Dark Matter Constraints on Composite Higgs Models

In composite Higgs models the pseudo-Nambu-Goldstone Boson (pNGB) nature of the Higgs field is an interesting alternative for explaning the smallness of the electroweak scale with respect to the beyond the Standard Model scale. In non-minimal models additional pNGB states are present and can be a Dark Matter (DM) candidate, if there is an approximate symmetry suppressing their decay. Here we assume that the low energy effective theory (for scales much below the compositeness scale) corresponds to the Standard Model with a pNGB Higgs doublet and a pNGB DM multiplet. We derive general effective DM Lagrangians for several possible DM representations (under the SM gauge group), including the singlet, doublet and triplet cases. Within this framework we discuss how the DM observables (relic abundance, direct and indirect detection) constrain the dimension-6 operators induced by the strong sector assuming that DM behaves as a Weakly Interacting Particle (WIMP) and that the relic abundance is settled through the freeze-out mechanism. We also apply our general results to two specific cosets: $SO(6)/SO(5)$ and $SO(6)/SO(4) \times SO(2)$, which contain a singlet and doublet DM candidate, respectively. In particular we show that if compositeness is a solution to the little hierarchy problem, representations larger than the triplet are strongly disfavored. Furthermore, we find that composite models can have viable DM candidates with much smaller direct detection cross-sections than their non-composite counterparts, making DM detection much more challenging.Comment: version accepted by JHE

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

The Elephant in the Room: A Systematic Review of the Application and Effects of Psychological Treatments for Pregnant Women with Dual Pathology (Mental Health and Substance-Related Disorders)

Abstract: Purpose: Maternal mental health and substance use, referred to as dual pathology, represent significant concerns associated with adverse pregnancy and birth outcomes, a prevalence higher than commonly anticipated. Nonetheless, a notable dearth exists ofevidence-based treatment protocols tailored for pregnant women with dual pathology. Methods: A systematic review, adhering to the PRISMA methodology, was conducted. Results: Out of the 57 identified papers deemed potentially relevant, only 2were ultimately included. Given the limited number of studies assessing the efficacy of psychological interventions utilizing randomized controlled trials (RCTs) for both mental health and substance misuse, and considering the diverse objectives and measures employed, definitive conclusions regarding the effectiveness of psychological interventions in this domain prove challenging. Conclusions: Maternal mental health appears to be the proverbial “elephant in the room”. The development of specialized and integrated interventions stands as an imperative to effectively address this pressing issue. As elucidated in the present review, these interventions ought to be grounded in empirical evidence. Furthermore, it is essential that such interventions undergo rigorous evaluation through RCTs to ascertain their efficacy levels. Ultimately, the provision of these interventions by psychology/psychiatric professionals, both within clinical practice and the RCTs themselves, is recommended to facilitate the generalizability of the results to specialized settings.2023-2

Dark Matter Constraints on Composite Higgs Models

info:eu-repo/semantics/publishe