder balance. Drawing from Australian case studies and global ESG challenges, we employ a mixed-methods approach to test hypotheses that EA maturity embeds ESG goals across business, information systems and technology layers, resolving trade-offs like renewable energy deployment versus biodiversity preservation. Regulatory pressures moderate these relationships, while stakeholder interest mediates, and EA capabilities mitigate conflicts. This emerging research offers a pragmatic roadmap for organizations to navigate complex environments, integrating ESG into their core for coherent, resilient, and equitable value creation

Enterprise Architecture Practice and Challenges in Achieving Sustainable Digital Transformation in Developing Countries

Information and communication technology (ICT) is crucial for enhancing organisations\u27 economic, environmental, and social sustainability, while Enterprise Architecture (EA) supports developing and managing organisational ICT resources. However, since established EA standards and frameworks are primarily deployed in the context of developed countries, there is a need to understand the unique cultural, institutional, and resource constraints developing countries face in implementing EA. This empirical study investigates EA\u27s current practices and challenges in developing countries, specifically Bangladesh, to support sustainable digital transformation. The research contributes to the EA understanding and sustainable digital transformation through literature analysis and interviews with professionals from diverse industries. The findings highlight a lack of understanding of EA among organisations striving to integrate environment, social and governance (ESG) factors into sustainability and ICT deployments. This study offers implications to research and practice related to challenges in practising EA in developing countries to support digital transformation and sustainability

The Role of Enterprise Architecture in Ensuring ESG Factors for Sustainability

Organisations increasingly recognise the importance of environmental, social, and governance (ESG) aspects for ensuring organisational and global sustainability. Digital transformation is helping organisations to integrate ESG factors into their operations and leverage information technology for economic, social, and environmental benefits. Enterprise architecture (EA) is a strategic approach that integrates business objectives with information technology systems and infrastructure to align with organisational goals and enable effective management, governance, and decision-making. Despite the growing recognition of the significance of ESG factors in promoting sustainable business practices, there are still obstacles to assuring ESG for organisational sustainability. The article explores the key issues in incorporating ESG factors for organisational sustainability and suggests ways EA can help address these challenges. The paper also proposes a conceptual design for the role of EA in ensuring ESG factors for organisational sustainability

EFFECT OF SEASONAL AND GEOGRAPHICAL VARIATION ON THE PHYTOCONSTITUENTS AND MEDICINAL PROPERTIES OF TRIBULUS TERRESTRIS

Abstract: Seasonal and geographical variations have impact on secondary plant metabolites in medicinal plants. In the present study an attempt was made to evaluate the phytochemical variation and its effect on the medicinal properties of Tribulus terrestris which was collected from two different seasons (Summer and winter) and from two different geographical regions i.e. Rafha, and Riyadh, Saudi Arabia (hot desert climate) and Bangalore, India (tropical savanna climate).The amount of Phenolic acids and flavonoids was evaluated by Folin ciocalteu method and Aluminum chloride colorimetric method respectively. Anti-oxidant activity was carried out for all the extracts by the DPPH method .The results revealed that the amount of phenolic acid and flavonoid was found to be higher i.e. 428 μgm and 295 μgm respectively in TT1-S which was in the sample collected during summer from the Rafha region. To further investigate the best season of collection of samples in Rafha, HPLC analysis was carried out for TT1-S and TT1 –W extracts using rutin and gallic acid as the standards; the amount of rutin and gallic acid was found to be higher in TT1-S. Furthermore analgesic activity was carried out for these extracts and the sample collected during summer exhibited significant activity when compared to the sample collected during winter. The results of this study give evidence that the season and geographical variations bring about a change in the plant metabolites which in turn affect the medicinal properties .From the results it is evident that the best season to collect the plant is during summer in Rafha as the amount of phytoconstituents is found to be more during this season Key words: Tribulus terrestris, seasonal, geographical, phytoconstituents, medicinal propertie

Effect of Soluble Epoxide Hydrolase on the Modulation of Coronary Reactive Hyperemia: Role of Oxylipins and PPARγ

Coronary reactive hyperemia (CRH) is a physiological response to ischemic insult that prevents the potential harm associated with an interruption of blood supply. The relationship between the pharmacologic inhibition of soluble epoxide hydrolase (sEH) and CRH response to a brief ischemia is not known. sEH is involved in the main catabolic pathway of epoxyeicosatrienoic acids (EETs), which are converted into dihydroxyeicosatrienoic acids (DHETs). EETs protect against ischemia/reperfusion injury and have numerous beneficial physiological effects. We hypothesized that inhibition of sEH by t-AUCB enhances CRH in isolated mouse hearts through changing the oxylipin profiles, including an increase in EETs/DHETs ratio. Compared to controls, t-AUCB–treated mice had increased CRH, including repayment volume (RV), repayment duration, and repayment/debt ratio (p \u3c 0.05). Treatment with t-AUCB significantly changed oxylipin profiles, including an increase in EET/DHET ratio, increase in EpOME/DiHOME ratio, increase in the levels of HODEs, decrease in the levels of mid-chain HETEs, and decrease in prostanoids (p \u3c 0.05). Treatment with MS-PPOH (CYP epoxygenase inhibitor) reduced CRH, including RV (p \u3c 0.05). Involvement of PPARγ in the modulation of CRH was demonstrated using a PPARγ-antagonist (T0070907) and a PPARγ-agonist (rosiglitazone). T0070907 reduced CRH (p \u3c 0.05), whereas rosiglitazone enhanced CRH (p \u3c 0.05) in isolated mouse hearts compared to the non-treated. These data demonstrate that sEH inhibition enhances, whereas CYP epoxygenases-inhibition attenuates CRH, PPARγ mediate CRH downstream of the CYP epoxygenases-EET pathway, and the changes in oxylipin profiles associated with sEH-inhibition collectively contributed to the enhanced CRH